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HEP-CAR SIGNED

Mechanisms underlying hepatocellular carcinoma pathogenesis and impact of co-morbidities.

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

HEP-CAR project word cloud

Explore the words cloud of the HEP-CAR project. It provides you a very rough idea of what is the project "HEP-CAR" about.

health screens host nonalcoholic sustained infection drug clinical lipidomic screening citizens declining oncogenic 695 cohorts individualized competence therapy liver highlighting generate prevention vivo explant diseases disease vitro virus excellence rating transfer deregulated cellular hepatocellular biased association heterogeneous easl pathogenesis 750 patients die ranging reflects public tissue combined diagnosis morbidity drivers tumour hep steatohepatitis tangible world communication gender morbidities mortality mechanistic patient deaths immunobiology nature malignancy women hcc incidence whilst humanized co treatment hepatitis cancers definition improvements car models nash mouse elpa men carcinoma genetic

Project "HEP-CAR" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITAETSKLINIKUM FREIBURG Organization address address: HUGSTETTER STRASSE 49 city: FREIBURG postcode: 79106 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	http://www.hep-car.eu/
Total cost	5˙698˙310 €
EC max contribution	5˙698˙310 € (100%)
Programme	1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
Code Call	H2020-PHC-2015-two-stage
Funding Scheme	RIA
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2019-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITAETSKLINIKUM FREIBURG UNIVERSITAETSKLINIKUM FREIBURG Organization address address: HUGSTETTER STRASSE 49 city: FREIBURG postcode: 79106 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (FREIBURG)	coordinator	771˙550.00
2	CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER Organization address address: CALLE ROSSELLO 149 PUERTA BJS city: BARCELONA postcode: 8036 website: http://www.idibaps.org/en_index.html contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	1˙012˙755.00
3	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Organization address address: WELLINGTON SQUARE UNIVERSITY OFFICES city: OXFORD postcode: OX1 2JD website: www.ox.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (OXFORD)	participant	828˙164.00
4	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	800˙000.00
5	DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG Organization address address: IM NEUENHEIMER FELD 280 city: HEIDELBERG postcode: 69120 website: www.dkfz.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	participant	600˙000.00
6	THE BABRAHAM INSTITUTE THE BABRAHAM INSTITUTE Organization address address: Babraham Hall city: CAMBRIDGE postcode: CB22 3AT website: www.babraham.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	participant	599˙380.00
7	UNIVERSITATSKLINIKUM HEIDELBERG UNIVERSITATSKLINIKUM HEIDELBERG Organization address address: IM NEUENHEIMER FELD 672 city: HEIDELBERG postcode: 69120 website: www.klinikum.uni-heidelberg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	participant	500˙000.00
8	HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH Organization address address: INGOLSTADTER LANDSTRASSE 1 city: NEUHERBERG postcode: 85764 website: www.helmholtz-muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (NEUHERBERG)	participant	399˙375.00
9	ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRLU ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRLU Organization address address: VIA FIORENTINA 151 city: SIENA postcode: 53100 website: www.altaweb.eu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (SIENA)	participant	180˙000.00
10	THE UNIVERSITY OF BIRMINGHAM THE UNIVERSITY OF BIRMINGHAM Organization address address: Edgbaston city: BIRMINGHAM postcode: B15 2TT website: www.bham.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BIRMINGHAM)	participant	7˙085.00

Map

Project objective

Hepatocellular carcinoma (HCC) is the most common liver malignancy, with an estimated 750,000 new cases and 695,000 deaths per year, rating third in incidence and mortality in the world. Whilst incidence and mortality for other cancers are declining, HCC represents an increasing public health problem in Europe with men having a higher incidence than women. Several liver diseases lead to HCC and become per definition co-morbidities, such as nonalcoholic steatohepatitis (NASH) or hepatitis B and C virus infection. Most patients die within one year of diagnosis and treatment failure reflects the heterogeneous nature of this tumour, highlighting the need to identify common and co-morbidity specific disease pathways for individualized therapy. HEP-CAR will focus on three leading HCC associated co-morbidities, specifically NASH and hepatitis B and C infection. Non-biased genetic and lipidomic screens will define cellular pathways that are deregulated in HCC and the impact of co-morbidities and gender. Next to established patient cohorts, several in vitro and in vivo models are available to evaluate the role of co-morbidities as drivers of host oncogenic pathways and to provide much needed pre-clinical models for mechanistic studies and future drug screening. We will develop new approaches to study the impact of co-morbidities on HCC immunobiology, ranging from state-of-art tissue explant models to novel humanized mouse models. The aim of HEP-CAR is to define host pathways that impact HCC pathogenesis and to assess their role in different co-morbidities and treatment responses. The research and clinical excellence will be combined with the knowledge transfer and communication competence of leading organizations such as the European Association for the Study of the Liver (EASL) and the European Liver Patients Association (ELPA). Thus, HEP-CAR will generate tangible and sustained improvements in the understanding, prevention and management of HCC for all European citizens.

Deliverables

List of deliverables.
Website development and management	Websites, patent fillings, videos etc.	2019-05-30 12:48:36

Take a look to the deliverables list in detail: detailed list of HEP-CAR deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Taiga Wakabayashi, Farid Ouhmich, Cristians Gonzalez-Cabrera, Emanuele Felli, Antonio Saviano, Vincent Agnus, Peter Savadjiev, Thomas F. Baumert, Patrick Pessaux, Jacques Marescaux, Benoit Gallix Radiomics in hepatocellular carcinoma: a quantitative review published pages: 546-559, ISSN: 1936-0533, DOI: 10.1007/s12072-019-09973-0	Hepatology International 13/5	2020-02-28
