#	Pagina
attuale pagina	/open-h2020/projects/198437/index.html
-1	/open-h2020/projects/218250/index.html

Opendata, web and dolomites

COSMIC SIGNED

Commitment, maturation and infectivity of sexual stage malaria parasites in natural infections

Total Cost €

EC-Contrib. €

Partnership

Views

Outcomes and
results

COSMIC project word cloud

Explore the words cloud of the COSMIC project. It provides you a very rough idea of what is the project "COSMIC" about.

environmental elimination cohorts presently faso epidemiological exposed stage questions occurs acquired sexual time assay infections influence immunohistochemistry explaining bloodstream differential stimulate sequestration dynamics naive mature commitment burkina composition mosquito responsible parasites developmental spread quantify treatment mosquitoes efficiency absence hypothesize intrinsic extrinsic delineate stages poorly bloodmeals human phenomenally efficient continuous volunteers subdermal natural comprehensively compartments gametocytes transmission preferential triggers circulation experimental naturally background combination first innovation maturation epidemiology malaria gametocyte infectivity vasculature parasite assays unknown

Project "COSMIC" data sheet

The following table provides information about the project.

Coordinator	STICHTING KATHOLIEKE UNIVERSITEIT Organization address address: GEERT GROOTEPLEIN NOORD 9 city: NIJMEGEN postcode: 6525 EZ website: www.radboudumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	https://www.radboudumc.nl/en/people/teun-bousema
Total cost	1˙500˙000 €
EC max contribution	1˙500˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-STG
Funding Scheme	ERC-STG
Starting year	2015
Duration (year-month-day)	from 2015-07-01 to 2020-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	STICHTING KATHOLIEKE UNIVERSITEIT STICHTING KATHOLIEKE UNIVERSITEIT Organization address address: GEERT GROOTEPLEIN NOORD 9 city: NIJMEGEN postcode: 6525 EZ website: www.radboudumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (NIJMEGEN)	coordinator	1˙345˙000.00
2	UNIVERSITY OF GLASGOW UNIVERSITY OF GLASGOW Organization address address: UNIVERSITY AVENUE city: GLASGOW postcode: G12 8QQ website: www.gla.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (GLASGOW)	participant	155˙000.00
3	HARVARD GLOBAL RESEARCH AND SUPPORT SERVICES INC. HARVARD GLOBAL RESEARCH AND SUPPORT SERVICES INC. Organization address address: OFFICE OF THE GENERAL COUNSEL, HOLYOKE CENTER, SUITE 980, MASSACHUSETTS AVENUE 1350 city: CAMBRIDGE postcode: 2138 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (CAMBRIDGE)	participant	0.00

Map

Project objective

Background: One of the major challenges for malaria control and elimination is the phenomenally efficient spread of malaria through sexual stage malaria parasites (gametocytes). The epidemiology and dynamics of gametocytes are poorly understood: it is presently unknown when commitment to gametocytes first occurs during infections and what intrinsic or extrinsic factors influence gametocyte production and infectivity to mosquitoes. I hypothesize that continuous early commitment to gametocyte production and the preferential sequestration of mature gametocytes in the subdermal vasculature are key to explaining the high efficiency of malaria transmission. Aim: This proposal has three main aims: i) to determine when commitment to gametocyte production first occurs during experimental and natural infections; ii) to delineate environmental triggers that stimulate gametocyte production in the absence and presence of treatment; iii) to quantify the differential distribution of parasite developmental stages in different compartments of the human bloodstream. Approach: We will use novel parasite stage composition assays in combination with epidemiological methods to determine the dynamics of gametocyte commitment and maturation during controlled malaria infections in malaria-naive volunteers and during naturally acquired malaria infections in cohorts exposed to malaria in Burkina Faso. A stage-specific immunohistochemistry assay will, for the first time, directly quantify malaria stage composition in the subdermal vasculature and mosquito bloodmeals and allow comparison with other compartments of the circulation. Importance and Innovation: This is the first study to comprehensively characterize gametocyte commitment, maturation and infectivity in experimental and natural infections. This proposal will provide insight in one of the most important questions for malaria elimination: what processes are responsible for the phenomenally efficient transmission of malaria.

