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EnzOx2 SIGNED

New enzymatic oxidation/oxyfunctionalization technologies for added value bio-based products

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

EnzOx2 project word cloud

Explore the words cloud of the EnzOx2 project. It provides you a very rough idea of what is the project "EnzOx2" about.

acids pharmaceutical biochemical free blocks building technologies furandicarboxylic specialized bottlenecks enzyme context unexplored 100 greener substrate bioprocess universities later optimized apis platform thiolate plastic producing lipid selective plastics shown chemical peroxygenases fdca diformylfuran sufficient chiracon co csic centre enzox2 plans novozymes dresden added fragrances radical world microbial renewable biotransformations engineered hmf jenabios pot institutes biorefineries perform acid hydroxylation stereo biomass aimplas special oxidoreductases reactions pilot regio fatty attain validated compounds oxidation bio self chiral flagship efficient firmenich heme flavours hydroxymethylfurfural sugar sustainable industrial biotechnology plant expertise active flavo enzymes copper feedstocks oxidases conversion oxidative economy delft oxyfunctionalization lipids components ava leaders steroids ingredients smes tools biochem clea terpenes block benefit

Project "EnzOx2" data sheet

The following table provides information about the project.

Coordinator	AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 website: http://www.csic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Project website	http://www.enzox2.eu
Total cost	5˙000˙000 €
EC max contribution	3˙000˙000 € (60%)
Programme	1. H2020-EU.3.2.6. (Bio-based Industries Joint Technology Initiative (BBI-JTI))
Code Call	H2020-BBI-PPP-2015-2-1
Funding Scheme	BBI-RIA
Starting year	2016
Duration (year-month-day)	from 2016-11-01 to 2019-10-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 website: http://www.csic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	coordinator	1˙306˙000.00
2	TECHNISCHE UNIVERSITAET DRESDEN TECHNISCHE UNIVERSITAET DRESDEN Organization address address: HELMHOLTZSTRASSE 10 city: DRESDEN postcode: 1069 website: http://www.tu-dresden.de/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (DRESDEN)	participant	450˙000.00
3	TECHNISCHE UNIVERSITEIT DELFT TECHNISCHE UNIVERSITEIT DELFT Organization address address: STEVINWEG 1 city: DELFT postcode: 2628 CN website: www.tudelft.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (DELFT)	participant	400˙000.00
4	Chiracon GmbH Chiracon GmbH Organization address address: BIOTECHNOLOGIEPARK TGZ 1 city: LUCKENWALDE postcode: 14943 website: www.chiracon contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (LUCKENWALDE)	participant	250˙000.00
5	JENABIOS GMBH JENABIOS GMBH Organization address address: LOBSTEDTER STRASSE 80 city: JENA postcode: 7749 website: www.jenabios.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (JENA)	participant	244˙000.00
6	UNIVERSIDAD DE SANTIAGO DE COMPOSTELA UNIVERSIDAD DE SANTIAGO DE COMPOSTELA Organization address address: COLEXIO DE SAN XEROME PRAZA DO OBRADOIRO S/N city: SANTIAGO DE COMPOSTELA postcode: 15782 website: http://www.usc.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (SANTIAGO DE COMPOSTELA)	participant	200˙000.00
7	AIMPLAS - ASOCIACION DE INVESTIGACION DE MATERIALES PLASTICOS Y CONEXAS AIMPLAS - ASOCIACION DE INVESTIGACION DE MATERIALES PLASTICOS Y CONEXAS Organization address address: CALLE GUSTAVE EIFFEL 4 PARQUE TECNOLOGICO DE PATERNA city: PATERNA VALENCIA postcode: 46980 website: www.aimplas.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (PATERNA VALENCIA)	participant	150˙000.00
8	AVA BIOCHEM BSL AG AVA BIOCHEM BSL AG Organization address address: ROTHAUSSTRASSE 61 city: MUTTENZ postcode: 4132 website: www.ava-biochem.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (MUTTENZ)	participant	0.00
9	CLEA TECHNOLOGIES BV CLEA TECHNOLOGIES BV Organization address address: DELFTECHPARK 34 city: DELFT postcode: 2628 XH website: www.cleatechnologies.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (DELFT)	participant	0.00
10	FIRMENICH SA FIRMENICH SA Organization address address: ROUTE DES JEUNES 1 city: GENEVE postcode: 1227 website: www.firmenich.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (GENEVE)	participant	0.00
11	NOVOZYMES A/S NOVOZYMES A/S Organization address address: Krogshoejvej 36 city: BAGSVAERD postcode: 2880 website: www.novozymes.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (BAGSVAERD)	participant	0.00