2019	Catrin Tauber, Liangliang Hao, Kaelyn Brown, Jihoon Lim, Sangeeta N. Bhatia, Frank J. Slack Inefficient induction of circulating TAA-specific CD8+ T-cell responses in hepatocellular carcinoma published pages: , ISSN: 1949-2553, DOI: 10.18632/oncotarget.27146	Oncotarget 10/50	2020-02-28
2016	Eloi R. Verrier, Che C. Colpitts, Camille Sureau, Thomas F. Baumert Hepatitis B virus receptors and molecular drug targets published pages: 567-573, ISSN: 1936-0533, DOI: 10.1007/s12072-016-9718-5	Hepatology International 10/4	2020-02-28
2019	Robert Montal, Carmen Andreu-Oller, Laia Bassaganyas, Roger Esteban-FabrÃ³, SebastiÃ¡n Moran, Carla Montironi, Agrin Moeini, Roser Pinyol, Judit Peix, Laia Cabellos, Augusto Villanueva, Daniela Sia, Vincenzo Mazzaferro, Manel Esteller, Josep M. Llovet Molecular portrait of high alpha-fetoprotein in hepatocellular carcinoma: implications for biomarker-driven clinical trials published pages: 340-343, ISSN: 0007-0920, DOI: 10.1038/s41416-019-0513-7	British Journal of Cancer 121/4	2020-02-28
2019	Antonio Saviano, Thomas F. Baumert Mortality from liver cirrhosis and HCC in the DAA era: success in viral control is darkened by raise of metabolic disease published pages: 307-310, ISSN: 2304-3881, DOI: 10.21037/hbsn.2019.01.21	HepatoBiliary Surgery and Nutrition 8/3	2020-02-28
2019	Emmanuel Thomas, Thomas F. Baumert Hepatitis B Virusâ€“Hepatocyte Interactions and Innate Immune Responses: Experimental Models and Molecular Mechanisms published pages: 301-314, ISSN: 0272-8087, DOI: 10.1055/s-0039-1685518	Seminars in Liver Disease 39/03	2020-02-28
2019	Pierluigi Ramadori, Thomas Klag, Nisar Peter Malek, Mathias Heikenwalder Platelets in chronic liver disease, from bench to bedside published pages: 448-459, ISSN: 2589-5559, DOI: 10.1016/j.jhepr.2019.10.001	JHEP Reports 1/6	2020-02-28
2020	Alessia VirzÃ¬, Armando Andres Roca Suarez, Thomas F. Baumert, Joachim Lupberger Rewiring Host Signaling: Hepatitis C Virus in Liver Pathogenesis published pages: a037366, ISSN: 2157-1422, DOI: 10.1101/cshperspect.a037366	Cold Spring Harbor Perspectives in Medicine 10/1	2020-02-28
2016	Mirjam B. Zeisel, Thomas F. Baumert Translation and protein expression of lncRNAs: Impact for liver disease and hepatocellular carcinoma published pages: 671-674, ISSN: 0270-9139, DOI: 10.1002/hep.28653	Hepatology 64/2	2020-02-28
2016	Eloi Verrier, Che Colpitts, Catherine Schuster, Mirjam Zeisel, Thomas Baumert Cell Culture Models for the Investigation of Hepatitis B and D Virus Infection published pages: 261, ISSN: 1999-4915, DOI: 10.3390/v8090261	Viruses 8/9	2020-02-28
2019	Florian Wrensch, Zhen-yong Keck, Steven K.H. Foung, Thomas F. Baumert Learning from a clinical cohort for HCV vaccine development published pages: 9-11, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2019.03.030	Journal of Hepatology 71/1	2020-02-28
2019	Peter AC Wing, Tamara Davenne, Jochen Wettengel, Alvina G Lai, Xiaodong Zhuang, Anindita Chakraborty, Valentina Dâ€™Arienzo, Catharina Kramer, Chunkyu Ko, James M Harris, Sabrina Schreiner, Martin Higgs, Stephanie Roessler, Joanna L Parish, Ulrike Protzer, Peter Balfe, Jan Rehwinkel, Jane A McKeating A dual role for SAMHD1 in regulating HBV cccDNA and RT-dependent particle genesis published pages: e201900355, ISSN: 2575-1077, DOI: 10.26508/lsa.201900355	Life Science Alliance 2/2	2020-02-28
2019	Eloi R Verrier, AmÃ©lie Weiss, Charlotte Bach, Laura Heydmann, Vincent Turon-Lagot, Arnaud Kopp, Houssein El Saghire, Emilie Crouchet, Patrick Pessaux, Thomas Garcia, Patrick Pale, Mirjam B Zeisel, Camille Sureau, Catherine Schuster, Laurent Brino, Thomas F Baumert Combined small molecule and loss-of-function screen uncovers estrogen receptor alpha and CAD as host factors for HDV infection and antiviral targets published pages: 158-167, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2018-317065	Gut 69/1	2020-02-28
2019	Maike Smits, Katharina Zoldan, Naveed Ishaque, Zuguang Gu, Katharina Jechow, Dominik Wieland, Christian Conrad, Roland Eils, Catherine Fauvelle, Thomas F. Baumert, Florian Emmerich, Bertram Bengsch, Christoph Neumann-Haefelin, Maike Hofmann, Robert Thimme, Tobias Boettler Follicular T helper cells shape the HCV-specific CD4+ T cell repertoire after virus elimination published pages: 998-1009, ISSN: 0021-9738, DOI: 10.1172/jci129642	Journal of Clinical Investigation 130/2	2020-02-28
2019	Joachim Lupberger, Tom Croonenborghs, Armando Andres Roca Suarez, Nicolaas Van Renne, Frank JÃ¼hling, Marine A. Oudot, Alessia VirzÃ¬, Simonetta Bandiera, Carole Jamey, GergÃ¶ Meszaros, Daniel Brumaru, Atish Mukherji, Sarah C. Durand, Laura Heydmann, Eloi R. Verrier, Hussein El Saghire, Nourdine Hamdane, Ralf Bartenschlager, Shaunt Fereshetian, Evelyn Ramberger, Rileen Sinha, Mohsen Nabian, Celine Combined Analysis of Metabolomes, Proteomes, and Transcriptomes of Hepatitis C Virusâ€“Infected Cells and Liver to Identify Pathways Associated With Disease Development published pages: 537-551.e9, ISSN: 0016-5085, DOI: 10.1053/j.gastro.2019.04.003	Gastroenterology 157/2	2020-02-28
2018	Alessia VirzÃ¬, Armando Roca Suarez, Thomas Baumert, Joachim Lupberger Oncogenic Signaling Induced by HCV Infection published pages: 538, ISSN: 1999-4915, DOI: 10.3390/v10100538	Viruses 10/10	2020-02-28
2016	Mirjam B. Zeisel, Thomas F. Baumert Hepatitis B virus: is a cure possible? published pages: 1129-1130, ISSN: 1751-2433, DOI: 10.1080/17512433.2016.1206466	Expert Review of Clinical Pharmacology 9/9	2020-02-28
2016	Rajiv G. Tawar, Laura Heydmann, Charlotte Bach, JÃ¶rg SchÃ¼ttrumpf, Shailesh Chavan, Barnabas J. King, C. Patrick McClure, Jonathan K. Ball, Patrick Pessaux, FranÃ§ois Habersetzer, Ralf Bartenschlager, Mirjam B. Zeisel, Thomas F. Baumert Broad neutralization of hepatitis C virus-resistant variants by Civacir hepatitis C immunoglobulin published pages: 1495-1506, ISSN: 0270-9139, DOI: 10.1002/hep.28767	Hepatology 64/5	2020-02-28
2019	Laurent Mailly, Florian Wrensch, Laura Heydmann, Catherine Fauvelle, Nicolas Brignon, Mirjam B. Zeisel, Patrick Pessaux, Zhen-yong Keck, Catherine Schuster, Thomas R. Fuerst, Steven K.H. Foung, Thomas F. Baumert In vivo combination of human anti-envelope glycoprotein E2 and -Claudin-1 monoclonal antibodies for prevention of hepatitis C virus infection published pages: 136-141, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2018.12.018	Antiviral Research 162	2020-02-27
