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PolarNet SIGNED

Principles of Polarity – Integrating genetic, biophysical and computational approaches to understand cell and tissue polarity

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

PolarNet project word cloud

Explore the words cloud of the PolarNet project. It provides you a very rough idea of what is the project "PolarNet" about.

players polarnet polarity biophysics strengthen combine imaging intersectoral translation cultured basic point functions forefront scientists tissues combination excellent industry base setting description biological mammalian multicellular perturbed provides animal opportunity genetics employ maintenance mechanical private theoretical disease performed model ranging biochemical expanding image academic polarize biology stage interactions biomedical tight train resolution starting generation cells stem underscored progress countries cell protein cancer medically organismal technological brings career experimental quantitative underlies organisms training external complementary fact establishment integrative successful biochemistry live principles insights broad multidisciplinary underlying motility organism fungi molecular

Project "PolarNet" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITEIT UTRECHT Organization address address: HEIDELBERGLAAN 8 city: UTRECHT postcode: 3584 CS website: www.uu.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	https://polarnet-itn.eu/
Total cost	3˙935˙968 €
EC max contribution	3˙935˙968 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2015
Funding Scheme	MSCA-ITN-ETN
Starting year	2015
Duration (year-month-day)	from 2015-10-01 to 2019-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITEIT UTRECHT UNIVERSITEIT UTRECHT Organization address address: HEIDELBERGLAAN 8 city: UTRECHT postcode: 3584 CS website: www.uu.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	coordinator	1˙276˙871.00
2	CARDIFF UNIVERSITY CARDIFF UNIVERSITY Organization address address: NEWPORT ROAD 30-36 city: CARDIFF postcode: CF24 ODE website: www.cardiff.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CARDIFF)	participant	546˙575.00
3	INSTITUT PASTEUR INSTITUT PASTEUR Organization address address: RUE DU DOCTEUR ROUX 25-28 city: PARIS CEDEX 15 postcode: 75724 website: http://www.pasteur.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS CEDEX 15)	participant	525˙751.00
4	THE FRANCIS CRICK INSTITUTE LIMITED THE FRANCIS CRICK INSTITUTE LIMITED Organization address address: 1 MIDLAND ROAD city: LONDON postcode: NW1 1AT website: www.crick.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	273˙287.00
5	UNIVERSITY COLLEGE LONDON UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	273˙287.00
6	UNIVERSITAT BASEL UNIVERSITAT BASEL Organization address address: PETERSPLATZ 1 city: BASEL postcode: 4051 website: www.unibas.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BASEL)	participant	265˙226.00
7	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	262˙875.00
8	INSTITUT CURIE INSTITUT CURIE Organization address address: rue d'Ulm 26 city: PARIS postcode: 75231 website: www.curie.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	262˙875.00
9	TECHNISCHE UNIVERSITAET DRESDEN TECHNISCHE UNIVERSITAET DRESDEN Organization address address: HELMHOLTZSTRASSE 10 city: DRESDEN postcode: 1069 website: http://www.tu-dresden.de/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (DRESDEN)	participant	249˙216.00
10	ELEVATE BV ELEVATE BV Organization address address: HEIDELBERGLAAN 8 city: UTRECHT postcode: 3584 CS website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	partner	0.00
11	NDS Ltd. NDS Ltd. Organization address address: 8th Floor Eastgate House city: Cardiff postcode: CF240AB website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (Cardiff)	partner	0.00
12	Scientific Volume Imaging BV Scientific Volume Imaging BV Organization address address: Laapersveld 63 city: Hilversum postcode: 1213 VB website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (Hilversum)	partner	0.00
13	Union Biometrica BVBA Union Biometrica BVBA Organization address address: Cipalstraat 3 city: Geel postcode: 2440 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (Geel)	partner	0.00

