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PATHAD SIGNED

Pathways to Alzheimer's disease

Total Cost €

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EC-Contrib. €

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 PATHAD project word cloud

Explore the words cloud of the PATHAD project. It provides you a very rough idea of what is the project "PATHAD" about.

interact    accumulate    modify    view    chemical    individuals    precede    alpha    dissect    therapies    csf    groundbreaking    pathological    fluid    beta    linear    biomarkers    pathology    modifications    brain    43    toxic    model    prognostic    brains    modified    cerebral    tdp    shown    monomers    alzheimer    biomarker    immune    induce    combination    questions    correlates    acquires    pathologies    validate    tools    technologies    activate    humans    onset    incubation    defective    accumulates    pathogenesis    pathad    aetiology    underlying    prior    therapeutic    relate    toxicity    treatments    clinical    hyperphosphorylation    moities    once    clearance    ing    aggregated    synuclein    clear    multiple    tau    mediated    cerebrospinal    certain    focussed    demonstrated    ad    abnormalities    pathophysiological    neuronal    hypothesis    forms    phenotypes    disease    diagnostic    amyloid    neurotoxicity    critical    starts    relatively    examine    putative    inadequate    materials    peptide    progression    symptoms    concomitantly    validating    broad    42    molecular   

Project "PATHAD" data sheet

The following table provides information about the project.

Coordinator
GOETEBORGS UNIVERSITET 

Organization address
address: VASAPARKEN
city: GOETEBORG
postcode: 405 30
website: www.gu.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Project website https://neurophys.gu.se/sektioner/psykiatri_och_neurokemi/neurokem
 Total cost 1˙985˙093 €
 EC max contribution 1˙985˙093 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-12-01   to  2021-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    GOETEBORGS UNIVERSITET SE (GOETEBORG) coordinator 1˙985˙093.00

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 Project objective

Critical to our understanding of Alzheimer’s disease (AD) and also to finding therapies is determining how key pathological factors interact and relate to neuronal toxicity, symptoms and disease progression. My research has focussed on amyloid beta (Aβ) moities and demonstrated that cerebrospinal fluid (CSF) Aβ42 correlates with cerebral Aβ pathology; that Aβ accumulates in the brain 10-20 years prior to onset of symptoms; and that CSF Aβ abnormalities precede CSF tau changes. However, it is increasingly clear that a simple linear model of AD aetiology and progression is inadequate. This proposal aims at developing and validating new diagnostic and prognostic biomarker tools to examine the AD pathogenesis in humans taking a broad view of AD’s multiple pathophysiological features and their putative biomarkers. The major questions, all relevant to therapeutic research, that will be addressed in my proposal include: (i) how are different forms of Aβ produced and modified; (ii) what is the toxicity of these different forms; (iii) how is this toxicity mediated; and iv) what other pathologies may contribute to or modify AD-like phenotypes? We and others have shown that Aβ monomers are relatively non-toxic. We will address the hypothesis that Aβ starts to accumulate in the brains of certain individuals due to defective clearance of the peptide. Once aggregated, Aβ acquires chemical modifications during brain incubation over years. These modified Aβ forms then induce tau hyperphosphorylation and concomitantly over-activate the immune system, resulting in neurotoxicity. Other pathologies, including α-synuclein and TDP-43, may contribute in this process. In PATHAD, we will develop and validate new diagnostic and prognostic tools using a combination of groundbreaking technologies and unique clinical materials to dissect the underlying molecular pathogenesis of AD in much greater detail than what has been possible before and facilitate the development of effective treatments.