Map

Project objective

Sustainable production of chemical building blocks and other added value products from plant biomass is required for a bio-based economy. However, the biomass biorefineries should benefit not only from the use of renewable feedstocks but also from greener and more efficient bio-chemical technologies. Previous projects have shown the potential of oxidative enzymes in the production of some added value compounds from biomass components. Of special interest are still unexplored oxidation/oxyfunctionalization reactions (of sugar and lipid compounds) by microbial oxidoreductases, including new (self-sufficient) heme-thiolate peroxygenases. In this context, EnzOx2 plans to develop a 100% biochemical conversion of bio-based 5-hydroxymethylfurfural (HMF) into diformylfuran, a platform chemical, and 2,5-furandicarboxylic acid (FDCA), a plastic building-block. Oxidases (flavo and copper/radical) and peroxygenases will be used to perform the three-step oxidation of HMF to FDCA in a co-substrate and side-product free, one-pot conversion. On the other hand, highly (regio/stereo) selective hydroxylation of plant lipids (such as fatty acids, terpenes and steroids) by peroxygenases will be optimized for cost-effective production of flavours and fragrances (F&F), active pharmaceutical ingredients (APIs) and others. ENZOX2 aims to solve some main bottlenecks in these industrial processes by the use of bio-chemical tools (new/engineered enzymes and optimized biotransformations), to be later validated at the pilot/flagship scale. To attain this objective the consortium includes: i) two world leaders in industrial enzymes (Novozymes) and F&F (Firmenich); ii) two chemical SMEs producing HMF and chiral APIs (AVA-Biochem and Chiracon); iii) two specialized biotechnology SMEs (JenaBios and CLEA); iv) one technology centre in the Plastics sector (AIMPLAS); and v) three CSIC institutes and two universities (Dresden and Delft) with expertise in enzyme reactions and bioprocess implementation.

Deliverables

List of deliverables.
Brochure describing the main results and their potential impact on different industrial sectors	Websites, patent fillings, videos etc.	2020-03-24 10:22:50
Dissemination and use of main project results, including publications and patent licensing	Documents, reports	2020-03-24 10:22:50
Brochure describing the main aspects of the project, including objectives and consortium	Websites, patent fillings, videos etc.	2019-10-30 08:57:13
Set-up of the project web-site including public and private parts	Websites, patent fillings, videos etc.	2019-10-30 08:57:13

