Opendata, web and dolomites
  1. home
  2. trasparenza
  3. open h2020
  4. biominab-3d

BiominAB-3D SIGNED

Revealing the composition and formation mechanism of carcinogenic asbestos bodies in human lungs

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0
 Outcomes and results

 BiominAB-3D project word cloud

Explore the words cloud of the BiominAB-3D project. It provides you a very rough idea of what is the project "BiominAB-3D" about.

unaltered    particulate    mechanism    doctors    man    thought    material    efficient    stay    question    employed    composition    tissue    microdiffraction    mesothelioma    preserving    innovative    toxic    strategies    prolonged    physicists    degradation    coating    environment    iron    incidence    scientists    microtomography    unclear    tridimensional    lung    fibres    biologists    vehicular    prevention    combined    edge    transmission    events    fluorescence    imaging    biological    interaction    reveal    revealing    science    despite    samples    responsible    cytotoxic    human    morphology    population    unprecedented    carcinogenic    electron    usually    deeper    medical    lungs    chemists    nature    techniques    aggressive    industrial    microscopy    physics    radiation    laboratory    made    synchrotron    lining    bodies    when    fundamental    cutting    elemental    fibers    extended    breaking    pulmonary    treatments    asbestos    combining    triggers    respiratory    nanoparticles    inhaled    chain    health    diseases    structure    cancer   

Project "BiominAB-3D" data sheet

The following table provides information about the project.

Coordinator		 CONSIGLIO NAZIONALE DELLE RICERCHE 

Organization address
address: PIAZZALE ALDO MORO 7
city: ROMA
postcode: 185
website: www.cnr.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Italy [IT]
 Project website http://biominab3d.altervista.org
 Total cost 180˙277 €
 EC max contribution 180˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-05-01   to  2018-05-22

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) coordinator 180˙277.00

Map

 Project objective

When it is inhaled, asbestos triggers a chain of events that can lead to mesothelioma, an aggressive cancer of the lung lining, and to lung cancer. After prolonged stay in the lungs the asbestos fibers develop an iron coating that is thought to be responsible for the cytotoxic response, and which nature is still unclear. The fibres with their coating, developed after prolonged stay in human lungs, are known as asbestos bodies. Despite the large and increasing incidence of respiratory/pulmonary diseases among the general population due to asbestos and other toxic fibers, the carcinogenic mechanism is not yet fully understood. A deeper knowledge of the interaction between the fibers and the biological tissue can help scientists to develop more efficient medical treatments and to improve prevention strategies. The proposed research project aims to reveal the composition and formation mechanism of asbestos bodies combining cutting-edge synchrotron radiation fluorescence and imaging microtomography and microdiffraction with transmission electron microscopy. Synchrotron radiation techniques will allow revealing the elemental distribution and morphology of unaltered lung tissue samples with unprecedented level of detail, preserving their tridimensional structure. Microdiffraction and transmission electron microscopy will reveal possible degradation of the embedded asbestos fibres, which is a long standing question. The project will exploit an innovative collaboration between physicists, chemists, doctors, and biologists. In particular, physics techniques usually employed in the field of fundamental research or in material science will be combined with laboratory methodologies, creating an environment favourable for breaking-through results. The methodologies developed during the project can be extended to the study of other toxic particulate, such as vehicular or industrial particulate matter and man-made nanoparticles, which are of increasing concern for human health.

 Publications

year authors and title journal last update
List of publications.
2017 Fabrizio Bardelli, Giulia Veronesi, Silvana Capella, Donata Bellis, Laurent Charlet, Alessia Cedola, Elena Belluso
New insights on the biomineralisation process developing in human lungs around inhaled asbestos fibres
published pages: 11, ISSN: 2045-2322, DOI: 10.1038/srep44862 		Scientific Reports 7/1 2019-06-13

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "BIOMINAB-3D" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "BIOMINAB-3D" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

RipGEESE (2020)

Identifying the ripples of gene regulation evolution in the evolution of gene sequences to determine when animal nervous systems evolved

Read More  

DEF2DEV (2019)

Identification of the mode of action of plant defensins during root development and plant defense responses.

Read More  

PreSpeech (2018)

Predicting speech: what and when does the brain predict during language comprehension?

Read More