Explore the words cloud of the ChroMe project. It provides you a very rough idea of what is the project "ChroMe" about.
The following table provides information about the project.
Coordinator |
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Organization address contact info |
Coordinator Country | Germany [DE] |
Project website | https://www.chromenetwork.eu |
Total cost | 3˙825˙128 € |
EC max contribution | 3˙825˙128 € (100%) |
Programme |
1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers) |
Code Call | H2020-MSCA-ITN-2015 |
Funding Scheme | MSCA-ITN-ETN |
Starting year | 2016 |
Duration (year-month-day) | from 2016-03-01 to 2020-02-29 |
Take a look of project's partnership.
Metabolic disorders are at pandemic levels. Based on recent estimates, ~50% of Europeans are overweight, 20% are obese and 10% have type II diabetes. Obesity and insulin resistance impact European health to the tune of €110 billion per year. These disorders have genetic, nutritional and lifestyle causes. However, the molecular mechanisms that link nutrients and lifestyle to gene activity and chromatin are poorly understood, and drug targets are only starting to be identified. Pioneering experiments by ChroMe labs now reveal how sugars, exercise, the gut microbiome and novel drugs regulate chromatin. These novel links promise to substantially improve our understanding and treatment of metabolic disorders. National governments and the EU invest major resources to address the burden of the “metabolic syndrome”. However, there is an urgent need for expert human capital able to dissect metabolic diseases, exploit new targets and establish innovative therapies. No local nor international program currently provides adequate training at this emerging interface of chromatin and metabolism.
ChroMe establishes a timely and intersectorial ETN that exploits Europe’s strengths in epigenetics, physiology and medicine to translate our molecular knowledge of chromatin–metabolism interactions into therapies. Our ESRs receive advanced training in emerging technologies, bioinformatic and translational approaches, and all engage in collaborative PhD projects co-supervised by academia and industry. ChroMe’s extensive transferable skills, dissemination and public engagement program equips our ESRs with the experience and personal network needed for a career in metabolic health. By systematically involving the non-academic sector at every level in our research, training and management, ChroMe will craft future European leaders with the necessary knowledge and skills to fight the metabolic syndrome pandemic.
Network website | Websites, patent fillings, videos etc. | 2019-09-13 11:18:42 |
Call for abstracts | Documents, reports | 2019-09-13 11:18:42 |
Take a look to the deliverables list in detail: detailed list of ChroMe deliverables.
year | authors and title | journal | last update |
---|---|---|---|
2018 |
Tess Tsai-Hsiu Lu, Steffen Heyne, Erez Dror, Eduard Casas, Laura Leonhardt, Thorina Boenke, Chih-Hsiang Yang, Sagar, Laura Arrigoni, Kevin Dalgaard, Raffaele Teperino, Lennart Enders, Madhan Selvaraj, Marius Ruf, Sunil J. Raja, Huafeng Xie, Ulrike Boenisch, Stuart H. Orkin, Francis C. Lynn, Brad G. Hoffman, Dominic Grün, Tanya Vavouri, Adelheid M. Lempradl, J. Andrew Pospisilik The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and Diabetes published pages: 1294-1308.e7, ISSN: 1550-4131, DOI: 10.1016/j.cmet.2018.04.013 |
Cell Metabolism 27/6 | 2020-04-15 |
2019 |
Joan Miro-Blanch, Oscar Yanes Epigenetic Regulation at the Interplay Between Gut Microbiota and Host Metabolism published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2019.00638 |
Frontiers in Genetics 10 | 2020-04-15 |
2020 |