2019	Roser Pinyol, Robert Montal, Laia Bassaganyas, Daniela Sia, Tadatoshi Takayama, Gar-Yang Chau, Vincenzo Mazzaferro, Sasan Roayaie, Han Chu Lee, Norihiro Kokudo, Zhongyang Zhang, Sara Torrecilla, Agrin Moeini, Leonardo Rodriguez-Carunchio, Edward Gane, Chris Verslype, Adina Emilia Croitoru, Umberto Cillo, Manuel de la Mata, Luigi Lupo, Simone Strasser, Joong-Won Park, Jordi Camps, Manel SolÃ©, Swan Molecular predictors of prevention of recurrence in HCC with sorafenib as adjuvant treatment and prognostic factors in the phase 3 STORM trial published pages: 1065-1075, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2018-316408	Gut 68/6	2020-02-27
2019	Cheng Li, Yang Wang, Tiantian Liu, Matthias Niklasch, Ke Qiao, Sarah Durand, Li Chen, Mifang Liang, Thomas F. Baumert, Shuping Tong, Michael Nassal, Yu-Mei Wen, Yong-Xiang Wang An E. coli-produced single-chain variable fragment (scFv) targeting hepatitis B virus surface protein potently inhibited virion secretion published pages: 118-129, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2018.12.019	Antiviral Research 162	2020-02-27
2019	Roser Pinyol, Daniela Sia, Josep M. Llovet Immune Exclusion-Wnt/CTNNB1 Class Predicts Resistance to Immunotherapies in HCC published pages: 2021-2023, ISSN: 1078-0432, DOI: 10.1158/1078-0432.ccr-18-3778	Clinical Cancer Research 25/7	2020-02-27
2019	Marina Ruiz de Galarreta, Erin Bresnahan, Pedro Molina-SÃ¡nchez, Katherine E. Lindblad, Barbara Maier, Daniela Sia, Marc Puigvehi, VerÃ³nica Miguela, MarÃa Casanova-Acebes, Maxime Dhainaut, Carlos Villacorta-Martin, Aatur D. Singhi, Akshata Moghe, Johann von Felden, Lauren Tal Grinspan, Shuang Wang, Alice O. Kamphorst, Satdarshan P. Monga, Brian D. Brown, Augusto Villanueva, Josep M. Llovet, Miri Î²-Catenin Activation Promotes Immune Escape and Resistance to Antiâ€“PD-1 Therapy in Hepatocellular Carcinoma published pages: 1124-1141, ISSN: 2159-8274, DOI: 10.1158/2159-8290.cd-19-0074	Cancer Discovery 9/8	2020-02-27
2019	Jianming Hu, Ulrike Protzer, Aleem Siddiqui Revisiting Hepatitis B Virus: Challenges of Curative Therapies published pages: , ISSN: 0022-538X, DOI: 10.1128/jvi.01032-19	Journal of Virology 93/20	2020-02-27
2019	Natascha Roehlen, Thomas F. Baumert Uncovering the mechanism of action of aspirin in HCC chemoprevention published pages: 21-22, ISSN: 2352-3964, DOI: 10.1016/j.ebiom.2019.07.047	EBioMedicine 46	2020-02-27
2017	Laurent Mailly, Mirjam B. Zeisel, Thomas F. Baumert Toward novel immunocompetent animal models for hepatitis B virus infection published pages: 691-693, ISSN: 0270-9139, DOI: 10.1002/hep.29249	Hepatology 66/3	2020-02-27
2019	Josep M. Llovet, Robert Montal, Augusto Villanueva Randomized trials and endpoints in advanced HCC: Role of PFS as a surrogate of survival published pages: 1262-1277, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2019.01.028	Journal of Hepatology 70/6	2020-02-27
2019	Agrin Moeini, Sara Torrecilla, Victoria Tovar, Carla Montironi, Carmen Andreu-Oller, Judit Peix, MÃ³nica Higuera, Dominik Pfister, Pierluigi Ramadori, Roser Pinyol, Manel SolÃ©, Mathias HeikenwÃ¤lder, Scott L. Friedman, Daniela Sia, Josep M. Llovet An Immune Gene Expression Signature Associated With Development of Human Hepatocellular Carcinoma Identifies Mice That Respond to Chemopreventive Agents published pages: 1383-1397.e11, ISSN: 0016-5085, DOI: 10.1053/j.gastro.2019.07.028	Gastroenterology 157/5	2020-02-27
2019	Karim Majzoub, Florian Wrensch, Thomas F. Baumert The Innate Antiviral Response in Animals: An Evolutionary Perspective from Flagellates to Humans published pages: 758, ISSN: 1999-4915, DOI: 10.3390/v11080758	Viruses 11/8	2020-02-27
2019	Atish Mukherji, Shannon M. Bailey, Bart Staels, Thomas F. Baumert The circadian clock and liver function in health and disease published pages: 200-211, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2019.03.020	Journal of Hepatology 71/1	2020-02-27
2019	Mohsen Malehmir, Dominik Pfister, Suchira Gallage, Marta Szydlowska, Donato Inverso, Elena Kotsiliti, Valentina Leone, Moritz Peiseler, Bas G. J. Surewaard, Dominik Rath, Adnan Ali, Monika Julia Wolf, Hannah Drescher, Marc E. Healy, Daniel Dauch, Daniela Kroy, Oliver Krenkel, Marlene Kohlhepp, Thomas Engleitner, Alexander Olkus, Tjeerd Sijmonsma, Julia Volz, Carsten Deppermann, David Stegner, Patr Platelet GPIbÎ± is a mediator and potential interventional target for NASH and subsequent liver cancer published pages: 641-655, ISSN: 1078-8956, DOI: 10.1038/s41591-019-0379-5	Nature Medicine 25/4	2020-02-27
2019	Chunkyu Ko, Romina Bester, Xue Zhou, Zhiheng Xu, Christoph Blossey, Julia Sacherl, Florian W. R. Vondran, Lu Gao, Ulrike Protzer A New Role for Capsid Assembly Modulators To Target Mature Hepatitis B Virus Capsids and Prevent Virus Infection published pages: , ISSN: 0066-4804, DOI: 10.1128/aac.01440-19	Antimicrobial Agents and Chemotherapy 64/1	2020-02-27
2019	Ghina Bou About, Emilie Thiebault, Marie Wattenhoferâ€DonzÃ©, Hugues Jacobs, Alain Guimond, Tania Sorg, Eric Robinet, Thomas F. Baumert, Laurent Monassier, Yann Herault Ultrasoundâ€Guided Approaches to Improve Orthotopic Mouse Xenograft Models for Hepatocellular Carcinoma published pages: , ISSN: 2161-2617, DOI: 10.1002/cpmo.62	Current Protocols in Mouse Biology 9/2	2020-02-20
2016	Catherine Fauvelle, Che C. Colpitts, Zhen-yong Keck, Brian G. Pierce, Steven K. H. Foung, Thomas F. Baumert Hepatitis C virus vaccine candidates inducing protective neutralizing antibodies published pages: 1535-1544, ISSN: 1476-0584, DOI: 10.1080/14760584.2016.1194759	Expert Review of Vaccines 15/12	2020-02-20
2017	Daniel J. Felmlee, Dominic GrÃ¼n, Thomas F. Baumert Zooming in on liver zonation published pages: 784-787, ISSN: 0270-9139, DOI: 10.1002/hep.29554	Hepatology 67/2	2020-02-20
2019	Josep M. Llovet, Robert Montal, Augusto Villanueva Randomized trials and endpoints in advanced HCC: Role of PFS as a surrogate of survival published pages: 1262-1277, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2019.01.028	Journal of Hepatology 70/6	2020-02-20
2020	Benjamin Goeppert, Trine Folseraas, Stephanie Roessler, Matthias Kloor, Annaâ€Lena Volckmar, Volker Endris, Ivo Buchhalter, Albrecht Stenzinger, Krzysztof Grzyb, Marit M. Grimsrud, Barbara Gornicka, Erik von Seth, Gary M. Reynolds, Andre Franke, Daniel N. Gotthardt, Arianeb Mehrabi, Angela Cheung, Joanne Verheij, Johanna Arola, Heikki MÃ¤kisalo, Tor J. Eide, SÃ¶ren Weidemann, John C. Cheville, Gi Genomic characterization of cholangiocarcinoma in primary sclerosing cholangitis reveals novel therapeutic opportunities published pages: , ISSN: 0270-9139, DOI: 10.1002/hep.31110	Hepatology	2020-02-20
