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STRATIFY SIGNED

Brain network based stratification of mental illness

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

STRATIFY project word cloud

Explore the words cloud of the STRATIFY project. It provides you a very rough idea of what is the project "STRATIFY" about.

clinical fundamental comorbidity phenotyping pharmaceutical 2000 adulthood framework disorders intervention meta depression applicable alcohol cognitive longitudinal disease informed prevalent predict adhd 300 modalities endpoints links period network formidable quantifiable environmental learning structural markers structure clusters interventions imaging artifical disorder spanning predictors gt 900 configurations adolescence data deep innovative subtypes serve emotional genomics ing behaviours discriminative carry machine establishment correspond generate components functional neurobehavioural classification characterising function trials burden identification cohort individuals validated genomic psychopathology optimize brain imagen diagnoses diagnostic neural examples neurobiological intelligence precision paradigmatic stratification mental patients neuroimaging targetted controls neurobehaviourally reduce population

Project "STRATIFY" data sheet

The following table provides information about the project.

Coordinator	KING'S COLLEGE LONDON Organization address address: STRAND city: LONDON postcode: WC2R 2LS website: www.kcl.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	https://imagen-europe.com/
Total cost	3˙394˙214 €
EC max contribution	3˙394˙214 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2015-AdG
Funding Scheme	ERC-ADG
Starting year	2016
Duration (year-month-day)	from 2016-10-01 to 2021-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KING'S COLLEGE LONDON KING'S COLLEGE LONDON Organization address address: STRAND city: LONDON postcode: WC2R 2LS website: www.kcl.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	2˙352˙066.00
2	UNIVERSITY OF SOUTHAMPTON UNIVERSITY OF SOUTHAMPTON Organization address address: Highfield city: SOUTHAMPTON postcode: SO17 1BJ website: http://www.southampton.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SOUTHAMPTON)	participant	354˙385.00
3	THE UNIVERSITY OF NOTTINGHAM THE UNIVERSITY OF NOTTINGHAM Organization address address: University Park city: NOTTINGHAM postcode: NG7 2RD website: www.nottingham.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (NOTTINGHAM)	participant	314˙162.00
4	CHARITE - UNIVERSITAETSMEDIZIN BERLIN CHARITE - UNIVERSITAETSMEDIZIN BERLIN Organization address address: Chariteplatz 1 city: BERLIN postcode: 10117 website: www.charite.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERLIN)	participant	191˙000.00
5	THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN Organization address address: College Green city: DUBLIN postcode: 2 website: www.tcd.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (DUBLIN)	participant	182˙601.00

Map

Project objective

To reduce the burden of mental disorders it is a formidable aim to identify widely applicable disease markers based on neural processes, which predict psychopathology and allow for targeted interventions. We will generate a neurobehavioural framework for stratification of psychopathology by characterising links between network properties of brain function and structure and reinforcement–related behaviours, which are fundamental components of some of the most prevalent mental disorders, major depression, alcohol use disorder and ADHD. We will assess if network configurations define subtypes within and if they correspond to comorbidity across these diagnoses. We will identify discriminative data modalities and characterize predictors of future psychopathology. To identify specific neurobehavioural clusters we will carry out precision phenotyping of 900 patients with major depression, ADHD and alcohol use disorders and 300 controls, which we will investigate with innovative deep machine learning methods derived from artifical intelligence research. Development of these methods will optimize exploitation of a wide range of assessment modalities, including functional and structural neuroimaging, cognitive, emotional as well as environmental measures. The neurobehavioural clusters resulting from this analysis will be validated in a longitudinal population-based imaging genomics cohort, the IMAGEN sample of over 2000 participants spanning the period from adolescence to adulthood and integrated with information generated from genomic and imaging-genomic meta-analyses of >300.000 individuals. By targeting specific neural processes the resulting stratification markers will serve as paradigmatic examples for a diagnostic classification, which is based upon quantifiable neurobiological measures, thus enabling targetted early intervention, identification of novel pharmaceutical targets and the establishment of neurobehaviourally informed endpoints for clinical trials.

