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rEnDOx SIGNED

REDOX SIGNALING AND METABOLIC STATES IN ANGIOGENESIS IN HEALTH AND DISEASE

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

rEnDOx project word cloud

Explore the words cloud of the rEnDOx project. It provides you a very rough idea of what is the project "rEnDOx" about.

health balance cancer pharmacological mechanisms repertoire selective plasticity signaling therapeutic time rel laboratories variations aberrant itself metabolic underlying shed nitric reveal vivo clinical insights identification animal excessive ecs signals angiogenesis cells metabolism genetic solid dysfunction preserve relevance valuable adapt reductive manipulation physiological rheostats adjust rheostat treatment strategy unclear small disease oxygen play strategies stress active ec edge normal molecular actions innovative biology ultimate oxidative gaining vertebrate exhibit cutting redox ones oxide platforms ubiad1 remarkable endothelial equipped light block alteration pathological models stages angiogenic imaging interactions complement mevalonate expertise collaborations

Project "rEnDOx" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITA DEGLI STUDI DI PADOVA Organization address address: VIA 8 FEBBRAIO 2 city: PADOVA postcode: 35122 website: www.unipd.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Project website	http://www.massimosantorolab.com
Total cost	1˙999˙827 €
EC max contribution	1˙999˙827 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-CoG
Funding Scheme	ERC-COG
Starting year	2016
Duration (year-month-day)	from 2016-07-01 to 2021-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITA DEGLI STUDI DI PADOVA UNIVERSITA DEGLI STUDI DI PADOVA Organization address address: VIA 8 FEBBRAIO 2 city: PADOVA postcode: 35122 website: www.unipd.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (PADOVA)	coordinator	1˙696˙074.00
2	UNIVERSITA DEGLI STUDI DI TORINO UNIVERSITA DEGLI STUDI DI TORINO Organization address address: VIA GIUSEPPE VERDI 8 city: TORINO postcode: 10124 website: www.unito.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (TORINO)	participant	303˙752.00

Map

Project objective

Endothelial cells (ECs) exhibit a remarkable and unique plasticity in terms of redox biology and metabolism. They can quickly adapt to oxygen, nitric oxide and metabolic variations. Therefore, EC must be equipped with a selective and unique repertoire of redox and metabolic mechanisms, that play a crucial role to preserve redox balance, and adjust metabolic conditions in both normal and pathological angiogenesis. The identification of such redox signaling and metabolic pathways is crucial to the gaining of better insights in endothelial biology and dysfunction. More importantly, these insights could be used to establish innovative therapeutic approaches for the treatment of those conditions where aberrant or excessive angiogenesis is the underlying cause of the disease itself. However, the formation, actions, key molecular interactions, and physiological and pathological relevance of redox signals in ECs remain unclear. Here, by using cutting-edge real-time redox imaging platforms, and innovative molecular and genetic approaches in different in vivo animal models, we will (1) reveal the working of redox signaling in EC in health and disease, (2) shed light on the novel role for the mevalonate metabolic pathway in angiogenesis and (3) provide solid evidence, that manipulation of endothelial redox and metabolic state by genetic alteration of the redox rheostat UBIAD1, is a valuable strategy by which to block pathological angiogenesis in vivo. The ultimate objective is to open the way for the development of innovative (cancer) therapeutic strategies and complement the existing ones based on genetic or pharmacological manipulation of redox rheostats to balance oxidative or reductive stress in angiogenic processes. The success of this project is built upon our major expertise in the field of angiogenesis in small vertebrate animal models as well as on the collaborations with leading laboratories that are active in research on the pre-clinical stages for angiogenesis-rel