Publications

List of publications.
year	authors and title	journal	last update
2018	AndrÃ© Lin OuÃ©draogo, Philip A. Eckhoff, Adrian J. F. Luty, Will Roeffen, Robert W. Sauerwein, Teun Bousema, Edward A. Wenger Modeling the impact of Plasmodium falciparum sexual stage immunity on the composition and dynamics of the human infectious reservoir for malaria in natural settings published pages: e1007034, ISSN: 1553-7374, DOI: 10.1371/journal.ppat.1007034	PLOS Pathogens 14/5	2020-03-11
2019	Elamaran Meibalan, Aissata Barry, Matthew P Gibbins, Shehu Awandu, Lisette Meerstein-Kessel, Fiona Achcar, Selina Bopp, Christopher Moxon, Amidou Diarra, Siaka Debe, Nicolas OuÃ©draogo, Ines Barry-Some, Emilie S Badoum, TraorÃ© Fagnima, Kjerstin Lanke, Bronner P GonÃ§alves, John Bradley, Dyann Wirth, Chris Drakeley, Wamdaogo Moussa Guelbeogo, Alfred B Tiono, Matthias Marti, Teun Bousema Plasmodium falciparum Gametocyte Density and Infectivity in Peripheral Blood and Skin Tissue of Naturally Infected Parasite Carriers in Burkina Faso published pages: , ISSN: 0022-1899, DOI: 10.1093/infdis/jiz680	The Journal of Infectious Diseases	2020-03-11
2018	Getasew Shitaye, Endalamaw Gadisa, Lynn Grignard, Girma Shumie, Wakweya Chali, Temesgen Menberu, Mulualem Belachew, Getaneh Tegegn, Sagni Challi, Jonathan Curry, Laleta Mahey, Tsegaye Hailu, Hassen Mamo, Menakath Menon, Taye Balcha, Abraham Aseffa, Chris Drakeley, Teun Bousema, Fitsum G. Tadesse Low and heterogeneous prevalence of glucose-6-phosphate dehydrogenase deficiency in different settings in Ethiopia using phenotyping and genotyping approaches published pages: , ISSN: 1475-2875, DOI: 10.1186/s12936-018-2437-8	Malaria Journal 17/1	2020-03-11
2019	Roos M. Jong, Surafel K. Tebeje, Lisette Meersteinâ€Kessel, Fitsum G. Tadesse, Matthijs M. Jore, Will Stone, Teun Bousema Immunity against sexual stage Plasmodium falciparum and Plasmodium vivax parasites published pages: 190-215, ISSN: 0105-2896, DOI: 10.1111/imr.12828	Immunological Reviews 293/1	2020-03-11
2019	Kathleen W. Dantzler, Siyuan Ma, Priscilla Ngotho, Will J. R. Stone, Dingyin Tao, Sanna Rijpma, Mariana De Niz, Sandra K. Nilsson Bark, Matthijs M. Jore, Tonke K. Raaijmakers, Angela M. Early, Ceereena Ubaida-Mohien, Leandro Lemgruber, Joseph J. Campo, Andy A. Teng, Timothy Q. Le, Cassidy L. Walker, Patricia Hermand, Philippe Deterre, D. Huw Davies, Phil Felgner, Isabelle Morlais, Dyann F. Wirth, Naturally acquired immunity against immature Plasmodium falciparum gametocytes published pages: eaav3963, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.aav3963	Science Translational Medicine 11/495	2020-03-11
2019	Alex K. Musiime, Joseph Okoth, Melissa Conrad, Daniel Ayo, Ismail Onyige, John Rek, Joaniter I. Nankabirwa, Emmanuel Arinaitwe, Moses R. Kamya, Grant Dorsey, Geert-Jan van Gemert, Sarah G. Staedke, Chris Drakeley, Teun Bousema, Chiara Andolina Is that a real oocyst? Insectary establishment and identification of Plasmodium falciparum oocysts in midguts of Anopheles mosquitoes fed on infected human blood in Tororo, Uganda published pages: , ISSN: 1475-2875, DOI: 10.1186/s12936-019-2922-8	Malaria Journal 18/1	2020-03-11