 Publications

year authors and title journal last update
List of publications.
2018 Nicholas M. Vogt, Kymberleigh A. Romano, Burcu F. Darst, Corinne D. Engelman, Sterling C. Johnson, Cynthia M. Carlsson, Sanjay Asthana, Kaj Blennow, Henrik Zetterberg, Barbara B. Bendlin, Federico E. Rey
The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer’s disease
published pages: , ISSN: 1758-9193, DOI: 10.1186/s13195-018-0451-2
Alzheimer\'s Research & Therapy 10/1 2019-08-29
2018 Ã…sa Sandelius, Henrik Zetterberg, Kaj Blennow, Rocco Adiutori, Andrea Malaspina, Matilde Laura, Mary M. Reilly, Alexander M. Rossor
Plasma neurofilament light chain concentration in the inherited peripheral neuropathies
published pages: e518-e524, ISSN: 0028-3878, DOI: 10.1212/wnl.0000000000004932
Neurology 90/6 2019-08-29
2018 Ram A. Sharma, Andrew W. Varga, Omonigho M. Bubu, Elizabeth Pirraglia, Korey Kam, Ankit Parekh, Margaret Wohlleber, Margo D. Miller, Andreia Andrade, Clifton Lewis, Samuel Tweardy, Maja Buj, Po L. Yau, Reem Sadda, Lisa Mosconi, Yi Li, Tracy Butler, Lidia Glodzik, Els Fieremans, James S. Babb, Kaj Blennow, Henrik Zetterberg, Shou E. Lu, Sandra G. Badia, Sergio Romero, Ivana Rosenzweig, Nadia Gossel
Obstructive Sleep Apnea Severity Affects Amyloid Burden in Cognitively Normal Elderly. A Longitudinal Study
published pages: 933-943, ISSN: 1073-449X, DOI: 10.1164/rccm.201704-0704oc
American Journal of Respiratory and Critical Care Medicine 197/7 2019-08-29
2018 Mony J. de Leon, Elizabeth Pirraglia, Ricardo S. Osorio, Lidia Glodzik, Les Saint-Louis, Hee-Jin Kim, Juan Fortea, Silvia Fossati, Eugene Laska, Carole Siegel, Tracy Butler, Yi Li, Henry Rusinek, Henrik Zetterberg, Kaj Blennow
The nonlinear relationship between cerebrospinal fluid Aβ42 and tau in preclinical Alzheimer’s disease
published pages: e0191240, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0191240
PLOS ONE 13/2 2019-08-29
2019 Charles Arber, Jamie Toombs, Christopher Lovejoy, Natalie S. Ryan, Ross W. Paterson, Nanet Willumsen, Eleni Gkanatsiou, Erik Portelius, Kaj Blennow, Amanda Heslegrave, Jonathan M. Schott, John Hardy, Tammaryn Lashley, Nick C. Fox, Henrik Zetterberg, Selina Wray
Familial Alzheimer’s disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta
published pages: , ISSN: 1359-4184, DOI: 10.1038/s41380-019-0410-8
Molecular Psychiatry 2019-08-29
2017 Brownjohn, Philip W.; Smith, James; Portelius, Erik; Serneels, Lutgarde; Kvartsberg, Hlin; De Strooper, Bart; Blennow, Kaj; Zetterberg, Henrik; Livesey, Frederick J.
Phenotypic Screening Identifies Modulators of Amyloid Precursor Protein Processing in Human Stem Cell Models of Alzheimer’s Disease
published pages: 870-882, ISSN: 2213-6711, DOI: 10.17863/CAM.9285
Stem Cell Reports 4 2019-08-29
2017 Katarina Nägga, Anna-Märta Gustavsson, Erik Stomrud, Daniel Lindqvist, Danielle van Westen, Kaj Blennow, Henrik Zetterberg, Olle Melander, Oskar Hansson
Increased midlife triglycerides predict brain β-amyloid and tau pathology 20 years later
published pages: e73-e81, ISSN: 0028-3878, DOI: 10.1212/wnl.0000000000004749
Neurology 90/1 2019-08-29
