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caLIBRAte SIGNED

Performance testing, calibration and implementation of a next generation system-of-systems Risk Governance Framework for nanomaterials

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

caLIBRAte project word cloud

Explore the words cloud of the caLIBRAte project. It provides you a very rough idea of what is the project "caLIBRAte" about.

safety anticipated generation quantitative environmental framework gate levels models banding scope tools calibrate risks model apparent computational regards stakeholders reg iso31000 performance assessments exposure nanotechnology designed decision risk screening nmp30 again mns safe web demonstrated followed linking versatile guidance mn governance perceived tested innovation nanomaterials training sensitivity revision toxicology 2015 surveillance demonstration human predictive stage calibration receive answers subject criteria matching enabled qualitative documents cooper

Project "caLIBRAte" data sheet

The following table provides information about the project.

Coordinator	DET NATIONALE FORSKNINGSCENTER FORARBEJDSMILJO Organization address address: LERSO PARKALLE 105 city: KOBENHAVN postcode: 2100 website: www.nrcwe.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Denmark [DK]
Project website	http://www.nanocalibrate.eu/
Total cost	9˙828˙106 €
EC max contribution	7˙999˙687 € (81%)
Programme	1. H2020-EU.2.1.2.2. (Ensuring the safe and sustainable development and application of nanotechnologies)
Code Call	H2020-NMP-2015-two-stage
Funding Scheme	RIA
Starting year	2016
Duration (year-month-day)	from 2016-05-01 to 2019-10-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	DET NATIONALE FORSKNINGSCENTER FORARBEJDSMILJO DET NATIONALE FORSKNINGSCENTER FORARBEJDSMILJO Organization address address: LERSO PARKALLE 105 city: KOBENHAVN postcode: 2100 website: www.nrcwe.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KOBENHAVN)	coordinator	1˙758˙981.00
2	STEINBEIS ADVANCED RISK TECHNOLOGIES GMBH STEINBEIS ADVANCED RISK TECHNOLOGIES GMBH Organization address address: FANGELSBACHSTRASSE 14 city: STUTTGART postcode: 70178 website: www.risk-technologies.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (STUTTGART)	participant	637˙500.00
3	UNITED KINGDOM RESEARCH AND INNOVATION UNITED KINGDOM RESEARCH AND INNOVATION Organization address address: POLARIS HOUSE NORTH STAR AVENUE city: SWINDON postcode: SN2 1FL website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SWINDON)	participant	502˙910.00
4	DANMARKS TEKNISKE UNIVERSITET DANMARKS TEKNISKE UNIVERSITET Organization address address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A city: KGS LYNGBY postcode: 2800 website: www.dtu.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KGS LYNGBY)	participant	474˙990.00
5	KAROLINSKA INSTITUTET KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	462˙770.00
6	DIALOGIK GEMEINNUETZIGE GESELLSCHAFT FUER KOMMUNIKATIONS- UND KOOPERATIONSFORSCHUNG mbH DIALOGIK GEMEINNUETZIGE GESELLSCHAFT FUER KOMMUNIKATIONS- UND KOOPERATIONSFORSCHUNG mbH Organization address address: Lerchenstraße 22 city: STUTTGART postcode: 70176 website: www.dialogik-expert.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (STUTTGART)	participant	411˙125.00
7	TYOTERVEYSLAITOS TYOTERVEYSLAITOS Organization address address: TOPELIUKSENKATU 41 B city: HELSINKI postcode: 250 website: www.ttl.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (HELSINKI)	participant	379˙825.00
8	RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU Organization address address: Antonie Van Leeuwenhoeklaan 9 city: BILTHOVEN postcode: 3721 MA website: www.rivm.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (BILTHOVEN)	participant	376˙382.00
9	ACONDICIONAMIENTO TARRASENSE ASSOCIACION ACONDICIONAMIENTO TARRASENSE ASSOCIACION Organization address address: CARRER DE LA INNOVACIO 2 city: TERRASSA postcode: 8225 website: www.leitat.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (TERRASSA)	participant	363˙425.00
10	TAMPEREEN KORKEAKOULUSAATIO SR TAMPEREEN KORKEAKOULUSAATIO SR Organization address address: KALEVANTIE 4 city: TAMPERE postcode: 33100 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (TAMPERE)	participant	357˙555.00
