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OptiQ-CanDo SIGNED

Hybrid Optical Interferometry for Quantitative Cancer Cell Diagnosis

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

OptiQ-CanDo project word cloud

Explore the words cloud of the OptiQ-CanDo project. It provides you a very rough idea of what is the project "OptiQ-CanDo" about.

progression frames monitoring breaking interferometry complete imaging tomographic nanometric sub diagnosis transformations hybrid rotation thickness cancer agents noise interferometric axis broadband risk powerful quantitative combined quantitatively characterization suggest toolbox holographic dimensional caused tweezers cells single lines morphological afford trap dielectrophoresis adherent mechanical optical rapid structural metastasis technologies off full contrast nano refractive capturing manipulations ground thousands technological physical tumor vitro free resolution dynamic external label sensing cell barriers live stages validation subjective overcoming critical additionally tool experimental mapping circulating recording cellular platform index efficient

Project "OptiQ-CanDo" data sheet

The following table provides information about the project.

Coordinator	TEL AVIV UNIVERSITY Organization address address: RAMAT AVIV city: TEL AVIV postcode: 69978 website: http://www.tau.ac.il/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Israel [IL]
Project website	http://www.eng.tau.ac.il/
Total cost	1˙916˙250 €
EC max contribution	1˙916˙250 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2015-STG
Funding Scheme	ERC-STG
Starting year	2016
Duration (year-month-day)	from 2016-07-01 to 2021-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	TEL AVIV UNIVERSITY TEL AVIV UNIVERSITY Organization address address: RAMAT AVIV city: TEL AVIV postcode: 69978 website: http://www.tau.ac.il/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (TEL AVIV)	coordinator	1˙916˙250.00

Map

Project objective

A major challenge in the field of optical imaging of live cells is to achieve label-free but still fully quantitative measurements, which afford high-resolution morphological and mechanical mapping at the single cell level. In particular, developing efficient, non-subjective, quantitative optical imaging technologies for cancer cell diagnosis is a challenging task. The ground-breaking goal of this research project is to establish a robust experimental toolbox for label-free optical diagnosis and monitoring of live cancer cells in-vitro and their potential of metastasis. Optical interferometry is able to provide a platform for imaging live cells quantitatively without the risk of effects caused by using external contrast agents. By overcoming critical technological barriers, I suggest novel hybrid optical interferometric approaches that provide a powerful nano-sensing tool for label-free quantitative measurement of cancer cells. This will be obtained by recording the dynamic quantitative, three-dimensional sub-nanometric structural and mechanical characterization of live cancer cells in different stages. For this aim, I will develop a novel low-noise broadband, common-path, off-axis interferometric system for sub-nanometric physical thickness and mechanical mapping of live cells in thousands of frames per second. Additionally, I will develop rapid tomographic approach for fully capturing the cell three-dimensional refractive-index distribution, as a tool to characterize cancer progression. Interferometry will be combined with multi-trap holographic optical tweezers and dielectrophoresis to enable complete cell manipulations including full rotation, imaging of non-adherent cells, and mechanical measurement validation. New set of interferometry-based quantitative parameters will be developed to enable characterization of cellular transformations, and used to characterize cancer cells with different metastasis potential, for cell lines and for circulating tumor cells.

Publications

List of publications.
year	authors and title	journal	last update
2017	Gili Dardikman, Simcha Mirsky, Mor Habaza, Yael Roichman, Natan T. Shaked Angular phase unwrapping of optically thick objects with a thin dimension published pages: 3347, ISSN: 1094-4087, DOI: 10.1364/OE.25.003347	Optics Express 25/4	2019-07-08
2017	Gili Dardikman, Nir A. Turko, Noa Nativ, Simcha K. Mirsky, Natan T. Shaked Optimal spatial bandwidth capacity in multiplexed off-axis holography for rapid quantitative phase reconstruction and visualization published pages: 33400, ISSN: 1094-4087, DOI: 10.1364/OE.25.033400	Optics Express 25/26	2019-07-08
2017	Mor Habaza, Michael Kirschbaum, Christian Guernth-Marschner, Gili Dardikman, Itay Barnea, Rafi Korenstein, Claus Duschl, Natan T. Shaked Rapid 3D Refractive-Index Imaging of Live Cells in Suspension without Labeling Using Dielectrophoretic Cell Rotation published pages: 1600205, ISSN: 2198-3844, DOI: 10.1002/advs.201600205	Advanced Science 4/2	2019-07-08

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