Publications

List of publications.
year	authors and title	journal	last update
2019	Hongtao Ruan, Yunyi Zhou, Qiang Luo, Gabriel H. Robert, Sylvane DesriviÃ¨res, Erin Burke Quinlan, ZhaoWen Liu, Tobias Banaschewski, Arun L.W. Bokde, Uli Bromberg, Christian BÃ¼chel, Herta Flor, Vincent Frouin, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure PaillÃ¨re Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Sarah Hohmann, Julia Adolescent binge drinking disrupts normal trajectories of brain functional organization and personality maturation published pages: 101804, ISSN: 2213-1582, DOI: 10.1016/j.nicl.2019.101804	NeuroImage: Clinical 22	2020-04-08
2018	Christine Macare, Francesca Ducci, Yuning Zhang, Barbara Ruggeri, Tianye Jia, Marika Kaakinen, Gursharan Kalsi, Pimphen Charoen, Filippo Casoni, Jan Peters, Uli Bromberg, Matthew Hill, Jessica Buxton, Alexandra Blakemore, Juha Veijola, Christian BÃ¼chel, Tobias Banaschewski, Arun L.W. Bokde, Patricia Conrod, Herta Flor, Vincent Frouin, JÃ¼rgen Gallinat, Hugh Garavan, Penny A. Gowland, Andreas Hein A neurobiological pathway to smoking in adolescence: TTC12-ANKK1-DRD2 variants and reward response published pages: 1103-1114, ISSN: 0924-977X, DOI: 10.1016/j.euroneuro.2018.07.101	European Neuropsychopharmacology 28/10	2020-04-08
2019	Philip A. Spechler, Bader Chaarani, Catherine Orr, Scott Mackey, Stephen T. Higgins, Tobias Banaschewski, Arun L.W. Bokde, Uli Bromberg, Christian BÃ¼chel, Erin Burke Quinlan, Patricia J. Conrod, Sylvane DesriviÃ¨res, Herta Flor, Vincent Frouin, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Juliane H. FrÃ¶hner, Michael N Neuroimaging Evidence for Right Orbitofrontal Cortex Differences in Adolescents With Emotional and Behavioral Dysregulation published pages: , ISSN: 0890-8567, DOI: 10.1016/j.jaac.2019.01.021	Journal of the American Academy of Child & Adolescent Psychiatry	2020-04-08
2019	Edward D Barker, Alex Ing, Francesca Biondo, Tianye Jia, Jean-Baptiste Pingault, Ebba Du Rietz, Yuning Zhang, Barbara Ruggeri, Tobias Banaschewski, Sarah Hohmann, Arun L. W Bokde, Uli Bromberg, Christian BÃ¼chel, Erin Burke Quinlan, Edmund Sounga-Barke, April B. Bowling, Sylvane DesriviÃ¨res, Herta Flor, Vincent Frouin, Hugh Garavan, Philip Asherson, Penny Gowland, Andreas Heinz, Bernd Ittermann, Do ADHD-impulsivity and BMI have shared polygenic and neural correlates? published pages: , ISSN: 1359-4184, DOI: 10.1038/s41380-019-0444-y	Molecular Psychiatry	2020-04-08
2018	Evangelos Papanastasiou, Elias Mouchlianitis, Dan W. Joyce, Philip McGuire, Tobias Banaschewski, Arun L. W. Bokde, Uli Bromberg, Christian BÃ¼chel, Erin Burke Quinlan, Sylvane DesriviÃ¨res, Herta Flor, Vincent Frouin, Hugh Garavan, Philip Spechler, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure PaillÃ¨re Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfan Examination of the Neural Basis of Psychoticlike Experiences in Adolescence During Reward Processing published pages: 1043, ISSN: 2168-622X, DOI: 10.1001/jamapsychiatry.2018.1973	JAMA Psychiatry 75/10	2020-04-08
