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caLIBRAte SIGNED

Performance testing, calibration and implementation of a next generation system-of-systems Risk Governance Framework for nanomaterials

Total Cost €

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EC-Contrib. €

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Partnership

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Project "caLIBRAte" data sheet

The following table provides information about the project.

Coordinator
DET NATIONALE FORSKNINGSCENTER FORARBEJDSMILJO 

Organization address
address: LERSO PARKALLE 105
city: KOBENHAVN
postcode: 2100
website: www.nrcwe.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website http://www.nanocalibrate.eu/
 Total cost 9˙828˙106 €
 EC max contribution 7˙999˙687 € (81%)
 Programme 1. H2020-EU.2.1.2.2. (Ensuring the safe and sustainable development and application of nanotechnologies)
 Code Call H2020-NMP-2015-two-stage
 Funding Scheme RIA
 Starting year 2016
 Duration (year-month-day) from 2016-05-01   to  2019-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DET NATIONALE FORSKNINGSCENTER FORARBEJDSMILJO DK (KOBENHAVN) coordinator 1˙758˙981.00
2    STEINBEIS ADVANCED RISK TECHNOLOGIES GMBH DE (STUTTGART) participant 637˙500.00
3    UNITED KINGDOM RESEARCH AND INNOVATION UK (SWINDON) participant 502˙910.00
4    DANMARKS TEKNISKE UNIVERSITET DK (KGS LYNGBY) participant 474˙990.00
5    KAROLINSKA INSTITUTET SE (STOCKHOLM) participant 462˙770.00
6    DIALOGIK GEMEINNUETZIGE GESELLSCHAFT FUER KOMMUNIKATIONS- UND KOOPERATIONSFORSCHUNG mbH DE (STUTTGART) participant 411˙125.00
7    TYOTERVEYSLAITOS FI (HELSINKI) participant 379˙825.00
8    RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU NL (BILTHOVEN) participant 376˙382.00
9    ACONDICIONAMIENTO TARRASENSE ASSOCIACION ES (TERRASSA) participant 363˙425.00
10    TAMPEREEN KORKEAKOULUSAATIO SR FI (TAMPERE) participant 357˙555.00
11    NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO NL (DEN HAAG) participant 336˙957.00
12    MISVIK BIOLOGY OY FI (TURKU) participant 326˙507.00
13    INSTITUT NATIONAL DE L ENVIRONNEMENT ET DES RISQUES INERIS FR (VERNEUIL EN HALATTE) participant 299˙115.00
14    FUNDACION GAIKER ES (ZAMUDIO) participant 297˙276.00
15    HELSINGIN YLIOPISTO FI (HELSINGIN YLIOPISTO) participant 269˙625.00
16    NANOTECHNOLOGY INDUSTRIES ASSOCIATION BE (BRUXELLES) participant 237˙212.00
17    GREENDECISION SRL IT (VENEZIA) participant 179˙630.00
18    ASSOCIAZIONE ITALIANA PER LA RICERCA INDUSTRIALE - AIRI IT (ROMA) participant 169˙375.00
19    UNIVERSITA CA' FOSCARI VENEZIA IT (VENEZIA) participant 158˙525.00
20    DUKE UNIVERSITY US (DURHAM NC) participant 0.00
21    EIDGENOESSISCHE ANSTALT FUER WASSERVERSORGUNG ABWASSERREINIGUNG UND GEWAESSERSCHUTZ CH (DUBENDORF) participant 0.00
22    EIDGENOSSISCHE MATERIALPRUFUNGS- UND FORSCHUNGSANSTALT CH (DUBENDORF) participant 0.00
23    NATIONAL HEALTH LABORATORY SERVICES ZA (SANDRINGHAM) participant 0.00
24    NATURAL ENVIRONMENT RESEARCH COUNCIL UK (SWINDON WILTSHIRE) participant 0.00
25    RESEARCH TRIANGLE INSTITUTE US (RESEARCH TRIANGLE PARK) participant 0.00
26    TTY-SAATIO FI (TAMPERE) participant 0.00

Map

 Project objective

The objective of the caLIBRAte project is to establish a state-of-the-art versatile Risk Governance framework for assessment and management of human and environmental risks of MN and MN-enabled products. The framework will be a web-based “system-of-systems” linking different models and methods for: 1) screening of apparent and perceived risks and trends in nanotechnology, 2) control banding, qualitative and fully integrated predictive quantitative risk assessment operational at different information levels, 3) safety-by-design and multi-criteria decision support methods, 4) risk surveillance, -management and -guidance documents. The risk management framework will support assessments of emerging and existing MN and MN-enabled products following the recent ISO31000 risk governance framework, as well as safety in innovation by matching models to the principle innovation steps in the “Cooper Stage-Gate®” product innovation model Control banding tools and quantitative models will be subject to sensitivity analysis and performance testing followed by a revision as needed. After revision the models will again be analyzed by sensitivity testing, calibration, performance tested to establish the uncertainties. After calibration, the models will be part of the framework, which will be demonstrated by case studies. Stakeholders will be involved for defining the user requirements of the framework and will receive training in the framework at the end. The caLIBRAte project proposal answers to the call of NMP30-2015: Next generation tools for risk governance of MNs. The project is specifically designed to address the key challenges defined in the scope of the call text. There is particular focus on model revision, calibration and demonstration of existing models and methods that support the risk governance framework in regards to safe innovation and already implemented nanomaterials. Next generation computational exposure assessment and -toxicology is anticipated in the framework

