Explore the words cloud of the FLUORODRUGS project. It provides you a very rough idea of what is the project "FLUORODRUGS" about.
The following table provides information about the project.
Coordinator |
THE UNIVERSITY OF EDINBURGH
Organization address contact info |
Coordinator Country | United Kingdom [UK] |
Project website | http://www.dynafluors.co.uk |
Total cost | 195˙454 € |
EC max contribution | 195˙454 € (100%) |
Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
Code Call | H2020-MSCA-IF-2015 |
Funding Scheme | MSCA-IF-EF-ST |
Starting year | 2017 |
Duration (year-month-day) | from 2017-01-01 to 2018-12-31 |
Take a look of project's partnership.
# | ||||
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1 | THE UNIVERSITY OF EDINBURGH | UK (EDINBURGH) | coordinator | 195˙454.00 |
FLUORODRUGS is a highly interdisciplinary project encompassing the design, synthesis and biological validation of novel smart chemical agents for highly sensitive diagnosis and specific treatment of cancer. I will prepare novel drug-fluorophores conjugates by combining macrophage-specific fluorophores with cytotoxic drugs using smart cleavable linkers. The activation of these smart agents in the tumour microenvironment will allow to not only to visualise in real-time but also to selectively ablate tumour-associated macrophages, which are essential for cancer progression. Further derivatization of the agents with specific ligands (i.e. chemokine CCL2) will yield probes for specific subpopulations of macrophages (i.e. CCR2 macrophages) that are critical in tumour metastasis. This strategy will minimise two of the major limitations of conventional cancer therapies: 1) drug resistance from cancer cells, and 2) toxic side effects derived from low cell specificity. Notably, the visualisation of immune cells in the tumour microenvironment will allow to monitor cancer progression in real-time and to run profiling studies to discover new biomarkers for cancer therapy. Initial in vitro studies to confirm the activity and selectivity of FLUORODRUGS will be performed in bone marrow-derived macrophages. Further, relevant mouse cancer models will be used to validate the theranostic agents in vivo. FLUORODRUGS will involve multidisciplinary training in biology, spectroscopy, pharmacology and imaging, and will render a unique generation of smart chemical tools to enhance diagnosis and treatment of cancer. This project will open a whole range of opportunities for my future career development in cancer biology and medicinal chemistry.
year | authors and title | journal | last update |
---|---|---|---|
2018 |
Richard J. Mellanby, Jamie I. Scott, Iris Mair, Antonio Fernandez, Louise Saul, Jochen Arlt, Monica Moral, Marc Vendrell Tricarbocyanine N -triazoles: the scaffold-of-choice for long-term near-infrared imaging of immune cells in vivo published pages: 7261-7270, ISSN: 2041-6520, DOI: 10.1039/c8sc00900g |
Chemical Science 9/36 | 2019-07-30 |
2017 |
Antonio Fernandez, Matthieu Vermeren, Duncan Humphries, Ramon Subiros-Funosas, Nicole Barth, Lara Campana, Alison MacKinnon, Yi Feng, Marc Vendrell Chemical Modulation of in Vivo Macrophage Function with Subpopulation-Specific Fluorescent Prodrug Conjugates published pages: 995-1005, ISSN: 2374-7943, DOI: 10.1021/acscentsci.7b00262 |
ACS Central Science 3/9 | 2019-07-30 |
2018 |
Antonio Fernandez, Marc Vendrell Fluorophore–Drug Conjugates To Unravel the Mechanisms of Action of Therapeutic Assets published pages: 175-176, ISSN: 0006-2960, DOI: 10.1021/acs.biochem.7b00889 |
Biochemistry 57/2 | 2019-07-30 |
2019 |
Sam Benson, Antonio Fernandez, Nicole D Barth, Fabio de Moliner, Mathew H Horrocks, Simon Herrington, Jose Luis Abad, Antonio Delgado, Lisa Kelly, Zi Chang, Yi Feng, Miyako Nishiura, Yuichiro Hori, Kazuya Kikuchi, Marc Vendrell SCOTfluors: Small, Conjugatable, Orthogonal and Tunable Fluorophores for in vivo Imaging of Cell Metabolism published pages: , ISSN: 1433-7851, DOI: 10.1002/anie.201900465 |
Angewandte Chemie | 2019-07-30 |
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The information about "FLUORODRUGS" are provided by the European Opendata Portal: CORDIS opendata.
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