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HYPERDIAMOND SIGNED

The Diamond Revolution in Hyperpolarized MR Imaging – Novel Platform and Nanoparticle Targeted Probe

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

HYPERDIAMOND project word cloud

Explore the words cloud of the HYPERDIAMOND project. It provides you a very rough idea of what is the project "HYPERDIAMOND" about.

diagnosis image limiting cumbersome centres small hyperpolarized clinical breakthrough first human imaging vacancy sensitive monitoring gt diagnostics resonance tomography quantum invasively easily molecular hyperpolarization vivo previously dosage nanotechnology commercialization nitrogen non revolution pyruvate innovation unseen nd technological diamond expensive probes probe positron demonstrated bridge clinically revolutionize undergoing conventional gap patients pet sensitivity viability cancer treatment hyperdiamond hyperpolarizer hour feasible hyperpolarizes layouts breakthroughs socioeconomic proved enormous producing prostate exhibit time minutes fits emission defects fold introduce extremely magnetic diamonds metabolic mri 1 primary improves nano diseases nv exhibiting technologies solution times

Project "HYPERDIAMOND" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITAET ULM Organization address address: HELMHOLTZSTRASSE 16 city: ULM postcode: 89081 website: www.uni-ulm.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	http://www.hyperdiamond-project.eu
Total cost	5˙073˙550 €
EC max contribution	4˙866˙050 € (96%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-PHC-2015-two-stage
Funding Scheme	RIA
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2020-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITAET ULM UNIVERSITAET ULM Organization address address: HELMHOLTZSTRASSE 16 city: ULM postcode: 89081 website: www.uni-ulm.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (ULM)	coordinator	1˙233˙863.00
2	NVISION IMAGING TECHNOLOGIES GMBH NVISION IMAGING TECHNOLOGIES GMBH Organization address address: ALBERT-EINSTEIN-ALLEE city: ULM postcode: 89081 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (ULM)	participant	685˙625.00
3	UNIVERSITE DE TOURS UNIVERSITE DE TOURS Organization address address: RUE DU PLAT D ETAIN 60 city: TOURS postcode: 37020 website: www.univ-tours.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (TOURS)	participant	627˙382.00
4	RESEARCH FUND OF THE HADASSAH MEDICAL ORGANIZATION (R.A) RESEARCH FUND OF THE HADASSAH MEDICAL ORGANIZATION (R.A) Organization address address: KIRYAT HADASSAH EIN KAREM city: JERUSALEM postcode: 91120 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (JERUSALEM)	participant	427˙750.00
5	KARLSRUHER INSTITUT FUER TECHNOLOGIE KARLSRUHER INSTITUT FUER TECHNOLOGIE Organization address address: KAISERSTRASSE 12 city: KARLSRUHE postcode: 76131 website: www.kit.edu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (KARLSRUHE)	participant	390˙125.00
6	AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH Organization address address: GIEFINGGASSE 4 city: WIEN postcode: 1210 website: http://www.ait.ac.at/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	379˙661.00
7	MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Organization address address: HOFGARTENSTRASSE 8 city: MUENCHEN postcode: 80539 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	366˙108.00
8	ARTTIC ARTTIC Organization address address: RUE DU DESSOUS DES BERGES 58A city: PARIS postcode: 75013 website: www.arttic.eu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	282˙580.00
9	KANFIT LTD KANFIT LTD Organization address address: 4 SHAUL AMOR AVENUE RAMAT GAVRIEL INDUSTRIAL ZONE city: MIGDAL HA-EMEK postcode: 2353004 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (MIGDAL HA-EMEK)	participant	272˙805.00
10	THE HEBREW UNIVERSITY OF JERUSALEM THE HEBREW UNIVERSITY OF JERUSALEM Organization address address: EDMOND J SAFRA CAMPUS GIVAT RAM city: JERUSALEM postcode: 91904 website: www.huji.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (JERUSALEM)	participant	200˙150.00
11	LM VAN MOPPES AND SONS SA LM VAN MOPPES AND SONS SA Organization address address: AVENUE DE LA PRAILLE 55 city: CAROUGE GE postcode: 1211 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (CAROUGE GE)	participant	0.00

