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CrUCCial SIGNED
Novel diagnostic and therapeutic approach to inflammatory bowel disease based on functional characterization of patients: the CrUCCial index
Total Cost €
0EC-Contrib. €
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0CrUCCial project word cloud
Explore the words cloud of the CrUCCial project. It provides you a very rough idea of what is the project "CrUCCial" about.
readouts
therapy
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autophagy
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Project "CrUCCial" data sheet
The following table provides information about the project.
| Coordinator |
KATHOLIEKE UNIVERSITEIT LEUVEN
Organization address contact info |
| Coordinator Country | Belgium [BE] |
| Total cost | 2˙494˙500 € |
| EC max contribution | 2˙494˙500 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2015-AdG |
| Funding Scheme | ERC-ADG |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-09-01 to 2021-08-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | KATHOLIEKE UNIVERSITEIT LEUVEN | BE (LEUVEN) | coordinator | 2˙494˙500.00 |
Map
Project objective
The clinical phenotype and the outcome of Crohn's disease (CD) and ulcerative colitis (UC), the opposite ends of chronic inflammatory bowel diseases (IBD), are heterogeneous and represent the result of a complex interplay of the gut microbiome with the immune system in genetically predisposed individuals. Disease management is much less heterogeneous as all patients are treated using non-specific anti-inflammatory agents, and only 30-50% achieve clinical and mucosal remission -the goal of therapy nowadays- therefore leaving large margins for improvement. The advances in knowledge about the factors triggering disease onset should be translated to approach the disease from a molecular angle. Key cellular pathways have emerged including bacterial recognition, autophagy, endoplasmic reticulum stress and intestinal barrier function. Functional/molecular characterization of these pathways in a given patient, correlation with meaningful clinical outcomes, and tailoring an individual therapeutic approach has never been attempted and will represent a breakthrough in the current paradigm of treating multifactorial inflammatory conditions. This project aims to functionally characterize patients with CD/UC for the major pathways by using integrated (epi)genetic, transcriptomic, immunologic, barrier integrity and metagenomic studies. From these readouts we will construct an index [the Crohn’s and Ulcerative Colitis Characterization and Intervention trial (CrUCCial) index], reflecting the proportional contribution of each of the pathogenic mechanisms in a given patient. We will next study the correlation of this index and its components to meaningful clinical outcomes and finally, the index will be tested in a pilot study of newly diagnosed patients in whom the disease will be targeted individually based on the components of the CrUCCial index. Our approach, from diagnosis over prognosis to therapy, will revolutionize the paradigm of disease management.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2017 |
Maaike Vancamelbeke, Séverine Vermeire The intestinal barrier: a fundamental role in health and disease published pages: 821-834, ISSN: 1747-4124, DOI: 10.1080/17474124.2017.1343143 |
Expert Review of Gastroenterology & Hepatology 11/9 | 2019-06-13 |
| 2017 |