2019	Savani Bartholdy, Owen G. Oâ€™Daly, Iain C. Campbell, Tobias Banaschewski, Gareth Barker, Arun L.W. Bokde, Uli Bromberg, Christian BÃ¼chel, Erin Burke Quinlan, Sylvane DesriviÃ¨res, Herta Flor, Vincent Frouin, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure PaillÃ¨re Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Sarah Hohmann, Julia Neural Correlates of Failed Inhibitory Control as an Early Marker of Disordered Eating in Adolescents published pages: 956-965, ISSN: 0006-3223, DOI: 10.1016/j.biopsych.2019.01.027	Biological Psychiatry 85/11	2020-04-08
2019	Matthew D. Albaugh, James. J. Hudziak, Alex Ing, Bader Chaarani, Edward Barker, Tianye Jia, Herve Lemaitre, Richard Watts, Catherine Orr, Philip A. Spechler, Claude Lepage, Vladimir Fonov, Louis Collins, Pierre Rioux, Alan C. Evans, Tobias Banaschewski, Arun L. W. Bokde, Uli Bromberg, Christian BÃ¼chel, Erin Burke Quinlan, Sylvane DesriviÃ¨res, Herta Flor, Vincent Frouin, Penny Gowland, Andreas He White matter microstructure is associated with hyperactive/inattentive symptomatology and polygenic risk for attention-deficit/hyperactivity disorder in a population-based sample of adolescents published pages: , ISSN: 0893-133X, DOI: 10.1038/s41386-019-0383-y	Neuropsychopharmacology	2020-04-08
2019	Monique Ernst, Brenda Benson, Eric Artiges, Adam X. Gorka, Herve Lemaitre, Tiffany Lago, Ruben Miranda, Tobias Banaschewski, Arun L. W. Bokde, Uli Bromberg, RÃ¼diger BrÃ¼hl, Christian BÃ¼chel, Anna Cattrell, Patricia Conrod, Sylvane DesriviÃ¨res, Tahmine Fadai, Herta Flor, Antoine Grigis, Juergen Gallinat, Hugh Garavan, Penny Gowland, Yvonne Grimmer, Andreas Heinz, Viola Kappel, Frauke Nees, Dimit Pubertal maturation and sex effects on the default-mode network connectivity implicated in mood dysregulation published pages: , ISSN: 2158-3188, DOI: 10.1038/s41398-019-0433-6	Translational Psychiatry 9/1	2020-04-08
2019	Wei Cheng, Edmund T Rolls, Trevor W Robbins, Weikang Gong, Zhaowen Liu, Wujun Lv, Jingnan Du, Hongkai Wen, Liang Ma, Erin Burke Quinlan, Hugh Garavan, Eric Artiges, Dimitri Papadopoulos Orfanos, Michael N Smolka, Gunter Schumann, Keith Kendrick, Jianfeng Feng Decreased brain connectivity in smoking contrasts with increased connectivity in drinking published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.40765	eLife 8	2020-04-08
2018	Frida Bayard, Charlotte Nymberg Thunell, Christoph AbÃ©, Rita Almeida, Tobias Banaschewski, Gareth Barker, Arun L. W. Bokde, Uli Bromberg, Christian BÃ¼chel, Erin Burke Quinlan, Sylvane DesriviÃ¨res, Herta Flor, Vincent Frouin, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure PaillÃ¨re Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, TomÃ¡Å¡ Paus, Lui Distinct brain structure and behavior related to ADHD and conduct disorder traits published pages: , ISSN: 1359-4184, DOI: 10.1038/s41380-018-0202-6	Molecular Psychiatry	2020-04-08
2017	Sarah J. Brislin, Christopher J. Patrick, Herta Flor, Frauke Nees, Angela Heinrich, Laura E. Drislane, James R. Yancey, Tobias Banaschewski, Arun L. W. Bokde, Uli Bromberg, Christian BÃ¼chel, Erin Burke Quinlan, Sylvane DesriviÃ¨res, Vincent Frouin, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure PaillÃ¨re Martinot, Dimitri Papadopoulos Orfanos, Luise Po Extending the Construct Network of Trait Disinhibition to the Neuroimaging Domain: Validation of a Bridging Scale for Use in the European IMAGEN Project published pages: 567-581, ISSN: 1073-1911, DOI: 10.1177/1073191118759748	Assessment 26/4	2020-04-08
