Explore the words cloud of the UM Cure 2020 project. It provides you a very rough idea of what is the project "UM Cure 2020" about.
The following table provides information about the project.
Coordinator |
INSTITUT CURIE
Organization address contact info |
Coordinator Country | France [FR] |
Project website | http://www.umcure2020.org |
Total cost | 7˙971˙101 € |
EC max contribution | 6˙183˙456 € (78%) |
Programme |
1. H2020-EU.3.1.3. (Treating and managing disease) |
Code Call | H2020-PHC-2015-two-stage |
Funding Scheme | RIA |
Starting year | 2016 |
Duration (year-month-day) | from 2016-01-01 to 2020-12-31 |
Take a look of project's partnership.
# | ||||
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1 | INSTITUT CURIE | FR (PARIS) | coordinator | 1˙659˙000.00 |
2 | ACADEMISCH ZIEKENHUIS LEIDEN | NL (LEIDEN) | participant | 1˙021˙540.00 |
3 | THE UNIVERSITY OF MANCHESTER | UK (MANCHESTER) | participant | 993˙956.00 |
4 | PAMGENE INTERNATIONAL BV | NL (DEN HAAG) | participant | 469˙625.00 |
5 | UNIVERSITEIT LEIDEN | NL (LEIDEN) | participant | 434˙376.00 |
6 | THE UNIVERSITY OF LIVERPOOL | UK (LIVERPOOL) | participant | 358˙604.00 |
7 | UNIVERSITA DEGLI STUDI DI TRENTO | IT (TRENTO) | participant | 304˙187.00 |
8 | FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD | PT (LISBOA) | participant | 248˙750.00 |
9 | SEEDING SCIENCE | FR (PARIS) | participant | 216˙875.00 |
10 | UNIWERSYTET JAGIELLONSKI | PL (KRAKOW) | participant | 213˙792.00 |
11 | PEP THERAPY | FR (EVRY) | participant | 191˙500.00 |
12 | MELANOMA PATIENT NETWORK EUROPE | SE (UPPSALA) | participant | 61˙250.00 |
13 | KARLSRUHER INSTITUT FUER TECHNOLOGIE | DE (KARLSRUHE) | participant | 10˙000.00 |
Uveal melanoma (UM) is a rare intraocular tumour with an incidence of 5 cases per million individuals per year. Up to 50% of UM patients develop metastases, most often in the liver, and these are invariably fatal. Despite new discoveries in the genetic and molecular background of the primary tumour, little is known about the metastatic disease; furthermore, there is no therapy to either prevent or treat UM metastases. In UM Cure 2020, we aim to identify and validate at the preclinical level novel therapeutic approaches for the treatment of UM metastases. For this purpose, the consortium brings together the major experts of UM in both patient care and basic/translational/clinical research, as well as patient representatives. An ambitious multidisciplinary approach is proposed to move from patient tissue characterisation to preclinical evaluation of single or combinations of drugs. This approach includes the characterisation of the genetic landscape of metastatic UM and its microenvironment, proteomic studies to address signal pathway deregulation and establishment of novel relevant in vitro and in vivo UM models. We also aim to validate accurate surrogate endpoint biomarkers to evaluate therapies and detect metastases as early as possible. Underpinning this will be the UM Cure 2020 virtual biobank registry, linking existing biobanks into a harmonised network, which will prospectively collect primary and metastatic UM samples. Together, our approach will lead to the identification of new therapies, allowing the initiation of UM-dedicated clinical trials sponsored by academia or pharma. Dissemination of results will include the building of a patient network across the countries as part of the consortium as well as a dedicated UM patient and caregiver’s data portal as part of the UM Cure 2020 website, in order to increase patient information and disease awareness.
Status of prospective collection and use of collected biosamples | Documents, reports | 2020-01-30 08:51:53 |
Release of main UM Cure 2020 communication tools | Documents, reports | 2020-01-30 08:51:53 |
Kick-off meeting | Documents, reports | 2020-01-30 08:51:53 |
Agreement on minimum dataset for all currently banked UM biosamples | Documents, reports | 2020-01-30 08:51:53 |
Take a look to the deliverables list in detail: detailed list of UM Cure 2020 deliverables.