Ahmed M. Abdelmoez, Laura Sardón Puig, Jonathon A. B. Smith, Brendan M. Gabriel, Mladen Savikj, Lucile Dollet, Alexander V. Chibalin, Anna Krook, Juleen R. Zierath, Nicolas J. Pillon Comparative profiling of skeletal muscle models reveals heterogeneity of transcriptome and metabolism published pages: C615-C626, ISSN: 0363-6143, DOI: 10.1152/ajpcell.00540.2019 |
American Journal of Physiology-Cell Physiology 318/3 | 2020-04-15 |
2018 |
Sarah Hurtado-Bagès, Iva Guberovic, Marcus Buschbeck The MacroH2A1.1 – PARP1 Axis at the Intersection Between Stress Response and Metabolism published pages: 1-10, ISSN: 1664-8021, DOI: 10.3389/fgene.2018.00417 |
Frontiers in Genetics 9 | 2020-04-15 |
2019 |
Paula Ortega-Prieto, Catherine Postic Carbohydrate Sensing Through the Transcription Factor ChREBP published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2019.00472 |
Frontiers in Genetics 10 | 2020-04-15 |
2018 |
Michael Maher, Jeannine Diesch, Raquel Casquero, Marcus Buschbeck Epigenetic-Transcriptional Regulation of Fatty Acid Metabolism and Its Alterations in Leukaemia published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2018.00405 |
Frontiers in Genetics 9 | 2020-04-15 |
2018 |
Evangelia Tzika, Tobias Dreker, Axel Imhof Epigenetics and Metabolism in Health and Disease published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2018.00361 |
Frontiers in Genetics 9 | 2020-04-15 |
2018 |
Silvia Raineri, Jane Mellor IDH1: Linking Metabolism and Epigenetics published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2018.00493 |
Frontiers in Genetics 9 | 2020-04-15 |
2018 |
Mar Quiñones, Omar Al-Massadi, Cintia Folgueira, Stephan Bremser, RosalÃa Gallego, Leonardo Torres-Leal, Roberta Haddad-Tóvolli, Cristina GarcÃa-Caceres, Rene Hernandez-Bautista, Brian Y. H. Lam, Daniel Beiroa, Estrella Sanchez-Rebordelo, Ana Senra, Jose A. Malagon, Patricia Valerio, Marcos F. Fondevila, Johan Fernø, Maria M. Malagon, Raian Contreras, Paul Pfluger, Jens C. Brüning, Giles Yeo p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1 published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-05711-6 |
Nature Communications 9/1 | 2020-04-15 |
2018 |
Laura Sardon Puig, Miriam Valera-Alberni, Carles Cantó, Nicolas J. Pillon Circadian Rhythms and Mitochondria: Connecting the Dots published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2018.00452 |
Frontiers in Genetics 9 | 2020-04-15 |
2018 |
Miriam Valera-Alberni, Carles Canto Mitochondrial stress management: a dynamic journey published pages: 253-274, ISSN: 2523-0204, DOI: 10.15698/cst2018.10.158 |
Cell Stress 2/10 | 2020-04-15 |
2018 |
Christophe O. Soulage, Laura Sardón Puig, Laurent Soulère, Bader Zarrouki, Michel Guichardant, Michel Lagarde, Nicolas J. Pillon Skeletal muscle insulin resistance is induced by 4-hydroxy-2-hexenal, a by-product of n-3 fatty acid peroxidation published pages: 688-699, ISSN: 0012-186X, DOI: 10.1007/s00125-017-4528-4 |
Diabetologia 61/3 | 2020-04-15 |
2019 |
Chih-Hsiang Yang, John Andrew Pospisilik Polyphenism – A Window Into Gene-Environment Interactions and Phenotypic Plasticity published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2019.00132 |
Frontiers in Genetics 10 | 2020-04-15 |
2020 |
Laura Sardon Puig, Nicolas J. Pillon, Erik Näslund, Anna Krook, Juleen R. Zierath Influence of obesity, weight loss, and free fatty acids on skeletal muscle clock gene expression published pages: E1-E10, ISSN: 0193-1849, DOI: 10.1152/ajpendo.00289.2019 |
American Journal of Physiology-Endocrinology and Metabolism 318/1 | 2020-04-15 |
2018 |
Marek Kozlowski, David Corujo, Michael Hothorn, Iva Guberovic, Imke K Mandemaker, Charlotte Blessing, Judith Sporn, Arturo Gutierrezâ€Triana, Rebecca Smith, Thomas Portmann, Mathias Treier, Klaus Scheffzek, Sebastien Huet, Gyula Timinszky, Marcus Buschbeck, Andreas G Ladurner MacroH2A histone variants limit chromatin plasticity through two distinct mechanisms published pages: 1-13, ISSN: 1469-221X, DOI: 10.15252/embr.201744445 |
