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UM Cure 2020 SIGNED

New therapies for uveal melanoma

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

UM Cure 2020 project word cloud

Explore the words cloud of the UM Cure 2020 project. It provides you a very rough idea of what is the project "UM Cure 2020" about.

genetic discoveries preclinical portal experts data 50 translational website trials establishment registry incidence basic multidisciplinary melanoma individuals 2020 metastatic collect endpoint harmonised evaluation signal care microenvironment patients detect validate network either background cure prevent liver clinical accurate biobanks fatal biobank identification building virtual brings surrogate caregiver landscape pharma vitro purpose drugs underpinning deregulation metastases million single tissue therapy rare disease samples sponsored invariably countries characterisation despite models treatment move intraocular little biomarkers molecular initiation combinations tumour proteomic therapies therapeutic uveal patient academia linking vivo treat primary um prospectively

Project "UM Cure 2020" data sheet

The following table provides information about the project.

Coordinator	INSTITUT CURIE Organization address address: rue d'Ulm 26 city: PARIS postcode: 75231 website: www.curie.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Project website	http://www.umcure2020.org
Total cost	7˙971˙101 €
EC max contribution	6˙183˙456 € (78%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-PHC-2015-two-stage
Funding Scheme	RIA
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2020-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INSTITUT CURIE INSTITUT CURIE Organization address address: rue d'Ulm 26 city: PARIS postcode: 75231 website: www.curie.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	coordinator	1˙659˙000.00
2	ACADEMISCH ZIEKENHUIS LEIDEN ACADEMISCH ZIEKENHUIS LEIDEN Organization address address: ALBINUSDREEF 2 city: LEIDEN postcode: 2333 ZA website: www.lumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	1˙021˙540.00
3	THE UNIVERSITY OF MANCHESTER THE UNIVERSITY OF MANCHESTER Organization address address: OXFORD ROAD city: MANCHESTER postcode: M13 9PL website: www.manchester.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (MANCHESTER)	participant	993˙956.00
4	PAMGENE INTERNATIONAL BV PAMGENE INTERNATIONAL BV Organization address address: WOLVENHOEK 10-12 city: DEN HAAG postcode: 5211 HH website: www.pamgene.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (DEN HAAG)	participant	469˙625.00
5	UNIVERSITEIT LEIDEN UNIVERSITEIT LEIDEN Organization address address: RAPENBURG 70 city: LEIDEN postcode: 2311 EZ website: www.universiteitleiden.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	434˙376.00
6	THE UNIVERSITY OF LIVERPOOL THE UNIVERSITY OF LIVERPOOL Organization address address: BROWNLOW HILL 765 FOUNDATION BUILDING city: LIVERPOOL postcode: L69 7ZX website: www.liverpool.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LIVERPOOL)	participant	358˙604.00
7	UNIVERSITA DEGLI STUDI DI TRENTO UNIVERSITA DEGLI STUDI DI TRENTO Organization address address: VIA CALEPINA 14 city: TRENTO postcode: 38122 website: www.unitn.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (TRENTO)	participant	304˙187.00
8	FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD Organization address address: AVENIDA BRASILIA, CENTRO DE INVESTIGACAO DA FUNDACAO CHAMPALIMAUD city: LISBOA postcode: 1400-038 website: http://fchampalimaud.org/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (LISBOA)	participant	248˙750.00
9	SEEDING SCIENCE SEEDING SCIENCE Organization address address: 19 RUE DE LA MARE city: PARIS postcode: 75020 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	216˙875.00
10	UNIWERSYTET JAGIELLONSKI UNIWERSYTET JAGIELLONSKI Organization address address: Ul. Golebia 24 city: KRAKOW postcode: 31007 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PL (KRAKOW)	participant	213˙792.00
11	PEP THERAPY PEP THERAPY Organization address address: 4 RUE PIERRE FONTAINE CAMPUS 3 city: EVRY postcode: 91058 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (EVRY)	participant	191˙500.00
12	MELANOMA PATIENT NETWORK EUROPE MELANOMA PATIENT NETWORK EUROPE Organization address address: FJALLBO SELKNA 152 city: UPPSALA postcode: 75597 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (UPPSALA)	participant	61˙250.00
13	KARLSRUHER INSTITUT FUER TECHNOLOGIE KARLSRUHER INSTITUT FUER TECHNOLOGIE Organization address address: KAISERSTRASSE 12 city: KARLSRUHE postcode: 76131 website: www.kit.edu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (KARLSRUHE)	participant	10˙000.00