2018	Isaie J Reuling, Lisanne A van de Schans, Luc E Coffeng, Kjerstin Lanke, Lisette Meerstein-Kessel, Wouter Graumans, Geert-Jan van Gemert, Karina Teelen, Rianne Siebelink-Stoter, Marga van de Vegte-Bolmer, Quirijn de Mast, AndrÃ© J van der Ven, Karen Ivinson, Cornelus C Hermsen, Sake de Vlas, John Bradley, Katharine A Collins, Christian F Ockenhouse, James McCarthy, Robert W Sauerwein, Teun Bousema A randomized feasibility trial comparing four antimalarial drug regimens to induce Plasmodium falciparum gametocytemia in the controlled human malaria infection model published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.31549	eLife 7	2020-02-21
2017	Will Stone, Patrick Sawa, Kjerstin Lanke, Sanna Rijpma, Robin Oriango, Maureen Nyaurah, Paul Osodo, Victor Osoti, Almahamoudou Mahamar, Halimatou Diawara, Rob Woestenenk, Wouter Graumans, Marga van de Vegte-Bolmer, John Bradley, Ingrid Chen, Joelle Brown, Giulia Siciliano, Pietro Alano, Roly Gosling, Alassane Dicko, Chris Drakeley, Teun Bousema A Molecular Assay to Quantify Male and Female Plasmodium falciparum Gametocytes: Results From 2 Randomized Controlled Trials Using Primaquine for Gametocyte Clearance published pages: 457-467, ISSN: 0022-1899, DOI: 10.1093/infdis/jix237	The Journal of Infectious Diseases 216/4	2020-02-21
2018	Katharine A. Collins, Claire Y.T. Wang, Matthew Adams, Hayley Mitchell, Melanie Rampton, Suzanne Elliott, Isaie J. Reuling, Teun Bousema, Robert Sauerwein, Stephan Chalon, JÃ¶rg J. MÃ¶hrle, James S. McCarthy A controlled human malaria infection model enabling evaluation of transmission-blocking interventions published pages: 1551-1562, ISSN: 0021-9738, DOI: 10.1172/JCI98012	Journal of Clinical Investigation 128/4	2020-02-21
2018	Alassane Dicko, Michelle E Roh, Halimatou Diawara, Almahamoudou Mahamar, Harouna M Soumare, Kjerstin Lanke, John Bradley, Koualy Sanogo, Daouda T Kone, Kalifa Diarra, Sekouba Keita, Djibrilla Issiaka, Sekou F Traore, Charles McCulloch, Will J R Stone, Jimee Hwang, Olaf MÃ¼ller, Joelle M Brown, Vinay Srinivasan, Chris Drakeley, Roly Gosling, Ingrid Chen, Teun Bousema Efficacy and safety of primaquine and methylene blue for prevention of Plasmodium falciparum transmission in Mali: a phase 2, single-blind, randomised controlled trial published pages: , ISSN: 1473-3099, DOI: 10.1016/S1473-3099(18)30044-6	The Lancet Infectious Diseases	2020-02-21
2017	Isaie J. Reuling, Will J. R. Stone, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Rianne Siebelink-Stoter, Wouter Graumans, Kjerstin Lanke, Teun Bousema, Robert W. Sauerwein Concentration of Plasmodium falciparum gametocytes in whole blood samples by magnetic cell sorting enhances parasite infection rates in mosquito feeding assays published pages: , ISSN: 1475-2875, DOI: 10.1186/s12936-017-1959-9	Malaria Journal 16/1	2020-02-21
2018	Jason P. Mooney, Aissata Barry, Bronner P. GonÃ§alves, Alfred B. Tiono, Shehu S. Awandu, Lynn Grignard, Chris J. Drakeley, Christian Bottomley, Teun Bousema, Eleanor M. Riley Haemolysis and haem oxygenase-1 induction during persistent â€œasymptomaticâ€ malaria infection in BurkinabÃ© children published pages: , ISSN: 1475-2875, DOI: 10.1186/s12936-018-2402-6	Malaria Journal 17/1	2020-02-21