2016	Che C. Colpitts, Thomas F. Baumert Hepatitis C virus cell entry: a target for novel antiviral strategies to address limitations of direct acting antivirals published pages: 741-748, ISSN: 1936-0533, DOI: 10.1007/s12072-016-9724-7	Hepatology International 10/5	2020-02-20
2018	Steven K. H. Foung, Thomas F. Baumert Editorial: Current Progress and Challenges in the Development of a B Cell Based Hepatitis C Virus Vaccine published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.02577	Frontiers in Immunology 9	2020-02-20
2019	Marina Ruiz de Galarreta, Erin Bresnahan, Pedro Molina-SÃ¡nchez, Katherine E. Lindblad, Barbara Maier, Daniela Sia, Marc Puigvehi, VerÃ³nica Miguela, MarÃa Casanova-Acebes, Maxime Dhainaut, Carlos Villacorta-Martin, Aatur D. Singhi, Akshata Moghe, Johann von Felden, Lauren Tal Grinspan, Shuang Wang, Alice O. Kamphorst, Satdarshan P. Monga, Brian D. Brown, Augusto Villanueva, Josep M. Llovet, Miri Î²-Catenin Activation Promotes Immune Escape and Resistance to Antiâ€“PD-1 Therapy in Hepatocellular Carcinoma published pages: 1124-1141, ISSN: 2159-8274, DOI: 10.1158/2159-8290.cd-19-0074	Cancer Discovery 9/8	2020-02-20
2019	Nourdine Hamdane, Frank JÃ¼hling, Emilie Crouchet, Houssein El Saghire, Christine Thumann, Marine A. Oudot, Simonetta Bandiera, Antonio Saviano, Clara Ponsolles, Armando Andres Roca Suarez, Shen Li, Naoto Fujiwara, Atsushi Ono, Irwin Davidson, Nabeel Bardeesy, Christian Schmidl, Christoph Bock, Catherine Schuster, Joachim Lupberger, FranÃ§ois Habersetzer, Michel DoffoÃ«l, Tullio Piardi, Daniele So HCV-Induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response published pages: 2313-2329.e7, ISSN: 0016-5085, DOI: 10.1053/j.gastro.2019.02.038	Gastroenterology 156/8	2020-02-20
2016	Simonetta Bandiera, C Billie Bian, Yujin Hoshida, Thomas F Baumert, Mirjam B Zeisel Chronic hepatitis C virus infection and pathogenesis of hepatocellular carcinoma published pages: 99-105, ISSN: 1879-6257, DOI: 10.1016/j.coviro.2016.09.010	Current Opinion in Virology 20	2020-02-20
2019	Valentina Dâ€™Arienzo, Andrea Magri, James M. Harris, Peter A. C. Wing, Chunkyu Ko, Claudia Orbegozo Rubio, Peter A. Revill, Ulrike Protzer, Peter Balfe, Jane A. McKeating A PCR assay to quantify patterns of HBV transcription published pages: , ISSN: 0022-1317, DOI: 10.1099/jgv.0.001373	Journal of General Virology	2020-02-20
2019	Thomas F. Baumert, Yujin Hoshida Addressing the Challenges of Hepatitis C Cure and Persistent Risk of Hepatocellular Carcinoma published pages: 441, ISSN: 1999-4915, DOI: 10.3390/v11050441	Viruses 11/5	2020-02-20
2019	Adam J. Gehring, Ulrike Protzer Targeting Innate and Adaptive Immune Responses to Cure Chronic HBV Infection published pages: 325-337, ISSN: 0016-5085, DOI: 10.1053/j.gastro.2018.10.032	Gastroenterology 156/2	2020-02-20
2017	Daniel GonÃ§alves-Carneiro, Jane A. McKeating, Dalan Bailey The Measles Virus Receptor SLAMF1 Can Mediate Particle Endocytosis published pages: e02255-16, ISSN: 0022-538X, DOI: 10.1128/JVI.02255-16	Journal of Virology 91/7	2019-07-02
2017	Emilie Crouchet, Mathieu LefÃ¨vre, Eloi R Verrier, Marine A Oudot, Thomas F Baumert, Catherine Schuster Extracellular lipid-free apolipoprotein E inhibits HCV replication and induces ABCG1-dependent cholesterol efflux published pages: 896-907, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2015-311289	Gut 66/5	2019-07-02
2017	Daniela Sia, Yang Jiao, Iris Martinez-Quetglas, Olga Kuchuk, Carlos Villacorta-Martin, Manuel Castro de Moura, Juan Putra, Genis Camprecios, Laia Bassaganyas, Nicholas Akers, Bojan Losic, Samuel Waxman, Swan N. Thung, Vincenzo Mazzaferro, Manel Esteller, Scott L. Friedman, Myron Schwartz, Augusto Villanueva, Josep M. Llovet Identification of an Immune-specific Class of Hepatocellular Carcinoma, Based on Molecular Features published pages: , ISSN: 0016-5085, DOI: 10.1053/j.gastro.2017.06.007	Gastroenterology pii: S0016-5085(17)35741-4	2019-07-02
2018	Thomas F. Baumert, Thomas Berg, Joseph K. Lim, David R. Nelson Status of Direct-Acting Antiviral Therapy for Hepatitis C Virus Infection and Remaining Challenges published pages: , ISSN: 0016-5085, DOI: 10.1053/j.gastro.2018.10.024	Gastroenterology	2019-07-02
2017	Victoria Tovar, Helena Cornella, Agrin Moeini, Samuel Vidal, Yujin Hoshida, Daniela Sia, Judit Peix, Laia Cabellos, Clara Alsinet, Sara Torrecilla, Iris Martinez-Quetglas, Juan JosÃ© Lozano, ChristÃ¨le Desbois-Mouthon, Manel SolÃ©, Josep Domingo-Domenech, Augusto Villanueva, Josep M Llovet Tumour initiating cells and IGF/FGF signalling contribute to sorafenib resistance in hepatocellular carcinoma published pages: 530-540, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2015-309501	Gut 66/3	2019-07-02
2016	Tao Wu, Emilie Heuillard, VÃ©ronique Lindner, Ghina Bou About, Mihaela Ignat, Jean-Philippe Dillenseger, Nicolas Anton, EugÃ©nie Dalimier, Francine GossÃ©, Gael FourÃ©, Franck Blindauer, CÃ©line Giraudeau, Hussein El-Saghire, Mourad Bouhadjar, Cynthia Calligaro, Tania Sorg, Philippe Choquet, Thierry Vandamme, Christophe Ferrand, Jacques Marescaux, Thomas F. Baumert, Michele Diana, Patrick Pessaux, Multimodal imaging of a humanized orthotopic model of hepatocellular carcinoma in immunodeficient mice published pages: 35230, ISSN: 2045-2322, DOI: 10.1038/srep35230	Scientific Reports 6/1	2019-07-02
2017	Agrin Moeini, Daniela Sia, Zhongyang Zhang, Genis Camprecios, Ashley Stueck, Hui Dong, Robert Montal, Laura Torrens, Iris Martinez-Quetglas, M. Isabel Fiel, Ke Hao, Augusto Villanueva, Swan N. Thung, Myron E. Schwartz, Josep M. Llovet Mixed hepatocellular cholangiocarcinoma tumors: Cholangiolocellular carcinoma is a distinct molecular entity published pages: 952-961, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2017.01.010	Journal of Hepatology 66/5	2019-07-02
2017	Daniela Sia, Augusto Villanueva, Scott L. Friedman, Josep M. Llovet Liver Cancer Cell of Origin, Molecular Class, and Effects onÂ Patient Prognosis published pages: 745-761, ISSN: 0016-5085, DOI: 10.1053/j.gastro.2016.11.048	Gastroenterology 152/4	2019-07-02
2017	Nicolaas Van Renne, Armando Andres Roca Suarez, Francois H T Duong, Claire Gondeau, Diego Calabrese, Nelly Fontaine, Amina Ababsa, Simonetta Bandiera, Tom Croonenborghs, Nathalie Pochet, Vito De Blasi, Patrick Pessaux, Tullio Piardi, Daniele Sommacale, Atsushi Ono, Kazuaki Chayama, Masashi Fujita, Hidewaki Nakagawa, Yujin Hoshida, Mirjam B Zeisel, Markus H Heim, Thomas F Baumert, Joachim Lupberger miR-135a-5p-mediated downregulation of protein tyrosine phosphatase receptor delta is a candidate driver of HCV-associated hepatocarcinogenesis published pages: gutjnl-2016-3122, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2016-312270	Gut pii: gutjnl-2016-312270	2019-07-02
