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SYNDEGEN SIGNED

Synaptic dysfunction in Neurodegenerative Diseases

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

SYNDEGEN project word cloud

Explore the words cloud of the SYNDEGEN project. It provides you a very rough idea of what is the project "SYNDEGEN" about.

aberrant locations smes interdisciplinary alzheimer genetically therapies site synuclein whereby parkinson experts purpose diseases sites pd begin strategies proteins cell mechanisms synaptic syndegen edge huntingtin training isolated degeneration representing alpha company partnership protein groups disease sufficiently synapse technologies questions amyloid misfolding asked ndds normal burden aggregation interactive imaging linked huntington cutting roles pathologically dysfunction points biology disorders collaborative beta broad ad university spread prone expertise students centres multidisciplinary train precursor physiological scientists societies neurons cellular hd young treatment tau talented gap molecular dysfunctional synapses innovative neurodegenerative stem aging localized academic

Project "SYNDEGEN" data sheet

The following table provides information about the project.

Coordinator	LUNDS UNIVERSITET Organization address address: Paradisgatan 5c city: LUND postcode: 22100 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Sweden [SE]
Project website	http://syndegen.eu
Total cost	3˙129˙428 €
EC max contribution	3˙129˙428 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2016
Funding Scheme	MSCA-ITN-ETN
Starting year	2017
Duration (year-month-day)	from 2017-01-01 to 2020-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	LUNDS UNIVERSITET LUNDS UNIVERSITET Organization address address: Paradisgatan 5c city: LUND postcode: 22100 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (LUND)	coordinator	790˙977.00
2	CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Organization address address: RUE MICHEL ANGE 3 city: PARIS postcode: 75794 website: www.cnrs.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	788˙626.00
3	DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV Organization address address: SIGMUND FREUD STRASSE 27 city: BONN postcode: 53127 website: www.dzne.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BONN)	participant	498˙432.00
4	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	participant	273˙287.00
5	ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Organization address address: BATIMENT CE 3316 STATION 1 city: LAUSANNE postcode: 1015 website: www.epfl.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (LAUSANNE)	participant	265˙226.00
6	UMECRINE AB UMECRINE AB Organization address address: NORRLANDS UNIVERSITETSSJUKHUS city: UMEA postcode: 901 85 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (UMEA)	participant	263˙659.00
7	UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS Organization address address: Robert-Koch-Strasse 40 city: GOETTINGEN postcode: 37075 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (GOETTINGEN)	participant	249˙216.00
8	EXPLORA NOVA SARL EXPLORA NOVA SARL Organization address address: RUE ALFRED KASTLER 15 city: LA ROCHELLE postcode: 17011 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (LA ROCHELLE)	participant	0.00
9	H. LUNDBECK AS H. LUNDBECK AS Organization address address: OTTILIAVEJ 7-9 city: VALBY postcode: 2500 website: www.lundbeck.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (VALBY)	partner	0.00
10	NEUROPROOF GMBH NEUROPROOF GMBH Organization address address: FRIEDRICH BARNEWITZ STR 4 city: ROSTOCK postcode: 18119 website: www.neuroproof.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (ROSTOCK)	partner	0.00
11	SKANE LANS LANDSTING SKANE LANS LANDSTING Organization address address: . city: KRISTIANSTAD postcode: 291 89 website: www.skane.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (KRISTIANSTAD)	partner	0.00
12	SWEDISH PARKINSON FOUNDATION SWEDISH PARKINSON FOUNDATION Organization address address: n.a. city: Stockholm postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (Stockholm)	partner	0.00
13	UMEA UNIVERSITET UMEA UNIVERSITET Organization address address: UNIVERSITETOMRADET city: UMEA postcode: 901 87 website: www.umu.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (UMEA)	partner	0.00
14	UNIVERSITAET ULM UNIVERSITAET ULM Organization address address: HELMHOLTZSTRASSE 16 city: ULM postcode: 89081 website: www.uni-ulm.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (ULM)	partner	0.00

Map

Project objective

Neurodegenerative diseases (NDDs) of aging are a growing burden on societies. Although studies on the degeneration of neurons have been a main focus of research, increasing evidence points to synapses as the site where Alzheimer’s disease (AD), Parkinson’s disease (PD) and Huntington’s disease (HD) begin. There is growing evidence that synapses are sites of early and aberrant protein misfolding, aggregation and spread in NDDs. A key problem in research on NDDs has been that the normal physiological roles at synapses of the aggregation-prone proteins (β- amyloid/amyloid precursor protein, tau, α-synuclein and huntingtin), which are linked pathologically and genetically to these diseases, are not known. Using cutting-edge technologies and multidisciplinary approaches the SYNDEGEN consortium aims to bring together leading experts in cell biology, synapse biology and imaging, stem cell biology and NDDs in Europe to determine the molecular and cellular mechanisms whereby synapses become dysfunctional in AD, PD and HD for the purpose of developing novel therapies. The goal of the consortium is to train talented young scientists in interdisciplinary, innovative and collaborative research aimed at the development of novel molecular based treatment strategies for these major diseases of aging. A gap in the training of students in these important diseases is that disease expertise and novel methods to study synapses are localized in isolated groups in different locations in the EU. Similar questions are being asked about the mechanisms of synaptic dysfunction in AD, PD and HD, but no one university or company has sufficiently broad knowledge and technical expertise required to study and develop therapies for synaptic dysfunction in these disorders. This training programme will be implemented in 6 academic centres and 2 SMEs representing a comprehensive, highly interactive and multidisciplinary partnership.

Publications

List of publications.
year	authors and title	journal	last update
2018	InÃªs Caldeira BrÃ¡s, LuÃsa V. Lopes, Tiago Fleming Outeiro Sensing Î±-Synuclein From the Outside via the Prion Protein: Implications for Neurodegeneration published pages: 1675-1684, ISSN: 0885-3185, DOI: 10.1002/mds.27478	Movement Disorders 33/11	2019-07-09
2018	InÃªs Caldeira BrÃ¡s, Sandra Tenreiro, Andreia M Silva, Tiago F Outeiro Identification of novel protein phosphatases as modifiers of alpha-synuclein aggregation in yeast published pages: , ISSN: 1567-1364, DOI: 10.1093/femsyr/foy108	FEMS Yeast Research 18/8	2019-07-09

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