Map

Project objective

Non-invasively imaging small numbers of molecular probes, to help image particular targets or pathways in vivo, is currently undergoing a technological revolution. Recent breakthroughs in molecular hyperpolarization proved > 10,000-fold increase in sensitivity on conventional magnetic resonance imaging (MRI) systems, thus providing insight into previously unseen metabolic processes with enormous potential for socioeconomic relevant diseases. E.g. pyruvate-based hyperpolarized imaging was clinically demonstrated to be effective for prostate cancer diagnostics in human patients. However, the current state-of-the-art hyperpolarization methods are expensive and cumbersome, limiting the access to hyperpolarization technology, and require long hyperpolarization times of 60-90 minutes per dosage; hyperpolarization probes exhibit short hyperpolarization duration (1-5 minutes), limiting the usage of hyperpolarization to metabolic imaging. A quantum technological breakthrough, Nitrogen-Vacancy defects (NV centres) in diamonds, is set to revolutionize the field of hyperpolarization for both hyperpolarizer and probes. The primary objective of HYPERDIAMOND is the development and commercialization of two new molecular imaging technologies for sensitive diagnosis and treatment monitoring, based on NV centres: The Diamond Hyperpolarizer will offer a cost- and time-effective solution for hyperpolarization that easily fits current MRI layouts, hyperpolarizes within 5 minutes, and improves clinical viability. The Nano-diamond (ND) Probe will introduce the first targeted MRI probe capable of achieving comparable molecular sensitivity to positron emission tomography (PET) with MRI systems, exhibiting extremely long hyperpolarization duration (~1 hour), and enabling non-metabolic hyperpolarized imaging. HYPERDIAMOND will bridge the gap between novel quantum and nanotechnology and their applications in hyperpolarized imaging, producing innovation not feasible with current technology.

Deliverables

List of deliverables.
Report on ND-probe hyperpolarization system	Documents, reports	2020-02-07 10:14:37
HYPERDIAMOND Public website	Websites, patent fillings, videos etc.	2020-02-07 10:14:37