2017	Fitsum G. Tadesse, Jodie A. Schildkraut, Teun Bousema, Alfred B. Tiono, Kjerstin Lanke, Chris Drakeley, Sanna R. Rijpma, Bronner P. GonÃ§alves, Robert Sauerwein, Issa Nebie Molecular Markers for Sensitive Detection of Plasmodium falciparum Asexual Stage Parasites and their Application in a Malaria Clinical Trial published pages: 188-198, ISSN: 0002-9637, DOI: 10.4269/ajtmh.16-0893	The American Journal of Tropical Medicine and Hygiene 97/1	2020-02-21
2016	Joseph Okebe, Teun Bousema, Muna Affara, Gian Luca Di Tanna, Edgard Dabira, Abdoulaye Gaye, Frank Sanya-Isijola, Henry Badji, Simon Correa, Davis Nwakanma, Jean-Pierre Van Geertruyden, Chris Drakeley, Umberto D\'Alessandro The Gametocytocidal Efficacy of Different Single Doses of Primaquine with Dihydroartemisinin-piperaquine in Asymptomatic Parasite Carriers in The Gambia: A Randomized Controlled Trial published pages: 348-355, ISSN: 2352-3964, DOI: 10.1016/j.ebiom.2016.10.032	EBioMedicine 13	2020-02-21
2017	Fitsum G. Tadesse, Lotus van den Hoogen, Kjerstin Lanke, Jodie Schildkraut, Kevin Tetteh, Abraham Aseffa, Hassen Mamo, Robert Sauerwein, Ingrid Felger, Chris Drakeley, Endalamaw Gadissa, Teun Bousema The shape of the iceberg: quantification of submicroscopic Plasmodium falciparum and Plasmodium vivax parasitaemia and gametocytaemia in five low endemic settings in Ethiopia published pages: , ISSN: 1475-2875, DOI: 10.1186/s12936-017-1749-4	Malaria Journal 16/1	2020-02-21
2017	Bronner P. GonÃ§alves, Helmi Pett, Alfred B. Tiono, Daryl Murry, Sodiomon B. Sirima, Mikko Niemi, Teun Bousema, Chris Drakeley, Rob ter Heine Age, Weight, and CYP2D6 Genotype Are Major Determinants of Primaquine Pharmacokinetics in African Children published pages: e02590-16, ISSN: 0066-4804, DOI: 10.1128/AAC.02590-16	Antimicrobial Agents and Chemotherapy 61/5	2020-02-21
2018	Ingrid Chen, Halimatou Diawara, Almahamoudou Mahamar, Koualy Sanogo, Sekouba Keita, Daouda Kone, Kalifa Diarra, Moussa Djimde, Mohamed Keita, Joelle Brown, Michelle E Roh, Jimee Hwang, Helmi Pett, Maxwell Murphy, Mikko Niemi, Bryan Greenhouse, Teun Bousema, Roly Gosling, Alassane Dicko Safety of Single-Dose Primaquine in G6PD-Deficient and G6PD-Normal Males in Mali Without Malaria: An Open-Label, Phase 1, Dose-Adjustment Trial published pages: , ISSN: 0022-1899, DOI: 10.1093/infdis/jiy014	The Journal of Infectious Diseases	2020-02-21
2017	Teun Bousema, Chris Drakeley Determinants of Malaria Transmission at the Population Level published pages: a025510, ISSN: 2157-1422, DOI: 10.1101/cshperspect.a025510	Cold Spring Harbor Perspectives in Medicine 7/12	2020-02-21
