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RULLIVER SIGNED

Rules of self-organization and reengineering of liver tissue

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

RULLIVER project word cloud

Explore the words cloud of the RULLIVER project. It provides you a very rough idea of what is the project "RULLIVER" about.

mouse introducing mechanisms digital unravel genetic predictably predictions fourth mammalian hepatocyte 3d interactions self chosen reengineer organization consist organ alter modify structure polarity regenerating liver components hepatocytes architecture function model first geometrical representation cell ultimate rules tissue molecular principles cellular generate physical basal structural apico assembly functional responsible cells forming vitro understand perturbations accurate sub adult underlying

Project "RULLIVER" data sheet

The following table provides information about the project.

Coordinator	MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Organization address address: HOFGARTENSTRASSE 8 city: Munich postcode: 80539 website: www.mpg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	http://n.a.
Total cost	2˙498˙013 €
EC max contribution	2˙498˙013 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2015-AdG
Funding Scheme	ERC-ADG
Starting year	2016
Duration (year-month-day)	from 2016-10-01 to 2021-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Organization address address: HOFGARTENSTRASSE 8 city: Munich postcode: 80539 website: www.mpg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Munich)	coordinator	2˙498˙013.00

Map

Project objective

We want to understand the rules of self-organization underlying tissue structure and function. To address this problem, we have chosen the mouse liver with its complex apico-basal polarity of hepatocytes and its unique 3D tissue organization. We aim at identifying the rules of self-organization of liver tissue and their implementation at the molecular level. Our ultimate goal is to demonstrate that it is possible to reengineer liver tissue structure. The first aim will be to develop a digital geometrical model of liver tissue, i.e. an accurate 3D digital representation of the cells, forming the tissue and their sub-cellular components, in the developing, adult and regenerating liver, and unravel the principles for how the cells are organized to generate liver cell architecture. In aims 2 and 3, we will identify the molecular mechanisms underlying such geometrical rules. In particular, the second aim will be to characterize the molecular mechanisms responsible for hepatocyte cell polarity and predictably modify cell organization in vitro. The third aim will consist of introducing genetic perturbations to alter hepatocyte cell organization (cell polarity) and cell-cell interactions to predictably modify the structure and function of liver tissue. The fourth aim will be to develop a physical model of liver tissue self-assembly and organization. The project is ambitious as it aims to understand the rules of tissue organization in 3D in a mammalian organ to such an extent that it is possible to make predictions of tissue response to genetic perturbations and reengineer it to modify its structural and functional properties.

Publications

List of publications.
year	authors and title	journal	last update
2019	Christian Franke, Urska Repnik, Sandra Segeletz, Nicolas Brouilly, Yannis Kalaidzidis, Jeanâ€Marc Verbavatz, Marino Zerial Correlative singleâ€molecule localization microscopy and electron tomography reveals endosome nanoscale domains published pages: 601-617, ISSN: 1398-9219, DOI: 10.1111/tra.12671	Traffic 20/8	2019-11-28
2019	HernÃ¡n Morales-Navarrete, Hidenori Nonaka, AndrÃ© Scholich, FabiÃ¡n Segovia-Miranda, Walter de Back, Kirstin Meyer, Roman L Bogorad, Victor Koteliansky, Lutz Brusch, Yannis Kalaidzidis, Frank JÃ¼licher, Benjamin M Friedrich, Marino Zerial Liquid-crystal organization of liver tissue published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.44860	eLife 8	2019-11-28
2017	Kirstin Meyer, Oleksandr Ostrenko, Georgios Bourantas, Hernan Morales-Navarrete, Natalie Porat-Shliom, Fabian Segovia-Miranda, Hidenori Nonaka, Ali Ghaemi, Jean-Marc Verbavatz, Lutz Brusch, Ivo Sbalzarini, Yannis Kalaidzidis, Roberto Weigert, Marino Zerial A Predictive 3D Multi-Scale Model of Biliary Fluid Dynamics in the Liver Lobule published pages: 277-290.e9, ISSN: 2405-4712, DOI: 10.1016/j.cels.2017.02.008	Cell Systems 4/3	2019-06-13

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