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HEAL-BY-MIRNA

microRNA replacement therapy for mature B cell neoplasias

Total Cost €

EC-Contrib. €

Partnership

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HEAL-BY-MIRNA project word cloud

Explore the words cloud of the HEAL-BY-MIRNA project. It provides you a very rough idea of what is the project "HEAL-BY-MIRNA" about.

nhl intratumoral dramatic positive tumor mirnas sensitive relapse complement treatment survival introducing mouse cell chronic leukemia chemotherapy proved strategy regression therapeutically diagnosed stage animal marketable neoplasias models arisen diseases replace mimic forms cancers fraction idea either imperative therapeutic synthetic mirna burkitt yielded xenograft diffuse cancer lentiviral 26 interventions 80000 neoplasia found cells re intravenous replacement exploited refractory lymphocytic tools social extends primary 60 lymphoma hodgkin action proof heal lines extremely alternative close vectors likewise multidrug efficient chop moving micrornas lymphomas 60000 block aggressive form expression deaths systemic lost mature leads

Project "HEAL-BY-MIRNA" data sheet

The following table provides information about the project.

Coordinator	CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.) Organization address address: CALLE MELCHOR FERNANDEZ ALMAGRO 3 city: MADRID postcode: 28029 website: www.cnic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Total cost	149˙750 €
EC max contribution	149˙750 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2015-PoC
Funding Scheme	ERC-POC
Starting year	2016
Duration (year-month-day)	from 2016-05-01 to 2017-10-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.) CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.) Organization address address: CALLE MELCHOR FERNANDEZ ALMAGRO 3 city: MADRID postcode: 28029 website: www.cnic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	coordinator	149˙750.00

Map

Project objective

Mature B cell neoplasias include most of Non-Hodgkin Lymphomas (NHL), such as Diffuse Large B Cell Lymphomas and Burkitt Lymphoma and also B cell Chronic Lymphocytic Leukemia. It is estimated that about 60000-80000 new cases of mature B cell neoplasias are diagnosed every year in Europe. About 60% of NHL present with aggressive forms, and need immediate therapeutic action. The most common choice of treatment for mature B cell neoplasia is chemotherapy, and particularly the multidrug R-CHOP, but a fraction of the cancers either are refractory to these therapeutic interventions or relapse after treatment. Indeed, NHL is the cause of close to 26,000 deaths per year in Europe. Therefore, alternative therapeutic targets are imperative to replace or complement the current approaches. microRNAs (miRNAs) have arisen as extremely promising therapeutic tools in a number of diseases, including cancer. We have identified a miRNA specific of mature B cells whose expression is lost in mature B cell neoplasias. We found that re-introducing this miRNA in lymphoma cells in animal xenograft models leads to a dramatic block of tumor growth and extends mouse survival. Our studies show that this miRNA is therapeutically efficient not only in the form of lentiviral vectors but also as a synthetic miRNA mimic. Likewise, both intratumoral and systemic, intravenous delivery of miRNA mimic have yielded positive regression results. In addition, established lymphoma cell lines as well as primary mature B cell lymphomas have proved sensitive to miRNA treatment. Therefore, we propose to take to proof of concept the idea that miRNA replacement is an efficient therapeutic strategy for the treatment of mature B cell lymphomas. With this HEAL-BY-MIRNA proposal we aim at moving forward this idea to a stage where it can be exploited to have social impact and to become a marketable product.

Publications

List of publications.
year	authors and title	journal	last update
2017	Nahikari BartolomÃ©-Izquierdo, Virginia G. de YÃ©benes, Angel F. Ãlvarez-Prado, Sonia M. Mur, Juan A. Lopez del Olmo, Sergio Roa, Jesus Vazquez and Almudena R. Ramiro miR-28 regulates the germinal center reaction and blocks tumor growth in preclinical models of non-Hodgkin lymphoma published pages: 2408-2419, ISSN: 0006-4971, DOI:	Blood	2019-06-13

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