Maaike Vancamelbeke, Tim Vanuytsel, Ricard Farré, Sare Verstockt, Marc Ferrante, Gert Van Assche, Paul Rutgeerts, Frans Schuit, Séverine Vermeire, Ingrid Arijs, Isabelle Cleynen Genetic and Transcriptomic Bases of Intestinal Epithelial Barrier Dysfunction in Inflammatory Bowel Disease published pages: 1718-1729, ISSN: 1078-0998, DOI: 10.1097/MIB.0000000000001246 |
Inflammatory Bowel Diseases 23/10 | 2019-06-13 |
| 2017 |
Wiebe Vanhove, Kris Nys, Ingrid Arijs, Isabelle Cleynen, Magali de Bruyn, Hannelie Korf, Marc Ferrante, Gert A. Van Assche, Severine Vermeire Tu1770 Genetic Defects in ER Stress and Autophagy Translate Into Increased Functional ER Stress Levels in Patients with Inflammatory Bowel Disease published pages: S963-S964, ISSN: 0016-5085, DOI: |
Gastroenterology 152/5 | 2019-06-13 |
| 2017 |
Kathleen Machiels, Marta Pozuelo del RÃo, João Sabino, Alba Santiago, David Campos, Albert Wolthuis, Anthony de Buck van Overstraeten, Andre D\'Hoore, Gert A. Van Assche, Marc Ferrante, Paul Rutgeerts, Gert De Hertogh, Severine Vermeire, Chaysavanh Manichanh Tu1857: Mucosal Recolonization after Ileocecal Resection Differs in Crohn\'s Disease Patients Developing Postoperative Recurrence published pages: S990, ISSN: 0016-5085, DOI: |
Gastroenterology 152/5 | 2019-06-13 |
| 2017 |
Manuel Noben, Wiebe Vanhove, Kaline Arnauts, Anabela Santo Ramalho, Gert Van Assche, Séverine Vermeire, Catherine Verfaillie, Marc Ferrante Human intestinal epithelium in a dish: Current models for research into gastrointestinal pathophysiology published pages: 1073-1081, ISSN: 2050-6406, DOI: 10.1177/2050640617722903 |
United European Gastroenterology Journal 5/8 | 2019-06-13 |
| 2018 |
S Verstockt, E Glorieus, M De Decker, B Verstockt, N Ardeshir Davani, V Ballet, G Van Assche, P Hindryckx, M Ferrante, D Laukens, F Mana, M De Vos, S Vermeire, I Cleynen P117 Serum proteomic analysis characterises newly diagnosed Crohn’s disease and ulcerative colitis depending on the age at diagnosis published pages: S151-S152, ISSN: 1873-9946, DOI: |
Journal of Crohn\'s and Colitis 12/supplement_1 | 2019-06-13 |
| 2018 |
B Verstockt, S Vermeire, S Verstockt, B Creyns, N Ardeshir Davani, C Breynaert, G Van Assche, G Van Assche, M Ferrante P035 Serum markers predict outcome to ustekinumab in patients with refractory Crohn’s disease and provide insides in the mechanism of action published pages: S110-S110, ISSN: 1873-9946, DOI: |
Journal of Crohn\'s and Colitis 12/supplement_1 | 2019-06-13 |
| 2018 |
B Verstockt, S Verstockt, M de Bruyn, K Machiels, H Blevi, V Ballet, G Van Assche, S Vermeire, M Ferrante P042 Decreased leukocyte trafficking may contribute to vedolizumab refractory disease after anti-TNF exposure in patients with ulcerative colitis published pages: S113-S113, ISSN: 1873-9946, DOI: |
Journal of Crohn\'s and Colitis 12/supplement_1 | 2019-06-13 |
| 2018 |
M Vancamelbeke, S Verstockt, M Ferrante, G Van Assche, S Vermeire, I Cleynen P084 Ileal gene expression changes are associated with colonic disease activity in patients with ulcerative colitis published pages: S134-S136, ISSN: 1873-9946, DOI: |
Journal of Crohn\'s and Colitis 12/supplement_1 | 2019-06-13 |
| 2018 |
K Machiels, M de Bruyn, S Verstockt, B Verstockt, G Van Assche, A Wolthuis, A d\'Hoore, M Ferrante, S Vermeire P010 Serum proteomic profiling in Crohn’s disease patients undergoing ileocolonic resection reveals discriminative inflammatory markers for endoscopic recurrence published pages: S096-S097, ISSN: 1873-9946, DOI: |
Journal of Crohn\'s and Colitis 12/supplement_1 | 2019-06-13 |
| 2018 |
C Caenepeel, S Vieira-Silva, J Sabino, K Machiels, G Falony, M Ferrante, G Van Assche, J Raes, S Vermeire P854 Quantitative microbiome profiling changes the described dysbiotic state in inflammatory bowel disease published pages: S548-S549, ISSN: 1873-9946, DOI: |
