EBAR SIGNED
Evidence Based Planning of Future Clinical Research
Total Cost €
0EC-Contrib. €
0Partnership
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Project "EBAR" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSITAET BERN
Organization address contact info |
| Coordinator Country | Switzerland [CH] |
| Project website | http://www.ispm.unibe.ch/research/research_groups/evidence_synthesis_methods/evidence_based_planning_of_clinical_research/index_eng.html |
| Total cost | 187˙419 € |
| EC max contribution | 187˙419 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2015 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-06-01 to 2018-05-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSITAET BERN | CH (BERN) | coordinator | 187˙419.00 |
Map
Project objective
Clinical studies that are planned without prior consideration of existing evidence potentially experiment with an unnecessarily large number of patients or try to answer a question to which the answer is already available. This project aims to develop a framework of efficient and sustainable research planning that minimizes cost and has the potential to direct resource allocation by optimally planning future clinical studies based on existing evidence. A circular updating process is suggested; before a trial is planned the existing evidence (a network meta-analysis) about the effectiveness of all competing interventions is considered and its conclusiveness is statistically evaluated. If further experiments are needed these are designed considering patient’s preferences and with an aim to render the existing evidence conclusive. The new data is then used to update the existing knowledge. This innovative approach to plan clinical studied requires methodological developments from various fields (biostatistics, operational research, epidemiology) and its feasibility will be evaluated in answering a real clinical question about the best intervention for a given condition and in designing a new trial. The circular updating process is of high interest to public research funding bodies, guideline developers and pharmaceutical companies. The project has a strong public engagement component as patients and major health care organizations are involved in many of the planned activities in the development of the circular updating process. The project will be carried out in a stimulating academic environment (University of Bern) with extensive experience in clinical trials and a secondment in Novartis is planned. I will acquire technical skills in clinical trials, will continue to produce high-impact publications and develop leadership skills. These additions to my curriculum will enable me to progress to an academic carrier in a high-profile European Institute.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2018 |
Georgia Salanti, Adriani Nikolakopoulou, Alex J. Sutton, Stephan Reichenbach, Sven Trelle, Huseyin Naci, Matthias Egger Planning a future randomized clinical trial based on a network of relevant past trials published pages: , ISSN: 1745-6215, DOI: 10.1186/s13063-018-2740-2 |
Trials 19/1 | 2019-06-13 |
| 2018 |
Adriani Nikolakopoulou, Dimitris Mavridis, Toshi A Furukawa, Andrea Cipriani, Andrea C Tricco, Sharon E Straus, George C M Siontis, Matthias Egger, Georgia Salanti Living network meta-analysis compared with pairwise meta-analysis in comparative effectiveness research: empirical study published pages: k585, ISSN: 0959-8138, DOI: 10.1136/bmj.k585 |
BMJ | 2019-06-13 |
| 2018 |
Matthew K Bagg, Georgia Salanti, James H McAuley Research Note: Comparing interventions with network meta-analysis published pages: 128-132, ISSN: 1836-9553, DOI: 10.1016/j.jphys.2018.02.014 |
Journal of Physiotherapy 64/2 | 2019-06-13 |
| 2018 |
Richard D Riley, Dan Jackson, Georgia Salanti, Danielle L Burke, Malcolm Price, Jamie Kirkham, Ian R White Multivariate and network meta-analysis of multiple outcomes and multiple treatments: rationale, concepts, and examples published pages: j3932, ISSN: 0959-8138, DOI: 10.1136/bmj.j3932 |
BMJ | 2019-06-13 |
| 2018 |
Marcel Zwahlen, Geogia Salanti Causal inference from experiment and observation published pages: 34-38, ISSN: 1362-0347, DOI: 10.1136/eb-2017-102859 |
Evidence Based Mental Health 21/1 | 2019-06-13 |
| 2018 |
George CM Siontis, Dimitris Mavridis, John P Greenwood, Bernadette Coles, Adriani Nikolakopoulou, Peter Jüni, Georgia Salanti, Stephan Windecker Outcomes of non-invasive diagnostic modalities for the detection of coronary artery disease: network meta-analysis of diagnostic randomised controlled trials published pages: k504, ISSN: 0959-8138, DOI: 10.1136/bmj.k504 |
BMJ | 2019-06-13 |
| 2016 |
A. Nikolakopoulou, D. Mavridis, M. Egger, G. Salanti Continuously updated network meta-analysis and statistical monitoring for timely decision-making published pages: , ISSN: 0962-2802, DOI: 10.1177/0962280216659896 |
Statistical Methods in Medical Research | 2019-06-13 |
| 2016 |
Toshi A Furukawa, Andrea Cipriani, Lauren Z Atkinson, Stefan Leucht, Yusuke Ogawa, Nozomi Takeshima, Yu Hayasaka, Anna Chaimani, Georgia Salanti Placebo response rates in antidepressant trials: a systematic review of published and unpublished double-blind randomised controlled studies published pages: 1059-1066, ISSN: 2215-0366, DOI: 10.1016/S2215-0366(16)30307-8 |
The Lancet Psychiatry 3/11 | 2019-06-13 |
| 2018 |
Alessandro Pompoli, Toshi A. Furukawa, Orestis Efthimiou, Hissei Imai, Aran Tajika, Georgia Salanti Dismantling cognitive-behaviour therapy for panic disorder: a systematic review and component network meta-analysis published pages: 1-9, ISSN: 0033-2917, DOI: 10.1017/S0033291717003919 |
Psychological Medicine | 2019-06-13 |
| 2018 |
Adriani Nikolakopoulou, Sven Trelle, Alex J Sutton, Matthias Egger, Georgia Salanti Synthesizing existing evidence to design future trials: survey of methodologists in Europe published pages: , ISSN: , DOI: |
online/ submitted to Trials | 2019-06-13 |
| 2016 |
Maria Petropoulou, Adriani Nikolakopoulou, Areti-Angeliki Veroniki, Patricia Rios, Afshin Vafaei, Wasifa Zarin, Myrsini Giannatsi, Shannon Sullivan, Andrea C. Tricco, Anna Chaimani, Matthias Egger, Georgia Salanti Bibliographic study showed improving statistical methodology of network meta-analyses published between 1999 and 2015 published pages: , ISSN: 0895-4356, DOI: 10.1016/j.jclinepi.2016.11.002 |
Journal of Clinical Epidemiology | 2019-06-13 |
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