2017	Che C. Colpitts, Thomas F. Baumert SMAD About Hepatitis C Virus Cell Entry andÂ Liver Disease published pages: 21-23, ISSN: 0016-5085, DOI: 10.1053/j.gastro.2016.11.029	Gastroenterology 152/1	2019-07-02
2017	Marc Ringehan, Jane A. McKeating, Ulrike Protzer Viral hepatitis and liver cancer published pages: 20160274, ISSN: 0962-8436, DOI: 10.1098/rstb.2016.0274	Philosophical Transactions of the Royal Society B: Biological Sciences 372/1732	2019-07-02
2017	Giulia Manzoni, Carine Marinach, Selma TopÃ§u, Sylvie Briquet, Morgane Grand, Matthieu Tolle, Marion Gransagne, Julien Lescar, Chiara Andolina, Jean-FranÃ§ois Franetich, Mirjam B Zeisel, Thierry Huby, Eric Rubinstein, Georges Snounou, Dominique Mazier, FranÃ§ois Nosten, Thomas F Baumert, Olivier Silvie Plasmodium P36 determines host cell receptor usage during sporozoite invasion published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.25903	eLife 6	2019-07-02
2017	Bachir Taouli, Yujin Hoshida, Suguru Kakite, Xintong Chen, Poh Seng Tan, Xiaochen Sun, Shingo Kihira, Kensuke Kojima, Sara Toffanin, M. Isabel Fiel, Hadassa Hirschfield, Mathilde Wagner, Josep M. Llovet Imaging-based surrogate markers of transcriptome subclasses and signatures in hepatocellular carcinoma: preliminary results published pages: , ISSN: 0938-7994, DOI: 10.1007/s00330-017-4844-6	European Radiology	2019-07-02
2016	Che C. Colpitts, Joachim Lupberger, Thomas F. Baumert Multifaceted role of E-cadherin in hepatitis C virus infection and pathogenesis published pages: 7298-7300, ISSN: 0027-8424, DOI: 10.1073/pnas.1607732113	Proceedings of the National Academy of Sciences 113/27	2019-07-02
2016	Simonetta Bandiera, Sophie Pernot, Hussein El Saghire, Sarah C. Durand, Christine Thumann, Emilie Crouchet, Tao Ye, Isabel Fofana, Marine A. Oudot, Jochen Barths, Catherine Schuster, Patrick Pessaux, Markus H. Heim, Thomas F. Baumert, Mirjam B. Zeisel Hepatitis C Virus-Induced Upregulation of MicroRNA miR-146a-5p in Hepatocytes Promotes Viral Infection and Deregulates Metabolic Pathways Associated with Liver Disease Pathogenesis published pages: 6387-6400, ISSN: 0022-538X, DOI: 10.1128/JVI.00619-16	Journal of Virology 90/14	2019-07-02
2016	Iris Martinez-Quetglas, Roser Pinyol, Daniel Dauch, Sara Torrecilla, Victoria Tovar, Agrin Moeini, Clara Alsinet, Anna Portela, Leonardo Rodriguez-Carunchio, Manel SolÃ©, Amaia Lujambio, Augusto Villanueva, Swan Thung, Manel Esteller, Lars Zender, Josep M. Llovet IGF2 Is Up-regulated by Epigenetic Mechanisms in Hepatocellular Carcinomas and Is an Actionable Oncogene Product in Experimental Models published pages: 1192-1205, ISSN: 0016-5085, DOI: 10.1053/j.gastro.2016.09.001	Gastroenterology 151/6	2019-07-02
2016	Josep M. Llovet, Jessica Zucman-Rossi, Eli Pikarsky, Bruno Sangro, Myron Schwartz, Morris Sherman, Gregory Gores Hepatocellular carcinoma published pages: 16018, ISSN: 2056-676X, DOI: 10.1038/nrdp.2016.18	Nature Reviews Disease Primers 2	2019-07-02
2017	Che C Colpitts, Rajiv G Tawar, Laurent Mailly, Christine Thumann, Laura Heydmann, Sarah C Durand, Fei Xiao, Eric Robinet, Patrick Pessaux, Mirjam B Zeisel, Thomas F Baumert Humanisation of a claudin-1-specific monoclonal antibody for clinical prevention and cure of HCV infection without escape published pages: gutjnl-2016-3125, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2016-312577	Gut pii: gutjnl-2016-312577	2019-07-02
2017	Eloi R. Verrier, Catherine Schuster, Thomas F. Baumert Advancing hepatitis B virus entry inhibitors published pages: 677-679, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2016.11.028	Journal of Hepatology 66/4	2019-07-02
2017	Michelle J. Farquhar, Isla S. Humphreys, Simon A. Rudge, Garrick K. Wilson, Bishnupriya Bhattacharya, Maria Ciaccia, Ke Hu, Qifeng Zhang, Laurent Mailly, Gary M. Reynolds, Margaret Ashcroft, Peter Balfe, Thomas F. Baumert, Stephanie Roessler, Michael J.O. Wakelam, Jane A. McKeating Autotaxin-lysophosphatidic acid receptor signalling regulates hepatitis C virus replication published pages: 919-929, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2017.01.009	Journal of Hepatology 66/5	2019-07-02
2017	Che C. Colpitts, Thomas F. Baumert SCARB1 variants and HCV infection: Host susceptibility is lost in translation published pages: 211-213, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2017.04.013	Journal of Hepatology 67(2)	2019-07-02
2017	Julien Bollard, VerÃ³nica Miguela, Marina Ruiz de Galarreta, Anu Venkatesh, C Billie Bian, Mark P Roberto, Victoria Tovar, Daniela Sia, Pedro Molina-SÃ¡nchez, Christie B Nguyen, Shigeki Nakagawa, Josep M Llovet, Yujin Hoshida, Amaia Lujambio Palbociclib (PD-0332991), a selective CDK4/6 inhibitor, restricts tumour growth in preclinical models of hepatocellular carcinoma published pages: 1286-1296, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2016-312268	Gut 66/7	2019-07-02
2017	Thomas F. Baumert, Frank JÃ¼hling, Atsushi Ono, Yujin Hoshida Hepatitis C-related hepatocellular carcinoma in the era of new generation antivirals published pages: , ISSN: 1741-7015, DOI: 10.1186/s12916-017-0815-7	BMC Medicine 15/1	2019-07-02
2017	Riccardo Lencioni, Robert Montal, Ferran Torres, Joong-Won Park, Thomas Decaens, Jean-Luc Raoul, Masatoshi Kudo, Charissa Chang, JosÃ© RÃos, Valerie Boige, Eric Assenat, Yoon-Koo Kang, Ho-Yeong Lim, Ian Walters, Josep M. Llovet Objective response by mRECIST as a predictor and potential surrogate end-point of overall survival in advanced HCC published pages: 1166-1172, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2017.01.012	Journal of Hepatology 66/6	2019-07-02
2016	EloiÂ R. Verrier, CheÂ C. Colpitts, Charlotte Bach, Laura Heydmann, Laetitia Zona, Fei Xiao, Christine Thumann, Emilie Crouchet, RaphaÃ«l Gaudin, Camille Sureau, FranÃ§ois-LoÃ¯c Cosset, JaneÂ A. McKeating, Patrick Pessaux, Yujin Hoshida, Catherine Schuster, MirjamÂ B. Zeisel, ThomasÂ F. Baumert Solute Carrier NTCP Regulates Innate Antiviral Immune Responses Targeting Hepatitis C Virus Infection of Hepatocytes published pages: 1357-1368, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2016.09.084	Cell Reports 17/5	2019-07-02
2017	Tanvi Khera, Daniel Todt, Koen Vercauteren, C. Patrick McClure, Lieven Verhoye, Ali Farhoudi, Sabin Bhuju, Robert Geffers, Thomas F. Baumert, Eike Steinmann, Philip Meuleman, Thomas Pietschmann, Richard J.P. Brown Tracking HCV protease population diversity during transmission and susceptibility of founder populations to antiviral therapy published pages: 129-137, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2017.01.001	Antiviral Research 139	2019-07-02