year | authors and title | journal | last update |
---|---|---|---|
2020 |
Didier Decaudin, Estelle Frisch Dit Leitz, Fariba Nemati, Malcy Tarin, Adnan Naguez, Mohamed Zerara, Benjamin Marande, Raquel Vivet-Noguer, Ensar Halilovic, Claire Fabre, Aart Jochemsen, Sergio Roman-Roman, Samar Alsafadi Preclinical evaluation of drug combinations identifies co-inhibition of Bcl-2/XL/W and MDM2 as a potential therapy in uveal melanoma published pages: 93-103, ISSN: 0959-8049, DOI: 10.1016/j.ejca.2019.12.012 |
European Journal of Cancer 126 | 2020-02-04 |
2019 |
Francesca Precazzini, Michael Pancher, Pamela Gatto, Ada Tushe, Valentina Adami, Viviana Anelli, Maria Caterina Mione Automated in vivo screen in zebrafish identifies Clotrimazole as targeting a metabolic vulnerability in a melanoma model published pages: , ISSN: 0012-1606, DOI: 10.1016/j.ydbio.2019.04.005 |
Developmental Biology | 2020-01-30 |
2019 |
Zahra Souri, Annemijn P. A. Wierenga, Christiaan van Weeghel, Pieter A. van der Velden, Wilma G. M. Kroes, Gregorius P. M. Luyten, Sjoerd H. van der Burg, Aart G. Jochemsen, Martine J. Jager Loss of BAP1 Is Associated with Upregulation of the NFkB Pathway and Increased HLA Class I Expression in Uveal Melanoma published pages: 1102, ISSN: 2072-6694, DOI: 10.3390/cancers11081102 |
Cancers 11/8 | 2020-01-30 |
2019 |
Christiaan van Weeghel, Annemijn P. A. Wierenga, Mieke Versluis, Thorbald van Hall, Pieter A. van der Velden, Wilma G. M. Kroes, Ulrich Pfeffer, Gregorius P. M. Luyten, Martine J. Jager Do GNAQ and GNA11 Differentially Affect Inflammation and HLA Expression in Uveal Melanoma? published pages: 1127, ISSN: 2072-6694, DOI: 10.3390/cancers11081127 |
Cancers 11/8 | 2020-01-30 |
2019 |
Souri, Wierenga, Mulder, Jochemsen, Jager HLA Expression in Uveal Melanoma: An Indicator of Malignancy and a Modifiable Immunological Target published pages: 1132, ISSN: 2072-6694, DOI: 10.3390/cancers11081132 |
Cancers 11/8 | 2020-01-30 |
2019 |
Mehmet Dogrusöz, Andrea Ruschel Trasel, Jinfeng Cao, Selҫuk Ҫolak, Sake I. van Pelt, Wilma G. M. Kroes, Amina F. A. S. Teunisse, Samar Alsafadi, Sjoerd G. van Duinen, Gregorius P. M. Luyten, Pieter A. van der Velden, Adriana Amaro, Ulrich Pfeffer, Aart G. Jochemsen, Martine J. Jager Differential Expression of DNA Repair Genes in Prognostically-Favorable versus Unfavorable Uveal Melanoma published pages: 1104, ISSN: 2072-6694, DOI: 10.3390/cancers11081104 |
Cancers 11/8 | 2020-01-30 |
2019 |
Annemijn P. A. Wierenga, Gülçin Gezgin, Els van Beelen, Michael Eikmans, Marijke Spruyt-Gerritse, Niels J. Brouwer, Mieke Versluis, Robert M. Verdijk, Sjoerd G. van Duinen, Marina Marinkovic, Gregorius P. M. Luyten, Martine J. Jager Soluble HLA in the Aqueous Humour of Uveal Melanoma Is Associated with Unfavourable Tumour Characteristics published pages: 1202, ISSN: 2072-6694, DOI: 10.3390/cancers11081202 |
Cancers 11/8 | 2020-01-30 |
2019 |
Niels J. Brouwer, Gülçin Gezgin, Annemijn P.A. Wierenga, Inge H.G. Bronkhorst, Marina Marinkovic, Gregorius P.M. Luyten, Mieke Versluis, Wilma G.M. Kroes, Pieter A. van der Velden, Robert M. Verdijk, Martine J. Jager Tumour Angiogenesis in Uveal Melanoma Is Related to Genetic Evolution published pages: 979, ISSN: 2072-6694, DOI: 10.3390/cancers11070979 |
Cancers 11/7 | 2020-01-30 |
2019 |
Manuel Rodrigues, Leanne de Koning, Sarah Coupland, Aart Jochemsen, Richard Marais, Marc-Henri Stern, André Valente, Raymond Barnhill, Nathalie Cassoux, Andrew Evans, Iain Galloway, Martine Jager, Ellen Kapiteijn, Bozena Romanowska-Dixon, Bettina Ryll, Sergio Roman-Roman, Sophie Piperno-Neumann So Close, yet so Far: Discrepancies between Uveal and Other Melanomas. A Position Paper from UM Cure 2020 published pages: 1032, ISSN: 2072-6694, DOI: 10.3390/cancers11071032 |
