PARPin SIGNED
Regulation of (ADP-ribosyl)ation signalling in the DNA damage response: elucidating the function of a novel PARP1/ARTD1 interactor
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0PARPin project word cloud
Explore the words cloud of the PARPin project. It provides you a very rough idea of what is the project "PARPin" about.
Project "PARPin" data sheet
The following table provides information about the project.
| Coordinator |
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Organization address contact info |
| Coordinator Country | United Kingdom [UK] |
| Project website | http://ivanahellab.wixsite.com/ivan-ahel-lab/home |
| Total cost | 183˙454 € |
| EC max contribution | 183˙454 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2015 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-03-01 to 2018-02-28 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD | UK (OXFORD) | coordinator | 183˙454.00 |
Map
Project objective
(ADP-ribosyl)ation is a dynamic post-translational modification synthesised by PARPs/ARTDs and regulates a diverse array of cellular processes, including the DNA damage response (DDR). The last decade has significantly improved our understanding of the key enzymes involved in (ADP-ribosyl)ation and the cellular pathways they function within. However, our understanding of how these enzymes are regulated is lacking and demands further investigation. In this proposal I seek to redress this. I have provided promising preliminary data identifying a novel uncharacterised interactor of PARP1 involved in the DDR. I expect that this novel protein will have a fundamental role in PARP1 biology in cells given that the two have co-evolved and form a protein complex in cells. I will implement newly available cutting-edge technologies, such as CRISPR-Cas9 and quantitative cell biology approaches, into an interdisciplinary strategy involving genetics, cell biology, structural biology and biochemistry. This strategy will allow me to address the following research objectives: (1) elucidate the function of this protein complex in genome maintenance (2) determine the atomic structure of the complex (3) define the physiological function of the protein complex using genetic mouse models. This timely and holistic approach will allow me to answer crucial outstanding questions related to the regulation of (ADP-ribosyl)ation signalling for the first time. Consequently, this will be the first mechanistic study of its function and therefore my research objectives are likely to yield original insights into novel aspects of (ADP-ribosyl)ation signalling. The objectives described in this proposal will enhance my potential to become an independent investigator by promoting the diversification of my technical competences through training at a world-leading institute and host laboratory. Therefore, the proposal is well aligned with the over-arching aims of the Work Programme.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2017 |
Juan José Bonfiglio, Pietro Fontana, Qi Zhang, Thomas Colby, Ian Gibbs-Seymour, Ilian Atanassov, Edward Bartlett, Roko Zaja, Ivan Ahel, Ivan Matic Serine ADP-Ribosylation Depends on HPF1 published pages: 932-940.e6, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2017.01.003 |
Molecular Cell 65/5 | 2019-06-13 |
| 2017 |
Marion Schuller, Kerstin Riedel, Ian Gibbs-Seymour, Kristin Uth, Christian Sieg, André P. Gehring, Ivan Ahel, Franz Bracher, Benedikt M. Kessler, Jonathan M. Elkins, Stefan Knapp Discovery of a Selective Allosteric Inhibitor Targeting Macrodomain 2 of Polyadenosine-Diphosphate-Ribose Polymerase 14 published pages: 2866-2874, ISSN: 1554-8929, DOI: 10.1021/acschembio.7b00445 |
ACS Chemical Biology 12/11 | 2019-06-13 |
| 2016 |
Christopher J. Staples, Giancarlo Barone, Katie N. Myers, Anil Ganesh, Ian Gibbs-Seymour, Abhijit A. Patil, Ryan D. Beveridge, Caroline Daye, Richard Beniston, Sarah Maslen, Ivan Ahel, J. Mark Skehel, Spencer J. Collis MRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the DNA Damage Response published pages: 2565-2575, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2016.07.087 |
Cell Reports 16/10 | 2019-06-13 |
| 2016 |
Ian Gibbs-Seymour, Pietro Fontana, Johannes Gregor Matthias Rack, Ivan Ahel HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation Activity published pages: 432-442, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2016.03.008 |
Molecular Cell 62/3 | 2019-06-13 |
| 2018 |
Dominika Kwasna, Syed Arif Abdul Rehman, Jayaprakash Natarajan, Stephen Matthews, Ross Madden, Virginia De Cesare, Simone Weidlich, Satpal Virdee, Ivan Ahel, Ian Gibbs-Seymour, Yogesh Kulathu Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability published pages: , ISSN: 1097-2765, DOI: 10.1016/j.molcel.2018.02.023 |
Molecular Cell | 2019-06-13 |
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "PARPIN" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "PARPIN" are provided by the European Opendata Portal: CORDIS opendata.