Explore the words cloud of the PATHAD project. It provides you a very rough idea of what is the project "PATHAD" about.
The following table provides information about the project.
Coordinator |
GOETEBORGS UNIVERSITET
Organization address contact info |
Coordinator Country | Sweden [SE] |
Project website | https://neurophys.gu.se/sektioner/psykiatri_och_neurokemi/neurokem |
Total cost | 1˙985˙093 € |
EC max contribution | 1˙985˙093 € (100%) |
Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
Code Call | ERC-2015-CoG |
Funding Scheme | ERC-COG |
Starting year | 2016 |
Duration (year-month-day) | from 2016-12-01 to 2021-11-30 |
Take a look of project's partnership.
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1 | GOETEBORGS UNIVERSITET | SE (GOETEBORG) | coordinator | 1˙985˙093.00 |
Critical to our understanding of Alzheimer’s disease (AD) and also to finding therapies is determining how key pathological factors interact and relate to neuronal toxicity, symptoms and disease progression. My research has focussed on amyloid beta (Aβ) moities and demonstrated that cerebrospinal fluid (CSF) Aβ42 correlates with cerebral Aβ pathology; that Aβ accumulates in the brain 10-20 years prior to onset of symptoms; and that CSF Aβ abnormalities precede CSF tau changes. However, it is increasingly clear that a simple linear model of AD aetiology and progression is inadequate. This proposal aims at developing and validating new diagnostic and prognostic biomarker tools to examine the AD pathogenesis in humans taking a broad view of AD’s multiple pathophysiological features and their putative biomarkers. The major questions, all relevant to therapeutic research, that will be addressed in my proposal include: (i) how are different forms of Aβ produced and modified; (ii) what is the toxicity of these different forms; (iii) how is this toxicity mediated; and iv) what other pathologies may contribute to or modify AD-like phenotypes? We and others have shown that Aβ monomers are relatively non-toxic. We will address the hypothesis that Aβ starts to accumulate in the brains of certain individuals due to defective clearance of the peptide. Once aggregated, Aβ acquires chemical modifications during brain incubation over years. These modified Aβ forms then induce tau hyperphosphorylation and concomitantly over-activate the immune system, resulting in neurotoxicity. Other pathologies, including α-synuclein and TDP-43, may contribute in this process. In PATHAD, we will develop and validate new diagnostic and prognostic tools using a combination of groundbreaking technologies and unique clinical materials to dissect the underlying molecular pathogenesis of AD in much greater detail than what has been possible before and facilitate the development of effective treatments.
year | authors and title | journal | last update |
---|---|---|---|
2018 |
Nicholas M. Vogt, Kymberleigh A. Romano, Burcu F. Darst, Corinne D. Engelman, Sterling C. Johnson, Cynthia M. Carlsson, Sanjay Asthana, Kaj Blennow, Henrik Zetterberg, Barbara B. Bendlin, Federico E. Rey The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer’s disease published pages: , ISSN: 1758-9193, DOI: 10.1186/s13195-018-0451-2 |
Alzheimer\'s Research & Therapy 10/1 | 2019-08-29 |
2018 |
Ã…sa Sandelius, Henrik Zetterberg, Kaj Blennow, Rocco Adiutori, Andrea Malaspina, Matilde Laura, Mary M. Reilly, Alexander M. Rossor Plasma neurofilament light chain concentration in the inherited peripheral neuropathies published pages: e518-e524, ISSN: 0028-3878, DOI: 10.1212/wnl.0000000000004932 |
Neurology 90/6 | 2019-08-29 |
2018 |
Ram A. Sharma, Andrew W. Varga, Omonigho M. Bubu, Elizabeth Pirraglia, Korey Kam, Ankit Parekh, Margaret Wohlleber, Margo D. Miller, Andreia Andrade, Clifton Lewis, Samuel Tweardy, Maja Buj, Po L. Yau, Reem Sadda, Lisa Mosconi, Yi Li, Tracy Butler, Lidia Glodzik, Els Fieremans, James S. Babb, Kaj Blennow, Henrik Zetterberg, Shou E. Lu, Sandra G. Badia, Sergio Romero, Ivana Rosenzweig, Nadia Gossel Obstructive Sleep Apnea Severity Affects Amyloid Burden in Cognitively Normal Elderly. A Longitudinal Study published pages: 933-943, ISSN: 1073-449X, DOI: 10.1164/rccm.201704-0704oc |
American Journal of Respiratory and Critical Care Medicine 197/7 | 2019-08-29 |
2018 |
Mony J. de Leon, Elizabeth Pirraglia, Ricardo S. Osorio, Lidia Glodzik, Les Saint-Louis, Hee-Jin Kim, Juan Fortea, Silvia Fossati, Eugene Laska, Carole Siegel, Tracy Butler, Yi Li, Henry Rusinek, Henrik Zetterberg, Kaj Blennow The nonlinear relationship between cerebrospinal fluid Aβ42 and tau in preclinical Alzheimer’s disease published pages: e0191240, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0191240 |