2016 Antoine Leuzy, Konstantinos Chiotis, Steen G. Hasselbalch, Juha O. Rinne, Alexandre de Mendonça, Markus Otto, Alberto Lleó, Miguel Castelo-Branco, Isabel Santana, Jarkko Johansson, Sarah Anderl-Straub, Christine A. F. von Arnim, Ambros Beer, Rafael Blesa, Juan Fortea, Sanna-Kaisa Herukka, Erik Portelius, Josef Pannee, Henrik Zetterberg, Kaj Blennow, Agneta Nordberg
Pittsburgh compound B imaging and cerebrospinal fluid amyloid-β in a multicentre European memory clinic study
published pages: 2540-2553, ISSN: 0006-8950, DOI: 10.1093/brain/aww160
Brain 139/9 2019-08-29
2017 Ibrahim Kaya, Wojciech Michno, Dimitri Brinet, Yasmine Iacone, Giulia Zanni, Kaj Blennow, Henrik Zetterberg, Jörg Hanrieder
Histology-Compatible MALDI Mass Spectrometry Based Imaging of Neuronal Lipids for Subsequent Immunofluorescent Staining
published pages: 4685-4694, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.7b00313
Analytical Chemistry 89/8 2019-06-18
2016 Filipe Brogueira Rodrigues, Lauren Byrne, Peter McColgan, Nicola Robertson, Sarah J. Tabrizi, Blair R. Leavitt, Henrik Zetterberg, Edward J. Wild
Cerebrospinal fluid total tau concentration predicts clinical phenotype in Huntington\'s disease
published pages: 22-25, ISSN: 0022-3042, DOI: 10.1111/jnc.13719
Journal of Neurochemistry 139/1 2019-06-18
2018 Andreas Bjorefeldt, Sebastian Illes, Henrik Zetterberg, Eric Hanse
Neuromodulation via the Cerebrospinal Fluid: Insights from Recent in Vitro Studies
published pages: , ISSN: 1662-5110, DOI: 10.3389/fncir.2018.00005
Frontiers in Neural Circuits 12 2019-06-18
2017 Shorena Janelidze, Josef Pannee, Alvydas Mikulskis, Ping Chiao, Henrik Zetterberg, Kaj Blennow, Oskar Hansson
Concordance Between Different Amyloid Immunoassays and Visual Amyloid Positron Emission Tomographic Assessment
published pages: 1492, ISSN: 2168-6149, DOI: 10.1001/jamaneurol.2017.2814
JAMA Neurology 74/12 2019-06-18
2017 Simon Sjödin, Oskar Hansson, Annika Öhrfelt, Gunnar Brinkmalm, Henrik Zetterberg, Ann Brinkmalm, Kaj Blennow
Mass Spectrometric Analysis of Cerebrospinal Fluid Ubiquitin in Alzheimer\'s Disease and Parkinsonian Disorders
published pages: 1700100, ISSN: 1862-8346, DOI: 10.1002/prca.201700100
PROTEOMICS - Clinical Applications 11/11-12 2019-06-18
2018 Isabelle Bos, Stephanie Vos, Rik Vandenberghe, Philip Scheltens, Sebastiaan Engelborghs, Giovanni Frisoni, José Luis Molinuevo, Anders Wallin, Alberto Lleó, Julius Popp, Pablo Martinez-Lage, Alison Baird, Richard Dobson, Cristina Legido-Quigley, Kristel Sleegers, Christine Van Broeckhoven, Lars Bertram, Mara ten Kate, Frederik Barkhof, Henrik Zetterberg, Simon Lovestone, Johannes Streffer, Pieter Jelle Visser
The EMIF-AD Multimodal Biomarker Discovery study: design, methods and cohort characteristics
published pages: , ISSN: 1758-9193, DOI: 10.1186/s13195-018-0396-5
Alzheimer\'s Research & Therapy 10/1 2019-06-18
2016 Petra Steinacker, Kaj Blennow, Steffen Halbgebauer, Song Shi, Viktoria Ruf, Patrick Oeckl, Armin Giese, Jens Kuhle, Dana Slivarichova, Henrik Zetterberg, Markus Otto
Neurofilaments in blood and CSF for diagnosis and prediction of onset in Creutzfeldt-Jakob disease