Map

Project objective

The ability of cells to polarize underlies the most basic biological functions such as motility and response to external challenges, but also the formation and maintenance of tissues in a multicellular organism. The importance of cell polarity is underscored by the fact that cell polarity is essential for animal development and is perturbed in disease states such as cancer. Understanding cell polarity requires knowledge of the molecular players involved and a quantitative description of their biochemical interactions, as well as the mechanical processes underlying polarity establishment. PolarNet brings together academic and private partners from 7 European countries to establish a multidisciplinary, intersectoral training and research programme that will study the basic principles of cell polarity. The research will combine complementary model systems ranging from fungi and cultured mammalian cells to whole organisms, and employ a broad set of approaches such as advanced genetics, protein biochemistry, high-resolution live imaging and image analysis, biophysics and theoretical modelling. This setting provides an opportunity to train early stage researchers in a unique combination of experimental and theoretical approaches. This will provide an excellent starting point for a successful career in the rapidly expanding field of multidisciplinary or ‘integrative’ biology. Training Europe’s next generation of scientists at the forefront of cell and organismal polarity research is crucial for progress in several medically important fields, including cancer research and stem cell biology. The tight collaboration with non-academic partners will strengthen the technological base of different projects and provide early stage researchers with insights into the translation potential of the performed studies and the career development opportunities in biomedical industry.

Deliverables

List of deliverables.
Analysis of Axin1, Axin2, and APC roles in liver and intestinal cell division	Documents, reports	2020-03-11 13:02:59
Mechanisms of mechanotransduction during division in epithelial tissue	Documents, reports	2020-03-11 13:03:37
Mechanistic role of microtubules in polarization of 3D-cultured epithelial cells	Documents, reports	2020-03-11 13:02:58
Mechanochemical model of PAR polarity patterning	Documents, reports	2020-03-11 13:02:59
Analysis of the mechanisms that maintain tissue integrity in seam epithelium	Documents, reports	2020-03-11 13:03:01
Biochemical characterization of the Scrib polarity complex	Documents, reports	2020-03-11 13:03:28
GTPase-regulator circuits essential for yeast and C. elegans polarity	Documents, reports	2020-03-11 13:03:31
Computational model of epithelial regeneration after wounding	Documents, reports	2020-03-11 13:01:44
Analysis of cell contact dependent transmission of Wnt-signal in seam cell PCP	Documents, reports	2020-03-11 13:01:49
Review article by the ESRs incorporating data obtained by PolarNet	Documents, reports	2020-03-11 13:02:59
Summaries of ESRs results placed on website by the ESRs	Websites, patent fillings, videos etc.	2020-03-11 13:03:00
Comprehensive, quantitative mathematical description of PAR polarity	Documents, reports	2020-03-11 13:03:36
Characterization of PAR, Crumbs and Scribble in C. elegans larval epithelia	Documents, reports	2020-03-11 13:03:32
Semi-automated culturing of organoids in a bioreactor	Documents, reports	2020-03-11 13:02:58
Video highlighting importance of polarity for website & youtube	Websites, patent fillings, videos etc.	2020-03-11 13:03:02
Super-resolution localization of polarity regulators at the plasma membrane	Documents, reports	2020-03-11 13:03:32
Symposium 2	Other	2020-03-11 13:03:01
Quantitative analyses of local polarity perturbations on polarized growth	Documents, reports	2020-03-11 13:03:30
Role of phosphoinositides in control of cell polarity during collective migration	Documents, reports	2020-03-11 13:03:29
Bi-weekly â€˜Polarizing Cellsâ€™ blog entry on website	Websites, patent fillings, videos etc.	2020-03-11 13:03:02
Symposium 3	Other	2020-03-11 13:03:02
ESRs evaluated for Doctorate degree application	Other	2020-03-11 13:03:31
Draft Periodic Report	Documents, reports	2019-06-19 17:44:45
Symposium 1	Other	2019-06-19 17:44:45
Midterm review Meeting	Other	2019-06-19 17:44:45
Summer School	Other	2019-06-19 17:44:45
Progress Report	Documents, reports	2019-06-19 17:44:45
Web presence	Websites, patent fillings, videos etc.	2019-06-19 17:44:45