PLOS ONE 13/2 | 2019-08-29 |
2019 |
Charles Arber, Jamie Toombs, Christopher Lovejoy, Natalie S. Ryan, Ross W. Paterson, Nanet Willumsen, Eleni Gkanatsiou, Erik Portelius, Kaj Blennow, Amanda Heslegrave, Jonathan M. Schott, John Hardy, Tammaryn Lashley, Nick C. Fox, Henrik Zetterberg, Selina Wray Familial Alzheimer’s disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta published pages: , ISSN: 1359-4184, DOI: 10.1038/s41380-019-0410-8 |
Molecular Psychiatry | 2019-08-29 |
2017 |
Brownjohn, Philip W.; Smith, James; Portelius, Erik; Serneels, Lutgarde; Kvartsberg, Hlin; De Strooper, Bart; Blennow, Kaj; Zetterberg, Henrik; Livesey, Frederick J. Phenotypic Screening Identifies Modulators of Amyloid Precursor Protein Processing in Human Stem Cell Models of Alzheimer’s Disease published pages: 870-882, ISSN: 2213-6711, DOI: 10.17863/CAM.9285 |
Stem Cell Reports 4 | 2019-08-29 |
2017 |
Katarina Nägga, Anna-Märta Gustavsson, Erik Stomrud, Daniel Lindqvist, Danielle van Westen, Kaj Blennow, Henrik Zetterberg, Olle Melander, Oskar Hansson Increased midlife triglycerides predict brain β-amyloid and tau pathology 20 years later published pages: e73-e81, ISSN: 0028-3878, DOI: 10.1212/wnl.0000000000004749 |
Neurology 90/1 | 2019-08-29 |
2016 |
Antoine Leuzy, Konstantinos Chiotis, Steen G. Hasselbalch, Juha O. Rinne, Alexandre de Mendonça, Markus Otto, Alberto Lleó, Miguel Castelo-Branco, Isabel Santana, Jarkko Johansson, Sarah Anderl-Straub, Christine A. F. von Arnim, Ambros Beer, Rafael Blesa, Juan Fortea, Sanna-Kaisa Herukka, Erik Portelius, Josef Pannee, Henrik Zetterberg, Kaj Blennow, Agneta Nordberg Pittsburgh compound B imaging and cerebrospinal fluid amyloid-β in a multicentre European memory clinic study published pages: 2540-2553, ISSN: 0006-8950, DOI: 10.1093/brain/aww160 |
Brain 139/9 | 2019-08-29 |
2017 |
Ibrahim Kaya, Wojciech Michno, Dimitri Brinet, Yasmine Iacone, Giulia Zanni, Kaj Blennow, Henrik Zetterberg, Jörg Hanrieder Histology-Compatible MALDI Mass Spectrometry Based Imaging of Neuronal Lipids for Subsequent Immunofluorescent Staining published pages: 4685-4694, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.7b00313 |
Analytical Chemistry 89/8 | 2019-06-18 |
2016 |
Filipe Brogueira Rodrigues, Lauren Byrne, Peter McColgan, Nicola Robertson, Sarah J. Tabrizi, Blair R. Leavitt, Henrik Zetterberg, Edward J. Wild Cerebrospinal fluid total tau concentration predicts clinical phenotype in Huntington\'s disease published pages: 22-25, ISSN: 0022-3042, DOI: 10.1111/jnc.13719 |
Journal of Neurochemistry 139/1 | 2019-06-18 |
2018 |
Andreas Bjorefeldt, Sebastian Illes, Henrik Zetterberg, Eric Hanse Neuromodulation via the Cerebrospinal Fluid: Insights from Recent in Vitro Studies published pages: , ISSN: 1662-5110, DOI: 10.3389/fncir.2018.00005 |
Frontiers in Neural Circuits 12 | 2019-06-18 |
2017 |
Shorena Janelidze, Josef Pannee, Alvydas Mikulskis, Ping Chiao, Henrik Zetterberg, Kaj Blennow, Oskar Hansson Concordance Between Different Amyloid Immunoassays and Visual Amyloid Positron Emission Tomographic Assessment published pages: 1492, ISSN: 2168-6149, DOI: 10.1001/jamaneurol.2017.2814 |
JAMA Neurology 74/12 | 2019-06-18 |
2017 |
Simon Sjödin, Oskar Hansson, Annika Öhrfelt, Gunnar Brinkmalm, Henrik Zetterberg, Ann Brinkmalm, Kaj Blennow Mass Spectrometric Analysis of Cerebrospinal Fluid Ubiquitin in Alzheimer\'s Disease and Parkinsonian Disorders published pages: 1700100, ISSN: 1862-8346, DOI: 10.1002/prca.201700100 |
PROTEOMICS - Clinical Applications 11/11-12 | 2019-06-18 |
2018 |
Isabelle Bos, Stephanie Vos, Rik Vandenberghe, Philip Scheltens, Sebastiaan Engelborghs, Giovanni Frisoni, José Luis Molinuevo, Anders Wallin, Alberto Lleó, Julius Popp, Pablo Martinez-Lage, Alison Baird, Richard Dobson, Cristina Legido-Quigley, Kristel Sleegers, Christine Van Broeckhoven, Lars Bertram, Mara ten Kate, Frederik Barkhof, Henrik Zetterberg, Simon Lovestone, Johannes Streffer, Pieter Jelle Visser The EMIF-AD Multimodal Biomarker Discovery study: design, methods and cohort characteristics published pages: , ISSN: 1758-9193, DOI: 10.1186/s13195-018-0396-5 |
Alzheimer\'s Research & Therapy 10/1 | 2019-06-18 |
2016 |
Petra Steinacker, Kaj Blennow, Steffen Halbgebauer, Song Shi, Viktoria Ruf, Patrick Oeckl, Armin Giese, Jens Kuhle, Dana Slivarichova, Henrik Zetterberg, Markus Otto Neurofilaments in blood and CSF for diagnosis and prediction of onset in Creutzfeldt-Jakob disease published pages: , ISSN: 2045-2322, DOI: 10.1038/srep38737 |
Scientific Reports 6/1 | 2019-06-18 |
2017 |