2017	Monique D. Appelman, Anindita Chakraborty, Ulrike Protzer, Jane A. McKeating, Stan F. J. van de Graaf N-Glycosylation of the Na+-Taurocholate Cotransporting Polypeptide (NTCP) Determines Its Trafficking and Stability and Is Required for Hepatitis B Virus Infection published pages: e0170419, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0170419	PLOS ONE 12/1	2019-07-02
2016	A. Moeini, D. Sia, N. Bardeesy, V. Mazzaferro, J. M. Llovet Molecular Pathogenesis and Targeted Therapies for Intrahepatic Cholangiocarcinoma published pages: 291-300, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-14-3296	Clinical Cancer Research 22/2	2019-07-02
2018	Anna Lorentzen, Paul F. Becker, Jan Kosla, Massimo Saini, Kathrin Weidele, Paolo Ronchi, Corinna Klein, Monika J. Wolf, Felix Geist, Bastian Seubert, Marc Ringelhan, Daniela Mihic-Probst, Knud Esser, Marko Roblek, Felix Kuehne, Gaia Bianco, Tracy Oâ€™Connor, Quentin MÃ¼ller, Kathleen Schuck, Sebastian Lange, Daniel Hartmann, Saskia Spaich, Olaf GroÃŸ, Jochen Utikal, Sebastian Haferkamp, Martin R. Sprick, Amruta Damle-Vartak, Alexander Hapfelmeier, Norbert HÃ¼ser, Ulrike Protzer, Andreas Trumpp, Dieter Saur, Nachiket Vartak, Christoph A. Klein, Bernhard Polzer, Lubor Borsig, Mathias Heikenwalder Single cell polarity in liquid phase facilitates tumour metastasis published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-03139-6	Nature Communications 9/1	2019-05-20
2018	Marc Ringelhan, Dominik Pfister, Tracy Oâ€™Connor, Eli Pikarsky, Mathias Heikenwalder The immunology of hepatocellular carcinoma published pages: 222-232, ISSN: 1529-2908, DOI: 10.1038/s41590-018-0044-z	Nature Immunology 19/3	2019-05-20
2019	Xiaodong Zhuang, Andrea Magri, Michelle Hill, Alvina G. Lai, Abhinav Kumar, Srinivasa Bhargav Rambhatla, Claire L. Donald, Andrea F. Lopez-Clavijo, Simon Rudge, Katherine Pinnick, Wai Hoong Chang, Peter A. C. Wing, Ryan Brown, Ximing Qin, Peter Simmonds, Thomas F. Baumert, David Ray, Andrew Loudon, Peter Balfe, Michael Wakelam, Sam Butterworth, Alain Kohl, Catherine L. Jopling, Nicole Zitzmann, Jane A. McKeating The circadian clock components BMAL1 and REV-ERBÎ± regulate flavivirus replication published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-08299-7	Nature Communications 10/1	2019-05-20
2018	Mohsen Malehmir, Dominik Pfister, Suchira Gallage, Marta Szydlowska, Donato Inverso, Elena Kotsiliti, Valentina Leone, Moritz Peiseler, Bas G.J. Surewaard, Dominik Rath, Sheikh Adnan Ali, Monika Julia Wolf, Hannah Drescher, Marc E. Healy, Daniel Dauch, Daniela Kroy, Oliver Krenkel, Marlene Kohlhepp, Thomas Engleitner, Alexander Olkus, Tjeerd Sijmonsma, Julia Volz, Carsten Deppermann, David Stegner, Patrick Helbling, CÃ©sar Nombela-Arrieta, Anahita Rafiei, Martina Steurer, Marcel Rall, Florian Baku, Caroline L. Wilson, Jack Leslie, Tracy O`Connor, Christopher C. Weston, David H. Adams, Lozan Sheriff, Ana Teijeiro, Marco Prinz, Ruzhica Bogeska, Natasha Anstee, Malte Bongers, Mike Notohamiprodjo, Tobias Geisler, Dominic J. Withers, Jerry Ware, Derek A. Mann, Hellmut Augustin, Alexandros Vegiopoulos, Michael Milsom, Adam J. Rose, Patricia F. Lalor, Josep M. Llovet, Roser Pinyol, Frank Tacke, Roland Rad, Nabil Djouder, Paul Kubes, Percy A. Knolle, Kristian Unger, Lars Zender, Bernhard Nieswandt, Meinrad Gawaz, Achim Weber and Mathias Heikenwalder Platelet GPIba is a mediator and potential interventional target for NASH and subsequent liver cancer published pages: in press, ISSN: 1078-8956, DOI:	Nature Medicine	2019-05-20
2018	Xiaodong Zhuang, Alvina G. Lai, Jane A. McKeating, Ian Rowe, Peter Balfe Daytime variation in hepatitis C virus replication kinetics following liver transplant published pages: 96, ISSN: 2398-502X, DOI: 10.12688/wellcomeopenres.14696.2	Wellcome Open Research 3	2019-05-20
2018	Alvina G. Lai, Donall Forde, Wai Hoong Chang, Fang Yuan, Xiaodong Zhuang, Claudia Orbegozo Rubio, Chun-Xiao Song, Jane A. McKeating Glucose and glutamine availability regulate HepG2 transcriptional responses to low oxygen published pages: 126, ISSN: 2398-502X, DOI: 10.12688/wellcomeopenres.14839.1	Wellcome Open Research 3	2019-05-20
2018	Athena Georgilis, Sabrina Klotz, Christopher J. Hanley, Nicolas Herranz, Benedikt Weirich, Beatriz Morancho, Ana Carolina Leote, Luana D\'Artista, Suchira Gallage, Marco Seehawer, Thomas Carroll, Gopuraja Dharmalingam, Keng Boon Wee, Marco Mellone, Joaquim Pombo, Danijela Heide, Ernesto Guccione, JoaquÃn Arribas, Nuno L. Barbosa-Morais, Mathias Heikenwalder, Gareth J. Thomas, Lars Zender, JesÃºs Gil PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells published pages: 85-102.e9, ISSN: 1535-6108, DOI: 10.1016/j.ccell.2018.06.007	Cancer Cell 34/1	2019-05-20
2017	Joe Grove, Ke Hu, Michelle J. Farquhar, Margaret Goodall, Lucas Walker, Mohammed Jamshad, Heidi E. Drummer, Roslyn M. Bill, Peter Balfe, Jane A. McKeating A new panel of epitope mapped monoclonal antibodies recognising the prototypical tetraspanin CD81 published pages: 82, ISSN: 2398-502X, DOI: 10.12688/wellcomeopenres.12058.1	Wellcome Open Research 2	2019-05-20
2018	Lucia Cardo, Isabel Nawroth, Peter J. Cail, Jane A. McKeating, Michael J. Hannon Metallo supramolecular cylinders inhibit HIV-1 TAR-TAT complex formation and viral replication in cellulo published pages: 13342, ISSN: 2045-2322, DOI: 10.1038/s41598-018-31513-3	Scientific Reports 8/1	2019-05-20
2017	Xiaodong Zhuang, Srinivasa Bhargav Rambhatla, Alvina G. Lai, Jane A. McKeating Interplay between circadian clock and viral infection published pages: 1283-1289, ISSN: 0946-2716, DOI: 10.1007/s00109-017-1592-7	Journal of Molecular Medicine 95/12	2019-05-20
2019	Anna L. McNaughton, Valentina Dâ€™Arienzo, M. Azim Ansari, Sheila F. Lumley, Margaret Littlejohn, Peter Revill, Jane A. McKeating, Philippa C. Matthews Insights From Deep Sequencing of the HBV Genomeâ€”Unique, Tiny, and Misunderstood published pages: 384-399, ISSN: 0016-5085, DOI: 10.1053/j.gastro.2018.07.058	Gastroenterology 156/2	2019-05-20
2018	Teegan R. Lim, Jonathan M. Hazlehurst, Andrei I. Oprescu, Matthew J. Armstrong, Sewa F. Abdullah, Nigel P. Davies, Robert Flintham, Peter Balfe, David J. Mutimer, Jane A. McKeating, Jeremy W. Tomlinson Hepatitis C virus infection is associated with hepatic and adipose tissue insulin resistance that improves after viral cure published pages: [Epub ahead of p, ISSN: 0300-0664, DOI: 10.1111/cen.13924	Clinical Endocrinology	2019-05-20