2018	Fitsum G Tadesse, Hannah C Slater, Wakweya Chali, Karina Teelen, Kjerstin Lanke, Mulualem Belachew, Temesgen Menberu, Girma Shumie, Getasew Shitaye, Lucy C Okell, Wouter Graumans, Geert-Jan van Gemert, Soriya Kedir, Addisu Tesfaye, Feleke Belachew, Wake Abebe, Hassen Mamo, Robert Sauerwein, Taye Balcha, Abraham Aseffa, Delenasaw Yewhalaw, Endalamaw Gadisa, Chris Drakeley, Teun Bousema The relative contribution of symptomatic and asymptomatic Plasmodium vivax and Plasmodium falciparum infections to the infectious reservoir in a low-endemic setting in Ethiopia published pages: , ISSN: 1058-4838, DOI: 10.1093/cid/cix1123	Clinical Infectious Diseases	2020-02-21
2018	Lynn Grignard, Bronner P. GonÃ§alves, Angela M. Early, Rachel F. Daniels, Alfred B. Tiono, Wamdaogo M. GuelbÃ©ogo, Alphonse OuÃ©draogo, Elke M. van Veen, Kjerstin Lanke, Amidou Diarra, Issa Nebie, Sodiomon B. Sirima, Geoff A. Targett, Sarah K. Volkman, Daniel E. Neafsey, Dyann F. Wirth, Teun Bousema, Chris Drakeley Transmission of molecularly undetectable circulating parasite clones leads to high infection complexity in mosquitoes post feeding published pages: 671-677, ISSN: 0020-7519, DOI: 10.1016/j.ijpara.2018.02.005	International Journal for Parasitology 48/8	2020-02-21
2018	Guido J. H. Bastiaens, Alfred B. Tiono, Joseph Okebe, Helmi E. Pett, Sam A. Coulibaly, Bronner P. GonÃ§alves, Muna Affara, Alphonse OuÃ©draogo, Edith C. Bougouma, Guillaume S. Sanou, Issa NÃ©biÃ©, John Bradley, Kjerstin H. W. Lanke, Mikko Niemi, Sodiomon B. Sirima, Umberto dâ€™Alessandro, Teun Bousema, Chris Drakeley Safety of single low-dose primaquine in glucose-6-phosphate dehydrogenase deficient falciparum-infected African males: Two open-label, randomized, safety trials published pages: e0190272, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0190272	PLOS ONE 13/1	2020-02-21
2016	Bronner P. GonÃ§alves, Chris Drakeley, Teun Bousema Infectivity of Microscopic and Submicroscopic Malaria Parasite Infections in Areas of Low Malaria Endemicity published pages: 1516-1517, ISSN: 0022-1899, DOI: 10.1093/infdis/jiw044	Journal of Infectious Diseases 213/9	2020-02-21
2015	Hannah C. Slater, Amanda Ross, AndrÃ© Lin OuÃ©draogo, Lisa J. White, Chea Nguon, Patrick G.T. Walker, Pengby Ngor, Ricardo Aguas, Sheetal P. Silal, Arjen M. Dondorp, Paul La Barre, Robert Burton, Robert W. Sauerwein, Chris Drakeley, Thomas A. Smith, Teun Bousema, Azra C. Ghani Assessing the impact of next-generation rapid diagnostic tests on Plasmodium falciparum malaria elimination strategies published pages: S94-S101, ISSN: 0028-0836, DOI: 10.1038/nature16040	Nature 528/7580	2020-02-21
2016	Hsiao-Han Chang, Elamaran Meibalan, Justin Zelin, Rachel Daniels, Alice C. Eziefula, Evan C. Meyer, Fitsum Tadesse, Lynn Grignard, Regina C. Joice, Chris Drakeley, Dyann F. Wirth, Sarah K. Volkman, Caroline Buckee, Teun Bousema, Matthias Marti Persistence of Plasmodium falciparum parasitemia after artemisinin combination therapy: evidence from a randomized trial in Uganda published pages: 26330, ISSN: 2045-2322, DOI: 10.1038/srep26330	Scientific Reports 6	2020-02-21
2016	Bronner P. GonÃ§alves, Alfred B. Tiono, Alphonse OuÃ©draogo, Wamdaogo M. GuelbÃ©ogo, John Bradley, Issa Nebie, DÃ©bÃ© Siaka, Kjerstin Lanke, Alice C. Eziefula, Amidou Diarra, Helmi Pett, Edith C. Bougouma, Sodiomon B. Sirima, Chris Drakeley, Teun Bousema Single low dose primaquine to reduce gametocyte carriage and Plasmodium falciparum transmission after artemether-lumefantrine in children with asymptomatic infection: a randomised, double-blind, placebo-controlled trial published pages: , ISSN: 1741-7015, DOI: 10.1186/s12916-016-0581-y	BMC Medicine 14/1	2020-02-21
