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DeMMYR SIGNED

Decoding the molecular mechanisms driving host adaptation of yellow rust on cereal crops and grasses

Total Cost €

EC-Contrib. €

Partnership

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DeMMYR project word cloud

Explore the words cloud of the DeMMYR project. It provides you a very rough idea of what is the project "DeMMYR" about.

successful mechanisms editing specialization closely previously erc drive global collect encode pathogens resistance susceptibility coupled colonization negligible resolve resist pathogenomics clusters genomic threat dataset families reveal contained infection extensive pioneered worldwide varieties levels population pathogen gene rust function genes had cereal pathogenicity disrupt uncovered genetic harvest genome molecular adapt specificity specialize isolates regions transcriptomic contribution grass grasses losses characterise expression barley races diversity evaluation resolution enhanced cocksfoot parallel expressed progression underlying yellow disease specialized host rye wheat provides insights unparalleled regulatory hosts precision triticale genetically effectors understand causing strains showed crops

Project "DeMMYR" data sheet

The following table provides information about the project.

Coordinator	JOHN INNES CENTRE Organization address address: NORWICH RESEARCH PARK COLNEY city: NORWICH postcode: NR4 7UH website: www.jic.bbsrc.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	1˙714˙779 €
EC max contribution	1˙714˙779 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2016-STG
Funding Scheme	ERC-STG
Starting year	2017
Duration (year-month-day)	from 2017-03-01 to 2022-02-28

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	JOHN INNES CENTRE JOHN INNES CENTRE Organization address address: NORWICH RESEARCH PARK COLNEY city: NORWICH postcode: NR4 7UH website: www.jic.bbsrc.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (NORWICH)	coordinator	1˙714˙779.00

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Project objective

Yellow rust (YR) disease is a major threat to cereal crops and grasses worldwide, causing significant losses to the global wheat harvest each year. The long-term aim of this research is to develop new varieties of wheat with enhanced resistance to YR. To do this, it is essential to understand host specificity - the ability of the pathogen to specialize on particular grass hosts, coupled with the ability of the host to resist infection by different strains of YR.

I recently pioneered a field-based 'pathogenomics' approach to enable a comprehensive evaluation of the genetic diversity of YR. This new method provides unparalleled resolution of the pathogen population that can identify gene families associated with the ability to cause disease on all the major hosts of YR in Europe, namely wheat barley, rye, triticale and cocksfoot grass. Using this approach, I previously uncovered a genetically distinct population of YR on triticale and showed that these isolates contained gene clusters that were specifically expressed in all isolates identified on triticale and had no or negligible levels of expression in all wheat YR isolates.

In this ERC project, I will use the pathogenomics approach to collect an extensive dataset of YR on all its major hosts, aiming to characterise genomic regions and the genes they encode to understand the underlying regulatory mechanisms that drive host specialization and adaptation. I will then assess changes at the transcriptomic level in closely related host-specialized YR races to provide insights into how pathogens adapt to new hosts. In parallel, I will identify host targets of effectors from YR to resolve the underlying molecular processes that are targeted by the pathogen to enable successful host-specific colonization. I will then disrupt the function of these host targets using precision genome editing to determine their contribution to YR pathogenicity and reveal novel susceptibility genes that are essential for pathogen progression.

Deliverables

List of deliverables.
Data management plan	Open Research Data Pilot	2019-05-31 11:58:51