Per Johansson, Erik G. Almqvist, Anders Wallin, Jan-Ove Johansson, Ulf Andreasson, Kaj Blennow, Henrik Zetterberg, Johan Svensson Reduced cerebrospinal fluid concentration of interleukin-12/23 subunit p40 in patients with cognitive impairment published pages: e0176760, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0176760 |
PLOS ONE 12/5 | 2019-06-18 |
2017 |
Anna Drews, Suman De, Patrick Flagmeier, David C. Wirthensohn, Wei-Hsin Chen, Daniel R. Whiten, Margarida Rodrigues, Cécile Vincke, Serge Muyldermans, Ross W. Paterson, Catherine F. Slattery, Nick C. Fox, Jonathan M. Schott, Henrik Zetterberg, Christopher M. Dobson, Sonia Gandhi, David Klenerman Inhibiting the Ca 2+ Influx Induced by Human CSF published pages: 3310-3316, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2017.11.057 |
Cell Reports 21/11 | 2019-06-18 |
2017 |
Johan Ljungqvist, Henrik Zetterberg, Marios Mitsis, Kaj Blennow, Thomas Skoglund Serum Neurofilament Light Protein as a Marker for Diffuse Axonal Injury: Results from a Case Series Study published pages: 1124-1127, ISSN: 0897-7151, DOI: 10.1089/neu.2016.4496 |
Journal of Neurotrauma 34/5 | 2019-06-18 |
2017 |
Tobias Skillbäck, Niklas Mattsson, Karl Hansson, Ekaterina Mirgorodskaya, Rahil Dahlén, Wiesje van der Flier, Philip Scheltens, Floor Duits, Oskar Hansson, Charlotte Teunissen, Kaj Blennow, Henrik Zetterberg, Johan Gobom A novel quantification-driven proteomic strategy identifies an endogenous peptide of pleiotrophin as a new biomarker of Alzheimer’s disease published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-13831-0 |
Scientific Reports 7/1 | 2019-06-18 |
2017 |
Pashtun Shahim, Henrik Zetterberg, Yelverton Tegner, Kaj Blennow Serum neurofilament light as a biomarker for mild traumatic brain injury in contact sports published pages: 1788-1794, ISSN: 0028-3878, DOI: 10.1212/WNL.0000000000003912 |
Neurology 88/19 | 2019-06-18 |
2018 |
Lenka Novakova, Avadhesh Kumar Singh, Markus Axelsson, Marcus Ståhlman, Martin Adiels, Clas Malmeström, Henrik Zetterberg, Jan Borén, Jan Lycke, Susanna L. Cardell, Maria Blomqvist Sulfatide isoform pattern in cerebrospinal fluid discriminates progressive MS from relapsing-remitting MS published pages: , ISSN: 0022-3042, DOI: 10.1111/jnc.14452 |
Journal of Neurochemistry | 2019-06-18 |
2017 |
Bob Olsson, Jonathan M. Schott, Kaj Blennow, Henrik Zetterberg The use of cerebrospinal fluid biomarkers to measure change in neurodegeneration in Alzheimer’s disease clinical trials published pages: 767-775, ISSN: 1473-7175, DOI: 10.1080/14737175.2017.1341311 |
Expert Review of Neurotherapeutics 17/8 | 2019-06-18 |
2018 |
Andrew P. Merluzzi, Cynthia M. Carlsson, Sterling C. Johnson, Suzanne E. Schindler, Sanjay Asthana, Kaj Blennow, Henrik Zetterberg, Barbara B. Bendlin Neurodegeneration, synaptic dysfunction, and gliosis are phenotypic of Alzheimer dementia published pages: 10.1212/WNL.0000, ISSN: 0028-3878, DOI: 10.1212/WNL.0000000000005901 |
Neurology | 2019-06-18 |
2018 |
Pashtun Shahim, Yelverton Tegner, Niklas Marklund, Kaj Blennow, Henrik Zetterberg Neurofilament light and tau as blood biomarkers for sports-related concussion published pages: e1780-e1788, ISSN: 0028-3878, DOI: 10.1212/WNL.0000000000005518 |
Neurology 90/20 | 2019-06-18 |
2018 |
Martin Olsson, Johan Ärlig, Jan Hedner, Kaj Blennow, Henrik Zetterberg Sleep deprivation and cerebrospinal fluid biomarkers for Alzheimer’s disease published pages: , ISSN: 0161-8105, DOI: 10.1093/sleep/zsy025 |
Sleep 41/5 | 2019-06-18 |
2018 |
Niklas Mattsson, Ruben Smith, Olof Strandberg, Sebastian Palmqvist, Michael Schöll, Philip S. Insel, Douglas Hägerström, Tomas Ohlsson, Henrik Zetterberg, Kaj Blennow, Jonas Jögi, Oskar Hansson Comparing 18 F-AV-1451 with CSF t-tau and p-tau for diagnosis of Alzheimer disease published pages: e388-e395, ISSN: 0028-3878, DOI: 10.1212/WNL.0000000000004887 |
Neurology 90/5 | 2019-06-18 |
2017 |
N.K. Magdalinou, A.J. Noyce, R. Pinto, E. Lindstrom, J. Holmén-Larsson, M. Holtta, K. Blennow, H.R. Morris, T. Skillbäck, T.T. Warner, A.J. Lees, I. Pike, M. Ward, H. Zetterberg, J. Gobom Identification of candidate cerebrospinal fluid biomarkers in parkinsonism using quantitative proteomics published pages: 65-71, ISSN: 1353-8020, DOI: 10.1016/j.parkreldis.2017.01.016 |
Parkinsonism & Related Disorders 37 | 2019-06-18 |
2017 |
Ronald Lautner, Philip S. Insel, Tobias Skillbäck, Bob Olsson, Mikael Landén, Giovanni B. Frisoni, Sanna-Kaisa Herukka, Harald Hampel, Anders Wallin, Lennart Minthon, Oskar Hansson, Kaj Blennow, Niklas Mattsson, Henrik Zetterberg Preclinical effects of APOE ε4 on cerebrospinal fluid Aβ42 concentrations published pages: , ISSN: 1758-9193, DOI: 10.1186/s13195-017-0313-3 |
