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SMARTDIAGNOS SIGNED

Next generation sepsis diagnosis

Total Cost €

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EC-Contrib. €

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Partnership

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Outcomes and
results

SMARTDIAGNOS project word cloud

Explore the words cloud of the SMARTDIAGNOS project. It provides you a very rough idea of what is the project "SMARTDIAGNOS" about.

50 array streamlined single body profiling accurate device appropriate worldwide blood patient urgent critical tools smartdiagnos quantification dna organs pathogens reduce concentration caused delay angle outcome saf health spread solid enhanced 3d treatment shorter circulation impaired mortality incidence direct fast human days shorten time correct multiplexing multiplex initial capability circumvent amount economic resistance potentially detection sensitivity 10 raw infection greatest culture public diagnosis dimentional biggest therapy fluorescence nucleic tissues antimicrobial clinical stay acid supercritical patients fatal 95 automation care innovative technologies rapid intensive extraction administered hour antibiotic precise combining hence pcr bacteria simplifying microstructure unfortunately sepsis microlens integrating 99 diagnostic arises mainly fungi selectivity issue earlier unlimited damages

Project "SMARTDIAGNOS" data sheet

The following table provides information about the project.

Coordinator	DANMARKS TEKNISKE UNIVERSITET Organization address address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A city: KGS LYNGBY postcode: 2800 website: www.dtu.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Denmark [DK]
Project website	http://www.smartdiagnos.eu
Total cost	4˙797˙602 €
EC max contribution	4˙027˙909 € (84%)
Programme	1. H2020-EU.2.1.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT))
Code Call	H2020-ICT-2015
Funding Scheme	IA
Starting year	2016
Duration (year-month-day)	from 2016-02-01 to 2020-01-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	DANMARKS TEKNISKE UNIVERSITET DANMARKS TEKNISKE UNIVERSITET Organization address address: ANKER ENGELUNDSVEJ 1 BYGNING 101 A city: KGS LYNGBY postcode: 2800 website: www.dtu.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KGS LYNGBY)	coordinator	1˙393˙615.00
2	CUBE DX GMBH CUBE DX GMBH Organization address address: WESTBAHNSTRASSE 55 city: ST VALENTIN postcode: 4300 website: www.cubedx.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (ST VALENTIN)	participant	721˙122.00
3	SCANDINAVIAN MICRO BIODEVICES APS SCANDINAVIAN MICRO BIODEVICES APS Organization address address: GAMMELGARDSVEJ 87C city: FARUM postcode: 3520 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (FARUM)	participant	699˙953.00
4	UNIVERSITAT FUR WEITERBILDUNG KREMS UNIVERSITAT FUR WEITERBILDUNG KREMS Organization address address: DR KARL DORREK STRASSE 30 city: KREMS postcode: 3500 website: http://www.donau-uni.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (KREMS)	participant	273˙550.00
5	TATAA BIOCENTER AB TATAA BIOCENTER AB Organization address address: ODINSGATAN 28 city: GOTEBORG postcode: 411 03 website: www.tataa.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (GOTEBORG)	participant	248˙624.00
6	HOGSKOLAN I SKOVDE HOGSKOLAN I SKOVDE Organization address address: HOGSKOLEVAGEN 1 city: SKOVDE postcode: 54 128 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (SKOVDE)	participant	183˙500.00
7	UNIVERZITA KARLOVA UNIVERZITA KARLOVA Organization address address: OVOCNY TRH 560/5 city: PRAHA 1 postcode: 116 36 website: www.cuni.cz contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CZ (PRAHA 1)	participant	130˙000.00
8	DIN DEUTSCHES INSTITUT FUER NORMUNG E.V. DIN DEUTSCHES INSTITUT FUER NORMUNG E.V. Organization address address: BURGGRAFENSTRASSE 6 city: BERLIN postcode: 10787 website: www.din.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERLIN)	participant	128˙337.00
9	UNILABS AB UNILABS AB Organization address address: BOX 1061 city: GOTEBORG postcode: 40522 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (GOTEBORG)	participant	126˙250.00
10	COPENHAGEN BUSINESS SCHOOL COPENHAGEN BUSINESS SCHOOL Organization address address: SOLBJERG PLADS 3 city: FREDERIKSBERG postcode: 2000 website: http://www.cbs.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (FREDERIKSBERG)	participant	122˙955.00