Map

Project objective

Uveal melanoma (UM) is a rare intraocular tumour with an incidence of 5 cases per million individuals per year. Up to 50% of UM patients develop metastases, most often in the liver, and these are invariably fatal. Despite new discoveries in the genetic and molecular background of the primary tumour, little is known about the metastatic disease; furthermore, there is no therapy to either prevent or treat UM metastases. In UM Cure 2020, we aim to identify and validate at the preclinical level novel therapeutic approaches for the treatment of UM metastases. For this purpose, the consortium brings together the major experts of UM in both patient care and basic/translational/clinical research, as well as patient representatives. An ambitious multidisciplinary approach is proposed to move from patient tissue characterisation to preclinical evaluation of single or combinations of drugs. This approach includes the characterisation of the genetic landscape of metastatic UM and its microenvironment, proteomic studies to address signal pathway deregulation and establishment of novel relevant in vitro and in vivo UM models. We also aim to validate accurate surrogate endpoint biomarkers to evaluate therapies and detect metastases as early as possible. Underpinning this will be the UM Cure 2020 virtual biobank registry, linking existing biobanks into a harmonised network, which will prospectively collect primary and metastatic UM samples. Together, our approach will lead to the identification of new therapies, allowing the initiation of UM-dedicated clinical trials sponsored by academia or pharma. Dissemination of results will include the building of a patient network across the countries as part of the consortium as well as a dedicated UM patient and caregiver’s data portal as part of the UM Cure 2020 website, in order to increase patient information and disease awareness.

Deliverables

List of deliverables.
Status of prospective collection and use of collected biosamples	Documents, reports	2020-01-30 08:51:53
Release of main UM Cure 2020 communication tools	Documents, reports	2020-01-30 08:51:53
Kick-off meeting	Documents, reports	2020-01-30 08:51:53
Agreement on minimum dataset for all currently banked UM biosamples	Documents, reports	2020-01-30 08:51:53