Alzheimer\'s Research & Therapy 9/1 | 2019-06-18 |
2017 |
Per Johansson, Erik G. Almqvist, Maria Bjerke, Anders Wallin, Jan-Ove Johansson, Ulf Andreasson, Kaj Blennow, Henrik Zetterberg, Johan Svensson Reduced Cerebrospinal Fluid Concentration of Apolipoprotein A-I in Patients with Alzheimer’s Disease published pages: 1017-1026, ISSN: 1387-2877, DOI: 10.3233/JAD-170226 |
Journal of Alzheimer\'s Disease 59/3 | 2019-06-18 |
2018 |
Tobias Skillbäck, Ronald Lautner, Niklas Mattsson, Jonathan M. Schott, Katarina Nägga, Lena Kilander, Anders Wimo, Bengt Winblad, Maria Eriksdotter, Kaj Blennow, Henrik Zetterberg Apolipoprotein E genotypes and longevity across dementia disorders published pages: , ISSN: 1552-5260, DOI: 10.1016/j.jalz.2018.02.003 |
Alzheimer\'s & Dementia | 2019-06-18 |
2017 |
Lauren M Byrne, Filipe B Rodrigues, Kaj Blennow, Alexandra Durr, Blair R Leavitt, Raymund A C Roos, Rachael I Scahill, Sarah J Tabrizi, Henrik Zetterberg, Douglas Langbehn, Edward J Wild Neurofilament light protein in blood as a potential biomarker of neurodegeneration in Huntington\'s disease: a retrospective cohort analysis published pages: 601-609, ISSN: 1474-4422, DOI: 10.1016/S1474-4422(17)30124-2 |
The Lancet Neurology 16/8 | 2019-06-18 |
2017 |
Henrik Zetterberg Applying fluid biomarkers to Alzheimer\'s disease published pages: C3-C10, ISSN: 0363-6143, DOI: 10.1152/ajpcell.00007.2017 |
American Journal of Physiology-Cell Physiology 313/1 | 2019-06-18 |
2017 |
Erik Portelius, Gunnar Brinkmalm, Josef Pannee, Henrik Zetterberg, Kaj Blennow, Rahil Dahlén, Ann Brinkmalm, Johan Gobom Proteomic studies of cerebrospinal fluid biomarkers of Alzheimer’s disease: an update published pages: 1007-1020, ISSN: 1478-9450, DOI: 10.1080/14789450.2017.1384697 |
Expert Review of Proteomics 14/11 | 2019-06-18 |
2018 |
Lena L. Law, Rachael N. Rol, Stephanie A. Schultz, Ryan J. Dougherty, Dorothy F. Edwards, Rebecca L. Koscik, Catherine L. Gallagher, Cynthia M. Carlsson, Barbara B. Bendlin, Henrik Zetterberg, Kaj Blennow, Sanjay Asthana, Mark A. Sager, Bruce P. Hermann, Sterling C. Johnson, Dane B. Cook, Ozioma C. Okonkwo Moderate intensity physical activity associates with CSF biomarkers in a cohort at risk for Alzheimer\'s disease published pages: 188-195, ISSN: 2352-8729, DOI: 10.1016/j.dadm.2018.01.001 |
Alzheimer\'s & Dementia: Diagnosis, Assessment & Disease Monitoring 10 | 2019-06-18 |
2017 |
Philip S.J. Weston, Teresa Poole, Natalie S. Ryan, Akshay Nair, Yuying Liang, Kirsty Macpherson, Ronald Druyeh, Ian B. Malone, R. Laila Ahsan, Hugh Pemberton, Jana Klimova, Simon Mead, Kaj Blennow, Martin N. Rossor, Jonathan M. Schott, Henrik Zetterberg, Nick C. Fox Serum neurofilament light in familial Alzheimer disease published pages: 2167-2175, ISSN: 0028-3878, DOI: 10.1212/WNL.0000000000004667 |
Neurology 89/21 | 2019-06-18 |
2016 |
Henrik Zetterberg, Kaj Blennow Fluid biomarkers for mild traumatic brain injury and related conditions published pages: 563-574, ISSN: 1759-4758, DOI: 10.1038/nrneurol.2016.127 |
Nature Reviews Neurology 12/10 | 2019-06-18 |
2017 |
Andreas Pikwer, Markus Castegren, Sijal Namdar, Kaj Blennow, Henrik Zetterberg, Niklas Mattsson Effects of surgery and propofol-remifentanil total intravenous anesthesia on cerebrospinal fluid biomarkers of inflammation, Alzheimer’s disease, and neuronal injury in humans: a cohort study published pages: , ISSN: 1742-2094, DOI: 10.1186/s12974-017-0950-2 |
Journal of Neuroinflammation 14/1 | 2019-06-18 |
2016 |
Linnea Sandin, Liza Bergkvist, Sangeeta Nath, Claudia Kielkopf, Camilla Janefjord, Linda Helmfors, Henrik Zetterberg, Kaj Blennow, Hongyun Li, Camilla Nilsberth, Brett Garner, Ann-Christin Brorsson, Katarina KÃ¥gedal Beneficial effects of increased lysozyme levels in Alzheimer\'s disease modelled in Drosophila melanogaster published pages: 3508-3522, ISSN: 1742-464X, DOI: 10.1111/febs.13830 |
The FEBS Journal 283/19 | 2019-06-18 |
2018 |
Katie E. Osborn, Dandan Liu, Lauren R. Samuels, Elizabeth E. Moore, Francis E. Cambronero, Lealani Mae Y. Acosta, Susan P. Bell, Michelle A. Babicz, Elizabeth A. Gordon, Kimberly R. Pechman, L. Taylor Davis, Katherine A. Gifford, Timothy J. Hohman, Kaj Blennow, Henrik Zetterberg, Angela L. Jefferson Cerebrospinal fluid β-amyloid 42 and neurofilament light relate to white matter hyperintensities published pages: 18-25, ISSN: 0197-4580, DOI: 10.1016/j.neurobiolaging.2018.03.028 |
Neurobiology of Aging 68 | 2019-06-18 |
2016 |
Bob Olsson, Ronald Lautner, Ulf Andreasson, Annika Öhrfelt, Erik Portelius, Maria Bjerke, Mikko Hölttä, Christoffer Rosén, Caroline Olsson, Gabrielle Strobel, Elizabeth Wu, Kelly Dakin, Max Petzold, Kaj Blennow, Henrik Zetterberg CSF and blood biomarkers for the diagnosis of Alzheimer\'s disease: a systematic review and meta-analysis published pages: 673-684, ISSN: 1474-4422, DOI: 10.1016/S1474-4422(16)00070-3 |
