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WIDENLIFE
Widening the Scientific Excellence for Studies on Women’s and Fetal Health and Wellbeing
Total Cost €
0EC-Contrib. €
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0WIDENLIFE project word cloud
Explore the words cloud of the WIDENLIFE project. It provides you a very rough idea of what is the project "WIDENLIFE" about.
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Project "WIDENLIFE" data sheet
The following table provides information about the project.
| Coordinator |
TARTU ULIKOOL
Organization address contact info |
| Coordinator Country | Estonia [EE] |
| Project website | https://sisu.ut.ee/widenlife |
| Total cost | 1˙064˙607 € |
| EC max contribution | 1˙064˙607 € (100%) |
| Programme |
1. H2020-EU.4.b. (Twinning of research institutions) |
| Code Call | H2020-TWINN-2015 |
| Funding Scheme | CSA |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-01-01 to 2018-12-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | TARTU ULIKOOL | EE (TARTU) | coordinator | 455˙380.00 |
| 2 | THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD | UK (OXFORD) | participant | 357˙252.00 |
| 3 | KATHOLIEKE UNIVERSITEIT LEUVEN | BE (LEUVEN) | participant | 251˙975.00 |
Map
Project objective
Given that one in six couples face infertility, often caused by female factors, women’s reproductive health is a significant medical and socio-economical challenge. Herein, while addressing this issue, the Estonian research on female reproductive health and medicine has rapidly developed with the lead of University of Tartu (UT). Nevertheless, the UT’s capacity and expertise still falls short of the leading institutions. At the same time, also the most competitive research groups face significant barriers to perform world-class science due to substantial networking gaps that still exist between previously non-linked research teams. TWINNING funding scheme is designed to overcome these aforementioned shortcomings. Thus UT has formed a WIDENLIFE consortium with its world-renowned partners: University of Oxford and Katholieke Universiteit Leuven, and altogether we have set two ambitious objectives to address. Firstly, for the UT: to become one of the leading research and teaching centres for reproductive and fetal medicine in Eastern and Northern Europe. Secondly, for all members of consortia: to intensify trilateral synergies between the research groups in the areas of female reproductive health and medicine. Our specific goals are to highlight the associations between female metabolic health and infertility, provide deeper understating for embryonal development, and offer new tools for infertility treatment and prenatal diagnostics. In order to resolve these objectives, exchange of know-how, ideas and information between the partners will be enhanced, creating the novel clinically valuable information through pooling the expertise and synergy of resources, interests and commitments by universities from Estonia, UK and Belgium. This could also mean a significant contribution to the scientific capacity of the Estonian research community as well as the health technology industry, which is one of the main focus areas for Estonian Smart Specialisation Strategy.
Deliverables
| Test for non-invasive identification of endometriosis, which has been validated in partner organisations | Demonstrators, pilots, prototypes | 2019-10-28 17:20:38 |
| Report 3 on dissemination performed as part of local events for the scientific and local communities | Documents, reports | 2019-10-28 17:20:39 |
| Report on utilizing the UTARTU’s endometrial biopsies for practical training (1) | Documents, reports | 2019-10-28 17:20:39 |
| Report on cross-applying opportunities for EGCUT and WTCCC datasets | Documents, reports | 2019-10-28 17:20:39 |