Journal of Crohn\'s and Colitis 12/supplement_1 | 2019-06-13 |
| 2017 |
Maaike Vancamelbeke, João Sabino, Lise Deroover, Greet Vandermeulen, Anja Luypaerts, Marc Ferrante, Gwen Falony, Sara Vieira-Silva, Kristin Verbeke, Jeroen Raes, Isabelle Cleynen, Severine Vermeire Tu1862 Profiling of the Fecal Microbiota and Metabolome in Patients with Inflammatory Bowel Disease and their Unaffected Relatives published pages: S991, ISSN: 0016-5085, DOI: |
Gastroenterology 152/5 | 2019-06-13 |
| 2017 |
Kathleen Machiels, Victoria Pascal, João Sabino, Alba Santiago, David Campos, Albert Wolthuis, Anthony de Buck van Overstraeten, Andre D\'Hoore, Gert A. Van Assche, Marc Ferrante, Paul Rutgeerts, Chaysavanh Manichanh, Severine Vermeire Tu1856: Impact of Ileocecal Resection in Crohn\'s Disease Patients on Fecal Microbiota published pages: S989-S990, ISSN: 0016-5085, DOI: |
Gastroenterology 152/5 | 2019-06-13 |
| 2018 |
M Vancamelbeke, V Ballet, N Ardeshir Davani, G Van Assche, M Ferrante, I Cleynen, S Vermeire P052 Protein biomarkers identify subclinical inflammation patterns in first-degree relatives of patients with inflammatory bowel disease published pages: S118-S119, ISSN: 1873-9946, DOI: |
Journal of Crohn\'s and Colitis 12/supplement_1 | 2019-06-13 |
| 2018 |
S Verstockt, B Verstockt, J Van Bouwel, W Meert, A Cortes Calabuig, V Brys, V Ballet, E Glorieus, M De Decker, G Van Assche, P Hindryckx, M Ferrante, D Laukens, F Mana, M De Vos, S Vermeire, I Cleynen P104 Gene expression profiles in inflamed colonic biopsies from newly diagnosed Crohn’s disease and ulcerative colitis patients differ depending on the age at diagnosis published pages: S146-S146, ISSN: 1873-9946, DOI: |
Journal of Crohn\'s and Colitis 12/supplement_1 | 2019-06-13 |
| 2018 |
M de Bruyn, V Ballet, S Verstockt, B Verstockt, G Van Assche, M Ferrante, K Machiels, S Vermeire OP003 Temporal changes in immune pathways with consecutive biological therapies as measured by serum proteomics published pages: S003-S003, ISSN: 1873-9946, DOI: |
Journal of Crohn\'s and Colitis 12/supplement_1 | 2019-06-13 |
| 2017 |
Wiebe Vanhove, Kris Nys, Ingrid Arijs, Isabelle Cleynen, Manuel Noben, Sebastiaan De Schepper, Gert Van Assche, Marc Ferrante, Séverine Vermeire Biopsy-derived Intestinal Epithelial Cell Cultures for Pathway-based Stratification of Patients With Inflammatory Bowel Disease published pages: 178-187, ISSN: 1873-9946, DOI: 10.1093/ecco-jcc/jjx122 |
Journal of Crohn\'s and Colitis 12/2 | 2019-06-13 |
| 2019 |
B Verstockt, S Verstockt, J Dehairs, V Ballet, H Blevi, W-J Wollants, C Breynaert, G Van Assche, S Vermeire, M Ferrante P385 TREM1, the first anti-TNF specific biomarker guiding therapeutic decision published pages: S300-S300, ISSN: 1873-9946, DOI: |
Journal of Crohn\'s and Colitis 13/Supplement_1 | 2019-05-27 |
| 2019 |
Bram Verstockt, Sare Verstockt, Brecht Creyns, Sophie Tops, Gert Van Assche, Ann Gils, Jan L. Ceuppens, Séverine Vermeire, Marc Ferrante, Christine Breynaert Mucosal IL13RA2 expression predicts nonresponse to anti-TNF therapy in Crohn\'s disease published pages: 572-581, ISSN: 0269-2813, DOI: 10.1111/apt.15126 |
Alimentary Pharmacology & Therapeutics 49/5 | 2019-05-27 |
| 2018 |
Maaike Vancamelbeke, Vera Ballet, Nooshin Ardeshir Davani, Gert A. Van Assche, Marc Ferrante, Isabelle Cleynen, Severine Vermeire Sa1784 - Unaffected First-Degree Relatives of Patients with Inflammatory Bowel Disease have Altered Profiles of Inflammation-Related Proteins published pages: S-393, ISSN: 0016-5085, DOI: |
