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VESCEL SIGNED

Vascular Engineering on chip using differentiated Stem Cells

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

VESCEL project word cloud

Explore the words cloud of the VESCEL project. It provides you a very rough idea of what is the project "VESCEL" about.

classes stenosis microfluidic throughput organs molecules microsensors vescel optimize vasculature constitute microenvironment alzheimer partly engineer microfabrication biopsies capability thrombus replace chip ms drugs promise nanoparticle combines material small barrier single extravasation printing offers biomedical human patient differentiation technologies form flexible diseases possibility differentiated models ph pervades organism monitoring realize vessels pluripotent refine hold blood line ideally 3r cells o2 brain suited microdroplet sclerosis cell peptide bbb multiple nd stem realization transport pressure platform realistic disease innovative malfunctioning animal thrombosis extremely plays creation 3d leukocyte 1000 model neurodegenerative reduce hipsc

Project "VESCEL" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITEIT TWENTE Organization address address: DRIENERLOLAAN 5 city: ENSCHEDE postcode: 7522 NB website: www.utwente.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	https://www.utwente.nl/en/eemcs/bios/research/
Total cost	2˙250˙000 €
EC max contribution	2˙250˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-ADG
Funding Scheme	ERC-ADG
Starting year	2015
Duration (year-month-day)	from 2015-10-01 to 2020-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITEIT TWENTE UNIVERSITEIT TWENTE Organization address address: DRIENERLOLAAN 5 city: ENSCHEDE postcode: 7522 NB website: www.utwente.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ENSCHEDE)	coordinator	2˙250˙000.00

Map

Project objective

Organs-on-chip hold great promise for the creation of complex and realistic disease models while having the potential to refine, reduce and (partly) replace existing animal models (3R principle). Of all organs, vasculature is extremely well-suited to realize on-chip since it pervades the whole organism, is present in all other organs, its malfunctioning plays a role in many diseases and finally is ideally suited to approach with microfabrication and microfluidic technologies. In the VESCEL program we propose the development of innovative technologies enabling the use of differentiated human induced pluripotent stem cells (hiPSC) to engineer blood vessels on chip that constitute realistic disease models for thrombosis and neurodegenerative (ND) diseases. The use of differentiated hiPSC allows the realization of blood vessels based upon patient-specific material, without the need for biopsies, while development of integrated microsensors for small molecules (pH, O2, NO) offers the possibility of on-line monitoring. To optimize the hiPSC differentiation conditions we propose the use of a microdroplet platform, that combines high-throughput capability (up to 1000 cells/s) with control of single cell microenvironment. We will also develop a new flexible technology for real 3D vasculature realization using advanced 3D printing technologies. These four innovative technology developments will be integrated in two biomedical applications to study two important classes of diseases, thrombosis and neurodegenerative (ND) diseases. For thrombosis we focus on the study of parameters such as blood pressure and stenosis as well as effects of drugs on thrombus formation, while for ND diseases study we will use a blood brain barrier (BBB) model to investigate nanoparticle and peptide transport across the BBB for a form of Alzheimer’s disease, as well as leukocyte extravasation for multiple sclerosis (MS).

Publications

List of publications.
year	authors and title	journal	last update
2019	Joshua Loessberg-Zahl, Andries D. van der Meer, Albert van den Berg, Jan C. T. Eijkel Flow focusing through gels as a tool to generate 3D concentration profiles in hydrogel-filled microfluidic chips published pages: 206-213, ISSN: 1473-0197, DOI: 10.1039/c8lc01140k	Lab on a Chip 19/2	2019-03-11
2018	Amy Cochrane, Hugo J. Albers, Robert Passier, Christine L. Mummery, Albert van den Berg, Valeria V. Orlova, Andries D. van der Meer Advanced in vitro models of vascular biology: Human induced pluripotent stem cells and organ-on-chip technology published pages: , ISSN: 0169-409X, DOI: 10.1016/j.addr.2018.06.007	Advanced Drug Delivery Reviews	2019-03-11
2017	Pedro F. Costa, Hugo J. Albers, John E. A. Linssen, Heleen H. T. Middelkamp, Linda van der Hout, Robert Passier, Albert van den Berg, Jos Malda, Andries D. van der Meer Mimicking arterial thrombosis in a 3D-printed microfluidic in vitro vascular model based on computed tomography angiography data published pages: 2785-2792, ISSN: 1473-0197, DOI: 10.1039/c7lc00202e	Lab on a Chip 17/16	2019-02-26
2017	Marinke W. van der Helm, Mathieu Odijk, Jean-Philippe Frimat, Andries D. van der Meer, Jan C.T. Eijkel, Albert van den Berg, Loes I. Segerink Fabrication and Validation of an Organ-on-chip System with Integrated Electrodes to Directly Quantify Transendothelial Electrical Resistance published pages: , ISSN: 1940-087X, DOI: 10.3791/56334	Journal of Visualized Experiments 127	2019-02-26
2018	Martijn P. Tibbe, Anne M. Leferink, Albert van den Berg, Jan C. T. Eijkel, Loes I. Segerink Microfluidic Gel Patterning Method by Use of a Temporary Membrane for Organ-On-Chip Applications published pages: 1700200, ISSN: 2365-709X, DOI: 10.1002/admt.201700200	Advanced Materials Technologies 3/3	2019-02-26
2018	Esther Tanumihardja, Wouter Olthuis, Albert van den Berg Ruthenium Oxide Nanorods as Potentiometric pH Sensor for Organs-On-Chip Purposes published pages: 2901, ISSN: 1424-8220, DOI: 10.3390/s18092901	Sensors 18/9	2019-02-26
2016	Marinke W. van der Helm, Mathieu Odijk, Jean-Philippe Frimat, Andries D. van der Meer, Jan C.T. Eijkel, Albert van den Berg, Loes I. Segerink Direct quantification of transendothelial electrical resistance in organs-on-chips published pages: 924-929, ISSN: 0956-5663, DOI: 10.1016/j.bios.2016.06.014	Biosensors and Bioelectronics 85	2019-02-26

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