The Lancet Neurology 15/7 | 2019-06-18 |
2016 |
Ulf Andreasson, Kaj Blennow, Henrik Zetterberg Update on ultrasensitive technologies to facilitate research on blood biomarkers for central nervous system disorders published pages: 98-102, ISSN: 2352-8729, DOI: 10.1016/j.dadm.2016.05.005 |
Alzheimer\'s & Dementia: Diagnosis, Assessment & Disease Monitoring 3 | 2019-06-18 |
2016 |
Ibrahim Kaya, Dimitri Brinet, Wojciech Michno, Stina Syvänen, Dag Sehlin, Henrik Zetterberg, Kaj Blennow, Jörg Hanrieder Delineating Amyloid Plaque Associated Neuronal Sphingolipids in Transgenic Alzheimer’s Disease Mice (tgArcSwe) Using MALDI Imaging Mass Spectrometry published pages: 347-355, ISSN: 1948-7193, DOI: 10.1021/acschemneuro.6b00391 |
ACS Chemical Neuroscience 8/2 | 2019-06-18 |
2016 |
Josef Pannee, Erik Portelius, Lennart Minthon, Johan Gobom, Ulf Andreasson, Henrik Zetterberg, Oskar Hansson, Kaj Blennow Reference measurement procedure for CSF amyloid beta (Aβ) 1-42 and the CSF Aβ 1-42 /Aβ 1-40 ratio - a cross-validation study against amyloid PET published pages: 651-658, ISSN: 0022-3042, DOI: 10.1111/jnc.13838 |
Journal of Neurochemistry 139/4 | 2019-06-18 |
2017 |
Oskar Hansson, Shorena Janelidze, Sara Hall, Nadia Magdalinou, Andrew J. Lees, Ulf Andreasson, Niklas Norgren, Jan Linder, Lars Forsgren, Radu Constantinescu, Henrik Zetterberg, Kaj Blennow Blood-based NfL published pages: 930-937, ISSN: 0028-3878, DOI: 10.1212/WNL.0000000000003680 |
Neurology 88/10 | 2019-06-18 |
2018 |
Niklas Mattsson, Colin Groot, Willemijn J. Jansen, Susan M. Landau, Victor L. Villemagne, Sebastiaan Engelborghs, Mark M. Mintun, Alberto Lleo, José Luis Molinuevo, William J. Jagust, Giovanni B. Frisoni, Adrian Ivanoiu, Gaël Chételat, Catarina Resende de Oliveira, Karen M. Rodrigue, Johannes Kornhuber, Anders Wallin, Aleksandra Klimkowicz-Mrowiec, Ramesh Kandimalla, Julius Popp, Pauline P. Aalten, Dag Aarsland, Daniel Alcolea, Ina S. Almdahl, Inês Baldeiras, Mark A. van Buchem, Enrica Cavedo, Kewei Chen, Ann D. Cohen, Stefan Förster, Juan Fortea, Kristian S. Frederiksen, Yvonne Freund-Levi, Kiran Dip Gill, Olymbia Gkatzima, Timo Grimmer, Harald Hampel, Sanna-Kaisa Herukka, Peter Johannsen, Koen van Laere, Mony J. de Leon, Wolfgang Maier, Jan Marcusson, Olga Meulenbroek, Hanne M. MøllergÃ¥rd, John C. Morris, Barbara Mroczko, Arto Nordlund, Sudesh Prabhakar, Oliver Peters, Lorena Rami, Eloy RodrÃguez-RodrÃguez, Catherine M. Roe, Eckart Rüther, Isabel Santana, Johannes Schröder, Sang W. Seo, Hilkka Soininen, Luiza Spiru, Erik Stomrud, Hanne Struyfs, Charlotte E. Teunissen, Frans R.J. Verhey, Stephanie J.B. Vos, Linda J.C. van Waalwijk van Doorn, Gunhild Waldemar, Ã…sa K. Wallin, Jens Wiltfang, Rik Vandenberghe, David J. Brooks, Tormod Fladby, Christopher C. Rowe, Alexander Drzezga, Marcel M. Verbeek, Marie Sarazin, David A. Wolk, Adam S. Fleisher, William E. Klunk, Duk L. Na, Pascual Sánchez-Juan, Dong Young Lee, Agneta Nordberg, Magda Tsolaki, Vincent Camus, Juha O. Rinne, Anne M. Fagan, Henrik Zetterberg, Kaj Blennow, Gil D. Rabinovici, Oskar Hansson, Bart N.M. van Berckel, Wiesje M. van der Flier, Philip Scheltens, Pieter Jelle Visser, Rik Ossenkoppele Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer\'s disease published pages: , ISSN: 1552-5260, DOI: 10.1016/j.jalz.2018.02.009 |
Alzheimer\'s & Dementia | 2019-06-18 |
2016 |
Joakim Bergman, Ann Dring, Henrik Zetterberg, Kaj Blennow, Niklas Norgren, Jonathan Gilthorpe, Tommy Bergenheim, Anders Svenningsson Neurofilament light in CSF and serum is a sensitive marker for axonal white matter injury in MS published pages: e271, ISSN: 2332-7812, DOI: 10.1212/NXI.0000000000000271 |
Neurology - Neuroimmunology Neuroinflammation 3/5 | 2019-06-18 |
2017 |
Suzanne J. Reid, Natasha E. Mckean, Kristen Henty, Erik Portelius, Kaj Blennow, Skye R. Rudiger, C. Simon Bawden, Renee R. Handley, Paul J. Verma, Richard L.M. Faull, Henry J. Waldvogel, Henrik Zetterberg, Russell G. Snell Alzheimer\'s disease markers in the aged sheep ( Ovis aries ) published pages: 112-119, ISSN: 0197-4580, DOI: 10.1016/j.neurobiolaging.2017.06.020 |
Neurobiology of Aging 58 | 2019-06-18 |
2017 |
Pashtun Shahim, Yelverton Tegner, Niklas Marklund, Kina Höglund, Erik Portelius, David L. Brody, Kaj Blennow, Henrik Zetterberg Astroglial activation and altered amyloid metabolism in human repetitive concussion published pages: 1400-1407, ISSN: 0028-3878, DOI: 10.1212/WNL.0000000000003816 |
Neurology 88/15 | 2019-06-18 |