published pages: , ISSN: 2045-2322, DOI: 10.1038/srep38737
Scientific Reports 6/1 2019-06-18
2017 Per Johansson, Erik G. Almqvist, Anders Wallin, Jan-Ove Johansson, Ulf Andreasson, Kaj Blennow, Henrik Zetterberg, Johan Svensson
Reduced cerebrospinal fluid concentration of interleukin-12/23 subunit p40 in patients with cognitive impairment
published pages: e0176760, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0176760
PLOS ONE 12/5 2019-06-18
2017 Anna Drews, Suman De, Patrick Flagmeier, David C. Wirthensohn, Wei-Hsin Chen, Daniel R. Whiten, Margarida Rodrigues, Cécile Vincke, Serge Muyldermans, Ross W. Paterson, Catherine F. Slattery, Nick C. Fox, Jonathan M. Schott, Henrik Zetterberg, Christopher M. Dobson, Sonia Gandhi, David Klenerman
Inhibiting the Ca 2+ Influx Induced by Human CSF
published pages: 3310-3316, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2017.11.057
Cell Reports 21/11 2019-06-18
2017 Johan Ljungqvist, Henrik Zetterberg, Marios Mitsis, Kaj Blennow, Thomas Skoglund
Serum Neurofilament Light Protein as a Marker for Diffuse Axonal Injury: Results from a Case Series Study
published pages: 1124-1127, ISSN: 0897-7151, DOI: 10.1089/neu.2016.4496
Journal of Neurotrauma 34/5 2019-06-18
2017 Tobias Skillbäck, Niklas Mattsson, Karl Hansson, Ekaterina Mirgorodskaya, Rahil Dahlén, Wiesje van der Flier, Philip Scheltens, Floor Duits, Oskar Hansson, Charlotte Teunissen, Kaj Blennow, Henrik Zetterberg, Johan Gobom
A novel quantification-driven proteomic strategy identifies an endogenous peptide of pleiotrophin as a new biomarker of Alzheimer’s disease
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-13831-0
Scientific Reports 7/1 2019-06-18
2017 Pashtun Shahim, Henrik Zetterberg, Yelverton Tegner, Kaj Blennow
Serum neurofilament light as a biomarker for mild traumatic brain injury in contact sports
published pages: 1788-1794, ISSN: 0028-3878, DOI: 10.1212/WNL.0000000000003912
Neurology 88/19 2019-06-18
2018 Lenka Novakova, Avadhesh Kumar Singh, Markus Axelsson, Marcus Ståhlman, Martin Adiels, Clas Malmeström, Henrik Zetterberg, Jan Borén, Jan Lycke, Susanna L. Cardell, Maria Blomqvist
Sulfatide isoform pattern in cerebrospinal fluid discriminates progressive MS from relapsing-remitting MS
published pages: , ISSN: 0022-3042, DOI: 10.1111/jnc.14452
Journal of Neurochemistry 2019-06-18
2017 Bob Olsson, Jonathan M. Schott, Kaj Blennow, Henrik Zetterberg
The use of cerebrospinal fluid biomarkers to measure change in neurodegeneration in Alzheimer’s disease clinical trials
published pages: 767-775, ISSN: 1473-7175, DOI: 10.1080/14737175.2017.1341311
Expert Review of Neurotherapeutics 17/8 2019-06-18
2018 Andrew P. Merluzzi, Cynthia M. Carlsson, Sterling C. Johnson, Suzanne E. Schindler, Sanjay Asthana, Kaj Blennow, Henrik Zetterberg, Barbara B. Bendlin
Neurodegeneration, synaptic dysfunction, and gliosis are phenotypic of Alzheimer dementia
published pages: 10.1212/WNL.0000, ISSN: 0028-3878, DOI: 10.1212/WNL.0000000000005901
Neurology 2019-06-18
2018 Pashtun Shahim, Yelverton Tegner, Niklas Marklund, Kaj Blennow, Henrik Zetterberg