Gastroenterology 154/6 | 2019-05-23 |
| 2017 |
K. Machiels, M. Pozuelo del RÃo, J. Sabino, A. Santiago, D. Campos, A. Wolthuis, A. De Buck van Overstraeten, A. D\'Hoore, G. Van Assche, M. Ferrante, P. Rutgeerts, G. De Hertogh, S. Vermeire, C. Manichanh OP038 Impact of ileocecal resection in Crohn\'s disease patients on mucosal microbiota published pages: S24-S25, ISSN: 1873-9946, DOI: |
Journal of Crohn\'s and Colitis 11/suppl_1 | 2019-05-27 |
| 2019 |
Maaike Vancamelbeke, Thessa Laeremans, Wiebe Vanhove, Kaline Arnauts, Anabela Santo Ramalho, Ricard Farré, Isabelle Cleynen, Marc Ferrante, Séverine Vermeire Butyrate does not protect against inflammation-induced loss of epithelial barrier function and cytokine production in primary cell monolayers from patients with ulcerative colitis published pages: , ISSN: 1873-9946, DOI: 10.1093/ecco-jcc/jjz064 |
Journal of Crohn\'s and Colitis | 2019-05-27 |
| 2019 |
S Verstockt, F Ver Donck, B Verstockt, E Glorieus, M De Decker, V Ballet, G Van Assche, D Laukens, M Ferrante, F Mana, M De Vos, S Vermeire, I Cleynen P827 Up-regulation of IL17-related pathways in affected colon from ulcerative colitis compared with Crohn’s disease published pages: S537-S538, ISSN: 1873-9946, DOI: |
Journal of Crohn\'s and Colitis 13/Supplement_1 | 2019-06-06 |
| 2019 |
P Sudhakar, B Verstockt, B Creyns, J Cremer, G van Assche, T Korcsmaros, M Ferrante, S Vermeire P001 Multi-omic data integration assisted identification of molecular features contributing to disease heterogeneity in Crohn\'s disease published pages: S085-S086, ISSN: 1873-9946, DOI: |
Journal of Crohn\'s and Colitis 13/Supplement_1 | 2019-05-27 |
| 2019 |
B Verstockt, P Sudahakar, B Creyns, S Verstockt, J Cremer, W-J Wollants, S Organe, T Korcsmaros, M Madgwick, G Van Assche, C Breynaert, S Vermeire, M Ferrante DOP70 An integrated multi-omics biomarker predicting endoscopic response in ustekinumab treated patients with Crohn\'s disease published pages: S072-S073, ISSN: 1873-9946, DOI: |
Journal of Crohn\'s and Colitis 13/Supplement_1 | 2019-05-27 |
| 2018 |
Sare Verstockt, Bram Verstockt, Jens Van Bouwel, Wim Meert, Alvaro Cortés Calabuig, Vanessa Brys, Vera Ballet, Elien Glorieus, Muriel De Decker, Gert A. Van Assche, Pieter Hindryckx, Marc Ferrante, Debby Laukens, Fazia Mana, Martine De Vos, Severine Vermeire, Isabelle Cleynen Tu1810 - Transcriptomic Profile of Inflamed Colonic Biopsies from Newly Diagnosed Crohn\'s Disease and Ulcerative Colitis Patients Depend on the age at Diagnosis published pages: S-1026, ISSN: 0016-5085, DOI: |
Gastroenterology 154/6 | 2019-06-06 |
| 2019 |
B Verstockt, S Verstockt, P Sudahakar, J Dehairs, H Blevi, G Van Assche, S Vermeire, M Ferrante DOP38 A vedolizumab specific four-gene colonic signature accurately predicting future endoscopic remission in patients with inflammatory bowel disease published pages: S048-S048, ISSN: 1873-9946, DOI: |
Journal of Crohn\'s and Colitis 13/Supplement_1 | 2019-05-27 |
| 2019 |
Bram Verstockt, Sare Verstockt, Jonas Dehairs, Vera Ballet, Helene Blevi, Willem-Jan Wollants, Christine Breynaert, Gert Van Assche, Séverine Vermeire, Marc Ferrante Low TREM1 expression in whole blood predicts anti-TNF response in inflammatory bowel disease published pages: 733-742, ISSN: 2352-3964, DOI: 10.1016/j.ebiom.2019.01.027 |
EBioMedicine 40 | 2019-05-27 |
| 2019 |
C Caenepeel, S Vieira-Silva, B Verstockt, M Ferrante, J Raes, S Vermeire P836 The predictive role of gut microbiota in treatment response to vedolizumab and ustekinumab in inflammatory bowel disease published pages: S542-S542, ISSN: 1873-9946, DOI: |