2018	Chunkyu Ko, Anindita Chakraborty, Wen-Min Chou, Julia Hasreiter, Jochen M. Wettengel, Daniela Stadler, Romina Bester, Theresa Asen, Ke Zhang, Karin Wisskirchen, Jane A. McKeating, Wang-Shick Ryu, Ulrike Protzer Hepatitis B virus genome recycling and de novo secondary infection events maintain stable cccDNA levels published pages: 1231-1241, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2018.08.012	Journal of Hepatology 69/6	2019-05-20
2018	Josep M. Llovet, Mihai Pavel, Jordi Rimola, Maria Alba Diaz, Jordi Colmenero, David Saavedra-Perez, Constantino Fondevila, Carmen Ayuso, Josep Fuster, Pere GinÃ¨s, Jordi Bruix, Juan Carlos Garcia-Valdecasas Pilot study of living donor liver transplantation for patients with hepatocellular carcinoma exceeding Milan Criteria (Barcelona Clinic Liver Cancer extended criteria) published pages: 369-379, ISSN: 1527-6465, DOI: 10.1002/lt.24977	Liver Transplantation 24/3	2019-05-20
2019	Benjamin Goeppert, Reka Toth, Stephan Singer, Thomas Albrecht, Daniel B. Lipka, Pavlo Lutsik, David Brocks, Marion Baehr, Oliver Muecke, Yassen Assenov, Lei Gu, Volker Endris, Albrecht Stenzinger, Arianeb Mehrabi, Peter Schirmacher, Christoph Plass, Dieter Weichenhan, Stephanie Roessler Integrative analysis defines distinct prognostic subgroups of intrahepatic cholangiocarcinoma published pages: , ISSN: 0270-9139, DOI: 10.1002/hep.30493	Hepatology	2019-05-20
2018	Mei-Le Keck, Florian Wrensch, Brian G. Pierce, Thomas F. Baumert, Steven K. H. Foung Mapping Determinants of Virus Neutralization and Viral Escape for Rational Design of a Hepatitis C Virus Vaccine published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.01194	Frontiers in Immunology 9	2019-05-20
2017	Yuchen Xia, Xiaoming Cheng, Christoph K. Blossey, Karin Wisskirchen, Knud Esser, Ulrike Protzer Secreted Interferon-Inducible Factors Restrict Hepatitis B and C Virus Entry In Vitro published pages: 1-12, ISSN: 2314-8861, DOI: 10.1155/2017/4828936	Journal of Immunology Research 2017	2019-05-20
2017	Sara Torrecilla, Daniela Sia, Andrew N. Harrington, Zhongyang Zhang, Laia Cabellos, Helena Cornella, Agrin Moeini, Genis Camprecios, Wei-Qiang Leow, Maria Isabel Fiel, Ke Hao, Laia Bassaganyas, Milind Mahajan, Swan N. Thung, Augusto Villanueva, Sander Florman, Myron E. Schwartz, Josep M. Llovet Trunk mutational events present minimal intra- and inter-tumoral heterogeneity in hepatocellular carcinoma published pages: 1222-1231, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2017.08.013	Journal of Hepatology 67/6	2019-05-20
2017	Che C. Colpitts, Thomas F. Baumert Claudins in viral infection: from entry to spread published pages: 27-34, ISSN: 0031-6768, DOI: 10.1007/s00424-016-1908-4	PflÃ¼gers Archiv - European Journal of Physiology 469/1	2019-05-20
2018	Armando Andres Roca Suarez, Thomas F. Baumert, Joachim Lupberger Beyond viral dependence: The pathological consequences of HCV-induced EGF signaling published pages: 564-566, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2018.05.033	Journal of Hepatology 69/3	2019-05-20
2018	Gesa von Olshausen, Maria Quasdorff, Romina Bester, Silke Arzberger, Chunkyu Ko, Maarten van de Klundert, Ke Zhang, Margarete Odenthal, Marc Ringelhan, Carien M. Niessen, Ulrike Protzer \"Hepatitis B virus promotes β-catenin-signalling and disassembly of adherens junctions in a Src kinase dependent fashion\" published pages: , ISSN: 1949-2553, DOI: 10.18632/oncotarget.26103	Oncotarget 9/74	2019-05-20
2018	Armando Andres Roca Suarez, Nicolaas Van Renne, Thomas F. Baumert, Joachim Lupberger Viral manipulation of STAT3: Evade, exploit, and injure published pages: e1006839, ISSN: 1553-7374, DOI: 10.1371/journal.ppat.1006839	PLOS Pathogens 14/3	2019-05-20
2017	Ulrike Protzer Viral hepatitis: The bumpy road to animal models for HBV infection published pages: 327-328, ISSN: 1759-5045, DOI: 10.1038/nrgastro.2017.44	Nature Reviews Gastroenterology & Hepatology 14/6	2019-05-20
2018	Roser Pinyol, Robert Montal, Laia Bassaganyas, Daniela Sia, Tadatoshi Takayama, Gar-Yang Chau, Vincenzo Mazzaferro, Sasan Roayaie, Han Chu Lee, Norihiro Kokudo, Zhongyang Zhang, Sara Torrecilla, Agrin Moeini, Leonardo Rodriguez-Carunchio, Edward Gane, Chris Verslype, Adina Emilia Croitoru, Umberto Cillo, Manuel de la Mata, Luigi Lupo, Simone Strasser, Joong-Won Park, Jordi Camps, Manel SolÃ©, Swan N Thung, Augusto Villanueva, Carol Pena, Gerold Meinhardt, Jordi Bruix, Josep M Llovet Molecular predictors of prevention of recurrence in HCC with sorafenib as adjuvant treatment and prognostic factors in the phase 3 STORM trial published pages: gutjnl-2018-3164, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2018-316408	Gut	2019-05-20
2017	Daniela Sia, Josep M. Llovet Liver cancer: Translating \'â€“omics\' results into precision medicine for hepatocellular carcinoma published pages: , ISSN: 1759-5045, DOI: 10.1038/nrgastro.2017.103	Nature Reviews Gastroenterology & Hepatology	2019-05-20
2018	Emilie Crouchet, Florian Wrensch, Catherine Schuster, Mirjam B. Zeisel, Thomas F. Baumert Host-targeting therapies for hepatitis C virus infection: current developments and future applications published pages: 175628481875948, ISSN: 1756-2848, DOI: 10.1177/1756284818759483	Therapeutic Advances in Gastroenterology 11	2019-05-20
2018	Mirjam B Zeisel, Punita Dhawan, Thomas F Baumert Tight junction proteins in gastrointestinal and liver disease published pages: gutjnl-2018-3169, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2018-316906	Gut	2019-05-20
2018	Eloi R. Verrier, Seung-Ae Yim, Laura Heydmann, Houssein El Saghire, Charlotte Bach, Vincent Turon-Lagot, Laurent Mailly, Sarah C. Durand, Julie Lucifora, David Durantel, Patrick Pessaux, Nicolas Manel, Ivan Hirsch, Mirjam B. Zeisel, Nathalie Pochet, Catherine Schuster, Thomas F. Baumert Hepatitis B Virus Evasion From Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase Sensing in Human Hepatocytes published pages: 1695-1709, ISSN: 0270-9139, DOI: 10.1002/hep.30054	Hepatology 68/5	2019-05-20
2018	Christin ElÃŸner, Benjamin Goeppert, Thomas Longerich, Anna-Lena Scherr, Jan Stindt, Lahiri Kanth Nanduri, Christian Rupp, Jakob Nikolas Kather, Nathalie Schmitt, Nicole Kautz, Kai Breuhahn, Lars Ismail, Danijela Heide, Jenny Hetzer, MarÃa GarcÃa-Beccaria, Nadine HÃ¶velmeyer, Ari Waisman, Toni Urbanik, Sebastian Mueller, Georg Gdynia, Jesus M. Banales, Stephanie Roessler, Peter Schirmacher, Dirk JÃ¤ger, Sebastian SchÃ¶lch, Verena Keitel, Mathias Heikenwalder, Henning Schulze-Bergkamen, Bruno Christian KÃ¶hler Nuclear Translocation of RELB is Increased in Diseased Human Liver and Promotes Ductular Reaction and Biliary Fibrosis in Mice published pages: , ISSN: 0016-5085, DOI: 10.1053/j.gastro.2018.11.018	Gastroenterology	2019-05-20