2018	Sambu Seo, Anne Beck, Caroline Matthis, Alexander Genauck, Tobias Banaschewski, Arun L.W. Bokde, Uli Bromberg, Christian BÃ¼chel, Erin Burke Quinlan, Herta Flor, Vincent Frouin, Hugh Garavan, Penny Gowland, Bernd Ittermann, Jeanâ€Luc Martinot, Marieâ€Laure PaillÃ¨re Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Sarah Hohmann, Juliane H. FrÃ¶hner, Michael N. Smolka, Henrik W Risk profiles for heavy drinking in adolescence: differential effects of gender published pages: 787-801, ISSN: 1355-6215, DOI: 10.1111/adb.12636	Addiction Biology 24/4	2020-04-08
2018	Erin Burke Quinlan, Edward D. Barker, Qiang Luo, Tobias Banaschewski, Arun L. W. Bokde, Uli Bromberg, Christian BÃ¼chel, Sylvane DesriviÃ¨res, Herta Flor, Vincent Frouin, Hugh Garavan, Bader Chaarani, Penny Gowland, Andreas Heinz, RÃ¼diger BrÃ¼hl, Jean-Luc Martinot, Marie-Laure PaillÃ¨re Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, TomÃ¡Å¡ Paus, Luise Poustka, Sarah Hohmann, Michael N. Smo Peer victimization and its impact on adolescent brain development and psychopathology published pages: , ISSN: 1359-4184, DOI: 10.1038/s41380-018-0297-9	Molecular Psychiatry	2020-04-08
2018	Zhipeng Cao, Marc Bennett, Catherine Orr, Ilknur Icke, Tobias Banaschewski, Gareth J. Barker, Arun L. W. Bokde, Uli Bromberg, Christian BÃ¼chel, Erin Burke Quinlan, Sylvane DesriviÃ¨res, Herta Flor, Vincent Frouin, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jeanâ€Luc Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, TomÃ¡Å¡ Paus, Luise Poustka, Sarah Hohmann, Juliane H. FrÃ¶h Mapping adolescent reward anticipation, receipt, and prediction error during the monetary incentive delay task published pages: 262-283, ISSN: 1065-9471, DOI: 10.1002/hbm.24370	Human Brain Mapping 40/1	2020-04-08
2019	Nicole Tay, Christine Macare, Yun Liu, Barbara Ruggeri, Tianye Jia, Congying Chu, Francesca Biondo, Alex Ing, Qiang Luo, Daniil Sarkysian, Tobias Banaschewski, Gareth J. Barker, Arun L.W. Bokde, Uli Bromberg, Christian BÃ¼chel, Erin Burke Quinlan, Sylvane DesriviÃ¨res, Herta Flor, Vincent Frouin, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Eric Artiges, Frauke N Allele-Specific Methylation of SPDEF : A Novel Moderator of Psychosocial Stress and Substance Abuse published pages: 146-155, ISSN: 0002-953X, DOI: 10.1176/appi.ajp.2018.17121360	American Journal of Psychiatry 176/2	2020-04-08
2018	Eva Velthorst, Sean Froudist-Walsh, Eli Stahl, Douglas Ruderfer, Ilyan Ivanov, Joseph Buxbaum, Tobias Banaschewski, Arun L. W. Bokde, Uli Bromberg Dipl-Psych, Christian BÃ¼chel, Erin Burke Quinlan, Sylvane DesriviÃ¨res, Herta Flor, Vincent Frouin, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Marie-Laure PaillÃ¨re Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, To Genetic risk for schizophrenia and autism, social impairment and developmental pathways to psychosis published pages: , ISSN: 2158-3188, DOI: 10.1038/s41398-018-0229-0	Translational Psychiatry 8/1	2020-04-08
2019	Matthew D. Albaugh, James. J. Hudziak, Catherine Orr, Philip A. Spechler, Bader Chaarani, Scott Mackey, Claude Lepage, Vladimir Fonov, Pierre Rioux, Alan C. Evans, Tobias Banaschewski, Arun L. W. Bokde, Uli Bromberg, Christian BÃ¼chel, Erin Burke Quinlan, Sylvane DesriviÃ¨res, Herta Flor, Antoine Grigis, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure PaillÃ¨re Martin Amygdalar reactivity is associated with prefrontal cortical thickness in a large population-based sample of adolescents published pages: e0216152, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0216152	PLOS ONE 14/5	2020-04-08
