Opendata, web and dolomites

DDREAMM SIGNED

Dna Damage REsponse: Actionabilities, Maps and Mechanisms

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 DDREAMM project word cloud

Explore the words cloud of the DDREAMM project. It provides you a very rough idea of what is the project "DDREAMM" about.

repair    aggressive    ranging    inherited    physical    inhibitors    reveal    molecule    cutting    suppressive    mechanistic    genomes    cancers    small    biology    explaining    maps    genome    deficiencies    multiple    editing    disorders    sophisticated    hypo    comprise    mass    resistance    damage    beginning    cas    precisely    lethal    logic    powerful    gene    insights    hyper    therapies    interaction    tools    transcriptional    framework    damaging    dna    technologies    types    networks    therapeutic    synthetic    signaling    fundamental    deeply    sporadic    viability    understand    yield    enzyme    multidisciplinary    diverse    cells    diseases    create    agents    genetic    uncover    functional    therapeutics    eukaryotic    treatments    protect    interrogate    spectrometry    sensitivity    phenotypes    ddr    generation    cellular    underpin    monitor    edge    morph    events    alleles    deficiency    cell    human    cancer    interactions    underpins    surveillance    outcomes    crispr    treat    sum    harnessed    hereditary    vulnerabilities    speed    chemical   

Project "DDREAMM" data sheet

The following table provides information about the project.

Coordinator
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH 

Organization address
address: Raemistrasse 101
city: ZUERICH
postcode: 8092
website: https://www.ethz.ch/de.html

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 8˙865˙965 €
 EC max contribution 8˙865˙965 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-SyG
 Funding Scheme ERC-SyG
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2026-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) coordinator 3˙428˙750.00
2    CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH AT (WIEN) participant 2˙954˙000.00
3    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 2˙483˙215.00

Map

 Project objective

To monitor and protect their genomes, eukaryotic cells have evolved sophisticated DNA-damage response (DDR) systems that comprise DNA repair and DNA-damage signaling processes. DDR deficiencies are associated with diverse human disorders, ranging from aggressive hereditary and sporadic cancers to inherited genetic diseases. The impact of DNA repair has also recently been harnessed to treat diseases through “synthetic lethal” cancer treatments and CRISPR-Cas genome editing. However, the fundamental interactions between DDR pathways that underpin such therapeutic opportunities are still not well understood. Furthermore, we are only just beginning to understand how suppressive functional interactions (so-called “synthetic viability”) can lead to resistance to DDR-targeting therapeutics. Our proposed research will address these important issues by using cutting-edge technologies in gene editing and chemical biology, and by taking a multidisciplinary approach to create deeply integrated genetic and physical maps of DDR pathways and interactions in many human cell types. Next-generation CRISPR-Cas transcriptional genome-wide approaches will be used to uncover hypo- and hyper-morph alleles that affect cellular sensitivity to DNA-damaging agents and DDR-enzyme inhibitors, thus providing insights into DDR events and explaining human DDR-deficiency phenotypes. Mass spectrometry and in-depth mechanistic studies will establish physical interaction networks within the genetic framework and reveal the signaling logic that underpins DDR outcomes and vulnerabilities. With chemical-genetic approaches, we will develop small molecule tools to precisely interrogate DDR pathways and that could lead to new therapeutic agents. In sum, our work should provide major insights into human genome surveillance in multiple cell types, yield powerful tools to precisely control DNA repair outcomes, and speed the development of new therapies for cancer and other diseases.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "DDREAMM" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "DDREAMM" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

KineTic (2020)

New Reagents for Quantifying the Routing and Kinetics of T-cell Activation

Read More  

E-DURA (2018)

Commercialization of novel soft neural interfaces

Read More  

NEUTRAMENTH (2018)

A redox-neutral process for the cost-efficient and environmentally friendly production of Menthol

Read More