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MMDYNASYS SIGNED

Molecular Motors, powering dynamic functional molecular systems

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

MMDYNASYS project word cloud

Explore the words cloud of the MMDYNASYS project. It provides you a very rough idea of what is the project "MMDYNASYS" about.

liquid chemical responsive sequential function temporal operate redox irradiation amplification genuine amphiphilic nanomechanical majority opening ranging rotary amplify dna transcription fantastic switching stimulation cell materials motion assembled cardiac multiple self regulate platform aggregate packages electro metastable effort interfaces divided manner nanostructures bright functional mechanical opportunity advantage biomolecular systems dynamic stimuli organization powering light assemblies spatio ultimately hydrogels induces dissipative energy molecular continuous crystal switches processive unidirectional assembly device scales motors photopharmacology provides invasive length drive equilibrium water

Project "MMDYNASYS" data sheet

The following table provides information about the project.

Coordinator	RIJKSUNIVERSITEIT GRONINGEN Organization address address: Broerstraat 5 city: GRONINGEN postcode: 9712CP website: www.rug.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	http://benferinga.com
Total cost	2˙499˙524 €
EC max contribution	2˙499˙524 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2015-AdG
Funding Scheme	ERC-ADG
Starting year	2016
Duration (year-month-day)	from 2016-09-01 to 2021-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	RIJKSUNIVERSITEIT GRONINGEN RIJKSUNIVERSITEIT GRONINGEN Organization address address: Broerstraat 5 city: GRONINGEN postcode: 9712CP website: www.rug.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (GRONINGEN)	coordinator	2˙499˙524.00

Map

Project objective

In this proposal the unique properties of unidirectional light driven molecular rotary motors will be built upon to achieve dynamic control of function and develop responsive systems with a particular focus on systems in water. Light-driven molecular rotary motors are distinct from the majority of molecular switches, as they allow sequential access to multiple functional states in a responsive system through non-invasive stimulation. Importantly, continuous irradiation induces continuous rotary motion which provides a unique opportunity to design dynamic systems and responsive materials that can be driven out-of-equilibrium. The research program is divided in four work-packages: a) chemical and redox driven unidirectional motors; here we will develop processive unidirectional motors that can use (electro)chemical energy in a continuous manner, b) amplification of motion; here rotary motors operate in assemblies to amplify mechanical function over a wide range of length scales. Specifically we will use liquid crystal-water interfaces as a unique platform to control motion and organization. c) dissipative self-assembly: molecular motors offer fantastic opportunities to control self-assembly and drive such systems out-of-equilibrium. We aim at metastable aggregate formation (hydrogels) and the design of amphiphilic motors for responsive self-assembled nanostructures; d)triggering biomolecular function; the goal is to use rotary motors to regulate DNA transcription and ultimately as genuine powering device to control cardiac cell function. In the emerging field of photopharmacology, we take advantage of non-invasive high spatio-temporal control that switching with light provides. The proposed research program is highly challenging but provides the comprehensive effort required to achieve control of complex nanomechanical systems and will opening a bright future for applications ranging from stimuli responsive materials to spatio-temporal control of biomolecular systems