Take a look to the deliverables list in detail: detailed list of EnzOx2 deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Javier Martin EvoluciÃ³n dirigida de la peroxigenasa inespecÃfica de agrocybe aegerita: tolerancia a disolventes orgÃ¡nicos mediante deriva genÃ©tica neutral y evoluciÃ³n adaptativa published pages: , ISSN: , DOI:		2020-01-28
2020	Javier ViÃ±a-Gonzalez, Angel T. Martinez, Victor Guallar, Miguel Alcalde Sequential oxidation of 5-hydroxymethylfurfural to furan-2,5-dicarboxylic acid by an evolved aryl-alcohol oxidase published pages: 140293, ISSN: 1570-9639, DOI: 10.1016/j.bbapap.2019.140293	Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1868/1	2020-01-28
2019	Ana Serrano, Eva CalviÃ±o, Juan Carro, MarÃa I. SÃ¡nchez-Ruiz, F. Javier CaÃ±ada, Angel T. MartÃnez Complete oxidation of hydroxymethylfurfural to furandicarboxylic acid by aryl-alcohol oxidase published pages: , ISSN: 1754-6834, DOI: 10.1186/s13068-019-1555-z	Biotechnology for Biofuels 12/1	2020-01-28
2019	Javier ViÃ±a Biotechnology platforms for aryl-alcohol oxidases by directed evolution published pages: , ISSN: , DOI:		2020-01-28
2018	Jan Kiebist Oxyfunktionalisierung pharmazeutisch relevanter Strukturen durch unspezifische Peroxygenasen der Familie I aus Dikarya-Pilzen published pages: , ISSN: , DOI:		2020-01-28
2019	IvÃ¡n Ayuso-FernÃ¡ndez, Jorge Rencoret, Ana GutiÃ©rrez, Francisco Javier Ruiz-DueÃ±as, Angel T. MartÃnez Peroxidase evolution in white-rot fungi follows wood lignin evolution in plants published pages: 17900-17905, ISSN: 0027-8424, DOI: 10.1073/pnas.1905040116	Proceedings of the National Academy of Sciences 116/36	2020-01-14
2019	Carmen Aranda Biotransformations of industrial interest catalyzed by fungal peroxygenases published pages: , ISSN: , DOI:		2020-01-14
2020	Sara Bello, Pedro MÃ©ndez-Trelles, Eva Rodil, Gumersindo Feijoo, Maria Teresa Moreira Towards improving the sustainability of bioplastics: Process modelling and life cycle assessment of two separation routes for 2,5-furandicarboxylic acid published pages: 116056, ISSN: 1383-5866, DOI: 10.1016/j.seppur.2019.116056	Separation and Purification Technology 233	2020-01-14
2019	Ivan Ayuso Resurrection of ancestral ligninolytic peroxidases ResurrecciÃ³n de peroxidasas ligninolÃticas ancestrales published pages: , ISSN: , DOI:		2020-01-14
2019	Jefferson O. Romero, Elena FernÃ¡ndez-Fueyo, FabiÃ¡n Avila-Salas, Rodrigo Recabarren, Jans Alzate-Morales, Angel T. MartÃnez Binding and Catalytic Mechanisms of Veratryl Alcohol Oxidation by Lignin Peroxidase: A Theoretical and Experimental Study published pages: 1066-1074, ISSN: 2001-0370, DOI: 10.1016/j.csbj.2019.07.002	Computational and Structural Biotechnology Journal 17	2020-01-14
2018	Sara Bello, Iana Salim, Pedro MÃ©ndez-Trelles, Eva Rodil, Gumersindo Feijoo, Maria Teresa Moreira Environmental sustainability assessment of HMF and FDCA production from lignocellulosic biomass through life cycle assessment (LCA) published pages: 105-115, ISSN: 0018-3830, DOI: 10.1515/hf-2018-0100	Holzforschung 73/1	2020-01-14
2018	Mercedes Ramirez-Escudero, Patricia Molina-Espeja, Patricia Gomez de Santos, Martin Hofrichter, Julia Sanz-Aparicio, Miguel Alcalde Structural Insights into the Substrate Promiscuity of a Laboratory-Evolved Peroxygenase published pages: 3259-3268, ISSN: 1554-8929, DOI: 10.1021/acschembio.8b00500	ACS Chemical Biology 13/12	2019-10-30