2018 |
Eileanoir B. Johnson, Lauren M. Byrne, Sarah Gregory, Filipe B. Rodrigues, Kaj Blennow, Alexandra Durr, Blair R. Leavitt, Raymund A. Roos, Henrik Zetterberg, Sarah J. Tabrizi, Rachael I. Scahill, Edward J. Wild Neurofilament light protein in blood predicts regional atrophy in Huntington disease published pages: e717-e723, ISSN: 0028-3878, DOI: 10.1212/WNL.0000000000005005 |
Neurology 90/8 | 2019-06-18 |
2017 |
Anders Martin Fjell, Ane-Victoria Idland, Roser Sala-Llonch, Leiv Otto Watne, Tom Borza, Anne Brækhus, Tarjei Lona, Henrik Zetterberg, Kaj Blennow, Torgeir Bruun Wyller, Kristine Beate Walhovd Neuroinflammation and Tau Interact with Amyloid in Predicting Sleep Problems in Aging Independently of Atrophy published pages: 1-11, ISSN: 1047-3211, DOI: 10.1093/cercor/bhx157 |
Cerebral Cortex | 2019-06-18 |
2018 |
Marthe Gurine Førland, Annika Öhrfelt, Ingvild Dalen, Ole-Bjørn Tysnes, Kaj Blennow, Henrik Zetterberg, Kenn Freddy Pedersen, Guido Alves, Johannes Lange Evolution of cerebrospinal fluid total α-synuclein in Parkinson\'s disease published pages: 4-8, ISSN: 1353-8020, DOI: 10.1016/j.parkreldis.2018.01.018 |
Parkinsonism & Related Disorders 49 | 2019-06-18 |
2016 |
A. Jeppsson, Mikko Höltta, H. Zetterberg, K. Blennow, C. Wikkelsø, Mats Tullberg Amyloid mis-metabolism in idiopathic normal pressure hydrocephalus published pages: , ISSN: 2045-8118, DOI: 10.1186/s12987-016-0037-y |
Fluids and Barriers of the CNS 13/1 | 2019-06-18 |
2018 |
Ram A. Sharma, Andrew W. Varga, Omonigho M. Bubu, Elizabeth Pirraglia, Korey Kam, Ankit Parekh, Margaret Wohlleber, Margo D. Miller, Andreia Andrade, Clifton Lewis, Samuel Tweardy, Maja Buj, Po L. Yau, Reem Sadda, Lisa Mosconi, Yi Li, Tracy Butler, Lidia Glodzik, Els Fieremans, James S. Babb, Kaj Blennow, Henrik Zetterberg, Shou E. Lu, Sandra G. Badia, Sergio Romero, Ivana Rosenzweig, Nadia Gosselin, Girardin Jean-Louis, David M. Rapoport, Mony J. de Leon, Indu Ayappa, Ricardo S. Osorio Obstructive Sleep Apnea Severity Affects Amyloid Burden in Cognitively Normal Elderly. A Longitudinal Study published pages: 933-943, ISSN: 1073-449X, DOI: 10.1164/rccm.201704-0704OC |
American Journal of Respiratory and Critical Care Medicine 197/7 | 2019-06-18 |
2018 |
Ã…sa Sandelius, Henrik Zetterberg, Kaj Blennow, Rocco Adiutori, Andrea Malaspina, Matilde Laura, Mary M. Reilly, Alexander M. Rossor Plasma neurofilament light chain concentration in the inherited peripheral neuropathies published pages: e518-e524, ISSN: 0028-3878, DOI: 10.1212/WNL.0000000000004932 |
Neurology 90/6 | 2019-06-18 |
2018 |
Wojciech Michno, Ibrahim Kaya, Sofie Nyström, Laurent Guerard, K. Peter R. Nilsson, Per Hammarström, Kaj Blennow, Henrik Zetterberg, Jörg Hanrieder Multimodal Chemical Imaging of Amyloid Plaque Polymorphism Reveals Aβ Aggregation Dependent Anionic Lipid Accumulations and Metabolism published pages: 8130-8138, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.8b01361 |
Analytical Chemistry 90/13 | 2019-06-18 |
2017 |
Lotta Agholme, Marcus Clarin, Eleni Gkanatsiou, Petronella Kettunen, Jasmine Chebli, Gunnar Brinkmalm, Kaj Blennow, Petra Bergström, Erik Portelius, Henrik Zetterberg Low-dose γ-secretase inhibition increases secretion of Aβ peptides and intracellular oligomeric Aβ published pages: 211-219, ISSN: 1044-7431, DOI: 10.1016/j.mcn.2017.10.009 |
Molecular and Cellular Neuroscience 85 | 2019-06-18 |
2018 |
Ibrahim Kaya, Henrik Zetterberg, Kaj Blennow, Jörg Hanrieder Shedding Light on the Molecular Pathology of Amyloid Plaques in Transgenic Alzheimer’s Disease Mice Using Multimodal MALDI Imaging Mass Spectrometry published pages: , ISSN: 1948-7193, DOI: 10.1021/acschemneuro.8b00121 |
ACS Chemical Neuroscience | 2019-06-18 |
2018 |
Andre Strydom, Amanda Heslegrave, Carla M. Startin, Kin Y. Mok, John Hardy, Jurgen Groet, Dean Nizetic, Henrik Zetterberg Neurofilament light as a blood biomarker for neurodegeneration in Down syndrome published pages: , ISSN: 1758-9193, DOI: 10.1186/s13195-018-0367-x |
Alzheimer\'s Research & Therapy 10/1 | 2019-06-18 |
2018 |