Take a look to the deliverables list in detail: detailed list of UM Cure 2020 deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2020	Didier Decaudin, Estelle Frisch Dit Leitz, Fariba Nemati, Malcy Tarin, Adnan Naguez, Mohamed Zerara, Benjamin Marande, Raquel Vivet-Noguer, Ensar Halilovic, Claire Fabre, Aart Jochemsen, Sergio Roman-Roman, Samar Alsafadi Preclinical evaluation of drug combinations identifies co-inhibition of Bcl-2/XL/W and MDM2 as a potential therapy in uveal melanoma published pages: 93-103, ISSN: 0959-8049, DOI: 10.1016/j.ejca.2019.12.012	European Journal of Cancer 126	2020-02-04
2019	Francesca Precazzini, Michael Pancher, Pamela Gatto, Ada Tushe, Valentina Adami, Viviana Anelli, Maria Caterina Mione Automated in vivo screen in zebrafish identifies Clotrimazole as targeting a metabolic vulnerability in a melanoma model published pages: , ISSN: 0012-1606, DOI: 10.1016/j.ydbio.2019.04.005	Developmental Biology	2020-01-30
2019	Zahra Souri, Annemijn P. A. Wierenga, Christiaan van Weeghel, Pieter A. van der Velden, Wilma G. M. Kroes, Gregorius P. M. Luyten, Sjoerd H. van der Burg, Aart G. Jochemsen, Martine J. Jager Loss of BAP1 Is Associated with Upregulation of the NFkB Pathway and Increased HLA Class I Expression in Uveal Melanoma published pages: 1102, ISSN: 2072-6694, DOI: 10.3390/cancers11081102	Cancers 11/8	2020-01-30
2019	Christiaan van Weeghel, Annemijn P. A. Wierenga, Mieke Versluis, Thorbald van Hall, Pieter A. van der Velden, Wilma G. M. Kroes, Ulrich Pfeffer, Gregorius P. M. Luyten, Martine J. Jager Do GNAQ and GNA11 Differentially Affect Inflammation and HLA Expression in Uveal Melanoma? published pages: 1127, ISSN: 2072-6694, DOI: 10.3390/cancers11081127	Cancers 11/8	2020-01-30
2019	Souri, Wierenga, Mulder, Jochemsen, Jager HLA Expression in Uveal Melanoma: An Indicator of Malignancy and a Modifiable Immunological Target published pages: 1132, ISSN: 2072-6694, DOI: 10.3390/cancers11081132	Cancers 11/8	2020-01-30
2019	Mehmet DogrusÃ¶z, Andrea Ruschel Trasel, Jinfeng Cao, SelÒ«uk Òªolak, Sake I. van Pelt, Wilma G. M. Kroes, Amina F. A. S. Teunisse, Samar Alsafadi, Sjoerd G. van Duinen, Gregorius P. M. Luyten, Pieter A. van der Velden, Adriana Amaro, Ulrich Pfeffer, Aart G. Jochemsen, Martine J. Jager Differential Expression of DNA Repair Genes in Prognostically-Favorable versus Unfavorable Uveal Melanoma published pages: 1104, ISSN: 2072-6694, DOI: 10.3390/cancers11081104	Cancers 11/8	2020-01-30
2019	Annemijn P. A. Wierenga, GÃ¼lÃ§in Gezgin, Els van Beelen, Michael Eikmans, Marijke Spruyt-Gerritse, Niels J. Brouwer, Mieke Versluis, Robert M. Verdijk, Sjoerd G. van Duinen, Marina Marinkovic, Gregorius P. M. Luyten, Martine J. Jager Soluble HLA in the Aqueous Humour of Uveal Melanoma Is Associated with Unfavourable Tumour Characteristics published pages: 1202, ISSN: 2072-6694, DOI: 10.3390/cancers11081202	Cancers 11/8	2020-01-30
2019	Niels J. Brouwer, GÃ¼lÃ§in Gezgin, Annemijn P.A. Wierenga, Inge H.G. Bronkhorst, Marina Marinkovic, Gregorius P.M. Luyten, Mieke Versluis, Wilma G.M. Kroes, Pieter A. van der Velden, Robert M. Verdijk, Martine J. Jager Tumour Angiogenesis in Uveal Melanoma Is Related to Genetic Evolution published pages: 979, ISSN: 2072-6694, DOI: 10.3390/cancers11070979	Cancers 11/7	2020-01-30
