IMMUNOALZHEIMER SIGNED
The role of immune cells in Alzheimer's disease
Total Cost €
0EC-Contrib. €
0Partnership
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Project "IMMUNOALZHEIMER" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSITA DEGLI STUDI DI VERONA
Organization address contact info |
| Coordinator Country | Italy [IT] |
| Project website | http://dp.univr.it/ |
| Total cost | 2˙500˙000 € |
| EC max contribution | 2˙500˙000 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2015-AdG |
| Funding Scheme | ERC-ADG |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-09-01 to 2021-08-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSITA DEGLI STUDI DI VERONA | IT (VERONA) | coordinator | 2˙500˙000.00 |
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Project objective
'Alzheimer’s disease is the most common form of dementia affecting more than 35 million people worldwide and its prevalence is projected to nearly double every 20 years with tremendous social and economical impact on the society. There is no cure for Alzheimer's disease and current drugs only temporarily improve disease symptoms. Alzheimer's disease is characterized by a progressive deterioration of cognitive functions, and the neuropathological features include amyloid beta deposition, aggregates of hyperphosphorylated tau protein, and the loss of neurons in the central nervous system (CNS). Research efforts in the past decades have been focused on neurons and other CNS resident cells, but this 'neurocentric' view has not resulted in disease-modifying therapies. Growing evidence suggests that inflammation mechanisms are involved in Alzheimer's disease and our team has recently shown an unexpected role for neutrophils in Alzheimer's disease, supporting the innovative idea that circulating leukocytes contribute to disease pathogenesis. The main goal of this project is to study the role of immune cells in animal models of Alzheimer's disease focusing on neutrophils and T cells. We will first study leukocyte-endothelial interactions in CNS microcirculation in intravital microscopy experiments. Leukocyte trafficking will be then studied inside the brain parenchyma by using two-photon microscopy, which will allow us to characterize leukocyte dynamic behaviour and the crosstalk between migrating leukocytes and CNS cells. The effect of therapeutic blockade of leukocyte-dependent inflammation mechanisms will be determined in animal models of Alzheimer's disease. Finally, the presence of immune cells will be studied on brain samples from Alzheimer's disease patients. Overall, IMMUNOALZHEIMER will generate fundamental knowledge to the understanding of the role of immune cells in neurodegeneration and will unveil novel therapeutic strategies to address Alzheimer’s disease.'
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2016 |
Rossi, Barbara; Constantin, Gabriela Live Imaging of Immune Responses in Experimental Models of Multiple Sclerosis published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2016.00506/full |
Frontiers in Immunology, Vol 7 (2016) 2 | 2019-06-13 |
| 2017 |
Elena Zenaro, Gennj Piacentino, Gabriela Constantin The blood-brain barrier in Alzheimer\'s disease published pages: 41-56, ISSN: 0969-9961, DOI: 10.1016/j.nbd.2016.07.007 |
Neurobiology of Disease 107 | 2019-06-13 |
| 2017 |
Enrica Caterina Pietronigro, Vittorina Della Bianca, Elena Zenaro, Gabriela Constantin NETosis in Alzheimer’s Disease published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2017.00211 |
Frontiers in Immunology 8 | 2019-06-13 |
| 2018 |
Alessia Farinazzo, Stefano Angiari, Ermanna Turano, Edoardo Bistaffa, Silvia Dusi, Serena Ruggieri, Roberta Bonafede, Raffaella Mariotti, Gabriela Constantin, Bruno Bonetti Nanovesicles from adipose-derived mesenchymal stem cells inhibit T lymphocyte trafficking and ameliorate chronic experimental autoimmune encephalomyelitis published pages: 1-11, ISSN: 2045-2322, DOI: 10.1038/s41598-018-25676-2 |
Scientific Reports 8/1 | 2019-05-27 |
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