Explore the words cloud of the CMIL project. It provides you a very rough idea of what is the project "CMIL" about.
The following table provides information about the project.
Coordinator |
CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH
Organization address contact info |
Coordinator Country | Austria [AT] |
Project website | https://cemm.at/research/funding/international-funding/erc-starting-grant-cmil/ |
Total cost | 1˙701˙011 € |
EC max contribution | 1˙701˙011 € (100%) |
Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
Code Call | ERC-2015-STG |
Funding Scheme | ERC-STG |
Starting year | 2016 |
Duration (year-month-day) | from 2016-04-01 to 2021-03-31 |
Take a look of project's partnership.
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1 | CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH | AT (WIEN) | coordinator | 1˙701˙011.00 |
Inflammation is a response to noxious stimuli and initiates tissue repair. If resolution fails, however, chronic inflammation develops, which drives tissue damage in many diseases including autoimmunity, cancer and infections. Inflammatory processes are increasingly being appreciated as tightly integrated with metabolic pathways. The molecular crosstalk occurs on different levels including secreted metabolites and cytokines. I hypothesise that this interface of metabolism and inflammation represents a functional rheostat that shapes tissue damage and disease.
Here, I propose to analyse the metabolic and inflammatory processes in a mouse model of chronic viral hepatitis. I chose this model to explore the inflammatory rheostat because the liver is the central organ for metabolism and a hotspot for receiving, processing and distributing local and systemic signals. Cutting-edge technologies including deep sequencing, quantitative proteomics and metabolomics will let us create longitudinal multi-dimensional maps of virus-induced alterations. Paired with immunological, virological and pathological analyses, I expect to identify novel regulatory nodes between metabolism and inflammation. Within our systems-wide experiments and supported by preliminary results, we will specifically focus on the immunomodulatory roles of the metabolite bile acids and oxidative metabolism. These as well as other candidates will be investigated by genetic and pharmacological perturbations in cell culture and in mouse models. Bioinformatics integration of the orthogonal profiling kinetics is expected to reveal novel properties of the molecular networks mediating between metabolism and inflammation.
This proposed cross-disciplinary approach aims to improve our understanding of the crosstalk of metabolism and inflammation. The results of this project may be relevant to viral hepatitis in man and bear broader implications for other inflammatory diseases.
year | authors and title | journal | last update |
---|---|---|---|
2019 |
Alexander Lercher, Anannya Bhattacharya, Alexandra M. Popa, Michael Caldera, Moritz F. Schlapansky, Hatoon Baazim, Benedikt Agerer, Bettina Gürtl, Lindsay Kosack, Peter Májek, Julia S. Brunner, Dijana Vitko, Theresa Pinter, Jakob-Wendelin Genger, Anna Orlova, Natalia Pikor, Daniela Reil, Maria Ozsvár-Kozma, Ulrich Kalinke, Burkhard Ludewig, Richard Moriggl, Keiryn L. Bennett, Jörg Menche, Paul Type I Interferon Signaling Disrupts the Hepatic Urea Cycle and Alters Systemic Metabolism to Suppress T Cell Function published pages: 1074-1087.e9, ISSN: 1074-7613, DOI: 10.1016/j.immuni.2019.10.014 |
Immunity 51/6 | 2020-02-19 |
2019 |
Lindsay Kosack, Bettina Wingelhofer, Alexandra Popa, Anna Orlova, Benedikt Agerer, Bojan Vilagos, Peter Majek, Katja Parapatics, Alexander Lercher, Anna Ringler, Johanna Klughammer, Mark Smyth, Kseniya Khamina, Hatoon Baazim, Elvin D. de Araujo, David A. Rosa, Jisung Park, Gary Tin, Siawash Ahmar, Patrick T. Gunning, Christoph Bock, Hannah V. Siddle, Gregory M. Woods, Stefan Kubicek, Elizabeth P. Murchison, Keiryn L. Bennett, Richard Moriggl, Andreas Bergthaler The ERBB-STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease published pages: 125-139.e9, ISSN: 1535-6108, DOI: 10.1016/j.ccell.2018.11.018 |
Cancer Cell 35/1 | 2020-01-29 |
2019 |
Hatoon Baazim, Martina Schweiger, Michael Moschinger, Haifeng Xu, Thomas Scherer, Alexandra Popa, Suchira Gallage, Adnan Ali, Kseniya Khamina, Lindsay Kosack, Bojan Vilagos, Mark Smyth, Alexander Lercher, Joachim Friske, Doron Merkler, Alan Aderem, Thomas H. Helbich, Mathias Heikenwälder, Philipp A. Lang, Rudolf Zechner, Andreas Bergthaler CD8+ T cells induce cachexia during chronic viral infection published pages: 701-710, ISSN: 1529-2908, DOI: 10.1038/s41590-019-0397-y |
Nature Immunology 20/6 | 2020-01-29 |
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The information about "CMIL" are provided by the European Opendata Portal: CORDIS opendata.
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