| Report on on-site and off-site trainings performed between UTARTU and UOXF to transfer knowledge on female metabolic health as a predictor of fertility | Documents, reports | 2019-10-28 17:20:38 |
| Report on off-site virtual trainings and consultations performed to apply the NIPT methods within clinical use at UTARTU (3) | Documents, reports | 2019-10-28 17:20:38 |
| Senior staff exchanges completed between UTARTU and KU LEUVEN to transfer knowledge for isolating and amplifying DNA and RNA from single blastomere cells and to deploy time-lapse and NIPT methods | Documents, reports | 2019-10-28 17:20:39 |
| Biobank samples shared for learning purposes (5) | Documents, reports | 2019-10-28 17:20:39 |
| Report 2 on dissemination performed as part of local events for the scientific and local communities | Documents, reports | 2019-10-28 17:20:39 |
| Report 2 on dissemination performed as part of international conferences | Documents, reports | 2019-10-28 17:20:39 |
| NIPT technology adopted in an initial format by UTARTU’s scientists | Demonstrators, pilots, prototypes | 2019-10-28 17:20:39 |
| Co-authored article on human preimplantation embryos as a result of PhD students’ short-term stay in KU LEUVEN (2) | Documents, reports | 2019-10-28 17:20:38 |
| Report on utilizing the UTARTU’s endometrial biopsies for practical training (2) | Documents, reports | 2019-10-28 17:20:39 |
| Biobank samples shared for learning purposes (4) | Documents, reports | 2019-10-28 17:20:38 |
| Second workshop held on “female reproduction: ovulatory disorders†| Documents, reports | 2019-10-28 17:20:39 |
| Report on on-site and off-site trainings performed between UTARTU and UOXF to transfer knowledge for analysing female reproductive ageing | Documents, reports | 2019-10-28 17:20:38 |
| Co-authored article on female metabolic health as a predictor of fertility as a result of a post-doc’s short-term stay in UOXF (2) | Documents, reports | 2019-10-28 17:20:38 |
| Joint article written on human preimplantation embryos | Documents, reports | 2019-10-28 17:20:39 |
| Co-authored article on female reproductive ageing as a result of a PhD students’ short-term stay in UOXF (2) | Documents, reports | 2019-10-28 17:20:39 |
| Co-authored article on female reproductive ageing as a result of a post-doc’s short-term stay in UOXF | Documents, reports | 2019-10-28 17:20:38 |
| Joint article written on fetal non-invasive genetic testing | Documents, reports | 2019-10-28 17:20:38 |
| Clinical use of NIPT technology | Demonstrators, pilots, prototypes | 2019-10-28 17:20:38 |
| Co-authored article on analysing and implementing fetal non-invasive genetic testing as a result of a PhD student’s short-term stay in KU LEUVEN | Documents, reports | 2019-10-28 17:20:38 |
| Summer school held in Tartu, Estonia | Documents, reports | 2019-10-28 17:20:39 |
| Report 3 on dissemination performed as part of international conferences | Documents, reports | 2019-10-28 17:20:38 |
| Co-authored article on endometrial receptivity, implantation and endometriosis as a result of a PhD student’s short-term stay in UOXF | Documents, reports | 2019-10-28 17:20:38 |
| Joint article written on female reproductive ageing | Documents, reports | 2019-10-28 17:20:38 |
| Co-authored article on female reproductive ageing as a result of a PhD students’ short-term stay in UOXF (1) | Documents, reports | 2019-10-28 17:20:39 |
| Report on off-site virtual trainings and consultations performed to apply the NIPT methods within clinical use at UTARTU (2) | Documents, reports | 2019-10-28 17:20:38 |
| Joint article written on endometrial receptivity, implantation and endometriosis | Documents, reports | 2019-10-28 17:20:38 |
| Clinical use of PGS in Tartu University Hospital | Demonstrators, pilots, prototypes | 2019-10-28 17:20:38 |