Cancers 11/7 | 2020-01-30 |
2019 |
Niels J. Brouwer, Annemijn P. A. Wierenga, Gülçin Gezgin, Marina Marinkovic, Gregorius P. M. Luyten, Wilma G. M. Kroes, Mieke Versluis, Pieter A. van der Velden, Robert M. Verdijk, Martine J. Jager Ischemia Is Related to Tumour Genetics in Uveal Melanoma published pages: 1004, ISSN: 2072-6694, DOI: 10.3390/cancers11071004 |
Cancers 11/7 | 2020-01-30 |
2019 |
Manuel Rodrigues, Lenha Mobuchon, Alexandre Houy, Samar Alsafadi, Sylvain Baulande, Odette Mariani, Benjamin Marande, Khadija Ait Rais, Monique K. Van der Kooij, Ellen H.W. Kapiteijn, Sieta Gassama, Sophie Gardrat, Raymond Barnhill, Vincent Servois, Rémi Dendale, Marc Putterman, Sarah Tick, Sophie Piperno-Neumann, Nathalie Cassoux, Gaelle Pierron, Joshua J Waterfall, Sergio Roman-Roman, Pascale M Evolutionary routes in metastatic uveal melanomas depend on MBD4 alterations. published pages: clincanres.1215., ISSN: 1078-0432, DOI: 10.1158/1078-0432.ccr-19-1215 |
Clinical Cancer Research | 2020-01-30 |
2018 |
Manuel Rodrigues, Lenha Mobuchon, Alexandre Houy, Alice Fiévet, Sophie Gardrat, Raymond L. Barnhill, Tatiana Popova, Vincent Servois, Aurore Rampanou, Aurore Mouton, Stéphane Dayot, Virginie Raynal, Michèle Galut, Marc Putterman, Sarah Tick, Nathalie Cassoux, Sergio Roman-Roman, François-Clément Bidard, Olivier Lantz, Pascale Mariani, Sophie Piperno-Neumann, Marc-Henri Stern Outlier response to anti-PD1 in uveal melanoma reveals germline MBD4 mutations in hypermutated tumors published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-04322-5 |
Nature Communications 9/1 | 2020-01-30 |
2018 |
Mark J. de Lange, Rogier J. Nell, Rajshri N. Lalai, Mieke Versluis, Ekaterina S. Jordanova, Gre P.M. Luyten, Martine J. Jager, Sjoerd H. van der Burg, Willem H. Zoutman, Thorbald van Hall, Pieter A. van der Velden Digital PCR-Based T-cell Quantification–Assisted Deconvolution of the Microenvironment Reveals that Activated Macrophages Drive Tumor Inflammation in Uveal Melanoma published pages: , ISSN: 1541-7786, DOI: 10.1158/1541-7786.MCR-18-0114 |
Molecular Cancer Research | 2020-01-30 |
2018 |
Sergio Roman-Roman, Marc-Henri Stern, Samar Alsafadi, Martine J. Jager, Mehmet Dogrusöz, Sarah E. Coupland, Maria Caterina Mione, Viviana Anelli, Francesca Precazzini, Lenha Mobuchon, Fariba Nemati, Didier Decaudin, Manuel Rodrigues, Olivier Lantz, Raymond Barnhill, Sophie Piperno-Neumann, Nathalie Cassoux, Laurence Desjardins, Gulçin Gezgin, Annemijn Wierenga, Aart J. Jochemsen, Kseniya A. Glin UM Cure 2020: New therapies for uveal melanoma published pages: 15-17, ISSN: 2398-7073, DOI: 10.21820/23987073.2018.2.15 |
Impact 2018/2 | 2020-01-30 |
2019 |
Leticia Dominguez-Berrocal, Erica Cirri, Xiguang Zhang, Laura Andrini, Gustavo H. Marin, Sophie Lebel-Binay, Angelita Rebollo New Therapeutic Approach for Targeting Hippo Signalling Pathway published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-41404-w |
Scientific Reports 9/1 | 2020-01-30 |
2018 |
Ewa Podgorska, Agnieszka Drzal, Zenon Matuszak, Jan Swakon, Andrzej Slominski, Martyna Elas, Krystyna Urbanska Calcitriol and Calcidiol Can Sensitize Melanoma Cells to Low–LET Proton Beam Irradiation published pages: 2236, ISSN: 1422-0067, DOI: 10.3390/ijms19082236 |
International Journal of Molecular Sciences 19/8 | 2020-01-30 |
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