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HyGlio SIGNED

Theranostic Injectable Hydrogel for Glioblastoma

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

HyGlio project word cloud

Explore the words cloud of the HyGlio project. It provides you a very rough idea of what is the project "HyGlio" about.

brain mild diagnosis adjustment burden molecular transport theranostic resistant combining variants bypassing penetration aggressive intracranial mechanisms selectivity damages treatment inhibition rapid introduce reduce magnetic incidence biological extremely healthy economic aggressiveness imaging tumor hard considerable invariably fatal gbm specificity resonance bbb drug nanoparticles efficient outcome maximizes strategies approximate frequent combines treat proposes efficacy median survival tool socio barriers agents therapy polymer tools innovative multifunctional glioblastoma patient multiforme gelling prognosis chemotherapy migrating hydrogel adults systemic advantages tissue hyglio multiple evolution spreading minimizing

Project "HyGlio" data sheet

The following table provides information about the project.

Coordinator	POLITECNICO DI TORINO Organization address address: CORSO DUCA DEGLI ABRUZZI 24 city: TORINO postcode: 10129 website: www.polito.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Project website	http://www.dimeas.polito.it/la_ricerca/gruppi/materiali_per_le_bionanotecnologie_e_laboratorio_biomedico
Total cost	244˙269 €
EC max contribution	244˙269 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-GF
Starting year	2016
Duration (year-month-day)	from 2016-09-30 to 2019-09-29

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	POLITECNICO DI TORINO POLITECNICO DI TORINO Organization address address: CORSO DUCA DEGLI ABRUZZI 24 city: TORINO postcode: 10129 website: www.polito.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (TORINO)	coordinator	244˙269.00
2	THE METHODIST HOSPITAL RESEARCH INSTITUTE THE METHODIST HOSPITAL RESEARCH INSTITUTE Organization address address: FANNIN STREET 6565 city: HOUSTON TX postcode: 77030 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (HOUSTON TX)	partner	0.00

Map

Project objective

Glioblastoma multiforme (GBM) is the most frequent brain tumor in adults and is characterized by invariably fatal prognosis. Although the incidence of GBM is less than 10 to 100,000, the median survival of approximate 1 year from diagnosis makes it a considerable socio-economic burden. The presence of biological barriers for effective drug transport to the brain, the strong migrating-ability of the tumor and its rapid evolution into more aggressive and treatment-resistant variants, make GBM extremely hard to treat with traditional systemic chemotherapy. The HyGlio project proposes an ambitious bottom-up approach to build a multifunctional tool for long-term imaging and treatment of GBM, combining multiple treatment strategies, patient-specificity, and BBB bypassing in an all-in-one system. The system combines the advantages of: (i) Intracranial treatment, which maximizes efficacy while minimizing side effects; (ii) mild gelling conditions of the hydrogel, which reduce potential damages to the healthy tissue; (iii) increased drug penetration and selectivity due to the use of targeted polymer nanoparticles; (iv) Inhibition of molecular mechanisms involved in GBM spreading and aggressiveness; (iv) theranostic potential, due to the presence of magnetic resonance imaging, agents for rapid therapy adjustment according to patient’s needs. The HyGlio project is expected to introduce innovative concepts and methodologies for the treatment of GBM, by providing advanced and promising tools for more efficient therapy and increased patient outcome.

Publications

List of publications.
year	authors and title	journal	last update
2019	G. Brachi, F. Bussolino, G. Ciardelli, C. Mattu NANOMEDICINE FOR IMAGING AND THERAPY OF PANCREATIC ADENOCARCINOMA published pages: , ISSN: 2296-4185, DOI: 10.3389/fbioe.2019.00307	Frontiers in Bioengineering and Biotechnology	2020-04-07
2019	Sharon Wei Ling Lee, Camilla Paoletti, Marco Campisi, Tatsuya Osaki, Giulia Adriani, Roger D. Kamm, Clara Mattu, Valeria Chiono MicroRNA delivery through nanoparticles published pages: , ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2019.10.007	Journal of Controlled Release	2020-04-07
2018	C. Mattu, G. Brachi, L. Menichetti, A. Flori, P. Armanetti, E. Ranzato, S. Martinotti, S. Nizzero, M. Ferrari, G. Ciardelli Alternating block copolymer-based nanoparticles as tools to modulate the loading of multiple chemotherapeutics and imaging probes published pages: , ISSN: 1742-7061, DOI: 10.1016/j.actbio.2018.09.021	Acta Biomaterialia	2020-04-07

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The information about "HYGLIO" are provided by the European Opendata Portal: CORDIS opendata.