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DRIVOME

Multi-modal interrogation of instinctive behaviours and intrahypothalamic connectivity

Total Cost €

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EC-Contrib. €

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Partnership

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 DRIVOME project word cloud

Explore the words cloud of the DRIVOME project. It provides you a very rough idea of what is the project "DRIVOME" about.

mouse    outlined    marital    familiar    kingdom    transgenic    sexual    cruder    difficult    anomalies    et    species    disorders    context    imaging    deep    mice    lee    neuronal    drives    network    1951    elucidate    optrode    daily    demonstrated    wakefulness    dyscontrol    fundamental    organization    1981    parental    encoded    lin    displays    instinctive    excessive    structures    drive    hypothalamic    2014    aponte    2013    connectome    feeding    mammalian    pace    2011    everyone    2015    lorenz    guide    architecture    syndrome    reside    circuits    potentially    jego    psychologically    infidelity    behaviours    indicators    wu    brain    opsins    possibly    emotions    coherent    photon    wiring    genetically    hunger    sex    episodic    marlin    cell    probing    networks    calcium    hypotheses    ripe    instincts    older    hypothalamus    charge    anatomical    uncovered    ethology    modern    diagram    gaining    tinbergen    newer    populations    insights    betley    intrahypothalamic    swanson    sleep    techniques    adamantidis    aggression    2007    situations    manipulations    drivome    anorexia    evident    orchestrated    recording    al    adaptive    animal    2000   

Project "DRIVOME" data sheet

The following table provides information about the project.

Coordinator
KING'S COLLEGE LONDON 

Organization address
address: STRAND
city: LONDON
postcode: WC2R 2LS
website: www.kcl.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://kclpure.kcl.ac.uk/portal/en/persons/mahesh-karnani
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2016
 Duration (year-month-day) from 2016-03-01   to  2018-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KING'S COLLEGE LONDON UK (LONDON) coordinator 183˙454.00

Map

 Project objective

Mammalian behaviour is driven by instincts such as hunger, sex and aggression which are familiar to everyone from daily experience. Anomalies in these instincts cause disorders such as anorexia, excessive sexual drive and episodic dyscontrol syndrome, and potentially also psychologically difficult situations like marital infidelity. Neuronal circuits that drive these instincts reside in the hypothalamus where research is gaining pace rapidly. Recent work has uncovered hypothalamic neuronal populations in mouse, that can drive the following fundamental mammalian behaviours: feeding (Aponte et al., 2011, Betley et al., 2015), sex/aggression (Lee et al., 2014, Lin et al., 2011), sleep/wakefulness (Adamantidis et al., 2007, Jego et al., 2013) and parental behaviours (Marlin et al., 2015, Wu et al., 2014). Older work has demonstrated similar effects with cruder manipulations of the hypothalamus in several species. Classical work in ethology (Lorenz, 1981, Tinbergen, 1951) as well as newer anatomical insights (Swanson, 2000) have outlined hypotheses for how neuronal network architecture may guide the organization of instinctive behaviours into the coherent, adaptive, context-relevant displays evident throughout the animal kingdom. Modern techniques (opsins, genetically encoded calcium indicators, transgenic mice, multi photon imaging of deep brain structures and optrode recording) are now ripe for comprehensive cell-type specific probing of the hypothalamic networks in charge of fundamental drives and possibly emotions. We propose to use these methods to elucidate the intrahypothalamic wiring diagram (the connectome of drives, or 'DRIVOME') that can explain how instincts are orchestrated.

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