2017	Josiane Bourque, Philip A. Spechler, StÃ©phane Potvin, Robert Whelan, Tobias Banaschewski, Arun L.W. Bokde, Uli Bromberg, Christian BÃ¼chel, Erin Burke Quinlan, Sylvane DesriviÃ¨res, Herta Flor, Vincent Frouin, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure PaillÃ¨re-Martinot, Sarah C. McEwen, Frauke Nees, Dimitri Papadopoulos Orfanos, TomÃ¡Å¡ Paus, Luise Poustka, Mi Functional Neuroimaging Predictors of Self-Reported Psychotic Symptoms in Adolescents published pages: 566-575, ISSN: 0002-953X, DOI: 10.1176/appi.ajp.2017.16080897	American Journal of Psychiatry 174/6	2020-04-08
2017	D A Gonzalez, T Jia, J H PinzÃ³n, S F Acevedo, S A Ojelade, B Xu, N Tay, S DesriviÃ¨res, J L Hernandez, T Banaschewski, C BÃ¼chel, A L W Bokde, P J Conrod, H Flor, V Frouin, J Gallinat, H Garavan, P A Gowland, A Heinz, B Ittermann, M Lathrop, J-L Martinot, T Paus, M N Smolka, A R Rodan, G Schumann, A Rothenfluh The Arf6 activator Efa6/PSD3 confers regional specificity and modulates ethanol consumption in Drosophila and humans published pages: 621-628, ISSN: 1359-4184, DOI: 10.1038/mp.2017.112	Molecular Psychiatry 23/3	2020-04-08
2017	Erin Burke Quinlan, Anna Cattrell, Tianye Jia, Eric Artiges, Tobias Banaschewski, Gareth Barker, Arun L.W. Bokde, Uli Bromberg, Christian BÃ¼chel, RÃ¼diger BrÃ¼hl, Patricia J. Conrod, Sylvane Desrivieres, Herta Flor, Vincent Frouin, JÃ¼rgen Gallinat, Hugh Garavan, Penny Gowland, Andreas Heinz, Jean-Luc Martinot, Marie-Laure PaillÃ¨re Martinot, Frauke Nees, Dimitri Papadopoulos-Orfanos, TomÃ¡Å¡ Paus, Luise Poustka, Michael N. Smolka, Nora C. Vetter, Henrik Walter, Robert Whelan, Jeffrey C. Glennon, Jan K. Buitelaar, Francesca HappÃ©, Eva Loth, Edward D. Barker, Gunter Schumann Psychosocial Stress and Brain Function in Adolescent Psychopathology published pages: 785-794, ISSN: 0002-953X, DOI: 10.1176/appi.ajp.2017.16040464	American Journal of Psychiatry 174/8	2020-04-08
2018	Nicholas D\'Alberto, Bader Chaarani, Catherine A. Orr, Philip A. Spechler, Matthew D. Albaugh, Nicholas Allgaier, Alexander Wonnell, Tobias Banaschewski, Arun L.W. Bokde, Uli Bromberg, Christian BÃ¼chel, Erin Burke Quinlan, Patricia J. Conrod, Sylvane DesriviÃ¨res, Herta Flor, Juliane H. FrÃ¶hner, Vincent Frouin, Penny Gowland, Andreas Heinz, Bernd Itterman, Jean-Luc Martinot, Marie-Laure PaillÃ¨re Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Trevor W. Robbins, Michael N. Smolka, Henrik Walter, Robert Whelan, Gunter Schumann, Alexandra S. Potter, Hugh Garavan Individual differences in stop-related activity are inflated by the adaptive algorithm in the stop signal task published pages: , ISSN: 1065-9471, DOI: 10.1002/hbm.24075	Human Brain Mapping	2020-04-08
2018	F. Nemmi, C. Nymberg, F. Darki, T. Banaschewski, A.L.W. Bokde, C. BÃ¼chel, H. Flor, V. Frouin, H. Garavan, P. Gowland, A. Heinz, J.-L. Martinot, F. Nees, T. Paus, M.N. Smolka, T.W. Robbins, G. Schumann, T. Klingberg Interaction between striatal volume and DAT1 polymorphism predicts working memory development during adolescence published pages: 191-199, ISSN: 1878-9293, DOI: 10.1016/j.dcn.2018.03.006	Developmental Cognitive Neuroscience 30	2020-04-08

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