2019	Patricia Molina-Espeja, Paloma Santos-Moriano, Eva GarcÃa-Ruiz, Antonio Ballesteros, Francisco Plou, Miguel Alcalde Structure-Guided Immobilization of an Evolved Unspecific Peroxygenase published pages: 1627, ISSN: 1422-0067, DOI: 10.3390/ijms20071627	International Journal of Molecular Sciences 20/7	2019-10-30
2019	Florian Tieves, SÃ©bastien Jean-Paul Willot, Morten Martinus Cornelis Harald vanâ€…Schie, Marine CharlÃ¨ne RenÃ©e Rauch, Sabry Hamdy Hamed Younes, Wuyuan Zhang, JiaJia Dong, Patricia Gomezâ€…deâ€…Santos, John Mick Robbins, Bettina Bommarius, Miguel Alcalde, Andreas Sebastian Bommarius, Frank Hollmann Formate Oxidase (FOx) from Aspergillus oryzae : One Catalyst Enables Diverse H 2 O 2 -Dependent Biocatalytic Oxidation Reactions published pages: 7873-7877, ISSN: 1433-7851, DOI: 10.1002/anie.201902380	Angewandte Chemie International Edition 58/23	2019-10-30
2018	Alexander Karich, Sebastian Kleeberg, RenÃ© Ullrich, Martin Hofrichter Enzymatic Preparation of 2,5-Furandicarboxylic Acid (FDCA)â€”A Substitute of Terephthalic Acidâ€”By the Joined Action of Three Fungal Enzymes published pages: 5, ISSN: 2076-2607, DOI: 10.3390/microorganisms6010005	Microorganisms 6/1	2019-10-30
2018	Javier Martin-Diaz, Carmen Paret, Eva GarcÃa-Ruiz, Patricia Molina-Espeja, Miguel Alcalde Shuffling the neutral drift of unspecific peroxygenase in Saccharomyces cerevisiae published pages: AEM.00808-18, ISSN: 0099-2240, DOI: 10.1128/AEM.00808-18	Applied and Environmental Microbiology	2019-10-30
2018	IvÃ¡n Ayuso-FernÃ¡ndez, Francisco J. Ruiz-DueÃ±as, Angel T. MartÃnez Evolutionary convergence in lignin-degrading enzymes published pages: 201802555, ISSN: 0027-8424, DOI: 10.1073/pnas.1802555115	Proceedings of the National Academy of Sciences	2019-10-30
2017	Enrico BÃ¼ttner, Anna Maria Gebauer, Martin Hofrichter, Christiane Liers, Harald Kellner Draft Genome Sequence of the Wood-Degrading Ascomycete Kretzschmaria deusta DSM 104547 published pages: e01076-17, ISSN: 2169-8287, DOI: 10.1128/genomeA.01076-17	Genome Announcements 5/43	2019-10-30
2017	Angel T. MartÃnez, Francisco J. Ruiz-DueÃ±as, Susana Camarero, Ana Serrano, Dolores Linde, Henrik Lund, Jesper Vind, Morten Tovborg, Owik M. Herold-Majumdar, Martin Hofrichter, Christiane Liers, RenÃ© Ullrich, Katrin Scheibner, Giovanni Sannia, Alessandra Piscitelli, Cinzia Pezzella, Mehmet E. Sener, Sibel KÄ±lÄ±Ã§, Willem J.H. van Berkel, Victor Guallar, Maria FÃ¡tima Lucas, Ralf Zuhse, Roland Ludwig, Frank Hollmann, Elena FernÃ¡ndez-Fueyo, Eric Record, Craig B. Faulds, Marta Tortajada, Ib Winckelmann, Jo-Anne Rasmussen, Mirjana Gelo-Pujic, Ana GutiÃ©rrez, JosÃ© C. del RÃo, Jorge Rencoret, Miguel Alcalde Oxidoreductases on their way to industrial biotransformations published pages: 815-831, ISSN: 0734-9750, DOI: 10.1016/j.biotechadv.2017.06.003	Biotechnology Advances 35/6	2019-10-30
2017	Juan Carro, Marta MartÃnez-JÃºlvez, Milagros Medina, Angel T. MartÃnez, Patricia Ferreira Protein dynamics promote hydride tunnelling in substrate oxidation by aryl-alcohol oxidase published pages: 28666-28675, ISSN: 1463-9076, DOI: 10.1039/C7CP05904C	Physical Chemistry Chemical Physics 19/42	2019-10-30
2018	Juan Carro, Elena FernÃ¡ndez-Fueyo, Carmen FernÃ¡ndez-Alonso, Javier CaÃ±ada, RenÃ© Ullrich, Martin Hofrichter, Miguel Alcalde, Patricia Ferreira, Angel T. MartÃnez Self-sustained enzymatic cascade for the production of 2,5-furandicarboxylic acid from 5-methoxymethylfurfural published pages: , ISSN: 1754-6834, DOI: 10.1186/s13068-018-1091-2	Biotechnology for Biofuels 11/1	2019-10-30