Journal of Crohn\'s and Colitis 13/Supplement_1 | 2019-06-06 |
| 2019 |
S Verstockt, F Ver Donck, B Verstockt, M Vancamelbeke, M De Decker, E Glorieus, V Ballet, G Van Assche, D Laukens, M Ferrante, F Mana, M De Vos, S Vermeire, I Cleynen P821 Distinct and common gene expression profiles between inflamed ileum and colon of newly diagnosed CD patients published pages: S533-S533, ISSN: 1873-9946, DOI: |
Journal of Crohn\'s and Colitis 13/Supplement_1 | 2019-06-06 |
| 2018 |
Maaike Vancamelbeke, Sare Verstockt, Marc Ferrante, Gert A. Van Assche, Severine Vermeire, Isabelle Cleynen Tu1808 - Colonic Inflammation Determines Ileal Gene Expression Changes in Ulcerative Colitis published pages: S-1025-S-1026, ISSN: 0016-5085, DOI: |
Gastroenterology 154/6 | 2019-05-27 |
| 2017 |
K. Machiels, V. Pascal, J. Sabino, A. Santiago, D. Campos, A. Wolthuis, A. De Buck van Overstraeten, A. D\'Hoore, G. Van Assche, M. Ferrante, P. Rutgeerts, C. Manichanh, S. Vermeire DOP044 Relationship between microbiota and development of early postoperative Crohn\'s disease recurrence published pages: S53-S53, ISSN: 1873-9946, DOI: |
Journal of Crohn\'s and Colitis 11/suppl_1 | 2019-05-27 |
| 2019 |
J Brooks, D Modos, P Sudhakar, D Fazekas, A Zoufir, A Watson, M Tremelling, B Verstockt, S Vermeire, A Bender, S Carding, T Korcsmaros OP10 Systems genomics of ulcerative colitis: combining GWAS and signalling networks for patient stratification and individualised drug targeting in ulcerative colitis published pages: S006-S007, ISSN: 1873-9946, DOI: |
Journal of Crohn\'s and Colitis 13/Supplement_1 | 2019-05-27 |
| 2018 |
Sare Verstockt, Elien Glorieus, Muriel De Decker, Bram Verstockt, Nooshin Ardeshir Davani, Vera Ballet, Gert A. Van Assche, Pieter Hindryckx, Marc Ferrante, Debby Laukens, Fazia Mana, Martine De Vos, Severine Vermeire, Isabelle Cleynen Sa1781 - Serological Markers Define Newly Diagnosed Crohn\'s Disease and Ulcerative Colitis Based on the age at Diagnosis published pages: S-392, ISSN: 0016-5085, DOI: |
Gastroenterology 154/6 | 2019-05-27 |
| 2017 |
M. Vancamelbeke, J. Sabino, L. Deroover, G. Vandermeulen, A. Luypaerts, M. Ferrante, G. Falony, S. Vieira-Silva, K. Verbeke, J. Raes, I. Cleynen, S. Vermeire P774 Metagenomics and metabolomics of patients with inflammatory bowel disease and their unaffected relatives published pages: S476-S477, ISSN: 1873-9946, DOI: |
Journal of Crohn\'s and Colitis 11/suppl_1 | 2019-05-27 |
| 2018 |
Magali de Bruyn, Vera Ballet, Sare Verstockt, Bram Verstockt, Gert A. Van Assche, Marc Ferrante, Kathleen Machiels, Severine Vermeire Tu1799 - Serum Proteomic Profiling Reveals Changes in Inflammatory Profiles with Consecutive Biological Therapies in Patients with Inflammatory Bowel Disease published pages: S-1023, ISSN: 0016-5085, DOI: |
Gastroenterology 154/6 | 2019-05-27 |
| 2018 |
Kathleen Machiels, Magali de Bruyn, Sare Verstockt, Bram Verstockt, Gert A. Van Assche, Albert Wolthuis, Andre D\'Hoore, Marc Ferrante, Severine Vermeire Su1794 - Discrimination of Endoscopic Postoperative Recurrence in Patients with Crohn\'s Disease using Serological Inflammatory Markers published pages: S-586-S-587, ISSN: 0016-5085, DOI: |
Gastroenterology 154/6 | 2019-05-27 |
| 2019 |
K Machiels, M Ferrante, N Davani, A Wolthuis, A D’Hoore, S Vermeire OP30 Serum proteomic profiling predicts and diagnoses pouchitis in ulcerative colitis patients undergoing ileal pouch-anal anastomosis published pages: S022-S023, ISSN: 1873-9946, DOI: |
Journal of Crohn\'s and Colitis 13/Supplement_1 | 2019-05-27 |
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