Map

Project objective

Sepsis is a potentially fatal condition that arises when the body’s response to an infection damages its own tissues and organs. It is mainly caused by bacteria and fungi, which spread through the blood circulation. It is one of the biggest public health issue in the EU and worldwide due to its high incidence, mortality, human and economic cost. Early diagnosis is crucial to the management of sepsis, as every hour of delay of appropriate antibiotic therapy increases mortality by 5-10%. Unfortunately, sepsis diagnosis remains one of the greatest clinical challenges in critical care. Current diagnostic methods, including blood culture and different nucleic acid based multiplex technologies, are impaired by the significant time-delay of 1-2 days and/or low sensitivity of 30-50%. Hence there is an urgent need to develop new diagnostic tools that can provide more accurate and earlier sepsis diagnosis, so that patients with sepsis can be administered with rapid and correct initial antimicrobial treatment. The SMARTDIAGNOS project will advance sepsis diagnosis by simplifying clinical sample analysis methods and integrating the currently required numerous steps into a single streamlined device. This will be achieved by combining a number of innovative technologies: 1) 3-dimentional sample concentration to process large amount of raw sample; 2) direct PCR in the 3D microstructure to circumvent DNA extraction step; 3) solid-phase PCR to achieve unlimited multiplexing capability; 4) supercritical angle fluorescence (SAF) microlens array for enhanced fluorescence detection and precise quantification of sepsis-related pathogens. The SMARTDIAGNOS system will go beyond the state of the art for shorter time (1-3 h), higher sensitivity (95%), higher selectivity (99%), multiplexing capability, antimicrobial resistance profiling, and automation. Fast and correct sepsis diagnosis will improve patient outcome, shorten intensive care stay and thus reduce health costs.

Publications

List of publications.
year	authors and title	journal	last update
2017	Tran Quang Hung, Wai Hoe Chin, Yi Sun, Anders Wolff, Dang Duong Bang A novel lab-on-chip platform with integrated solid phase PCR and Supercritical Angle Fluorescence (SAF) microlens array for highly sensitive and multiplexed pathogen detection published pages: 217-223, ISSN: 0956-5663, DOI: 10.1016/j.bios.2016.11.028	Biosensors and Bioelectronics 90	2020-02-24
2018	Vivek Priy Dave, Tien Anh Ngo, Anna-Karin Pernestig, Diana Tilevik, Krishna Kant, Trieu Nguyen, Anders Wolff, Dang Duong Bang MicroRNA amplification and detection technologies: opportunities and challenges for point of care diagnostics published pages: , ISSN: 0023-6837, DOI: 10.1038/s41374-018-0143-3	Laboratory Investigation	2020-02-24
2019	Aaydha C. Vinayaka, Tien A. Ngo, Krishna Kant, Pia Engelsmann, Vivek P. Dave, Mohammad-Ali Shahbazi, Anders Wolff, Dang D. Bang Rapid detection of Salmonella enterica in food samples by a novel approach with combination of sample concentration and direct PCR published pages: 224-230, ISSN: 0956-5663, DOI: 10.1016/j.bios.2018.09.078	Biosensors and Bioelectronics 129	2020-02-24
2018	Krishna Kant, Mohammad-Ali Shahbazi, Vivek Priy Dave, Tien Anh Ngo, Vinayaka Aaydha Chidambara, Linh Quyen Than, Dang Duong Bang, Anders Wolff Microfluidic devices for sample preparation and rapid detection of foodborne pathogens published pages: 1003-1024, ISSN: 0734-9750, DOI: 10.1016/j.biotechadv.2018.03.002	Biotechnology Advances 36/4	2020-02-24
2018	Trieu Nguyen, Sune ZoÃ«ga Andreasen, Anders Wolff, Dang Duong Bang From Lab on a Chip to Point of Care Devices: The Role of Open Source Microcontrollers published pages: 403, ISSN: 2072-666X, DOI: 10.3390/mi9080403	Micromachines 9/8	2020-02-24
2018	Matthias Pilecky, Anita Schildberger, Dorothea Orth-HÃ¶ller, Viktoria Weber Pathogen enrichment from human whole blood for the diagnosis of bloodstream infection: Prospects and limitations published pages: , ISSN: 0732-8893, DOI: 10.1016/j.diagmicrobio.2018.11.015	Diagnostic Microbiology and Infectious Disease	2020-02-24
2017	Jon Ashley, Mohammad-Ali Shahbazi, Krishna Kant, Vinayaka Aaydha Chidambara, Anders Wolff, Dang Duong Bang, Yi Sun Molecularly imprinted polymers for sample preparation and biosensing in food analysis: Progress and perspectives published pages: 606-615, ISSN: 0956-5663, DOI: 10.1016/j.bios.2017.01.018	Biosensors and Bioelectronics 91	2020-02-24
2019	K. Kant, T.A. Ngo, M. Matteucci, A. Wolff Fabrication of 3D microstructure array on chip for rapid pathogen detection published pages: 774-782, ISSN: 0925-4005, DOI: 10.1016/j.snb.2018.11.008	Sensors and Actuators B: Chemical 281	2020-02-24

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