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Microbes4U

Study of the therapeutic potential of an Akkermansia muciniphila-based products in subjects with an increased cardio-metabolic risk.

Total Cost €

EC-Contrib. €

Partnership

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Microbes4U project word cloud

Explore the words cloud of the Microbes4U project. It provides you a very rough idea of what is the project "Microbes4U" about.

poc disorders gut urgent mass hypertension diabetes comorbidities microbial people calorie host individual worldwide metabolism insulin influence grade susceptibility beneficial found patients human akkermansia contributed risk weight suggested solution mice inflammation bacteria health status resistance microbes4u cholesterolemia demonstration humans fat epidemic proof candidate interesting obesity representing efficacy muciniphila body microbiota dyslipidemia environmental restriction cardio erc gain diet subjected glycemia abundance discovered metabolic observations obese administration markers reached therapeutic overweight safety treatment exactly public inflammatory putative

Project "Microbes4U" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITE CATHOLIQUE DE LOUVAIN Organization address address: PLACE DE L UNIVERSITE 1 city: LOUVAIN LA NEUVE postcode: 1348 website: www.uclouvain.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Belgium [BE]
Total cost	149˙375 €
EC max contribution	149˙375 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2015-PoC
Funding Scheme	ERC-POC
Starting year	2016
Duration (year-month-day)	from 2016-07-01 to 2017-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITE CATHOLIQUE DE LOUVAIN UNIVERSITE CATHOLIQUE DE LOUVAIN Organization address address: PLACE DE L UNIVERSITE 1 city: LOUVAIN LA NEUVE postcode: 1348 website: www.uclouvain.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LOUVAIN LA NEUVE)	coordinator	149˙375.00

Map

Project objective

Overweight and obesity have reached worldwide epidemic level. Both overweight and obesity are characterized by comorbidities such as cardio-metabolic risk factors (i.e., insulin resistance, type 2 diabetes, hypertension, dyslipidemia, low-grade inflammation) representing a major public health problem. Therefore, it is urgent to find a therapeutic solution to target all these metabolic disorders.

Among the environmental factors able to influence the individual susceptibility to gain weight and to develop metabolic disorders associated with obesity, we have contributed to the demonstration that gut bacteria (i.e, gut microbiota) influence host metabolism. We recently discovered a putative interesting microbial candidate, namely Akkermansia muciniphila. More exactly, we found that the administration of Akkermansia muciniphila reduced body weight gain, fat mass gain, glycemia, cholesterolemia and inflammatory markers in diet-induced obese mice. Moreover, in overweight/obese patients subjected to a calorie restriction diet, the higher abundance of Akkermansia muciniphila was associated with a better cardio-metabolic status. These observations suggested that the administration of Akkermansia muciniphila in overweight or obese people could be a very interesting therapeutic solution. Currently, no human study have investigated the beneficial effects of Akkermansia muciniphila administration on obesity and metabolic disorders.

Thus, the main objective of this ERC POC project “Microbes4U” is to get the proof of concept in humans of the safety and efficacy of Akkermansia muciniphila administration in the treatment of overweight, obesity and metabolic disorders associated such as insulin resistance, type-2 diabetes and dyslipidemia.

Publications

List of publications.
year	authors and title	journal	last update
2016	P D Cani Interactions between gut microbes and host cells control gut barrier and metabolism published pages: S28-S31, ISSN: 2046-2166, DOI: 10.1038/ijosup.2016.6	International Journal of Obesity Supplements 6/S1	2019-06-13

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The information about "MICROBES4U" are provided by the European Opendata Portal: CORDIS opendata.