Explore the words cloud of the CoronaTag project. It provides you a very rough idea of what is the project "CoronaTag" about.
The following table provides information about the project.
Coordinator |
TECHNISCHE UNIVERSITEIT EINDHOVEN
Organization address contact info |
Coordinator Country | Netherlands [NL] |
Project website | https://www.tue.nl/en/university/departments/biomedical-engineering/research/research-groups/molecular-biosensing-for-medical-diagnostics-mbx/ |
Total cost | 165˙598 € |
EC max contribution | 165˙598 € (100%) |
Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
Code Call | H2020-MSCA-IF-2015 |
Funding Scheme | MSCA-IF-EF-ST |
Starting year | 2016 |
Duration (year-month-day) | from 2016-03-01 to 2018-02-28 |
Take a look of project's partnership.
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1 | TECHNISCHE UNIVERSITEIT EINDHOVEN | NL (EINDHOVEN) | coordinator | 165˙598.00 |
Nanoparticles (from 1 to 1000 nM in diameter) are widely used in point-of-care diagnostics due to their large surface area and versatile biofunctionalization. However, when used in matrices such as blood plasma and other complex biological fluids, nanoparticles are known to attract proteins that form coronas around the nanoparticles. These coronas block binding sites, cause non-specific interactions, and cause aggregation among the nanoparticles, resulting in lower signals, higher background, and large variabilities in the assays. Proteomics studies have analyzed the overall protein corona composition on different nanoparticles, depending on size, surface chemistry etc. Microscopic studies have been used to monitor the kinetics of corona formation on nanoparticles in simplified systems. However, protein-protein interactions and cooperative effects in corona formation, and their interference in diagnostic assays involving affinity reagents, have not been studied yet in a comprehensive way. In this proposal, I will adress those questions using DNA-assisted protein technology, where proteins are labeled with DNA barcode tags. The ligation of proximal barcodes will reveal protein-protein co-localizations within coronas and their interactions with affinity reagents such as antibodies. The analysis will give unique insight in the internal structure of coronas and will shed light on the origin of corona-induced nanoparticle-nanoparticle aggregation processes and nanoparticle-surface interactions, which is very important for nanoparticle-based point-of-care diagnostics.
year | authors and title | journal | last update |
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2018 |
Emiel W. A. Visser, Junhong Yan, Leo J. van IJzendoorn, Menno W. J. Prins Continuous biomarker monitoring by particle mobility sensing with single molecule resolution published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-04802-8 |
Nature Communications 9/1 | 2019-06-13 |
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The information about "CORONATAG" are provided by the European Opendata Portal: CORDIS opendata.