11	NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO Organization address address: ANNA VAN BUERENPLEIN 1 city: DEN HAAG postcode: 2595 DA website: www.tno.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (DEN HAAG)	participant	336˙957.00
12	MISVIK BIOLOGY OY MISVIK BIOLOGY OY Organization address address: KARJAKATU 35 B city: TURKU postcode: 20520 website: www.misvik.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (TURKU)	participant	326˙507.00
13	INSTITUT NATIONAL DE L ENVIRONNEMENT ET DES RISQUES INERIS INSTITUT NATIONAL DE L ENVIRONNEMENT ET DES RISQUES INERIS Organization address address: Parc Technologique Alata city: VERNEUIL EN HALATTE postcode: 60550 website: www.ineris.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (VERNEUIL EN HALATTE)	participant	299˙115.00
14	FUNDACION GAIKER FUNDACION GAIKER Organization address address: PARQUE TECNOLOGICO DE VIZCAYA, EDIFICIO 202 city: ZAMUDIO postcode: 48170 website: www.gaiker.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (ZAMUDIO)	participant	297˙276.00
15	HELSINGIN YLIOPISTO HELSINGIN YLIOPISTO Organization address address: YLIOPISTONKATU 3 city: HELSINGIN YLIOPISTO postcode: 14 website: www.helsinki.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (HELSINGIN YLIOPISTO)	participant	269˙625.00
16	NANOTECHNOLOGY INDUSTRIES ASSOCIATION NANOTECHNOLOGY INDUSTRIES ASSOCIATION Organization address address: AVENUE DE TERVUEREN 143 city: BRUXELLES postcode: 1150 website: www.nanotechia.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BRUXELLES)	participant	237˙212.00
17	GREENDECISION SRL GREENDECISION SRL Organization address address: VIA TORINO 155/A city: VENEZIA postcode: 30172 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (VENEZIA)	participant	179˙630.00
18	ASSOCIAZIONE ITALIANA PER LA RICERCA INDUSTRIALE - AIRI ASSOCIAZIONE ITALIANA PER LA RICERCA INDUSTRIALE - AIRI Organization address address: Viale Gorizia 25C city: ROMA postcode: 198 website: www.airi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	participant	169˙375.00
19	UNIVERSITA CA' FOSCARI VENEZIA UNIVERSITA CA' FOSCARI VENEZIA Organization address address: DORSODURO 3246 city: VENEZIA postcode: 30123 website: www.unive.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (VENEZIA)	participant	158˙525.00
20	DUKE UNIVERSITY DUKE UNIVERSITY Organization address address: ALLEN BUILDING 207 city: DURHAM NC postcode: 27708 website: www.duke.edu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (DURHAM NC)	participant	0.00
21	EIDGENOESSISCHE ANSTALT FUER WASSERVERSORGUNG ABWASSERREINIGUNG UND GEWAESSERSCHUTZ EIDGENOESSISCHE ANSTALT FUER WASSERVERSORGUNG ABWASSERREINIGUNG UND GEWAESSERSCHUTZ Organization address address: UBERLANDSTRASSE 133 city: DUBENDORF postcode: 8600 website: www.eawag.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (DUBENDORF)	participant	0.00
22	EIDGENOSSISCHE MATERIALPRUFUNGS- UND FORSCHUNGSANSTALT EIDGENOSSISCHE MATERIALPRUFUNGS- UND FORSCHUNGSANSTALT Organization address address: UEBERLANDSTRASSE 129 city: DUBENDORF postcode: 8600 website: www.empa.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (DUBENDORF)	participant	0.00
23	NATIONAL HEALTH LABORATORY SERVICES NATIONAL HEALTH LABORATORY SERVICES Organization address address: MODDERFONTEIN ROAD 1 GAUTENG city: SANDRINGHAM postcode: 2131 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ZA (SANDRINGHAM)	participant	0.00
24	NATURAL ENVIRONMENT RESEARCH COUNCIL NATURAL ENVIRONMENT RESEARCH COUNCIL Organization address address: Polaris House, North Star Avenue city: SWINDON WILTSHIRE postcode: SN2 1EU website: http://www.nerc.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SWINDON WILTSHIRE)	participant	0.00
25	RESEARCH TRIANGLE INSTITUTE RESEARCH TRIANGLE INSTITUTE Organization address address: CORNWALLIS ROAD 3040 city: RESEARCH TRIANGLE PARK postcode: 27709 website: www.rti-hs.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (RESEARCH TRIANGLE PARK)	participant	0.00
26	TTY-SAATIO TTY-SAATIO Organization address address: KORKEAKOULUNKATU 10 city: TAMPERE postcode: 33720 website: www.tut.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (TAMPERE)	participant	0.00