2018	Carmen Aranda, RenÃ© Ullrich, Jan Kiebist, Katrin Scheibner, JosÃ© C. del RÃo, Martin Hofrichter, Angel T. MartÃnez, Ana GutiÃ©rrez Selective synthesis of the resveratrol analogue 4,4â€²-dihydroxy- trans -stilbene and stilbenoids modification by fungal peroxygenases published pages: 2394-2401, ISSN: 2044-4753, DOI: 10.1039/c8cy00272j	Catalysis Science & Technology 8/9	2019-10-30
2016	VerÃ³nica SÃ¡ez-JimÃ©nez, Jorge Rencoret, Miguel Angel RodrÃguez-Carvajal, Ana GutiÃ©rrez, Francisco Javier Ruiz-DueÃ±as, Angel T. MartÃnez Role of surface tryptophan for peroxidase oxidation of nonphenolic lignin published pages: nn, ISSN: 1754-6834, DOI: 10.1186/s13068-016-0615-x	Biotechnology for Biofuels 9/1	2019-10-30
2017	David RodrÃguez-Escribano, Felipe de Salas, Isabel Pardo, Susana Camarero High-Throughput Screening Assay for Laccase Engineering toward Lignosulfonate Valorization published pages: 1793, ISSN: 1422-0067, DOI: 10.3390/ijms18081793	International Journal of Molecular Sciences 18/8	2019-10-30
2017	Sandra Acebes, Francisco J. Ruiz-DueÃ±as, Mario Toubes, Veronica SÃ¡ez-JimÃ©nez, Marta PÃ©rez-Boada, M. FÃ¡tima Lucas, Angel T. MartÃnez, Victor Guallar Mapping the Long-Range Electron Transfer Route in Ligninolytic Peroxidases published pages: 3946-3954, ISSN: 1520-6106, DOI: 10.1021/acs.jpcb.7b00835	The Journal of Physical Chemistry B 121/16	2019-10-30
2017	Jan Kiebist, Kai-Uwe Schmidtke, JÃ¶rg Zimmermann, Harald Kellner, Nico Jehmlich, RenÃ© Ullrich, Daniel ZÃ¤nder, Martin Hofrichter, Katrin Scheibner A peroxygenase from Chaetomium globosum catalyzes the selective oxygenation of testosterone published pages: , ISSN: 1439-4227, DOI: 10.1002/cbic.201600677	ChemBioChem	2019-10-30
2018	Juan Carro, Patricia Ferreira, Angel T. MartÃnez, Giovanni Gadda Stepwise Hydrogen Atom and Proton Transfers in Dioxygen Reduction by Aryl-Alcohol Oxidase published pages: 1790-1797, ISSN: 0006-2960, DOI: 10.1021/acs.biochem.8b00106	Biochemistry 57/11	2019-10-30
2017	Alexander Karich, RenÃ© Ullrich, Katrin Scheibner, Martin Hofrichter Fungal Unspecific Peroxygenases Oxidize the Majority of Organic EPA Priority Pollutants published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2017.01463	Frontiers in Microbiology 8	2019-10-30
2018	Patricia Gomez de Santos, Marina CaÃ±ellas, Florian Tieves, Sabry H. H. Younes, Patricia Molina-Espeja, Martin Hofrichter, Frank Hollmann, Victor Guallar, Miguel Alcalde Selective Synthesis of the Human Drug Metabolite 5â€²-Hydroxypropranolol by an Evolved Self-Sufficient Peroxygenase published pages: 4789-4799, ISSN: 2155-5435, DOI: 10.1021/acscatal.8b01004	ACS Catalysis	2019-10-30
2017	AndrÃ©s Olmedo, JosÃ© C. del RÃo, Jan Kiebist, RenÃ© Ullrich, Martin Hofrichter, Katrin Scheibner, Angel T. MartÃnez, Ana GutiÃ©rrez Fatty Acid Chain Shortening by a Fungal Peroxygenase published pages: 16985-16989, ISSN: 0947-6539, DOI: 10.1002/chem.201704773	Chemistry - A European Journal 23/67	2019-10-30
2018	Juan Carro, Pep Amengual-Rigo, Ferran Sancho, Milagros Medina, Victor Guallar, Patricia Ferreira, Angel T. MartÃnez Multiple implications of an active site phenylalanine in the catalysis of aryl-alcohol oxidase published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-26445-x	Scientific Reports 8/1	2019-10-30