| Joint article written on female metabolic health as a predictor of fertility | Documents, reports | 2019-10-28 17:20:38 |
| Co-authored article on human preimplantation embryos as a result of PhD students’ short-term stay in KU LEUVEN (1) | Documents, reports | 2019-10-28 17:20:38 |
| Report 1 on dissemination performed as part of international conferences | Documents, reports | 2019-10-28 17:20:38 |
| Biobank samples shared for learning purposes (3) | Documents, reports | 2019-10-28 17:20:38 |
| First workshop held on “female reproduction: ovulatory disorders†| Documents, reports | 2019-10-28 17:20:38 |
| Report on off-site virtual trainings and consultations performed to apply the NIPT methods within clinical use at UTARTU (1) | Documents, reports | 2019-10-28 17:20:38 |
| Co-authored article on analysing and implementing fetal non-invasive genetic testing as a result of a post-doc’s short-term stay in KU LEUVEN | Documents, reports | 2019-10-28 17:20:38 |
| Report 1 on dissemination performed as part of local events for the scientific and local communities | Documents, reports | 2019-10-28 17:20:38 |
| Workshop held on single cell genomics | Documents, reports | 2019-10-28 17:20:38 |
| Biobank samples shared for learning purposes (2) | Documents, reports | 2019-10-28 17:20:38 |
| Biobank samples shared for learning purposes (1) | Documents, reports | 2019-10-28 17:20:38 |
| Co-authored article on female metabolic health as a predictor of fertility as a result of a PhD student’s short-term stay in UOXF (1) | Documents, reports | 2019-10-28 17:20:38 |
Take a look to the deliverables list in detail: detailed list of WIDENLIFE deliverables.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2017 |
Dmitry Shungin, Wei Q. Deng, Tibor V. Varga, Jian\'an Luan, Evelin Mihailov, Andres Metspalu, Andrew P. Morris, Nita G. Forouhi, Cecilia Lindgren, Patrik K. E. Magnusson, Nancy L. Pedersen, Göran Hallmans, Audrey Y. Chu, Anne E. Justice, Mariaelisa Graff, Thomas W. Winkler, Lynda M. Rose, Claudia Langenberg, L. Adrienne Cupples, Paul M. Ridker, Nicholas J. Wareham, Ken K. Ong, Ruth J. F. Loos, Daniel I. Chasman, Erik Ingelsson, Tuomas O. Kilpeläinen, Robert A. Scott, Reedik Mägi, Guillaume Paré, Paul W. Franks Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions published pages: e1006812, ISSN: 1553-7404, DOI: 10.1371/journal.pgen.1006812 |
PLOS Genetics 13/6 | 2019-10-28 |
| 2016 |
O. Tšuiko, M. Nõukas, O. Žilina, K. Hensen, J.S. Tapanainen, R. Mägi, M. Kals, P.A. Kivistik, K. Haller-Kikkatalo, A. Salumets, A. Kurg Copy number variation analysis detects novel candidate genes involved in follicular growth and oocyte maturation in a cohort of premature ovarian failure cases published pages: 1913-1925, ISSN: 0268-1161, DOI: 10.1093/humrep/dew142 |
Human Reproduction 31/8 | 2019-10-28 |
| 2016 |
Gerly Sillaste, Lauris Kaplinski, Riho Meier, Ãœlle Jaakma, Elo Eriste, Andres Salumets A novel hypothesis for histone-to-protamine transition in Bos taurus spermatozoa published pages: 241-251, ISSN: 1470-1626, DOI: 10.1530/REP-16-0441 |
Reproduction 153/3 | 2019-10-28 |
| 2017 |
Olga Mazina, Anni Allikalt, Juha S. Tapanainen, Andres Salumets, Ago Rinken Determination of biological activity of gonadotropins hCG and FSH by Förster resonance energy transfer based biosensors published pages: 42219, ISSN: 2045-2322, DOI: 10.1038/srep42219 |
Scientific Reports 7 | 2019-10-28 |
| 2017 |
Kadri Haller-Kikkatalo, Kristi Alnek, Andres Metspalu, Evelin Mihailov, Kaja Metsküla, Kalle Kisand, Heti Pisarev, Andres Salumets, Raivo Uibo Demographic associations for autoantibodies in disease-free individuals of a European population published pages: 44846, ISSN: 2045-2322, DOI: 10.1038/srep44846 |
Scientific Reports 7 | 2019-10-28 |
| 2016 |