Take a look to the deliverables list in detail: detailed list of HYPERDIAMOND deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2020	Lujuan Xu, Marco Raabe, Maksymilian Marek Zegota, Joao Nogueira, Vijay Chudasama, Seah Ling Kuan, Tanja Weil Site-selective protein modification via disulfide rebridging for fast tetrazine/trans-cyclooctene bioconjugation published pages: , ISSN: 1477-0520, DOI: 10.1039/c9ob02687h	Organic & Biomolecular Chemistry	2020-02-07
2019	Jonas Friebel, Christopher P. Ender, Markus Mezger, Jasper Michels, Manfred Wagner, Kenneth B. Wagener, Tanja Weil Synthesis of Precision Poly(1,3-adamantylene alkylene)s via Acyclic Diene Metathesis Polycondensation published pages: 4483-4491, ISSN: 0024-9297, DOI: 10.1021/acs.macromol.9b00294	Macromolecules 52/12	2020-02-07
2019	Pierpaolo Moscariello, Marco Raabe, Weina Liu, Sandra Bernhardt, Haoyuan Qi, Ute Kaiser, Yuzhou Wu, Tanja Weil, Heiko J. Luhmann, Jana Hedrich Unraveling In Vivo Brain Transport of Proteinâ€Coated Fluorescent Nanodiamonds published pages: 1902992, ISSN: 1613-6810, DOI: 10.1002/smll.201902992	Small	2020-02-07
2019	Shen Han, Marco Raabe, Lorna Hodgson, Judith Mantell, Paul Verkade, Theo Lasser, Katharina Landfester, Tanja Weil, Ingo Lieberwirth High-Contrast Imaging of Nanodiamonds in Cells by Energy Filtered and Correlative Light-Electron Microscopy: Toward a Quantitative Nanoparticle-Cell Analysis published pages: 2178-2185, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.9b00752	Nano Letters 19/3	2020-02-07
2019	Genov, Genko T.; Aharon, Nati; Jelezko, Fedor; Retzker, Alex Mixed Dynamical Decoupling published pages: , ISSN: , DOI:	Quantum Physics 1	2020-02-07
2018	Unden, Thomas; Tomek, Nikolas; Weggler, Timo; Frank, Florian; London, Paz; Zopes, Jonathan; Degen, Christian; Raatz, Nicole; Meijer, Jan; Watanabe, Hideyuki; Itoh, Kohei M.; Plenio, Martin B.; Naydenov, Boris; Jelezko, Fedor Coherent control of solid state nuclear spin nano-ensembles published pages: , ISSN: , DOI:	1	2020-02-07
2017	Alexander Stark, Nati Aharon, Thomas Unden, Daniel Louzon, Alexander Huck, Alex Retzker, Ulrik L. Andersen, Fedor Jelezko Narrow-bandwidth sensing of high-frequency fields with continuous dynamical decoupling published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-01159-2	Nature Communications 8/1	2020-02-07
2017	N Aharon, M Drewsen, A Retzker Enhanced quantum sensing with multi-level structures of trapped ions published pages: 34006, ISSN: 2058-9565, DOI: 10.1088/2058-9565/aa771a	Quantum Science and Technology 2/3	2020-02-07
2017	Rotem, Amit; Gefen, Tuvia; Schmitt, Simon; McGuiness, Liam; Jelezko, Fedor; Retzker, Alex Limits on spectral resolution measurements by quantum probes published pages: , ISSN: , DOI:	1	2020-02-07
2018	Pierpaolo Moscariello, David Y. W. Ng, Malin Jansen, Tanja Weil, Heiko J. Luhmann, Jana Hedrich Brain Delivery of Multifunctional Dendrimer Protein Bioconjugates published pages: 1700897, ISSN: 2198-3844, DOI: 10.1002/advs.201700897	Advanced Science	2020-02-07
2016	N Aharon, I Cohen, F Jelezko, A Retzker Fully robust qubit in atomic and molecular three-level systems published pages: 123012, ISSN: 1367-2630, DOI: 10.1088/1367-2630/aa4fd3	New Journal of Physics 18/12	2020-02-07
2017	Bikram Keshari Agrawalla, Tao Wang, Andreas Riegger, Matthias P. Domogalla, Kerstin Steinbrink, Thilo DÃ¶rfler, Xi Chen, Felix Boldt, Markus Lamla, Jens Michaelis, Seah Ling Kuan, Tanja Weil Chemoselective Dual Labeling of Native and Recombinant Proteins published pages: 29-34, ISSN: 1043-1802, DOI: 10.1021/acs.bioconjchem.7b00675	Bioconjugate Chemistry 29/1	2020-02-07
2017	David Y. W. Ng, Roman Vill, Yuzhou Wu, Kaloian Koynov, Yu Tokura, Weina Liu, Susanne Sihler, Andreas Kreyes, Sandra Ritz, Holger Barth, Ulrich Ziener, Tanja Weil Directing intracellular supramolecular assembly with N-heteroaromatic quaterthiophene analogues published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-02020-2	Nature Communications 8/1	2020-02-07
2017	Cohen, Itsik; Unden, Thomas; Jelezko, Fedor; Retzker, Alex Protecting a nuclear spin from a noisy electron spin in diamond published pages: , ISSN: , DOI:	1	2020-02-07
2018	Seah Ling Kuan, Stephan Fischer, Susanne Hafner, Tao Wang, Tatiana Syrovets, Weina Liu, Yu Tokura, David Yuen Wah Ng, Andreas Riegger, Christina FÃ¶rtsch, Daniela JÃ¤ger, Thomas F. E. Barth, Thomas Simmet, Holger Barth, Tanja Weil Boosting Antitumor Drug Efficacy with Chemically Engineered Multidomain Proteins published pages: 1701036, ISSN: 2198-3844, DOI: 10.1002/advs.201701036	Advanced Science 5/8	2020-02-07

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