2019	Manuel Rodrigues, Leanne de Koning, Sarah Coupland, Aart Jochemsen, Richard Marais, Marc-Henri Stern, AndrÃ© Valente, Raymond Barnhill, Nathalie Cassoux, Andrew Evans, Iain Galloway, Martine Jager, Ellen Kapiteijn, Bozena Romanowska-Dixon, Bettina Ryll, Sergio Roman-Roman, Sophie Piperno-Neumann So Close, yet so Far: Discrepancies between Uveal and Other Melanomas. A Position Paper from UM Cure 2020 published pages: 1032, ISSN: 2072-6694, DOI: 10.3390/cancers11071032	Cancers 11/7	2020-01-30
2019	Niels J. Brouwer, Annemijn P. A. Wierenga, GÃ¼lÃ§in Gezgin, Marina Marinkovic, Gregorius P. M. Luyten, Wilma G. M. Kroes, Mieke Versluis, Pieter A. van der Velden, Robert M. Verdijk, Martine J. Jager Ischemia Is Related to Tumour Genetics in Uveal Melanoma published pages: 1004, ISSN: 2072-6694, DOI: 10.3390/cancers11071004	Cancers 11/7	2020-01-30
2019	Manuel Rodrigues, Lenha Mobuchon, Alexandre Houy, Samar Alsafadi, Sylvain Baulande, Odette Mariani, Benjamin Marande, Khadija Ait Rais, Monique K. Van der Kooij, Ellen H.W. Kapiteijn, Sieta Gassama, Sophie Gardrat, Raymond Barnhill, Vincent Servois, RÃ©mi Dendale, Marc Putterman, Sarah Tick, Sophie Piperno-Neumann, Nathalie Cassoux, Gaelle Pierron, Joshua J Waterfall, Sergio Roman-Roman, Pascale M Evolutionary routes in metastatic uveal melanomas depend on MBD4 alterations. published pages: clincanres.1215., ISSN: 1078-0432, DOI: 10.1158/1078-0432.ccr-19-1215	Clinical Cancer Research	2020-01-30
2018	Manuel Rodrigues, Lenha Mobuchon, Alexandre Houy, Alice FiÃ©vet, Sophie Gardrat, Raymond L. Barnhill, Tatiana Popova, Vincent Servois, Aurore Rampanou, Aurore Mouton, StÃ©phane Dayot, Virginie Raynal, MichÃ¨le Galut, Marc Putterman, Sarah Tick, Nathalie Cassoux, Sergio Roman-Roman, FranÃ§ois-ClÃ©ment Bidard, Olivier Lantz, Pascale Mariani, Sophie Piperno-Neumann, Marc-Henri Stern Outlier response to anti-PD1 in uveal melanoma reveals germline MBD4 mutations in hypermutated tumors published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-04322-5	Nature Communications 9/1	2020-01-30
2018	Mark J. de Lange, Rogier J. Nell, Rajshri N. Lalai, Mieke Versluis, Ekaterina S. Jordanova, Gre P.M. Luyten, Martine J. Jager, Sjoerd H. van der Burg, Willem H. Zoutman, Thorbald van Hall, Pieter A. van der Velden Digital PCR-Based T-cell Quantificationâ€“Assisted Deconvolution of the Microenvironment Reveals that Activated Macrophages Drive Tumor Inflammation in Uveal Melanoma published pages: , ISSN: 1541-7786, DOI: 10.1158/1541-7786.MCR-18-0114	Molecular Cancer Research	2020-01-30
2018	Sergio Roman-Roman, Marc-Henri Stern, Samar Alsafadi, Martine J. Jager, Mehmet DogrusÃ¶z, Sarah E. Coupland, Maria Caterina Mione, Viviana Anelli, Francesca Precazzini, Lenha Mobuchon, Fariba Nemati, Didier Decaudin, Manuel Rodrigues, Olivier Lantz, Raymond Barnhill, Sophie Piperno-Neumann, Nathalie Cassoux, Laurence Desjardins, GulÃ§in Gezgin, Annemijn Wierenga, Aart J. Jochemsen, Kseniya A. Glin UM Cure 2020: New therapies for uveal melanoma published pages: 15-17, ISSN: 2398-7073, DOI: 10.21820/23987073.2018.2.15	Impact 2018/2	2020-01-30
2019	Leticia Dominguez-Berrocal, Erica Cirri, Xiguang Zhang, Laura Andrini, Gustavo H. Marin, Sophie Lebel-Binay, Angelita Rebollo New Therapeutic Approach for Targeting Hippo Signalling Pathway published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-41404-w	Scientific Reports 9/1	2020-01-30
2018	Ewa Podgorska, Agnieszka Drzal, Zenon Matuszak, Jan Swakon, Andrzej Slominski, Martyna Elas, Krystyna Urbanska Calcitriol and Calcidiol Can Sensitize Melanoma Cells to Lowâ€“LET Proton Beam Irradiation published pages: 2236, ISSN: 1422-0067, DOI: 10.3390/ijms19082236	International Journal of Molecular Sciences 19/8	2020-01-30

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