2018	RenÃ© Ullrich, Marzena Poraj-Kobielska, Steffi Scholze, Claire Halbout, Martin Sandvoss, Marek J. Pecyna, Katrin Scheibner, Martin Hofrichter Side chain removal from corticosteroids by unspecific peroxygenase published pages: 84-93, ISSN: 0162-0134, DOI: 10.1016/j.jinorgbio.2018.03.011	Journal of Inorganic Biochemistry 183	2019-10-30
2017	Ivan Mateljak, Thierry Tron, Miguel Alcalde Evolved Î±-factor prepro-leaders for directed laccase evolution in Saccharomyces cerevisiae published pages: 1830-1836, ISSN: 1751-7915, DOI: 10.1111/1751-7915.12838	Microbial Biotechnology 10/6	2019-10-30
2018	Sabrina Leonhardt, Enrico BÃ¼ttner, Anna Maria Gebauer, Martin Hofrichter, Harald Kellner Draft Genome Sequence of the Sordariomycete Lecythophora ( Coniochaeta ) hoffmannii CBS 245.38 published pages: e01510-17, ISSN: 2169-8287, DOI: 10.1128/genomeA.01510-17	Genome Announcements 6/7	2019-10-30
2017	IvÃ¡n Ayuso-FernÃ¡ndez, Angel T. MartÃnez, Francisco J. Ruiz-DueÃ±as Experimental recreation of the evolution of lignin-degrading enzymes from the Jurassic to date published pages: , ISSN: 1754-6834, DOI: 10.1186/s13068-017-0744-x	Biotechnology for Biofuels 10/1	2019-10-30
2019	IvÃ¡n Ayuso-FernÃ¡ndez, Antonio L. Deâ€…Lacey, Francisco J. CaÃ±ada, Francisco J. Ruiz-DueÃ±as, Angel T. MartÃnez Increase of Redox Potential during the Evolution of Enzymes Degrading Recalcitrant Lignin published pages: 2708-2712, ISSN: 0947-6539, DOI: 10.1002/chem.201805679	Chemistry - A European Journal 25/11	2019-10-30
2018	JiaJia Dong, Elena FernÃ¡ndez-Fueyo, Frank Hollmann, Caroline E. Paul, Milja Pesic, Sandy Schmidt, Yonghua Wang, Sabry Younes, Wuyuan Zhang Biocatalytic Oxidation Reactions: A Chemist\'s Perspective published pages: 9238-9261, ISSN: 1433-7851, DOI: 10.1002/anie.201800343	Angewandte Chemie International Edition 57/30	2019-10-30
2019	Florian Tieves, Fabio Tonin, Elena FernÃ¡ndez-Fueyo, John M. Robbins, Bettina Bommarius, Andreas S. Bommarius, Miguel Alcalde, Frank Hollmann Energising the E-factor: The E+-factor published pages: 1311-1314, ISSN: 0040-4020, DOI: 10.1016/j.tet.2019.01.065	Tetrahedron 75/10	2019-10-30
2019	Carmen Aranda, MartÃ Municoy, VÃctor Guallar, Jan Kiebist, Katrin Scheibner, RenÃ© Ullrich, JosÃ© C. del RÃo, Martin Hofrichter, Angel T. MartÃnez, Ana GutiÃ©rrez Selective synthesis of 4-hydroxyisophorone and 4-ketoisophorone by fungal peroxygenases published pages: , ISSN: 2044-4753, DOI: 10.1039/c8cy02114g	Catalysis Science & Technology	2019-10-30
2017	Juan R. Carro Aramburu Nuevas oxidorreductasas GMC de basidiomicetos ligninolÃticos: Screening genÃ³mico, mecanismo catalÃtico y potencial biotecnolÃ³gico published pages: , ISSN: , DOI:		2019-10-30
2018	Olmedo, AndrÃ©s Nuevas reacciones de interÃ©s industrial con peroxigenasas fÃºngicas published pages: , ISSN: , DOI:		2019-10-30
2018	Elena FernÃ¡ndez-Fueyo, Irene DavÃ³-Siguero, David Almendral, Dolores Linde, Maria Camilla Baratto, Rebecca Pogni, Antonio Romero, Victor Guallar, Angel T. MartÃnez Description of a Non-Canonical Mn(II)-Oxidation Site in Peroxidases published pages: 8386-8395, ISSN: 2155-5435, DOI: 10.1021/acscatal.8b02306	ACS Catalysis 8/9	2019-10-30
2017	Diana M. Mate, Miguel A. Palomino, Patricia Molina-Espeja, Javier Martin-Diaz, Miguel Alcalde Modification of the peroxygenative:peroxidative activity ratio in the unspecific peroxygenase from Agrocybe aegerita by structure-guided evolution published pages: , ISSN: 1741-0126, DOI: 10.1093/protein/gzw073	Protein Engineering Design and Selection	2019-10-30

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