EMBO reports 19/10 | 2020-04-15 |
2019 |
Mario A. Lauterbach, Jasmin E. Hanke, Magdalini Serefidou, Matthew S.J. Mangan, Carl-Christian Kolbe, Timo Hess, Maximilian Rothe, Romina Kaiser, Florian Hoss, Jan Gehlen, Gudrun Engels, Maike Kreutzenbeck, Susanne V. Schmidt, Anette Christ, Axel Imhof, Karsten Hiller, Eicke Latz Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase published pages: 997-1011.e7, ISSN: 1074-7613, DOI: 10.1016/j.immuni.2019.11.009 |
Immunity 51/6 | 2020-04-15 |
2020 |
Nicolas J. Pillon, Brendan M. Gabriel, Lucile Dollet, Jonathon A. B. Smith, Laura Sardón Puig, Javier Botella, David J. Bishop, Anna Krook, Juleen R. Zierath Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-13869-w |
Nature Communications 11/1 | 2020-04-15 |
2018 |
VÃctor Sánchez-Gaya, Salvador CasanÃ-Galdón, Manuel Ugidos, Zheng Kuang, Jane Mellor, Ana Conesa, Sonia Tarazona Elucidating the Role of Chromatin State and Transcription Factors on the Regulation of the Yeast Metabolic Cycle: A Multi-Omic Integrative Approach published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2018.00578 |
Frontiers in Genetics 9 | 2020-04-15 |
2018 |
Katrin Pfuhlmann, Sonja C. Schriever, Peter Baumann, Dhiraj G. Kabra, Luke Harrison, Sithandiwe E. Mazibuko-Mbeje, Raian E. Contreras, Eleni Kyriakou, Stephanie E. Simonds, Tony Tiganis, Michael A. Cowley, Stephen C. Woods, Martin Jastroch, Christoffer Clemmensen, Meri De Angelis, Karl-Werner Schramm, Michael Sattler, Ana C. Messias, Matthias H. Tschöp, Paul T. Pfluger Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1 published pages: 2456-2465, ISSN: 0012-1797, DOI: 10.2337/db18-0146 |
Diabetes 67/11 | 2020-04-15 |
2019 |
Raian E. Contreras, Sonja C. Schriever, Paul T. Pfluger Physiological and Epigenetic Features of Yoyo Dieting and Weight Control published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2019.01015 |
Frontiers in Genetics 10 | 2020-04-15 |
2018 |
Berta Font-Cunill, Luis Arnes, Jorge Ferrer, Lori Sussel, Anthony Beucher Long Non-coding RNAs as Local Regulators of Pancreatic Islet Transcription Factor Genes published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2018.00524 |
Frontiers in Genetics 9 | 2020-04-15 |
2019 |
Haris A. Khan, Carla E. Margulies The Role of Mammalian Creb3-Like Transcription Factors in Response to Nutrients published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2019.00591 |
Frontiers in Genetics 10 | 2020-04-15 |
2019 |
Magdalini Serefidou, Anuroop Venkateswaran Venkatasubramani, Axel Imhof The Impact of One Carbon Metabolism on Histone Methylation published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2019.00764 |
Frontiers in Genetics 10 | 2020-04-15 |
2019 |
Tia Tyrsett Kuo, Andreas G. Ladurner Exploiting the Circadian Clock for Improved Cancer Therapy: Perspective From a Cell Biologist published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2019.01210 |
Frontiers in Genetics 10 | 2020-04-15 |
2017 |
Marie Boutant, Sameer S Kulkarni, Magali Joffraud, Joanna Ratajczak, Miriam Valeraâ€Alberni, Roy Combe, Antonio Zorzano, Carles Cantó Mfn2 is critical for brown adipose tissue thermogenic function published pages: 1543-1558, ISSN: 0261-4189, DOI: 10.15252/embj.201694914 |
The EMBO Journal 36/11 | 2019-09-13 |
2017 |
Melanija Posavec Marjanović, Sarah Hurtado-Bagès, Maximilian Lassi, Vanesa Valero, Roberto Malinverni, Hélène Delage, Miriam Navarro, David Corujo, Iva Guberovic, Julien Douet, Pau Gama-Perez, Pablo M Garcia-Roves, Ivan Ahel, Andreas G Ladurner, Oscar Yanes, Philippe Bouvet, Mònica Suelves, Raffaele Teperino, J Andrew Pospisilik, Marcus Buschbeck MacroH2A1.1 regulates mitochondrial respiration by limiting nuclear NAD+ consumption published pages: 902-910, ISSN: 1545-9993, DOI: 10.1038/nsmb.3481 |
Nature Structural & Molecular Biology 24/11 | 2019-09-13 |
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