2018	A Vogel, A Cervantes, I Chau, B Daniele, J Llovet, T Meyer, J -C Nault, U Neumann, J Ricke, B Sangro, P Schirmacher, C Verslype, C J Zech, D Arnold, E Martinelli Hepatocellular carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-upâ€ published pages: iv238-iv255, ISSN: 0923-7534, DOI: 10.1093/annonc/mdy308	Annals of Oncology 29/Supplement_4	2019-05-20
2018	Shan Wan, Anne-Sophie Meyer, Sofia Maria Elisabeth Weiler, Christian Rupp, Marcell TÃ³th, Carsten Sticht, Stephan Singer, Stefan Thomann, Stephanie Roessler, Marina Schorpp-Kistner, Jennifer Schmitt, Norbert Gretz, Peter Angel, Darjus Felix Tschaharganeh, Jens Marquardt, Peter Schirmacher, Federico Pinna, Kai Breuhahn Cytoplasmic localization of the cell polarity factor scribble supports liver tumor formation and tumor cell invasiveness published pages: 1842-1856, ISSN: 0270-9139, DOI: 10.1002/hep.29669	Hepatology 67/5	2019-05-20
2017	Yong Li, Yuchen Xia, Meifang Han, Guang Chen, Dake Zhang, Wolfgang E. Thasler, Ulrike Protzer, Qin Ning IFN-Î±-mediated Base Excision Repair Pathway Correlates with Antiviral Response Against Hepatitis B Virus Infection published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-13082-z	Scientific Reports 7/1	2019-05-20
2018	Carla Eller, Laura Heydmann, Che C. Colpitts, Eloi R. Verrier, Catherine Schuster, Thomas F. Baumert The functional role of sodium taurocholate cotransporting polypeptide NTCP in the life cycle of hepatitis B, C and D viruses published pages: 3895-3905, ISSN: 1420-682X, DOI: 10.1007/s00018-018-2892-y	Cellular and Molecular Life Sciences 75/21	2019-05-20
2019	Gaetan Ligat, Catherine Schuster, Thomas F. Baumert Hepatitis B Virus Core Variants, Liver Fibrosis, and Hepatocellular Carcinoma published pages: 5-8, ISSN: 0270-9139, DOI: 10.1002/hep.30231	Hepatology 69/1	2019-05-20
2018	Josep M. Llovet, Robert Montal, Daniela Sia, Richard S. Finn Molecular therapies and precision medicine for hepatocellular carcinoma published pages: 599-616, ISSN: 1759-4774, DOI: 10.1038/s41571-018-0073-4	Nature Reviews Clinical Oncology 15/10	2019-05-20
2018	Florian Wrensch, Emilie Crouchet, Gaetan Ligat, Mirjam B. Zeisel, Zhen-Yong Keck, Steven K. H. Foung, Catherine Schuster, Thomas F. Baumert Hepatitis C Virus (HCV)â€“Apolipoprotein Interactions and Immune Evasion and Their Impact on HCV Vaccine Design published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.01436	Frontiers in Immunology 9	2019-05-20
2017	David Wolski, Peter K. Foote, Diana Y. Chen, Lia L. Lewis-Ximenez, Catherine Fauvelle, Jasneet Aneja, Andreas Walker, Pierre Tonnerre, Almudena Torres-Cornejo, Daniel Kvistad, Sabrina Imam, Michael T. Waring, Damien C. Tully, Todd M. Allen, Raymond T. Chung, JÃ¶rg Timm, W. Nicholas Haining, Arthur Y. Kim, Thomas F. Baumert, Georg M. Lauer Early Transcriptional Divergence Marks Virus-Specific Primary Human CD8+ T Cells in Chronic versus Acute Infection published pages: 648-663.e8, ISSN: 1074-7613, DOI: 10.1016/j.immuni.2017.09.006	Immunity 47/4	2019-05-20
2017	Yuchen Xia, Ulrike Protzer Control of Hepatitis B Virus by Cytokines published pages: 18, ISSN: 1999-4915, DOI: 10.3390/v9010018	Viruses 9/1	2019-05-20
2017	Zhirong Zhang, GergÃ¶ Meszaros, Wan-ting He, Yanfang Xu, Helena de Fatima Magliarelli, Laurent Mailly, Michael Mihlan, Yansheng Liu, Marta Puig GÃ¡mez, Alexander Goginashvili, Adrien Pasquier, Olga Bielska, BÃ©nÃ©dicte Neven, Pierre Quartier, Rudolf Aebersold, Thomas F. Baumert, Philippe Georgel, Jiahuai Han, Romeo Ricci Protein kinase D at the Golgi controls NLRP3 inflammasome activation published pages: 2671-2693, ISSN: 0022-1007, DOI: 10.1084/jem.20162040	The Journal of Experimental Medicine 214/9	2019-05-20
2017	Marianna HÃ¶sel, Maria Quasdorff, Marc Ringelhan, Hamid Kashkar, Svenja Debey-Pascher, Martin F. Sprinzl, Jan-Hendrik Bockmann, Silke Arzberger, Dennis Webb, Gesa von Olshausen, Achim Weber, Joachim L. Schultze, Hildegard BÃ¼ning, Mathias Heikenwalder, Ulrike Protzer Hepatitis B Virus Activates Signal Transducer and Activator of Transcription 3 Supporting Hepatocyte Survival and Virus Replication published pages: 339-363, ISSN: 2352-345X, DOI: 10.1016/j.jcmgh.2017.07.003	Cellular and Molecular Gastroenterology and Hepatology 4/3	2019-05-20
2017	Che C. Colpitts, Raymond T. Chung, Thomas F. Baumert Entry Inhibitors: A Perspective for Prevention of Hepatitis C Virus Infection in Organ Transplantation published pages: 620-623, ISSN: 2373-8227, DOI: 10.1021/acsinfecdis.7b00091	ACS Infectious Diseases 3/9	2019-05-20
2017	Gholamreza Haqshenas, Jianmin Wu, Kaylene J. Simpson, Roger J. Daly, Hans J. Netter, Thomas F. Baumert, Christian Doerig Signalome-wide assessment of host cell response to hepatitis C virus published pages: 15158, ISSN: 2041-1723, DOI: 10.1038/ncomms15158	Nature Communications 8	2019-05-20
2018	Peter R. Galle, Alejandro Forner, Josep M. Llovet, Vincenzo Mazzaferro, Fabio Piscaglia, Jean-Luc Raoul, Peter Schirmacher, ValÃ©rie Vilgrain EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma published pages: 182-236, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2018.03.019	Journal of Hepatology 69/1	2019-05-20
2017	Isabelle Desombere, Ahmed Atef Mesalam, Richard A. Urbanowicz, Freya Van Houtte, Lieven Verhoye, Zhen-Yong Keck, Ali Farhoudi, Koen Vercauteren, Karin E. Weening, Thomas F. Baumert, Arvind H. Patel, Steven K.H. Foung, Jonathan Ball, Geert Leroux-Roels, Philip Meuleman A novel neutralizing human monoclonal antibody broadly abrogates hepatitis C virus infection in vitro and in vivo published pages: 53-64, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2017.10.015	Antiviral Research 148	2019-05-20
2018	Ismail Labgaa, Carlos Villacorta-Martin, Delia Dâ€™Avola, Amanda J. Craig, Johann von Felden, Sebastiao N. Martins-Filho, Daniela Sia, Ashley Stueck, Stephen C. Ward, M. Isabel Fiel, Milind Mahajan, Parissa Tabrizian, Swan N. Thung, Celina Ang, Scott L. Friedman, Josep M. Llovet, Myron Schwartz, Augusto Villanueva A pilot study of ultra-deep targeted sequencing of plasma DNA identifies driver mutations in hepatocellular carcinoma published pages: 3740-3752, ISSN: 0950-9232, DOI: 10.1038/s41388-018-0206-3	Oncogene 37/27	2019-05-20
2018	Alessia VirzÃ¬, Armando Roca Suarez, Thomas Baumert, Joachim Lupberger Oncogenic Signaling Induced by HCV Infection published pages: 538, ISSN: 1999-4915, DOI: 10.3390/v10100538	Viruses 10/10	2019-05-20

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "HEP-CAR" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "HEP-CAR" are provided by the European Opendata Portal: CORDIS opendata.