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NEWRON SIGNED

New and mature neurons in adult circuits: telling memories apart

Total Cost €

0

EC-Contrib. €

0

Partnership

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 NEWRON project word cloud

Explore the words cloud of the NEWRON project. It provides you a very rough idea of what is the project "NEWRON" about.

circuit    input    spiking    insights    population    overlapping    intriguingly    photon    virtual    other    animal    involvement    mature    experiments    intracellular    optogenetic    hippocampal    small    selectively    optical    newborn    how    life    generating    pattern    cellular    born    behaviours    patterns    suggested    brain    recordings    representing    cells    behaviour    memories    suprathreshold    constantly    resemble    causally    adult    synaptic    tools    distinguish    combines    trigger    representations    separation    network    dentate    interfere    manipulate    output    fundamental    action    inputs    frontier    memory    imaging    termed    physiological    monitor    closely    cell    neuronal    gyrus    types    encoded    granule    incorporate    tasks    neurons    convert    combine    completion    ca2    spike    navigation    drive    differentially    mechanisms    molecular    environment    function    questions    serve    transform    supplied    subthreshold    decorrelated    mouse    storage    purpose    potentials   

Project "NEWRON" data sheet

The following table provides information about the project.

Coordinator
INSTITUT PASTEUR 

Organization address
address: RUE DU DOCTEUR ROUX 25-28
city: PARIS CEDEX 15
postcode: 75724
website: http://www.pasteur.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website https://research.pasteur.fr/en/project/erc-2015-stg-newron/
 Total cost 1˙498˙955 €
 EC max contribution 1˙498˙955 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT PASTEUR FR (PARIS CEDEX 15) coordinator 1˙498˙955.00

Map

 Project objective

How does the brain distinguish between memories that closely resemble each other? The hippocampal dentate gyrus has been suggested to serve this purpose by generating non-overlapping memory representations in a process termed “pattern separation”. Intriguingly, during adult life, the dentate gyrus is constantly supplied with new neurons, providing new circuit elements that can incorporate into the neuronal network. How the activity of new adult-born neurons and mature granule cells combines to drive the production and storage of distinct memories represents a new frontier in understanding brain function. However, to determine how these neurons transform similar synaptic input patterns into decorrelated spike output patterns representing distinct memories, we need to monitor and manipulate their subthreshold and suprathreshold activity during behaviour. To address these challenges, we will combine molecular, physiological and optical approaches in the mouse dentate gyrus during navigation in a virtual reality environment. We will use intracellular recordings to assess how hippocampal neurons convert synaptic inputs into spike output, 2-photon Ca2 imaging to monitor population activity in the hippocampal circuit, and optogenetic tools to causally test the involvement of specific cell types. These experiments will allow us to address the following key questions: 1. Which behaviours trigger action potentials in identified newborn and mature dentate gyrus neurons? 2. How do synaptic inputs drive spiking in newborn and mature neurons during behaviour? 3. How are small changes in an environment encoded by synaptic inputs to newborn and mature neurons? 4. Can we differentially manipulate the activity of new and mature cells to selectively interfere with animal behaviour during pattern separation and completion tasks? Understanding the role of new and mature neurons in hippocampal function will provide fundamental insights into the cellular mechanisms of memory formation.

 Publications

year authors and title journal last update
List of publications.
2019 Naila Haq, Christoph Schmidt-Hieber, Fernando J. Sialana, Lorenza Ciani, Janosch P. Heller, Michelle Stewart, Liz Bentley, Sara Wells, Richard J. Rodenburg, Patrick M. Nolan, Elizabeth Forsythe, Michael C. Wu, Gert Lubec, P. Salinas, Michael Häusser, Philip L. Beales, Sofia Christou-Savina
Loss of Bardet-Biedl syndrome proteins causes synaptic aberrations in principal neurons
published pages: e3000414, ISSN: 1545-7885, DOI: 10.1371/journal.pbio.3000414
PLOS Biology 17/9 2019-12-16
2017 Christoph Schmidt-Hieber, Gabija Toleikyte, Laurence Aitchison, Arnd Roth, Beverley A Clark, Tiago Branco, Michael Häusser
Active dendritic integration as a mechanism for robust and precise grid cell firing
published pages: 1114-1121, ISSN: 1097-6256, DOI: 10.1038/nn.4582
Nature Neuroscience 20/8 2019-06-19
2018 Christoph Schmidt-Hieber
How Does a Memory Find Its Neurons?
published pages: 1800189, ISSN: 0265-9247, DOI: 10.1002/bies.201800189
BioEssays 40/11 2019-04-18

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