Explore the words cloud of the REPSUMODDT project. It provides you a very rough idea of what is the project "REPSUMODDT" about.
The following table provides information about the project.
Coordinator |
IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE
Organization address contact info |
Coordinator Country | Italy [IT] |
Total cost | 1˙991˙250 € |
EC max contribution | 1˙991˙250 € (100%) |
Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
Code Call | ERC-2015-CoG |
Funding Scheme | ERC-COG |
Starting year | 2016 |
Duration (year-month-day) | from 2016-07-01 to 2021-06-30 |
Take a look of project's partnership.
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1 | IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE | IT (MILANO) | coordinator | 1˙991˙250.00 |
Accurate chromosomal DNA replication is of fundamental importance for cellular function, genome integrity and development. In response to replication perturbations, DNA damage response (DDR) and DNA damage tolerance (DDT) pathways become activated and are crucial for detection and tolerance of lesions, as well as for facilitating replication completion and supporting chromosome structural integrity. While important functions and key players of these regulatory processes have been outlined, much less is known about the choreography and mechanistic interplay between DDR and DDT during replication. Moreover, the principles by which they uniquely or commonly affect replication-associated chromosome integrity remain poorly understood. Here, we will use novel tools and a palette of ingenious genetic, molecular and proteomic based experimental strategies, to investigate the replication stress response triggered by diverse endogenous and exogenous cues, and to identify the underlying mechanisms. We will define the principles of local and temporal regulation of DDT in response to genotoxic stress, with a focus on the mechanisms of SUMO-regulated DNA metabolism processes. Additionally, we will investigate the topological DNA transitions triggered at intrinsically difficult to replicate genomic regions, stalled and terminal forks, with the aim of identifying key mechanisms and regulators of replication integrity at specific complex genomic regions or following specific types of replication stress. Finally, we will explore the relationship between DDT, replication fork architecture and sister chromatid cohesion in the context of DDR- and SUMO-orchestrated DNA transactions. We expect that these studies will reveal new aspects of how replication-associated DNA metabolism processes are inter-related and regulated, uniformly or at specific loci in the genome, and will break new ground in areas of replication mechanisms and chromosome integrity in general.
year | authors and title | journal | last update |
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2018 |
Maria G Iacovella, Michael Bremang, Omer Basha, Luciano Giacò, Walter Carotenuto, Cristina Golfieri, Barnabas Szakal, Marianna Dal Maschio, Valentina Infantino, Galina V Beznoussenko, Chinnu R Joseph, Clara Visintin, Alexander A Mironov, Rosella Visintin, Dana Branzei, Sébastien Ferreira-Cerca, Esti Yeger-Lotem, Peter De Wulf Integrating Rio1 activities discloses its nutrient-activated network in Saccharomyces cerevisiae published pages: 7586-7611, ISSN: 0305-1048, DOI: 10.1093/nar/gky618 |
Nucleic Acids Research 46/15 | 2019-06-18 |
2016 |
Dana Branzei, Andrea Ciliberto Not all roads lead to Cdk1 published pages: 395-396, ISSN: 1538-4101, DOI: 10.1080/15384101.2016.1274585 |
Cell Cycle 16/5 | 2019-06-18 |
2018 |
Ireneusz Litwin, Tomasz Bakowski, Barnabas Szakal, Ewa Pilarczyk, Ewa Maciaszczykâ€Dziubinska, Dana Branzei, Robert Wysocki Errorâ€free DNA damage tolerance pathway is facilitated by the Irc5 translocase through cohesin published pages: e98732, ISSN: 0261-4189, DOI: 10.15252/embj.201798732 |