Willemijn J. Jansen, Rik Ossenkoppele, Betty M. Tijms, Anne M. Fagan, Oskar Hansson, William E. Klunk, Wiesje M. van der Flier, Victor L. Villemagne, Giovanni B. Frisoni, Adam S. Fleisher, Alberto Lleó, Mark A. Mintun, Anders Wallin, Sebastiaan Engelborghs, Duk L. Na, Gäel Chételat, José Luis Molinuevo, Susan M. Landau, Niklas Mattsson, Johannes Kornhuber, Osama Sabri, Christopher C. Rowe, Lucilla Parnetti, Julius Popp, Tormod Fladby, William J. Jagust, Pauline Aalten, Dong Young Lee, Rik Vandenberghe, Catarina Resende de Oliveira, Elisabeth Kapaki, Lutz Froelich, Adrian Ivanoiu, Tomasz Gabryelewicz, Marcel M. Verbeek, Páscual Sanchez-Juan, Helmut Hildebrandt, Vincent Camus, Marzena Zboch, David J. Brooks, Alexander Drzezga, Juha O. Rinne, Andrew Newberg, Alexandre de Mendonça, Marie Sarazin, Gil D. Rabinovici, Karine Madsen, Milica G. Kramberger, Agneta Nordberg, Vincent Mok, Barbara Mroczko, David A. Wolk, Philipp T. Meyer, Magda Tsolaki, Philip Scheltens, Frans R. J. Verhey, Pieter Jelle Visser, Dag Aarsland, Daniel Alcolea, Myriam Alexander, Ina S. Almdahl, Steven E. Arnold, Inês Baldeiras, Henryk Barthel, Bart N.M. van Berckel, Kaj Blennow, Mark A. van Buchem, Enrica Cavedo, Kewei Chen, Elena Chipi, Ann D. Cohen, Stefan Förster, Juan Fortea, Kristian S. Frederiksen, Yvonne Freund-Levi, Olymbia Gkatzima, Mark Forrest Gordon, Timo Grimmer, Harald Hampel, Lucrezia Hausner, Sabine Hellwig, Sanna-Kaisa Herukka, Peter Johannsen, Aleksandra Klimkowicz-Mrowiec, Sebastian Köhler, Norman Koglin, Koen van Laere, Mony de Leon, Viviana Lisetti, Wolfgang Maier, Jan Marcusson, Olga Meulenbroek, Hanne M. MøllergÃ¥rd, John C. Morris, Arto Nordlund, Gerald P. Novak, George P. Paraskevas, Gayan Perera, Oliver Peters, Inez H. G. B. Ramakers, Lorena Rami, Eloy RodrÃguez-RodrÃguez, Catherine M. Roe, Uros Rot, Eckart Rüther, Isabel Santana, Johannes Schröder, Sang W. Seo, Hilkka Soininen, Luiza Spiru, Erik Stomrud, Hanne Struyfs, Charlotte E. Teunissen, Stephanie J. B. Vos, Linda J. C. van Waalwijk van Doorn, Gunhild Waldemar, Ã…sa K. Wallin, Jens Wiltfang, Henrik Zetterberg Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia published pages: 84, ISSN: 2168-622X, DOI: 10.1001/jamapsychiatry.2017.3391 |
JAMA Psychiatry 75/1 | 2019-06-18 |
2017 |
Albert M. Anderson, Jeffrey L. Lennox, Mark M. Mulligan, David W. Loring, Henrik Zetterberg, Kaj Blennow, Cari Kessing, Rajeth Koneru, Kirk Easley, William R. Tyor Cerebrospinal fluid interferon alpha levels correlate with neurocognitive impairment in ambulatory HIV-Infected individuals published pages: 106-112, ISSN: 1355-0284, DOI: 10.1007/s13365-016-0466-z |
Journal of NeuroVirology 23/1 | 2019-06-18 |
2017 |
Sebastian Palmqvist, Michael Schöll, Olof Strandberg, Niklas Mattsson, Erik Stomrud, Henrik Zetterberg, Kaj Blennow, Susan Landau, William Jagust, Oskar Hansson Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-01150-x |
Nature Communications 8/1 | 2019-06-18 |
2016 |
Pashtun Shahim, Magnus Gren, Victor Liman, Ulf Andreasson, Niklas Norgren, Yelverton Tegner, Niklas Mattsson, Niels Andreasen, Martin Öst, Henrik Zetterberg, Bengt Nellgård, Kaj Blennow Serum neurofilament light protein predicts clinical outcome in traumatic brain injury published pages: , ISSN: 2045-2322, DOI: 10.1038/srep36791 |
Scientific Reports 6/1 | 2019-06-18 |
2016 |
Filipe Brogueira Rodrigues, Lauren M. Byrne, Peter McColgan, Nicola Robertson, Sarah J. Tabrizi, Henrik Zetterberg, Edward J. Wild Cerebrospinal Fluid Inflammatory Biomarkers Reflect Clinical Severity in Huntington’s Disease published pages: e0163479, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0163479 |
PLOS ONE 11/9 | 2019-06-18 |
2018 |
Lisbeth Evered, Brendan Silbert, David A. Scott, Henrik Zetterberg, Kaj Blennow Association of Changes in Plasma Neurofilament Light and Tau Levels With Anesthesia and Surgery published pages: 542, ISSN: 2168-6149, DOI: 10.1001/jamaneurol.2017.4913 |
JAMA Neurology 75/5 | 2019-06-18 |
2017 |
Avadhesh Kumar Singh, Lenka Novakova, Markus Axelsson, Clas Malmeström, Henrik Zetterberg, Jan Lycke, Susanna L. Cardell High Interferon-γ Uniquely in Vδ1 T Cells Correlates with Markers of Inflammation and Axonal Damage in Early Multiple Sclerosis published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2017.00260 |
Frontiers in Immunology 8 | 2019-06-18 |
2017 |
Katarina Nägga, Anna-Märta Gustavsson, Erik Stomrud, Daniel Lindqvist, Danielle van Westen, Kaj Blennow, Henrik Zetterberg, Olle Melander, Oskar Hansson Increased midlife triglycerides predict brain β-amyloid and tau pathology 20 years later published pages: e73-e81, ISSN: 0028-3878, DOI: 10.1212/WNL.0000000000004749 |
Neurology 90/1 | 2019-06-18 |
2017 |
Ibrahim Kaya, Dimitri Brinet, Wojciech Michno, Mehmet Başkurt, Henrik Zetterberg, Kaj Blenow, Jörg Hanrieder Novel Trimodal MALDI Imaging Mass Spectrometry (IMS3) at 10 μm Reveals Spatial Lipid and Peptide Correlates Implicated in Aβ Plaque Pathology in Alzheimer’s Disease published pages: 2778-2790, ISSN: 1948-7193, DOI: 10.1021/acschemneuro.7b00314 |
ACS Chemical Neuroscience 8/12 | 2019-06-18 |
2017 |