Nageswara Rao Boggavarapu, Sujata Lalitkumar, Vijay Joshua, Sergo Kasvandik, Andres Salumets, Parameswaran Grace Lalitkumar, Kristina Gemzell-Danielsson Compartmentalized gene expression profiling of receptive endometrium reveals progesterone regulated ENPP3 is differentially expressed and secreted in glycosylated form published pages: , ISSN: 2045-2322, DOI: 10.1038/srep33811 |
Scientific Reports 6/1 | 2019-10-28 |
| 2016 |
Airi Tiirats, Triin Viltrop, Margit Nõukas, Ene Reimann, Andres Salumets, Sulev Kõks C14orf132 gene is possibly related to extremely low birth weight published pages: , ISSN: 1471-2156, DOI: 10.1186/s12863-016-0439-5 |
BMC Genetics 17/1 | 2019-10-28 |
| 2016 |
Triin Laisk-Podar, Cecilia M. Lindgren, Maire Peters, Juha S. Tapanainen, Cornelis B. Lambalk, Andres Salumets, Reedik Mägi Ovarian Physiology and GWAS: Biobanks, Biology, and Beyond published pages: 516-528, ISSN: 1043-2760, DOI: 10.1016/j.tem.2016.04.011 |
Trends in Endocrinology & Metabolism 27/7 | 2019-10-28 |
| 2016 |
Lusine Aghajanova, Signe Altmäe, Sergo Kasvandik, Andres Salumets, Anneli Stavreus-Evers, Linda C. Giudice Stanniocalcin-1 expression in normal human endometrium and dysregulation in endometriosis published pages: 681-691.e1, ISSN: 0015-0282, DOI: 10.1016/j.fertnstert.2016.05.023 |
Fertility and Sterility 106/3 | 2019-10-28 |
| 2016 |
Natalia Pervjakova, Silva Kasela, Andrew P Morris, Mart Kals, Andres Metspalu, Cecilia M Lindgren, Andres Salumets, Reedik Mägi Imprinted genes and imprinting control regions show predominant intermediate methylation in adult somatic tissues published pages: 789-799, ISSN: 1750-1911, DOI: 10.2217/epi.16.8 |
Epigenomics 8/6 | 2019-10-28 |
| 2016 |
Merli Saare, Vijayachitra Modhukur, Marina Suhorutshenko, Balaji Rajashekar, Kadri Rekker, Deniss Sõritsa, Helle Karro, Pille Soplepmann, Andrei Sõritsa, Cecilia M. Lindgren, Nilufer Rahmioglu, Alexander Drong, Christian M. Becker, Krina T. Zondervan, Andres Salumets, Maire Peters The influence of menstrual cycle and endometriosis on endometrial methylome published pages: , ISSN: 1868-7075, DOI: 10.1186/s13148-015-0168-z |
Clinical Epigenetics 8/1 | 2019-10-28 |
| 2016 |
Kaarel Krjutškov, Mariann Koel, Anne Mari Roost, Shintaro Katayama, Elisabet Einarsdottir, Eeva-Mari Jouhilahti, Cilla Söderhäll, Ülle Jaakma, Mario Plaas, Liselotte Vesterlund, Hannes Lohi, Andres Salumets, Juha Kere Globin mRNA reduction for whole-blood transcriptome sequencing published pages: , ISSN: 2045-2322, DOI: 10.1038/srep31584 |
Scientific Reports 6/1 | 2019-10-28 |
| 2018 |
Hindrek Teder, Mariann Koel, Priit Paluoja, Tatjana Jatsenko, Kadri Rekker, Triin Laisk-Podar, Viktorija Kukuškina, Agne Velthut-Meikas, Olga Fjodorova, Maire Peters, Juha Kere, Andres Salumets, Priit Palta, Kaarel Krjutškov TAC-seq: targeted DNA and RNA sequencing for precise biomarker molecule counting published pages: , ISSN: 2056-7944, DOI: 10.1038/s41525-018-0072-5 |
npj Genomic Medicine 3/1 | 2019-10-28 |
| 2018 |
Heidi Marjonen, Pauliina Auvinen, Hanna Kahila, Olga Tšuiko, Sulev Kõks, Airi Tiirats, Triin Viltrop, Timo Tuuri, Viveca Söderström-Anttila, Anne-Maria Suikkari, Andres Salumets, Aila Tiitinen, Nina Kaminen-Ahola rs10732516 polymorphism at the IGF2/H19 locus associates with genotype-specific effects on placental DNA methylation and birth weight of newborns conceived by assisted reproductive technology published pages: , ISSN: 1868-7075, DOI: 10.1186/s13148-018-0511-2 |
Clinical Epigenetics 10/1 | 2019-10-28 |
| 2018 |
Sakthivignesh Ponandai-Srinivasan, Karin L Andersson, Monica Nister, Merli Saare, Halima A Hassan, Suby J Varghese, Maire Peters, Andres Salumets, Kristina Gemzell-Danielsson, Parameswaran Grace Luther Lalitkumar Aberrant expression of genes associated with stemness and cancer in endometria and endometrioma in a subset of women with endometriosis published pages: 1924-1938, ISSN: 0268-1161, DOI: 10.1093/humrep/dey241 |