Map

Project objective

The objective of the caLIBRAte project is to establish a state-of-the-art versatile Risk Governance framework for assessment and management of human and environmental risks of MN and MN-enabled products. The framework will be a web-based “system-of-systems” linking different models and methods for: 1) screening of apparent and perceived risks and trends in nanotechnology, 2) control banding, qualitative and fully integrated predictive quantitative risk assessment operational at different information levels, 3) safety-by-design and multi-criteria decision support methods, 4) risk surveillance, -management and -guidance documents. The risk management framework will support assessments of emerging and existing MN and MN-enabled products following the recent ISO31000 risk governance framework, as well as safety in innovation by matching models to the principle innovation steps in the “Cooper Stage-Gate®” product innovation model Control banding tools and quantitative models will be subject to sensitivity analysis and performance testing followed by a revision as needed. After revision the models will again be analyzed by sensitivity testing, calibration, performance tested to establish the uncertainties. After calibration, the models will be part of the framework, which will be demonstrated by case studies. Stakeholders will be involved for defining the user requirements of the framework and will receive training in the framework at the end. The caLIBRAte project proposal answers to the call of NMP30-2015: Next generation tools for risk governance of MNs. The project is specifically designed to address the key challenges defined in the scope of the call text. There is particular focus on model revision, calibration and demonstration of existing models and methods that support the risk governance framework in regards to safe innovation and already implemented nanomaterials. Next generation computational exposure assessment and -toxicology is anticipated in the framework

Deliverables

List of deliverables.
caLIBRAte summary report of annual dissemination and communication activities	Documents, reports	2020-03-17 15:11:12
Review article with completed evaluation and guidance on prioritisation of innovative hazard exposure and risk assessment models towards applications in the stage-gate model	Websites, patent fillings, videos etc.	2020-03-17 15:11:12
caLIBRAte decision support tools	Other	2020-03-17 15:11:12
D.3.3 Report on improvements of environmental risk assessment models and user guidance	Documents, reports	2020-03-17 15:11:12
Integrated HRA models, in the format of a suite of computational models and written guidance documentation	Other	2020-03-17 15:11:12
Project webinars on project website and social media	Websites, patent fillings, videos etc.	2020-03-17 15:11:12
Results of gap analysis	Documents, reports	2020-03-17 15:11:12
Report addressing the compilation of omics data sets, network inference and benchmarks for gap identification	Documents, reports	2020-03-17 15:11:12
Plan for dissemination, implementation and exploitation	Documents, reports	2020-03-17 15:11:12
Comprehensive analysis of available tools and methodologies for Horizon Scanning	Documents, reports	2020-03-17 15:11:11
Inventory of existing value-chain case-studies	Documents, reports	2020-03-17 15:11:11
caLIBRAte logo and website	Websites, patent fillings, videos etc.	2020-03-17 15:11:11
Document on quality criteria for data	Documents, reports	2020-03-17 15:11:11