Take a look to the deliverables list in detail: detailed list of PolarNet deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Bertille Bance, Shailaja Seetharaman, CÃ©cile Leduc, Batiste BoÃ«da, Sandrine Etienne-Manneville Microtubule acetylation but not detyrosination promotes focal adhesion dynamics and astrocyte migration published pages: jcs225805, ISSN: 0021-9533, DOI: 10.1242/jcs.225805	Journal of Cell Science 132/7	2019-11-28
2019	Eric C. Arakel, Martina Huranova, Alejandro F. Estrada, E-Ming Rau, Anne Spang, Blanche Schwappach Dissection of GTPase-activating proteins reveals functional asymmetry in the COPI coat of budding yeast published pages: jcs232124, ISSN: 0021-9533, DOI: 10.1242/jcs.232124	Journal of Cell Science 132/16	2019-11-28
2020	Eric Victor van Leen, Florencia di Pietro, Yohanns BellaÃ¯che Oriented cell divisions in epithelia: from force generation to force anisotropy by tension, shape and vertices published pages: 9-16, ISSN: 0955-0674, DOI: 10.1016/j.ceb.2019.07.013	Current Opinion in Cell Biology 62	2019-11-28
2018	Shailaja Seetharaman, Sandrine Etienne-Manneville Integrin diversity brings specificity in mechanotransduction published pages: 49-64, ISSN: 0248-4900, DOI: 10.1111/boc.201700060	Biology of the Cell 110/3	2019-11-28
2018	Sonja Hinz, Gemma Navarro, Dasiel Borroto-Escuela, Benjamin F. Seibt, York-Christoph Ammon, Elisabetta de Filippo, Azeem Danish, Svenja K. Lacher, Barbora ÄŒervinkovÃ¡, Muhammad Rafehi, Kjell Fuxe, Anke C. Schiedel, Rafael Franco, Christa E. MÃ¼ller Adenosine A_2A receptor ligand recognition and signaling is blocked by A_2B receptors published pages: , ISSN: 1949-2553, DOI: 10.18632/oncotarget.24423	Oncotarget 9/17	2019-11-28
2019	Nathan Jespersen, Aidan Estelle, Nathan Waugh, Norman E Davey, Cecilia Blikstad, York-Christoph Ammon, Anna Akhmanova, Ylva Ivarsson, David A Hendrix, Elisar Barbar Systematic identification of recognition motifs for the hub protein LC8 published pages: e201900366, ISSN: 2575-1077, DOI: 10.26508/lsa.201900366	Life Science Alliance 2/4	2019-11-28
2018	Chiara De Pascalis, Carlos PÃ©rez-GonzÃ¡lez, Shailaja Seetharaman, Batiste BoÃ«da, Benoit Vianay, Mithila Burute, CÃ©cile Leduc, Nicolas Borghi, Xavier Trepat, Sandrine Etienne-Manneville Intermediate filaments control collective migration by restricting traction forces and sustaining cellâ€“cell contacts published pages: 3031-3044, ISSN: 0021-9525, DOI: 10.1083/jcb.201801162	The Journal of Cell Biology 217/9	2019-11-28
2019	PatrÃcia M. Silva, Charles Puerner, Agnese Seminara, Martine Bassilana, Robert A. Arkowitz Secretory Vesicle Clustering in Fungal Filamentous Cells Does Not Require Directional Growth published pages: 2231-2245.e5, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2019.07.062	Cell Reports 28/8	2019-11-28
2020	Amalia Riga, Victoria G Castiglioni, Mike Boxem New insights into apical-basal polarization in epithelia published pages: 1-8, ISSN: 0955-0674, DOI: 10.1016/j.ceb.2019.07.017	Current Opinion in Cell Biology 62	2019-11-28
2020	Eider Valle-Encinas, Trevor C. Dale Wnt ligand and receptor patterning in the liver published pages: 17-25, ISSN: 0955-0674, DOI: 10.1016/j.ceb.2019.07.014	Current Opinion in Cell Biology 62	2019-11-28
2019	Jacob D. Reich, Lars Hubatsch, Rukshala Illukkumbura, Florent Peglion, Tom Bland, Nisha Hirani, Nathan W. Goehring Regulated Activation of the PAR Polarity Network Ensures a Timely and Specific Response to Spatial Cues published pages: 1911-1923.e5, ISSN: 0960-9822, DOI: 10.1016/j.cub.2019.04.058	Current Biology 29/12	2019-11-28
2019	Shailaja Seetharaman, Sandrine Etienne-Manneville Microtubules at focal adhesions â€“ a double-edged sword published pages: jcs232843, ISSN: 0021-9533, DOI: 10.1242/jcs.232843	Journal of Cell Science 132/19	2019-11-28
2019	Miao Yu, Shimin Le, York-Christoph Ammon, Benjamin T. Goult, Anna Akhmanova, Jie Yan Force-Dependent Regulation of Talinâ€“KANK1 Complex at Focal Adhesions published pages: 5982-5990, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.9b01732	Nano Letters 19/9	2019-11-28

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