Publications

List of publications.
year	authors and title	journal	last update
2017	Michael Wegener, Mickel J. Hansen, Arnold J. M. Driessen, Wiktor Szymanski, Ben L. Feringa Photocontrol of Antibacterial Activity: Shifting from UV to Red Light Activation published pages: 17979-17986, ISSN: 0002-7863, DOI: 10.1021/jacs.7b09281	Journal of the American Chemical Society 139/49	2020-03-20
2017	Bartosz Krajnik, Jiawen Chen, Matthew A. Watson, Scott L. Cockroft, Ben L. Feringa, Johan Hofkens Defocused Imaging of UV-Driven Surface-Bound Molecular Motors published pages: 7156-7159, ISSN: 0002-7863, DOI: 10.1021/jacs.7b02758	Journal of the American Chemical Society 139/21	2020-03-20
2017	Thomas van Leeuwen, G. Henrieke Heideman, Depeng Zhao, Sander J. Wezenberg, Ben L. Feringa In situ control of polymer helicity with a non-covalently bound photoresponsive molecular motor dopant published pages: 6393-6396, ISSN: 1359-7345, DOI: 10.1039/c7cc03188b	Chem. Commun. 53/48	2020-03-20
2017	Tao Yan, Ben L. Feringa, Katalin Barta Direct N-alkylation of unprotected amino acids with alcohols published pages: eaao6494, ISSN: 2375-2548, DOI: 10.1126/sciadv.aao6494	Science Advances 3/12	2020-03-20
2018	Diederik Roke, Sander J. Wezenberg, Ben L. Feringa Molecular rotary motors: Unidirectional motion around double bonds published pages: 9423-9431, ISSN: 0027-8424, DOI: 10.1073/pnas.1712784115	Proceedings of the National Academy of Sciences 115/38	2020-03-20
2017	JiÅ™Ã Kaleta, Jiawen Chen, Guillaume Bastien, Martin DraÄÃnskÃ½, Milan MaÅ¡Ã¡t, Charles T. Rogers, Ben L. Feringa, Josef Michl Surface Inclusion of Unidirectional Molecular Motors in Hexagonal Tris( o -phenylene)cyclotriphosphazene published pages: 10486-10498, ISSN: 0002-7863, DOI: 10.1021/jacs.7b05404	Journal of the American Chemical Society 139/30	2020-03-20
2018	Jiawen Chen, JÃ©rÃ´me Vachon, Ben L. Feringa Design, Synthesis, and Isomerization Studies of Light-Driven Molecular Motors for Single Molecular Imaging published pages: 6025-6034, ISSN: 0022-3263, DOI: 10.1021/acs.joc.8b00654	The Journal of Organic Chemistry 83/11	2020-03-20
2017	Thomas van Leeuwen, Anouk S. Lubbe, Peter Å tacko, Sander J. Wezenberg, Ben L. Feringa Dynamic control of function by light-driven molecular motors published pages: 96, ISSN: 2397-3358, DOI: 10.1038/s41570-017-0096	Nature Reviews Chemistry 1/12	2020-03-20
2017	Jos C. M. Kistemaker, Peter Å tacko, Diederik Roke, Alexander T. Wolters, G. Henrieke Heideman, Mu-Chieh Chang, Pieter van der Meulen, Johan Visser, Edwin Otten, Ben L. Feringa Third-Generation Light-Driven Symmetric Molecular Motors published pages: 9650-9661, ISSN: 0002-7863, DOI: 10.1021/jacs.7b04412	Journal of the American Chemical Society 139/28	2020-03-20
2018	Thomas vanâ€…Leeuwen, Wojciech Danowski, Stefano F. Pizzolato, Peter Å tacko, Sander J. Wezenberg, Ben L. Feringa Braking of a Light-Driven Molecular Rotary Motor by Chemical Stimuli published pages: 81-84, ISSN: 0947-6539, DOI: 10.1002/chem.201704747	Chemistry - A European Journal 24/1	2020-03-20
2017	Anouk S. Lubbe, Sander J. Wezenberg, Ben L. Feringa Artificial microtubules burst with energy published pages: 11804-11805, ISSN: 0027-8424, DOI: 10.1073/pnas.1716868114	Proceedings of the National Academy of Sciences 114/45	2020-03-20
2018	Anouk S. Lubbe, Qing Liu, Sanne J. Smith, Jan Willem de Vries, Jos C. M. Kistemaker, Alex H. de Vries, Ignacio Faustino, Zhuojun Meng, Wiktor Szymanski, Andreas Herrmann, Ben L. Feringa Photoswitching of DNA Hybridization Using a Molecular Motor published pages: 5069-5076, ISSN: 0002-7863, DOI: 10.1021/jacs.7b09476	Journal of the American Chemical Society 140/15	2020-03-20
2017	Thomas van Leeuwen, Wojciech Danowski, Edwin Otten, Sander J. Wezenberg, Ben L. Feringa Asymmetric Synthesis of Second-Generation Light-Driven Molecular Motors published pages: 5027-5033, ISSN: 0022-3263, DOI: 10.1021/acs.joc.7b00852	The Journal of Organic Chemistry 82/10	2020-03-20
2017	Peter Å tacko, Jos C. M. Kistemaker, Thomas van Leeuwen, Mu-Chieh Chang, Edwin Otten, Ben L. Feringa Locked synchronous rotor motion in a molecular motor published pages: 964-968, ISSN: 0036-8075, DOI: 10.1126/science.aam8808	Science 356/6341	2020-03-20
2018	Christopher R. Hall, Wesley R. Browne, Ben L. Feringa, Stephen R. Meech Mapping the Excited-State Potential Energy Surface of a Photomolecular Motor published pages: 6203-6207, ISSN: 1433-7851, DOI: 10.1002/anie.201802126	Angewandte Chemie International Edition 57/21	2020-03-20
2018	Sander J. Wezenberg, Ben L. Feringa Supramolecularly directed rotary motion in a photoresponsive receptor published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-04249-x	Nature Communications 9/1	2020-03-20
2017	Thomas van Leeuwen, Jasper Pol, Diederik Roke, Sander J. Wezenberg, Ben L. Feringa Visible-Light Excitation of a Molecular Motor with an Extended Aromatic Core published pages: 1402-1405, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.7b00317	Organic Letters 19/6	2020-03-20
2017	Salma Kassem, Thomas van Leeuwen, Anouk S. Lubbe, Miriam R. Wilson, Ben L. Feringa, David A. Leigh Artificial molecular motors published pages: 2592-2621, ISSN: 0306-0012, DOI: 10.1039/c7cs00245a	Chemical Society Reviews 46/9	2020-03-20

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