The EMBO Journal 37/18 | 2019-06-18 |
2017 |
Michele Giannattasio, Dana Branzei S-phase checkpoint regulations that preserve replication and chromosome integrity upon dNTP depletion published pages: 2361-2380, ISSN: 1420-682X, DOI: 10.1007/s00018-017-2474-4 |
Cellular and Molecular Life Sciences 74/13 | 2019-06-18 |
2018 |
Anjana Srivatsan, Bin-Zhong Li, Barnabas Szakal, Dana Branzei, Christopher D. Putnam, Richard D. Kolodner The Swr1 chromatin-remodeling complex prevents genome instability induced by replication fork progression defects published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06131-2 |
Nature Communications 9/1 | 2019-06-18 |
2018 |
Takuya Abe, Ryotaro Kawasumi, Michele Giannattasio, Sabrina Dusi, Yui Yoshimoto, Keiji Miyata, Koyuki Umemura, Kouji Hirota, Dana Branzei AND-1 fork protection function prevents fork resection and is essential for proliferation published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-05586-7 |
Nature Communications 9/1 | 2019-06-18 |
2017 |
Ryotaro Kawasumi, Takuya Abe, Hiroshi Arakawa, Massimiliano Garre, Kouji Hirota, Dana Branzei ESCO1/2\'s roles in chromosome structure and interphase chromatin organization published pages: 2136-2150, ISSN: 0890-9369, DOI: 10.1101/gad.306084.117 |
Genes & Development 31/21 | 2019-06-18 |
2017 |
Dana Branzei, Barnabas Szakal Building up and breaking down: mechanisms controlling recombination during replication published pages: 381-394, ISSN: 1040-9238, DOI: 10.1080/10409238.2017.1304355 |
Critical Reviews in Biochemistry and Molecular Biology 52/4 | 2019-06-18 |
2018 |
Takuya Abe, Masato Ooka, Ryotaro Kawasumi, Keiji Miyata, Minoru Takata, Kouji Hirota, Dana Branzei Warsaw breakage syndrome DDX11 helicase acts jointly with RAD17 in the repair of bulky lesions and replication through abasic sites published pages: 8412-8417, ISSN: 0027-8424, DOI: 10.1073/pnas.1803110115 |
Proceedings of the National Academy of Sciences 115/33 | 2019-06-18 |
2018 |
Takuya Abe, Masato Ooka, Ryotaro Kawasumi, Keiji Miyata, Minoru Takata, Kouji Hirota, Dana Branzei Warsaw breakage syndrome DDX11 helicase acts jointly with RAD17 in the repair of bulky lesions and replication through abasic sites published pages: 8412-8417, ISSN: 0027-8424, DOI: 10.1073/pnas.1803110115 |
Proceedings of the National Academy of Sciences 115/33 | 2019-05-09 |
2018 |
Anjana Srivatsan, Bin-Zhong Li, Barnabas Szakal, Dana Branzei, Christopher D. Putnam, Richard D. Kolodner The Swr1 chromatin-remodeling complex prevents genome instability induced by replication fork progression defects published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06131-2 |
Nature Communications 9/1 | 2019-05-09 |
2018 |
Maria G Iacovella, Michael Bremang, Omer Basha, Luciano Giacò, Walter Carotenuto, Cristina Golfieri, Barnabas Szakal, Marianna Dal Maschio, Valentina Infantino, Galina V Beznoussenko, Chinnu R Joseph, Clara Visintin, Alexander A Mironov, Rosella Visintin, Dana Branzei, Sébastien Ferreira-Cerca, Esti Yeger-Lotem, Peter De Wulf Integrating Rio1 activities discloses its nutrient-activated network in Saccharomyces cerevisiae published pages: 7586-7611, ISSN: 0305-1048, DOI: 10.1093/nar/gky618 |
Nucleic Acids Research 46/15 | 2019-05-09 |
2018 |
Ireneusz Litwin, Tomasz Bakowski, Barnabas Szakal, Ewa Pilarczyk, Ewa Maciaszczykâ€Dziubinska, Dana Branzei, Robert Wysocki Errorâ€free DNA damage tolerance pathway is facilitated by the Irc5 translocase through cohesin published pages: e98732, ISSN: 0261-4189, DOI: 10.15252/embj.201798732 |
The EMBO Journal 37/18 | 2019-05-09 |
2019 |
Michele Giannattasio, Dana Branzei DNA Replication Through Strand Displacement During Lagging Strand DNA Synthesis in Saccharomyces cerevisiae published pages: 167, ISSN: 2073-4425, DOI: 10.3390/genes10020167 |
Genes 10/2 | 2019-08-29 |
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