 Deliverables

List of deliverables.
caLIBRAte summary report of annual dissemination and communication activities Documents, reports 2020-03-17 15:11:12
Review article with completed evaluation and guidance on prioritisation of innovative hazard exposure and risk assessment models towards applications in the stage-gate model Websites, patent fillings, videos etc. 2020-03-17 15:11:12
caLIBRAte decision support tools Other 2020-03-17 15:11:12
D.3.3 Report on improvements of environmental risk assessment models and user guidance Documents, reports 2020-03-17 15:11:12
Integrated HRA models, in the format of a suite of computational models and written guidance documentation Other 2020-03-17 15:11:12
Project webinars on project website and social media Websites, patent fillings, videos etc. 2020-03-17 15:11:12
Results of gap analysis Documents, reports 2020-03-17 15:11:12
Report addressing the compilation of omics data sets, network inference and benchmarks for gap identification Documents, reports 2020-03-17 15:11:12
Plan for dissemination, implementation and exploitation Documents, reports 2020-03-17 15:11:12
Comprehensive analysis of available tools and methodologies for Horizon Scanning Documents, reports 2020-03-17 15:11:11
Inventory of existing value-chain case-studies Documents, reports 2020-03-17 15:11:11
caLIBRAte logo and website Websites, patent fillings, videos etc. 2020-03-17 15:11:11
Document on quality criteria for data Documents, reports 2020-03-17 15:11:11