Human Reproduction 33/10 | 2019-10-28 |
| 2017 |
Tiina Drell, Jelena Štšepetova, Jaak Simm, Kristiina Rull, Aira Aleksejeva, Anne Antson, Vallo Tillmann, Madis Metsis, Epp Sepp, Andres Salumets, Reet Mändar The Influence of Different Maternal Microbial Communities on the Development of Infant Gut and Oral Microbiota published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-09278-y |
Scientific Reports 7/1 | 2019-10-28 |
| 2017 |
L.C. Gemmell, K.E. Webster, S. Kirtley, K. Vincent, K.T. Zondervan, C.M. Becker The management of menopause in women with a history of endometriosis: a systematic review published pages: 481-500, ISSN: 1355-4786, DOI: 10.1093/humupd/dmx011 |
Human Reproduction Update 23/4 | 2019-10-28 |
| 2017 |
Nilufer Rahmioglu, Alexander W Drong, Helen Lockstone, Thomas Tapmeier, Karin Hellner, Merli Saare, Triin Laisk-Podar, Christine Dew, Emily Tough, George Nicholson, Maire Peters, Andrew P Morris, Cecilia M Lindgren, Christian M Becker, Krina T Zondervan Variability of genome-wide DNA methylation and mRNA expression profiles in reproductive and endocrine disease related tissues published pages: 897-908, ISSN: 1559-2294, DOI: 10.1080/15592294.2017.1367475 |
Epigenetics 12/10 | 2019-10-28 |
| 2017 |
Viktorija Kukushkina, Vijayachitra Modhukur, Marina Suhorutšenko, Maire Peters, Reedik Mägi, Nilufer Rahmioglu, Agne Velthut-Meikas, Signe Altmäe, Francisco J. Esteban, Jaak Vilo, Krina Zondervan, Andres Salumets, Triin Laisk-Podar DNA methylation changes in endometrium and correlation with gene expression during the transition from pre-receptive to receptive phase published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-03682-0 |
Scientific Reports 7/1 | 2019-10-28 |
| 2018 |
Marina Suhorutshenko, Viktorija Kukushkina, Agne Velthut-Meikas, Signe Altmäe, Maire Peters, Reedik Mägi, Kaarel Krjutškov, Mariann Koel, Francisco M Codoñer, Juan Fco Martinez-Blanch, Felipe Vilella, Carlos Simón, Andres Salumets, Triin Laisk Endometrial receptivity revisited: endometrial transcriptome adjusted for tissue cellular heterogeneity published pages: 2074-2086, ISSN: 0268-1161, DOI: 10.1093/humrep/dey301 |
Human Reproduction 33/11 | 2019-10-28 |
| 2017 |
Kadri Rekker, Merli Saare, Elo Eriste, Tõnis Tasa, Viktorija Kukuškina, Anne Mari Roost, Kristi Anderson, Külli Samuel, Helle Karro, Andres Salumets, Maire Peters High-throughput mRNA sequencing of stromal cells from endometriomas and endometrium published pages: 93-100, ISSN: 1470-1626, DOI: 10.1530/rep-17-0092 |
Reproduction 154/1 | 2019-10-28 |
| 2018 |
Kadri Rekker, Signe Altmäe, Marina Suhorutshenko, Maire Peters, Juan F. Martinez-Blanch, Francisco M. Codoñer, Felipe Vilella, Carlos Simón, Andres Salumets, Agne Velthut-Meikas A Two-Cohort RNA-seq Study Reveals Changes in Endometrial and Blood miRNome in Fertile and Infertile Women published pages: 574, ISSN: 2073-4425, DOI: 10.3390/genes9120574 |
Genes 9/12 | 2019-10-28 |
| 2018 |
Olga Tšuiko, Tatjana Jatsenko, Lalit Kumar Parameswaran Grace, Ants Kurg, Joris Robert Vermeesch, Fredrik Lanner, Signe Altmäe, Andres Salumets A speculative outlook on embryonic aneuploidy: Can molecular pathways be involved? published pages: , ISSN: 0012-1606, DOI: 10.1016/j.ydbio.2018.01.014 |
Developmental Biology | 2019-10-28 |
| 2018 |
Martin Sauk, Olga Žilina, Ants Kurg, Eva-Liina Ustav, Maire Peters, Priit Paluoja, Anne Mari Roost, Hindrek Teder, Priit Palta, Nathalie Brison, Joris R. Vermeesch, Kaarel Krjutškov, Andres Salumets, Lauris Kaplinski NIPTmer: rapid k-mer-based software package for detection of fetal aneuploidies published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-23589-8 |
Scientific Reports 8/1 | 2019-10-28 |
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The information about "WIDENLIFE" are provided by the European Opendata Portal: CORDIS opendata.