Explore the words cloud of the OPTBIOMAN project. It provides you a very rough idea of what is the project "OPTBIOMAN" about.
The following table provides information about the project.
Coordinator |
TECHNISCHE UNIVERSITEIT EINDHOVEN
Organization address contact info |
Coordinator Country | Netherlands [NL] |
Project website | https://sites.google.com/site/tugcemartagan/publications |
Total cost | 177˙598 € |
EC max contribution | 177˙598 € (100%) |
Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
Code Call | H2020-MSCA-IF-2015 |
Funding Scheme | MSCA-IF-EF-RI |
Starting year | 2016 |
Duration (year-month-day) | from 2016-03-01 to 2018-02-28 |
Take a look of project's partnership.
# | ||||
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1 | TECHNISCHE UNIVERSITEIT EINDHOVEN | NL (EINDHOVEN) | coordinator | 177˙598.00 |
An inter-disciplinary modelling and optimization framework will be developed to economically optimize biomanufacturing decision under high process variability, failure risks, and expensive operating costs. New stochastic models will be developed to link the underlying biological and chemical dynamics of the biomanufacturing processes (cell-level dynamics) with the financial trade-offs in terms of yield, quality, operating costs, and failure risks (manufacturing system-level dynamics). In particular, the research project will model and analyze the economics of the upstream fermentation and downstream purification operations. Novel approximations and heuristics will be developed based on the unique features of the problem setting in order to solve large size problems encountered in industry practices. Optimal (near-optimal) operating policies will be theoretically and numerically analyzed for both upstream fermentation and downstream chromatography operating decisions. The framework will provide timely and effective tools and models to economically optimize biomanufacturing decisions. A solid inter-disciplinary research foundation will be built combining the knowledge from the biological and chemical engineering, stochastic control, reliability theory, and manufacturing systems engineering. This research project will expand and strengthen the industry network of the OPAC group at Eindhoven University of Technology towards the emerging biomanufacturing industry in the Europe. The tools and models developed in this project will be relevant to the European industry practices, and will benefit the European society by making these therapeutic drugs more accessible in the future.
year | authors and title | journal | last update |
---|---|---|---|
2018 |
T. Martagan, Y. Limon, A. Krishnamurthy, T. Foti, P. A. Leland Aldevron Accelerates Growth Using Operations Research in Biomanufacturing published pages: , ISSN: 0092-2102, DOI: |
Interfaces (Forthcoming Paper) | 2019-10-08 |
2016 |
Akçay, A., Martagan, T. Stochastic simulation under input uncertainty for contract manufacturer selection in pharmaceutical industry published pages: , ISSN: , DOI: |
Proceedings of the Winter Simulation Conference | 2019-06-13 |
2017 |
Martagan, T., Krishnamurthy, A. Leland, P. A., Maravelias, C. Performance Guarantees and Optimal Purification Decisions for Engineered Proteins published pages: , ISSN: 0030-364X, DOI: |
Operations Research | 2019-06-13 |
2017 |
Akçay, A., Martagan, T. Simulation-based production planning for engineer-to-order systems with random yield published pages: , ISSN: , DOI: |
Proceedings of the Winter Simulation Conference | 2019-06-13 |
2019 |
Martagan, T., Krishnamurthy, A. Leland, P. A. Managing Trade-offs in Protein Manufacturing: How much to waste? published pages: , ISSN: 1523-4614, DOI: |
Manufacturing and Service Operations Management (Forthcoming Paper) | 2019-06-13 |
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The information about "OPTBIOMAN" are provided by the European Opendata Portal: CORDIS opendata.