MARA SIGNED
Molecular Analytical Robotics Assays
Total Cost €
0EC-Contrib. €
0Partnership
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0MARA project word cloud
Explore the words cloud of the MARA project. It provides you a very rough idea of what is the project "MARA" about.
Project "MARA" data sheet
The following table provides information about the project.
| Coordinator |
AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH
Organization address contact info |
| Coordinator Country | Austria [AT] |
| Project website | http://www.maraproject.eu/ |
| Total cost | 3˙996˙477 € |
| EC max contribution | 3˙996˙477 € (100%) |
| Programme |
1. H2020-EU.1.2.1. (FET Open) |
| Code Call | H2020-FETOPEN-2014-2015-RIA |
| Funding Scheme | RIA |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-12-01 to 2020-05-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH | AT (WIEN) | coordinator | 1˙649˙517.00 |
| 2 | IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE | UK (LONDON) | participant | 647˙250.00 |
| 3 | ALBERT-LUDWIGS-UNIVERSITAET FREIBURG | DE (FREIBURG) | participant | 581˙250.00 |
| 4 | Pure Biologics Spolka Akcyjna | PL (WROCLAW) | participant | 570˙000.00 |
| 5 | AARHUS UNIVERSITET | DK (AARHUS C) | participant | 548˙460.00 |
| 6 | APTA BIOSCIENCES LIMITED | UK (LEDBURY HEREFORDSHIRE) | participant | 0.00 |
Map
Project objective
Diagnostic tests are essential to provide a targeted treatment of infectious diseases and to contain the further spread of multidrug resistant pathogens. Current methods are based either on cultivation or on PCR and have significant limitations concerning the clinical requirements to characterise pathogens including their resistance mechanisms within 3 hours. In MARA, we will develop and combine three radically novel technologies that will lead to substantial breakthroughs in science, medicine and industry and, as proof-of principle, use them to create a DNA-based molecular toolkit characterising pathogens. First, the detection of pathogen-associated antigens will be performed by Autonomous Detection Nucleic Acids (AUDENA) that are independent of any laboratory instruments and sophisticated processing. The realisation of the AUDENA concept will lead to an autonomous, stable, simple and very economic novel sensor class applicable for any water-soluble substances. The second revolutionary technology in MARA employs a novel approach in protein mimicry and creation of artificial enzymes, which represents a breakthrough in several disciplines, such as biotechnology, biomedical manufacturing and the energy sector. The third breakthrough in this project represents the development of a Molecular Robot (MORO) that can specifically identify target cells and destroy them. In MARA, the MORO will be used for the lysis of bacterial cells to release intracellular antibiotic resistance associated antigens, but the long-term vision anticipates an application as antibiotic replacement for infectious diseases and a therapeutic agent for cancer treatment, which would represent one of the most important breakthroughs in medicine in the recent years. To meet the highly ambitious objectives pointed out in this proposal, MARA is driven by a complementary, multidisciplinary team of leading experts, with a young, high-profile scientist in the lead.
Deliverables
| DNA origami design software | Open Research Data Pilot | 2019-05-07 20:49:08 |
| Data management plan | Documents, reports | 2019-05-24 18:18:49 |
| Collaborative website | Websites, patent fillings, videos etc. | 2019-05-24 18:18:44 |
Take a look to the deliverables list in detail: detailed list of MARA deliverables.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2017 |
M. Florencia Haurat, Ana Sofia Figueiredo, Lena Hoffmann, Lingling Li, Katharina Herr, Amanda J. Wilson, Morgan Beeby, Jörg Schaber, Sonja-Verena Albers ArnS, a kinase involved in starvation-induced archaellum expression published pages: 181-194, ISSN: 0950-382X, DOI: 10.1111/mmi.13550 |
Molecular Microbiology 103/1 | 2019-05-07 |
| 2018 |
H. Miao, E. De Llano, T. Isenberg, M. E. Gröller, I. Barišić, I. Viola DimSUM: Dimension and Scale Unifying Map for Visual Abstraction of DNA Origami Structures published pages: 403-413, ISSN: 0167-7055, DOI: 10.1111/cgf.13429 |
Computer Graphics Forum 37/3 | 2019-05-07 |
| 2018 |
Haichao Miao, Elisa De Llano, Johannes Sorger, Yasaman Ahmadi, Tadija Kekic, Tobias Isenberg, M. Eduard Groller, Ivan Barisic, Ivan Viola Multiscale Visualization and Scale-Adaptive Modification of DNA Nanostructures published pages: 1014-1024, ISSN: 1077-2626, DOI: 10.1109/TVCG.2017.2743981 |
IEEE Transactions on Visualization and Computer Graphics 24/1 | 2019-05-07 |
| 2016 |
Dominik Esser, Lena Hoffmann, Trong Khoa Pham, Christopher Bräsen, Wen Qiu, Phillip C. Wright, Sonja-Verena Albers, Bettina Siebers Protein phosphorylation and its role in archaeal signal transduction published pages: 625-647, ISSN: 1574-6976, DOI: 10.1093/femsre/fuw020 |
FEMS Microbiology Reviews 40/5 | 2019-05-07 |
| 2017 |
M. Florencia Haurat, Ana Sofia Figueiredo, Lena Hoffmann, Lingling Li, Katharina Herr, Amanda J. Wilson, Morgan Beeby, Jörg Schaber, Sonja-Verena Albers ArnS, a kinase involved in starvation-induced archaellum expression published pages: 181-194, ISSN: 0950-382X, DOI: 10.1111/mmi.13550 |
Molecular Microbiology 103/1 | 2019-05-07 |
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