Take a look to the deliverables list in detail: detailed list of caLIBRAte deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	C. Ribalta, A. LÃ³pez-Lilao, S. EstupiÃ±Ã¡, A.S. Fonseca, A. TobÃas, A. GarcÃa-Cobos, M.C. MinguillÃ³n, E. Monfort, M. Viana Health risk assessment from exposure to particles during packing in working environments published pages: 474-487, ISSN: 0048-9697, DOI: 10.1016/j.scitotenv.2019.03.347	Science of The Total Environment 671	2020-03-17
2019	Neeraj Shandilya, Eelco Kuijpers, Ilse Tuinman, Wouter Fransman Powder Intrinsic Properties as Dustiness Predictor for an Efficient Exposure Assessment? published pages: 1029-1045, ISSN: 2398-7308, DOI: 10.1093/annweh/wxz065	Annals of Work Exposures and Health 63/9	2020-03-17
2019	Henning Wigger, Delphine Kawecki, Bernd Nowack, VÃ©ronique Adam Systematic consideration of parameter uncertainty and variability in probabilistic species sensitivity distributions published pages: , ISSN: 1551-3777, DOI: 10.1002/ieam.4214	Integrated Environmental Assessment and Management	2020-03-17
2019	Yaping Cai, Bernd Nowack, Henning Wigger Identifying ecotoxicological descriptors to enable predictive hazard assessments of nano-TiO2 from a meta-analysis of ecotoxicological data published pages: 100180, ISSN: 2452-0748, DOI: 10.1016/j.impact.2019.100180	NanoImpact 15	2020-03-17
2018	Marvin Martens, Tim Verbruggen, Penny Nymark, Roland GrafstrÃ¶m, Lyle D. Burgoon, Hristo Aladjov, Fernando Torres AndÃ³n, Chris T. Evelo, Egon L. Willighagen Introducing WikiPathways as a Data-Source to Support Adverse Outcome Pathways for Regulatory Risk Assessment of Chemicals and Nanomaterials published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2018.00661	Frontiers in Genetics 9	2020-03-17
2019	Khara Grieger, Jacob L. Jones, Steffen Foss Hansen, Christine Ogilvie Hendren, Keld Alstrup Jensen, Jennifer Kuzma, Anders Baun Best practices from nano-risk analysis relevant for other emerging technologies published pages: 998-1001, ISSN: 1748-3387, DOI: 10.1038/s41565-019-0572-1	Nature Nanotechnology 14/11	2020-03-17
2018	Ana S. Fonseca, Eelco Kuijpers, Kirsten I. Kling, Marcus Levin, Antti J. Koivisto, Signe H. Nielsen, W. Fransman, Yijri Fedutik, Keld A. Jensen, Ismo K. Koponen Particle release and control of worker exposure during laboratory-scale synthesis, handling and simulated spills of manufactured nanomaterials in fume hoods published pages: , ISSN: 1388-0764, DOI: 10.1007/s11051-018-4136-3	Journal of Nanoparticle Research 20/2	2020-03-17
2018	Henning Wigger, Wendel Wohlleben, Bernd Nowack Redefining environmental nanomaterial flows: consequences of the regulatory nanomaterial definition on the results of environmental exposure models published pages: 1372-1385, ISSN: 2051-8153, DOI: 10.1039/c8en00137e	Environmental Science: Nano 5/6	2020-03-17
2019	Andrea Porcari, Elisabetta Borsella, Christina Benighaus, Khara Grieger, Panagiotis Isigonis, Somik Chakravarty, Pete Kines & Keld Alstrup Jensen From risk perception to risk governance in nanotechnology: a multi-stakeholder study published pages: , ISSN: 1388-0764, DOI:	Journal of Nanoparticle Research 2019, 21: 245	2020-03-17