G. G. Kovacs, U. Andreasson, V. Liman, G. Regelsberger, M. I. Lutz, K. Danics, E. Keller, H. Zetterberg, K. Blennow Plasma and cerebrospinal fluid tau and neurofilament concentrations in rapidly progressive neurological syndromes: a neuropathology-based cohort published pages: 1326-e77, ISSN: 1351-5101, DOI: 10.1111/ene.13389 |
European Journal of Neurology 24/11 | 2019-06-18 |
2017 |
H. Zetterberg Review: Tau in biofluids - relation to pathology, imaging and clinical features published pages: 194-199, ISSN: 0305-1846, DOI: 10.1111/nan.12378 |
Neuropathology and Applied Neurobiology 43/3 | 2019-06-18 |
2018 |
Laura Donker Kaat, Lieke H. Meeter, Wan Zheng Chiu, Shami Melhem, Agnita J.W. Boon, Kaj Blennow, Henrik Zetterberg, John C. van Swieten Serum neurofilament light chain in progressive supranuclear palsy published pages: , ISSN: 1353-8020, DOI: 10.1016/j.parkreldis.2018.06.018 |
Parkinsonism & Related Disorders | 2019-06-18 |
2018 |
Tammaryn Lashley, Jonathan M. Schott, Philip Weston, Christina E. Murray, Henny Wellington, Ashvini Keshavan, Sandrine C. Foti, Martha Foiani, Jamie Toombs, Jonathan D. Rohrer, Amanda Heslegrave, Henrik Zetterberg Molecular biomarkers of Alzheimer\'s disease: progress and prospects published pages: dmm031781, ISSN: 1754-8403, DOI: 10.1242/dmm.031781 |
Disease Models & Mechanisms 11/5 | 2019-06-18 |
2017 |
Shorena Janelidze, Joakim Hertze, Katarina Nägga, Karin Nilsson, Christer Nilsson, Malin Wennström, Danielle van Westen, Kaj Blennow, Henrik Zetterberg, Oskar Hansson Increased blood-brain barrier permeability is associated with dementia and diabetes but not amyloid pathology or APOE genotype published pages: 104-112, ISSN: 0197-4580, DOI: 10.1016/j.neurobiolaging.2016.11.017 |
Neurobiology of Aging 51 | 2019-06-18 |
2018 |
M. Axelsson, M. Sjögren, O. Andersen, K. Blennow, H. Zetterberg, J. Lycke Neurofilament light protein levels in cerebrospinal fluid predict long-term disability of Guillain-Barré syndrome: A pilot study published pages: 143-150, ISSN: 0001-6314, DOI: 10.1111/ane.12927 |
Acta Neurologica Scandinavica 138/2 | 2019-06-18 |
2018 |
Lina Bergman, Henrik Zetterberg, Helena Kaihola, Henrik Hagberg, Kaj Blennow, Helena Ã…kerud Blood-based cerebral biomarkers in preeclampsia: Plasma concentrations of NfL, tau, S100B and NSE during pregnancy in women who later develop preeclampsia - A nested case control study published pages: e0196025, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0196025 |
PLOS ONE 13/5 | 2019-06-18 |
2016 |
Petra Bergström, Lotta Agholme, Faisal Hayat Nazir, Tugce Munise Satir, Jamie Toombs, Henrietta Wellington, Joakim Strandberg, Thomas Olsson Bontell, Hlin Kvartsberg, Maria Holmström, Cecilia Boreström, Stina Simonsson, Tilo Kunath, Anders Lindahl, Kaj Blennow, Eric Hanse, Erik Portelius, Selina Wray, Henrik Zetterberg Amyloid precursor protein expression and processing are differentially regulated during cortical neuron differentiation published pages: , ISSN: 2045-2322, DOI: 10.1038/srep29200 |
Scientific Reports 6/1 | 2019-06-18 |
2018 |
Flora H. Duits, Gunnar Brinkmalm, Charlotte E. Teunissen, Ann Brinkmalm, Philip Scheltens, Wiesje M. Van der Flier, Henrik Zetterberg, Kaj Blennow Synaptic proteins in CSF as potential novel biomarkers for prognosis in prodromal Alzheimer’s disease published pages: , ISSN: 1758-9193, DOI: 10.1186/s13195-017-0335-x |
Alzheimer\'s Research & Therapy 10/1 | 2019-06-18 |
2017 |
Tobias Skillbäck, Louise Delsing, Jane Synnergren, Niklas Mattsson, Shorena Janelidze, Katarina Nägga, Lena Kilander, Ryan Hicks, Anders Wimo, Bengt Winblad, Oskar Hansson, Kaj Blennow, Maria Eriksdotter, Henrik Zetterberg CSF/serum albumin ratio in dementias: a cross-sectional study on 1861 patients published pages: 1-9, ISSN: 0197-4580, DOI: 10.1016/j.neurobiolaging.2017.06.028 |
Neurobiology of Aging 59 | 2019-06-18 |
2017 |
Niklas Mattsson, Michael Schöll, Olof Strandberg, Ruben Smith, Sebastian Palmqvist, Philip S Insel, Douglas Hägerström, Tomas Ohlsson, Henrik Zetterberg, Jonas Jögi, Kaj Blennow, Oskar Hansson 18 Fâ€AVâ€1451 and CSF Tâ€tau and Pâ€tau as biomarkers in Alzheimer\'s disease published pages: 1212-1223, ISSN: 1757-4676, DOI: 10.15252/emmm.201707809 |
EMBO Molecular Medicine 9/9 | 2019-06-18 |
2016 |
Annika Öhrfelt, Ann Brinkmalm, Julien Dumurgier, Gunnar Brinkmalm, Oskar Hansson, Henrik Zetterberg, Elodie Bouaziz-Amar, Jacques Hugon, Claire Paquet, Kaj Blennow The pre-synaptic vesicle protein synaptotagmin is a novel biomarker for Alzheimer’s disease published pages: , ISSN: 1758-9193, DOI: 10.1186/s13195-016-0208-8 |
Alzheimer\'s Research & Therapy 8/1 | 2019-06-18 |
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "PATHAD" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "PATHAD" are provided by the European Opendata Portal: CORDIS opendata.