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Neobetacell SIGNED

Neogenesis of new functional Beta Cells through Modulation of Neurogenin-3 Expression to provide Regenerative Therapy for Diabetes Patients

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

Neobetacell project word cloud

Explore the words cloud of the Neobetacell project. It provides you a very rough idea of what is the project "Neobetacell" about.

isolated differentiation therapy disorder islets postnatal injections beta daily disease mediated functional dependent transcription pancreas donor replacement genuine progression regulation neurogenin3 risk cytokine manner cells transplantable first pro transplantation mellitus exocrine regeneration tidm sugar cure cardiovascular insulin mouse multidisciplinary blood clinically potentially consists levels elevated human delay tools treatments actions model ideal endocrine clinical convert secondary experiments gained complications pharmacological exogenous shortage destruction limited expression strategy cell candidate serve vivo immune geminin acinar metabolic diabetes cadaveric utilizes humanized treatment create platform unprecedented chronic therapies paving

Project "Neobetacell" data sheet

The following table provides information about the project.

Coordinator	VRIJE UNIVERSITEIT BRUSSEL Organization address address: PLEINLAAN 2 city: BRUSSEL postcode: 1050 website: www.vub.ac.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Belgium [BE]
Total cost	1˙499˙875 €
EC max contribution	1˙499˙875 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2015-STG
Funding Scheme	ERC-STG
Starting year	2016
Duration (year-month-day)	from 2016-10-01 to 2021-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	VRIJE UNIVERSITEIT BRUSSEL VRIJE UNIVERSITEIT BRUSSEL Organization address address: PLEINLAAN 2 city: BRUSSEL postcode: 1050 website: www.vub.ac.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BRUSSEL)	coordinator	1˙499˙875.00

Map

Project objective

Diabetes mellitus is a chronic metabolic disorder characterized by elevated blood sugar levels with increased risk of cardiovascular complications. The currently available therapy for type 1 diabetes (TIDM) consists of daily injections of exogenous insulin in order to delay disease progression. However, these treatments do not provide a real cure since long-term secondary complications cannot be avoided. As TIDM is characterized by the highly specific immune-mediated destruction of one cell type, this disease represents a particularly ideal candidate for cell replacement therapy. Transplantation of human islets, isolated from cadaveric donor pancreas, potentially represents a genuine cure for TIDM but is limited by a shortage of transplantable islets. In the current application I will create an unprecedented humanized mouse model to test pharmacological therapies for diabetes. In a first step I will study the actions of Geminin on the regulation of the pro-endocrine transcription factor Neurogenin3 during mouse and human development and postnatal beta cell regeneration from the exocrine cells of the pancreas. These experiments will provide tools to control Neurogenin3 expression and thus endocrine cell differentiation in the human pancreas. Using the knowledge gained from in vivo mouse studies, I will create a novel clinically relevant humanized mouse model. I will use this model to develop a cytokine-based treatment to convert human acinar cells to functional beta-like cells in a Neurogenin3 dependent way. Finally, I will design a strategy to deliver the pro-endocrine treatment in a cell-specific manner. The humanized model will serve as a unique platform to test treatment for human diabetes in the pre-clinical phase. This project utilizes a multidisciplinary approach to develop a strategy based on pharmacological treatment rather than cell therapy, paving the way for clinical application.

Publications

List of publications.
year	authors and title	journal	last update
2018	Shiue-Cheng Tang, Luc Baeyens, Chia-Ning Shen, Shih-Jung Peng, Hung-Jen Chien, David W. Scheel, Chester E. Chamberlain, Michael S. German Human pancreatic neuro-insular network in health and fatty infiltration published pages: 168-181, ISSN: 0012-186X, DOI: 10.1007/s00125-017-4409-x	Diabetologia 61/1	2019-06-06
2018	Andreia V. Pinho, Mathias Van Bulck, Lorraine Chantrill, Mehreen Arshi, Tatyana Sklyarova, David Herrmann, Claire Vennin, David Gallego-Ortega, Amanda Mawson, Marc Giry-Laterriere, Astrid Magenau, Gunther Leuckx, Luc Baeyens, Anthony J. Gill, Phoebe Phillips, Paul Timpson, Andrew V. Biankin, Jianmin Wu, Ilse Rooman ROBO2 is a stroma suppressor gene in the pancreas and acts via TGF-Î² signalling published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-07497-z	Nature Communications 9/1	2019-06-06
2018	Violette Coppens, Gunter Leuckx, Yves Heremans, Willem Staels, Yannick Verdonck, Luc Baeyens, Nico De Leu, Harry Heimberg Semi-automated digital measurement as the method of choice for beta cell mass analysis published pages: e0191249, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0191249	PLOS ONE 13/2	2019-06-06
2018	Luc Baeyens, Marie Lemper, Willem Staels, Sofie De Groef, Nico De Leu, Yves Heremans, Michael S. German, Harry Heimberg (Re)generating Human Beta Cells: Status, Pitfalls, and Perspectives published pages: 1143-1167, ISSN: 0031-9333, DOI: 10.1152/physrev.00034.2016	Physiological Reviews 98/3	2019-06-06
2018	Willem Staels, Yannick Verdonck, Yves Heremans, Gunter Leuckx, Sofie De Groef, Carlo Heirman, Eelco de Koning, Conny Gysemans, Kris Thielemans, Luc Baeyens, Harry Heimberg, Nico De Leu Vegf-A mRNA transfection as a novel approach to improve mouse and human islet graft revascularisation published pages: 1804-1810, ISSN: 0012-186X, DOI: 10.1007/s00125-018-4646-7	Diabetologia 61/8	2019-06-06
2017	Zachary Pappalardo, Deeksha Gambhir Chopra, Thomas G. Hennings, Hunter Richards, Justin Choe, Katherine Yang, Luc Baeyens, Kenny Ang, Steven Chen, Michelle Arkin, Michael S. German, Michael T. McManus, Gregory M. Ku A Whole-Genome RNA Interference Screen Reveals a Role for Spry2 in Insulin Transcription and the Unfolded Protein Response published pages: 1703-1712, ISSN: 0012-1797, DOI: 10.2337/db16-0962	Diabetes 66/6	2019-06-06

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