2019	Michael Burkard, Alexander Betz, Kristin Schirmer, Anze Zupanic Common gene expression patterns in environmental model organisms exposed to engineered nanomaterials: a meta-analysis published pages: , ISSN: 0013-936X, DOI: 10.1021/acs.est.9b05170	Environmental Science & Technology	2020-03-17
2017	Penny Nymark, Linda Rieswijk, Friederike Ehrhart, Nina Jeliazkova, Georgia Tsiliki, Haralambos Sarimveis, Chris T Evelo, Vesa Hongisto, Pekka Kohonen, Egon Willighagen, Roland C GrafstrÃ¶m A Data Fusion Pipeline for Generating and Enriching Adverse Outcome Pathway Descriptions published pages: 264-275, ISSN: 1096-6080, DOI: 10.1093/toxsci/kfx252	Toxicological Sciences 162/1	2020-03-17
2019	Panagiotis Isigonis, Danail Hristozov, Christina Benighaus, Elisa Giubilato, Khara Grieger, Lisa Pizzol, Elena Semenzin, Igor Linkov, Alex Zabeo, Antonio Marcomini Risk Governance of Nanomaterials: Review of Criteria and Tools for Risk Communication, Evaluation, and Mitigation published pages: 696, ISSN: 2079-4991, DOI: 10.3390/nano9050696	Nanomaterials 9/5	2020-03-17
2019	Sara NÃ¸rgaard SÃ¸rensen, Anders Baun, Michael Burkard, Miikka Dal Maso, Steffen Foss Hansen, Samuel Harrison, Rune Hjorth, Stephen Lofts, Marianne Matzke, Bernd Nowack, Willie Peijnenburg, Mikko PoikkimÃ¤ki, Joris T. K. Quik, Kristin Schirmer, Anja Verschoor, Henning Wigger, David J. Spurgeon Evaluating environmental risk assessment models for nanomaterials according to requirements along the product innovation Stage-Gate process published pages: 505-518, ISSN: 2051-8153, DOI: 10.1039/c8en00933c	Environmental Science: Nano 6/2	2020-03-17
2019	Henning Wigger, Bernd Nowack Material-specific properties applied to an environmental risk assessment of engineered nanomaterials â€“ implications on grouping and read-across concepts published pages: 1-21, ISSN: 1743-5390, DOI: 10.1080/17435390.2019.1568604	Nanotoxicology 10	2020-03-17
2018	Benjamin D. Trump, Danail Hristozov, Timothy Malloy, Igor Linkov Risk associated with engineered nanomaterials: Different tools for different ways to govern published pages: 9-13, ISSN: 1748-0132, DOI: 10.1016/j.nantod.2018.03.002	Nano Today 21	2020-03-17
2019	Alex Zabeo, Jeffrey M. Keisler, Danail Hristozov, Antonio Marcomini, Igor Linkov Value of information analysis for assessing risks and benefits of nanotechnology innovation published pages: 11, ISSN: 2190-4707, DOI: 10.1186/s12302-019-0194-0	Environmental Sciences Europe 31/1	2020-03-17
2019	Carla Ribalta, Antti J. Koivisto, Ana LÃ³pez-Lilao, Sara EstupiÃ±Ã¡, MarÃa C. MinguillÃ³n, Eliseo Monfort, Mar Viana Testing the performance of one and two box models as tools for risk assessment of particle exposure during packing of inorganic fertilizer published pages: 2423-2436, ISSN: 0048-9697, DOI: 10.1016/j.scitotenv.2018.09.379	Science of The Total Environment 650	2020-03-17
2017	Pekka Kohonen, Juuso A. Parkkinen, Egon L. Willighagen, Rebecca Ceder, Krister Wennerberg, Samuel Kaski, Roland C. GrafstrÃ¶m A transcriptomics data-driven gene space accurately predicts liver cytopathology and drug-induced liver injury published pages: 15932, ISSN: 2041-1723, DOI: 10.1038/ncomms15932	Nature Communications 8	2020-03-17

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