Publications

List of publications.
year	authors and title	journal	last update
2018	Roxana E. Oberkersch, Massimo M. Santoro Role of amino acid metabolism in angiogenesis published pages: , ISSN: 1537-1891, DOI: 10.1016/j.vph.2018.11.001	Vascular Pharmacology	2019-05-23
2018	E. Zulato, F. Ciccarese, V. Agnusdei, M. Pinazza, G. Nardo, E. Iorio, M. Curtarello, M. Silic-Benussi, E. Rossi, C. Venturoli, E. Panieri, M.M. Santoro, V. Di Paolo, L. Quintieri, V. Ciminale, S. Indraccolo LKB1 loss is associated with glutathione deficiency under oxidative stress and sensitivity of cancer cells to cytotoxic drugs and Î³-irradiation published pages: 479-490, ISSN: 0006-2952, DOI: 10.1016/j.bcp.2018.09.019	Biochemical Pharmacology 156	2019-05-23
2018	Massimo Mattia Santoro Fashioning blood vessels by ROS signalling and metabolism published pages: 35-42, ISSN: 1084-9521, DOI: 10.1016/j.semcdb.2017.08.002	Seminars in Cell & Developmental Biology 80	2019-03-18
2018	Dougall M. Norris, Massimo M. Santoro Before the Pump published pages: 2763-2764, ISSN: 1079-5642, DOI: 10.1161/atvbaha.118.311893	Arteriosclerosis, Thrombosis, and Vascular Biology 38/12	2019-03-18
2018	Sanjay Sinha, Massimo Mattia Santoro New models to study vascular mural cell embryonic origin: implications in vascular diseases published pages: 481-491, ISSN: 0008-6363, DOI: 10.1093/cvr/cvy005	Cardiovascular Research 114/4	2019-03-18
2016	Raj Sewduth, Massimo M. Santoro â€œDecodingâ€ Angiogenesis: New Facets Controlling Endothelial Cell Behavior published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2016.00306	Frontiers in Physiology 7	2019-03-18
2018	Oliver A. Stone, Mohamed El-Brolosy, Kerstin Wilhelm, Xiaojing Liu, Ana M. RomÃ£o, Elisabetta Grillo, Jason K. H. Lai, Stefan GÃ¼nther, Sylvia Jeratsch, Carsten Kuenne, I-Ching Lee, Thomas Braun, Massimo M. Santoro, Jason W. Locasale, Michael Potente, Didier Y. R. Stainier Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06406-8	Nature Communications 9/1	2019-03-18
2018	Katia Rupel, Luisa Zupin, Andrea Colliva, Anselmo Kamada, Augusto Poropat, Giulia Ottaviani, Margherita Gobbo, Lidia Fanfoni, Rossella Gratton, Massimo Santoro, Roberto Di Lenarda, Matteo Biasotto, Serena Zacchigna Photobiomodulation at Multiple Wavelengths Differentially Modulates Oxidative Stress In Vitro and In Vivo published pages: 1-11, ISSN: 1942-0900, DOI: 10.1155/2018/6510159	Oxidative Medicine and Cellular Longevity 2018	2019-03-18
2018	Jacoba J. Louw, Ricardo Nunes Bastos, Xiaowen Chen, CÃ©line Verdood, Anniek Corveleyn, Yaojuan Jia, Jeroen Breckpot, Marc Gewillig, Hilde Peeters, Massimo M. Santoro, Francis Barr, Koenraad Devriendt Compound heterozygous loss-of-function mutations in KIF20A are associated with a novel lethal congenital cardiomyopathy in two siblings published pages: e1007138, ISSN: 1553-7404, DOI: 10.1371/journal.pgen.1007138	PLOS Genetics 14/1	2019-03-18
2016	E Panieri, M M Santoro ROS homeostasis and metabolism: a dangerous liason in cancer cells published pages: e2253, ISSN: 2041-4889, DOI: 10.1038/cddis.2016.105	Cell Death and Disease 7/6	2019-05-31
2017	Dafne Gays, Christopher Hess, Annalisa Camporeale, Ugo Ala, Paolo Provero, Christian Mosimann, Massimo M. Santoro An exclusive cellular and molecular network governs intestinal smooth muscle cell differentiation in vertebrates published pages: 464-478, ISSN: 0950-1991, DOI: 10.1242/dev.133926	Development 144/3	2019-05-31
2017	Emiliano Panieri, Massimo M. Santoro Data on metabolic-dependent antioxidant response in the cardiovascular tissues of living zebrafish under stress conditions published pages: 427-432, ISSN: 2352-3409, DOI: 10.1016/j.dib.2017.04.034	Data in Brief 12	2019-05-31
2016	Giulia Mana, Fabiana Clapero, Emiliano Panieri, Valentina Panero, Ralph T. BÃ¶ttcher, Hui-Yuan Tseng, Federico Saltarin, Elena Astanina, Katarzyna I. Wolanska, Mark R. Morgan, Martin J. Humphries, Massimo M. Santoro, Guido Serini, Donatella Valdembri PPFIA1 drives active Î±5Î²1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis published pages: 13546, ISSN: 2041-1723, DOI: 10.1038/ncomms13546	Nature Communications 7	2019-05-31
2017	Xiaowen Chen, Dafne Gays, Carlo Milia, Massimo M. Santoro Cilia Control Vascular Mural Cell Recruitment in Vertebrates published pages: 1033-1047, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2016.12.044	Cell Reports 18/4	2019-05-31
2016	Saravana K. Ramasamy, Anjali P. Kusumbe, Maria Schiller, Dagmar Zeuschner, M. Gabriele Bixel, Carlo Milia, Jaba Gamrekelashvili, Anne Limbourg, Alexander Medvinsky, Massimo M. Santoro, Florian P. Limbourg, Ralf H. Adams Blood flow controls bone vascular function and osteogenesis published pages: 13601, ISSN: 2041-1723, DOI: 10.1038/ncomms13601	Nature Communications 7	2019-05-31
2017	Emiliano Panieri, Carlo Millia, Massimo M. Santoro Real-time quantification of subcellular H2O2 and glutathione redox potential in living cardiovascular tissues published pages: , ISSN: 0891-5849, DOI: 10.1016/j.freeradbiomed.2017.02.022	Free Radical Biology and Medicine	2019-05-31

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