Take a look to the deliverables list in detail:  detailed list of caLIBRAte deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 C. Ribalta, A. López-Lilao, S. Estupiñá, A.S. Fonseca, A. Tobías, A. García-Cobos, M.C. Minguillón, E. Monfort, M. Viana
Health risk assessment from exposure to particles during packing in working environments
published pages: 474-487, ISSN: 0048-9697, DOI: 10.1016/j.scitotenv.2019.03.347
Science of The Total Environment 671 2020-03-17
2019 Neeraj Shandilya, Eelco Kuijpers, Ilse Tuinman, Wouter Fransman
Powder Intrinsic Properties as Dustiness Predictor for an Efficient Exposure Assessment?
published pages: 1029-1045, ISSN: 2398-7308, DOI: 10.1093/annweh/wxz065
Annals of Work Exposures and Health 63/9 2020-03-17
2019 Henning Wigger, Delphine Kawecki, Bernd Nowack, Véronique Adam
Systematic consideration of parameter uncertainty and variability in probabilistic species sensitivity distributions
published pages: , ISSN: 1551-3777, DOI: 10.1002/ieam.4214
Integrated Environmental Assessment and Management 2020-03-17
2019 Yaping Cai, Bernd Nowack, Henning Wigger
Identifying ecotoxicological descriptors to enable predictive hazard assessments of nano-TiO2 from a meta-analysis of ecotoxicological data
published pages: 100180, ISSN: 2452-0748, DOI: 10.1016/j.impact.2019.100180
NanoImpact 15 2020-03-17
2018 Marvin Martens, Tim Verbruggen, Penny Nymark, Roland Grafström, Lyle D. Burgoon, Hristo Aladjov, Fernando Torres Andón, Chris T. Evelo, Egon L. Willighagen
Introducing WikiPathways as a Data-Source to Support Adverse Outcome Pathways for Regulatory Risk Assessment of Chemicals and Nanomaterials
published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2018.00661
Frontiers in Genetics 9 2020-03-17
2019 Khara Grieger, Jacob L. Jones, Steffen Foss Hansen, Christine Ogilvie Hendren, Keld Alstrup Jensen, Jennifer Kuzma, Anders Baun
Best practices from nano-risk analysis relevant for other emerging technologies
published pages: 998-1001, ISSN: 1748-3387, DOI: 10.1038/s41565-019-0572-1
Nature Nanotechnology 14/11 2020-03-17
2018 Ana S. Fonseca, Eelco Kuijpers, Kirsten I. Kling, Marcus Levin, Antti J. Koivisto, Signe H. Nielsen, W. Fransman, Yijri Fedutik, Keld A. Jensen, Ismo K. Koponen
Particle release and control of worker exposure during laboratory-scale synthesis, handling and simulated spills of manufactured nanomaterials in fume hoods
published pages: , ISSN: 1388-0764, DOI: 10.1007/s11051-018-4136-3
Journal of Nanoparticle Research 20/2 2020-03-17
2018 Henning Wigger, Wendel Wohlleben, Bernd Nowack
Redefining environmental nanomaterial flows: consequences of the regulatory nanomaterial definition on the results of environmental exposure models
published pages: 1372-1385, ISSN: 2051-8153, DOI: 10.1039/c8en00137e
Environmental Science: Nano 5/6 2020-03-17
2019 Andrea Porcari, Elisabetta Borsella, Christina Benighaus, Khara Grieger, Panagiotis Isigonis, Somik Chakravarty, Pete Kines & Keld Alstrup Jensen
From risk perception to risk governance in nanotechnology: a multi-stakeholder study
published pages: , ISSN: 1388-0764, DOI:
Journal of Nanoparticle Research 2019, 21: 245 2020-03-17
2019 Michael Burkard, Alexander Betz, Kristin Schirmer, Anze Zupanic
Common gene expression patterns in environmental model organisms exposed to engineered nanomaterials: a meta-analysis
published pages: , ISSN: 0013-936X, DOI: 10.1021/acs.est.9b05170
Environmental Science & Technology 2020-03-17
2017 Penny Nymark, Linda Rieswijk, Friederike Ehrhart, Nina Jeliazkova, Georgia Tsiliki, Haralambos Sarimveis, Chris T Evelo, Vesa Hongisto, Pekka Kohonen, Egon Willighagen, Roland C Grafström
A Data Fusion Pipeline for Generating and Enriching Adverse Outcome Pathway Descriptions
published pages: 264-275, ISSN: 1096-6080, DOI: 10.1093/toxsci/kfx252
Toxicological Sciences 162/1 2020-03-17
2019 Panagiotis Isigonis, Danail Hristozov, Christina Benighaus, Elisa Giubilato, Khara Grieger, Lisa Pizzol, Elena Semenzin, Igor Linkov, Alex Zabeo, Antonio Marcomini
Risk Governance of Nanomaterials: Review of Criteria and Tools for Risk Communication, Evaluation, and Mitigation
published pages: 696, ISSN: 2079-4991, DOI: 10.3390/nano9050696
Nanomaterials 9/5 2020-03-17
2019 Sara Nørgaard Sørensen, Anders Baun, Michael Burkard, Miikka Dal Maso, Steffen Foss Hansen, Samuel Harrison, Rune Hjorth, Stephen Lofts, Marianne Matzke, Bernd Nowack, Willie Peijnenburg, Mikko Poikkimäki, Joris T. K. Quik, Kristin Schirmer, Anja Verschoor, Henning Wigger, David J. Spurgeon
Evaluating environmental risk assessment models for nanomaterials according to requirements along the product innovation Stage-Gate process
published pages: 505-518, ISSN: 2051-8153, DOI: 10.1039/c8en00933c
Environmental Science: Nano 6/2 2020-03-17
2019 Henning Wigger, Bernd Nowack
Material-specific properties applied to an environmental risk assessment of engineered nanomaterials – implications on grouping and read-across concepts
published pages: 1-21, ISSN: 1743-5390, DOI: 10.1080/17435390.2019.1568604
Nanotoxicology 10 2020-03-17
2018 Benjamin D. Trump, Danail Hristozov, Timothy Malloy, Igor Linkov
Risk associated with engineered nanomaterials: Different tools for different ways to govern
published pages: 9-13, ISSN: 1748-0132, DOI: 10.1016/j.nantod.2018.03.002
Nano Today 21 2020-03-17
2019 Alex Zabeo, Jeffrey M. Keisler, Danail Hristozov, Antonio Marcomini, Igor Linkov
Value of information analysis for assessing risks and benefits of nanotechnology innovation
published pages: 11, ISSN: 2190-4707, DOI: 10.1186/s12302-019-0194-0
Environmental Sciences Europe 31/1 2020-03-17
2019 Carla Ribalta, Antti J. Koivisto, Ana López-Lilao, Sara Estupiñá, María C. Minguillón, Eliseo Monfort, Mar Viana
Testing the performance of one and two box models as tools for risk assessment of particle exposure during packing of inorganic fertilizer
published pages: 2423-2436, ISSN: 0048-9697, DOI: 10.1016/j.scitotenv.2018.09.379
Science of The Total Environment 650 2020-03-17
2017 Pekka Kohonen, Juuso A. Parkkinen, Egon L. Willighagen, Rebecca Ceder, Krister Wennerberg, Samuel Kaski, Roland C. Grafström
A transcriptomics data-driven gene space accurately predicts liver cytopathology and drug-induced liver injury
published pages: 15932, ISSN: 2041-1723, DOI: 10.1038/ncomms15932
Nature Communications 8 2020-03-17

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