2016	Alassane Dicko, Joelle M Brown, Halimatou Diawara, Ibrahima Baber, Almahamoudou Mahamar, Harouna M Soumare, Koualy Sanogo, Fanta Koita, Sekouba Keita, Sekou F Traore, Ingrid Chen, Eugenie Poirot, Jimee Hwang, Charles McCulloch, Kjerstin Lanke, Helmi Pett, Mikko Niemi, FranÃ§ois Nosten, Teun Bousema, Roly Gosling Primaquine to reduce transmission of Plasmodium falciparum malaria in Mali: a single-blind, dose-ranging, adaptive randomised phase 2 trial published pages: 674-684, ISSN: 1473-3099, DOI: 10.1016/S1473-3099(15)00479-X	The Lancet Infectious Diseases 16/6	2020-02-21
2016	Abdulla S, Achan J, Adam I, Alemayehu BH, Allan R, Allen EN, Anvikar AR, Arinaitwe E, Ashley EA, Sot M, Asih PB, Awab GR, Barnes KI, Bassat Q, de ManhiÃ§a S, Baudin E, BjÃ¶rkman A, Bompart F, Bonnet M, Borrmann S, Bousema T, Carrara VI, Sot M, Cenci F, Tau S, Checchi F, Cot M, Dahal P, D\'Alessandro U, Deloron P, Djimde A, Dondorp A, Dorsey G, Doumbo OK, Drakeley CJ, Duparc S, Espie E, Faiz A, Falade CO, Fanello C, Faye B, Diop UC, Filler S, Fofana B, Fogg C, Gansane A, Faso B, Gaye O, Diop UC, Genton B, Gething PW, Gonzalez R, de ManhiÃ§a S, Grandesso F, Greenwood B, Grivoyannis A, Guerin PJ, Hamed K, Hatz C, Hay I, Humphreys GS, Hwang J, Janssens B, FrontiÃ¨res MS, Jima D, Juma E, Kachur SP, Kager P, Kamya MR, Kapulu M, Karema C, Kayentao K, Kiechel JR, Kofoed PE, Lameyre V, Lee SJ, Lell B, Marsh K, MÃ¥rtensson A, Massougbodji A, Mayxay M, McGready R, Sot M, Menan H, Menendez C, Meremikwu M, Mockenhaupt FP, Moreira C, Nabasumba C, Nambozi M, Ndiaye JL, Diop UC, Newton PN, Ngasala BE, Nosten F, Sot M, Nsanzabana C, Offianan AT, Oguike M, Ogutu R, Olliaro P, Omar A, Osorio L, Owusu-Agyei S, Penali LK, Pene M, Diop UC, Peshu J, Piola P, Premji Z, Price RN, Ramharter M, TÃ¼bingen U, Rombo L, Roper C, Rosenthal PJ, Sagara I, Sawa P, Schallig HD, Schramm B, Shekalaghe SA, Sibley CH, Sirima S, Faso B, Smithuis F, Diop UC, Staedke SG, Stepniewska K, Sutanto I, Sutherland CJ, Swarthout TD, FrontiÃ¨res MS, Syafruddin D, Sylla K, de Parasitologie-Mycologie MÃ©dicale S, Diop UC, Talisuna AO, Taylor WR, Temu EA, Kuile FT, Tinto H, Dioulasso B, Faso B, Dioulasso B, Faso B, Tjitra E, Ursing J, Valecha N, van den Broek I, FrontiÃ¨res MS, van Herp M, FrontiÃ¨res MS, van Vugt M, Ward SA, White NJ, Winstanley PA, Woodrow CJ, Yeka A, Zwang J. Gametocyte carriage in uncomplicated Plasmodium falciparum malaria following treatment with artemisinin combination therapy: a systematic review and meta-analysis of individual patient data published pages: , ISSN: 1741-7015, DOI: 10.1186/s12916-016-0621-7	BMC Medicine 14/1	2020-02-21

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "COSMIC" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "COSMIC" are provided by the European Opendata Portal: CORDIS opendata.