Take a look to the deliverables list in detail: detailed list of DeMMYR deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Diane G. O. Saunders, Zacharias A. Pretorius, Mogens S. HovmÃ¸ller Tackling the re-emergence of wheat stem rust in Western Europe published pages: , ISSN: 2399-3642, DOI: 10.1038/s42003-019-0294-9	Communications Biology 2/1	2019-10-29
2019	M. Carvajal-Yepes, K. Cardwell, A. Nelson, K. A. Garrett, B. Giovani, D. G. O. Saunders, S. Kamoun, J. P. Legg, V. Verdier, J. Lessel, R. A. Neher, R. Day, P. Pardey, M. L. Gullino, A. R. Records, B. Bextine, J. E. Leach, S. Staiger, J. Tohme A global surveillance system for crop diseases published pages: 1237-1239, ISSN: 0036-8075, DOI: 10.1126/science.aaw1572	Science 364/6447	2019-10-29
2019	Willem H.P. Boshoff, Botma Visser, Clare Lewis, Thomas Michael Adams, Diane Saunders, Tarekegn Terefe, Tegwe Soko, Nyasha Chuiraise, Zacharias A. Pretorius First Report of Puccinia striiformis f. sp. tritici , Causing Stripe Rust of Wheat, in Zimbabwe published pages: , ISSN: 0191-2917, DOI: 10.1094/pdis-07-19-1395-pdn	Plant Disease	2019-10-29
2017	Vanessa Bueno-Sancho, Antoine Persoons, Amelia Hubbard, Luis Enrique Cabrera-Quio, Clare M Lewis, Pilar Corredor-Moreno, Daniel C E Bunting, Sajid Ali, Soonie Chng, David P Hodson, Ricardo Madariaga Burrows, Rosie Bryson, Jane Thomas, Sarah Holdgate, Diane G O Saunders Pathogenomic Analysis of Wheat Yellow Rust Lineages Detects Seasonal Variation and Host Specificity published pages: 3282-3296, ISSN: 1759-6653, DOI: 10.1093/gbe/evx241	Genome Biology and Evolution 9/12	2019-10-29
2019	E.S. Orton, C.M. Lewis, P.E. Davey, G.V. Radhakrishnan, D.G.O. Saunders Stem rust ( Puccina graminis ) identified on spring barley in the UK adjacent to infected Berberis vulgaris published pages: 11, ISSN: 2044-0588, DOI: 10.5197/j.2044-0588.2019.040.011	New Disease Reports 40	2019-10-29
2019	Pilar Corredorâ€Moreno, Diane G. O. Saunders Expecting the unexpected: factors influencing the emergence of fungal and oomycete plant pathogens published pages: , ISSN: 0028-646X, DOI: 10.1111/nph.16007	New Phytologist	2019-10-29
2019	Guru V. Radhakrishnan, Nicola M. Cook, Vanessa Bueno-Sancho, Clare M. Lewis, Antoine Persoons, Abel Debebe Mitiku, Matthew Heaton, Phoebe E. Davey, Bekele Abeyo, Yoseph Alemayehu, Ayele Badebo, Marla Barnett, Ruth Bryant, Jeron Chatelain, Xianming Chen, Suomeng Dong, Tina Henriksson, Sarah Holdgate, Annemarie F. Justesen, Jay Kalous, Zhensheng Kang, Szymon Laczny, Jean-Paul Legoff, Driecus Lesch, MARPLE, a point-of-care, strain-level disease diagnostics and surveillance tool for complex fungal pathogens published pages: , ISSN: 1741-7007, DOI: 10.1186/s12915-019-0684-y	BMC Biology 17/1	2019-10-29
2018	Clare M. Lewis, Antoine Persoons, Daniel P. Bebber, Rose N. Kigathi, Jens Maintz, Kim Findlay, Vanessa Bueno-Sancho, Pilar Corredor-Moreno, Sophie A. Harrington, Ngonidzashe Kangara, Anna Berlin, Richard GarcÃa, Silvia E. GermÃ¡n, Alena HanzalovÃ¡, David P. Hodson, Mogens S. HovmÃ¸ller, Julio Huerta-Espino, Muhammed Imtiaz, Javed Iqbal Mirza, Annemarie F. Justesen, Rients E. Niks, Ali Omrani, Meh Potential for re-emergence of wheat stem rust in the United Kingdom published pages: , ISSN: 2399-3642, DOI: 10.1038/s42003-018-0013-y	Communications Biology 1/1	2019-10-08

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