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DanioPattern SIGNED

Development and Evolution of Colour Patterns in Danio species

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

DanioPattern project word cloud

Explore the words cloud of the DanioPattern project. It provides you a very rough idea of what is the project "DanioPattern" about.

cas9 direct spectacularly environment golden functions mode foundation analysed recognition sexual chromatophore altered thorough mutants interactions fins vertebrate building mechanisms junctions channels explore mediated evolution evolutionary blue mate genus colour danio patterns patterning lay stripe closely lineage allelic diversities tailfins pattern basis genome opportunity molecular genetic candidate divergent kin displays zebrafish disease body understand model prominent influence revealed animals significance alternating exchanging variants species pigment organism insights tracing biodiversity crispr anal vertebrates variation stripes conspicuous rerio biology transcriptomes tested genes diversity play evolve chromatophores sequences single cellular first natural communication fundamental camouflage

Project "DanioPattern" data sheet

The following table provides information about the project.

Coordinator	MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Organization address address: HOFGARTENSTRASSE 8 city: Munich postcode: 80539 website: www.mpg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Total cost	2˙250˙000 €
EC max contribution	2˙250˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2015-AdG
Funding Scheme	ERC-ADG
Starting year	2016
Duration (year-month-day)	from 2016-11-01 to 2021-04-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Organization address address: HOFGARTENSTRASSE 8 city: Munich postcode: 80539 website: www.mpg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Munich)	coordinator	2˙250˙000.00

Map

Project objective

Colour patterns are prominent features of many animals and have important functions in communication such as camouflage, kin recognition and mate selection. Colour patterns are highly variable and evolve rapidly leading to large diversities even within a single genus. As targets for natural as well as sexual selection, they are of high evolutionary significance. The zebrafish (Danio rerio), a vertebrate model organism for the study of development and disease, displays a conspicuous pattern of alternating blue and golden stripes on the body and on the anal- and tailfins. Mutants with spectacularly altered patterns have been analysed, and novel approaches in lineage tracing have provided first insights into the cellular and molecular basis of colour patterning. These studies revealed that the mechanisms at play are novel and of fundamental interest to the biology of pattern formation. Closely related Danio species have very divergent colour patterns in body and fins offering the unique opportunity to study development and evolution of colour patterns in vertebrates building on the thorough analysis of one model species. Our research in zebrafish will explore the basis of direct interactions between chromatophores mediated by channels and junctions. We will investigate the divergent mode of stripe formation in the fins and the molecular influence of the cellular environment on chromatophore interactions. In closely related Danio species, we will investigate the cellular interactions during pattern formation. We will analyse transcriptomes and genome sequences to identify candidate genes providing the molecular basis for pigment pattern diversity. These candidate genes will be tested by creating mutants and exchanging allelic variants using the CRISPR/Cas9 system. The work will lay the foundation to understand not only the genetic basis of variation in colour pattern formation between Danio species, but also the evolution of biodiversity in other vertebrates.

Publications

List of publications.
year	authors and title	journal	last update
2020	Anastasia Eskova, Hans Georg FrohnhÃ¶fer, Christiane NÃ¼sslein-Volhard, Uwe Irion Galanin Signaling in the Brain Regulates Color Pattern Formation in Zebrafish published pages: 298-303.e3, ISSN: 0960-9822, DOI: 10.1016/j.cub.2019.11.033	Current Biology 30/2	2020-02-19
2019	Uwe Irion, Christiane NÃ¼sslein-Volhard The identification of genes involved in the evolution of color patterns in fish published pages: 31-38, ISSN: 0959-437X, DOI: 10.1016/j.gde.2019.07.002	Current Opinion in Genetics & Development 57	2020-01-28
2018	Andrey Fadeev, Patricia Mendoza-Garcia, Uwe Irion, Jikui Guan, Kathrin Pfeifer, Stephanie Wiessner, Fabrizio Serluca, Ajeet Pratap Singh, Christiane NÃ¼sslein-Volhard, Ruth H. Palmer ALKALs are in vivo ligands for ALK family receptor tyrosine kinases in the neural crest and derived cells published pages: E630-E638, ISSN: 0027-8424, DOI: 10.1073/pnas.1719137115	Proceedings of the National Academy of Sciences 115/4	2019-04-13

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