Neurofilament light and tau as blood biomarkers for sports-related concussion
published pages: e1780-e1788, ISSN: 0028-3878, DOI: 10.1212/WNL.0000000000005518
Neurology 90/20 2019-06-18
2018 Martin Olsson, Johan Ärlig, Jan Hedner, Kaj Blennow, Henrik Zetterberg
Sleep deprivation and cerebrospinal fluid biomarkers for Alzheimer’s disease
published pages: , ISSN: 0161-8105, DOI: 10.1093/sleep/zsy025
Sleep 41/5 2019-06-18
2018 Niklas Mattsson, Ruben Smith, Olof Strandberg, Sebastian Palmqvist, Michael Schöll, Philip S. Insel, Douglas Hägerström, Tomas Ohlsson, Henrik Zetterberg, Kaj Blennow, Jonas Jögi, Oskar Hansson
Comparing 18 F-AV-1451 with CSF t-tau and p-tau for diagnosis of Alzheimer disease
published pages: e388-e395, ISSN: 0028-3878, DOI: 10.1212/WNL.0000000000004887
Neurology 90/5 2019-06-18
2017 N.K. Magdalinou, A.J. Noyce, R. Pinto, E. Lindstrom, J. Holmén-Larsson, M. Holtta, K. Blennow, H.R. Morris, T. Skillbäck, T.T. Warner, A.J. Lees, I. Pike, M. Ward, H. Zetterberg, J. Gobom
Identification of candidate cerebrospinal fluid biomarkers in parkinsonism using quantitative proteomics
published pages: 65-71, ISSN: 1353-8020, DOI: 10.1016/j.parkreldis.2017.01.016
Parkinsonism & Related Disorders 37 2019-06-18
2017 Ronald Lautner, Philip S. Insel, Tobias Skillbäck, Bob Olsson, Mikael Landén, Giovanni B. Frisoni, Sanna-Kaisa Herukka, Harald Hampel, Anders Wallin, Lennart Minthon, Oskar Hansson, Kaj Blennow, Niklas Mattsson, Henrik Zetterberg
Preclinical effects of APOE ε4 on cerebrospinal fluid Aβ42 concentrations
published pages: , ISSN: 1758-9193, DOI: 10.1186/s13195-017-0313-3
Alzheimer\'s Research & Therapy 9/1 2019-06-18
2017 Per Johansson, Erik G. Almqvist, Maria Bjerke, Anders Wallin, Jan-Ove Johansson, Ulf Andreasson, Kaj Blennow, Henrik Zetterberg, Johan Svensson
Reduced Cerebrospinal Fluid Concentration of Apolipoprotein A-I in Patients with Alzheimer’s Disease
published pages: 1017-1026, ISSN: 1387-2877, DOI: 10.3233/JAD-170226
Journal of Alzheimer\'s Disease 59/3 2019-06-18
2018 Tobias Skillbäck, Ronald Lautner, Niklas Mattsson, Jonathan M. Schott, Katarina Nägga, Lena Kilander, Anders Wimo, Bengt Winblad, Maria Eriksdotter, Kaj Blennow, Henrik Zetterberg
Apolipoprotein E genotypes and longevity across dementia disorders
published pages: , ISSN: 1552-5260, DOI: 10.1016/j.jalz.2018.02.003
Alzheimer\'s & Dementia 2019-06-18
2017 Lauren M Byrne, Filipe B Rodrigues, Kaj Blennow, Alexandra Durr, Blair R Leavitt, Raymund A C Roos, Rachael I Scahill, Sarah J Tabrizi, Henrik Zetterberg, Douglas Langbehn, Edward J Wild
Neurofilament light protein in blood as a potential biomarker of neurodegeneration in Huntington\'s disease: a retrospective cohort analysis
published pages: 601-609, ISSN: 1474-4422, DOI: 10.1016/S1474-4422(17)30124-2
The Lancet Neurology 16/8 2019-06-18
2017 Henrik Zetterberg
Applying fluid biomarkers to Alzheimer\'s disease
published pages: C3-C10, ISSN: 0363-6143, DOI: 10.1152/ajpcell.00007.2017
American Journal of Physiology-Cell Physiology 313/1 2019-06-18
2017 Erik Portelius, Gunnar Brinkmalm, Josef Pannee, Henrik Zetterberg, Kaj Blennow, Rahil Dahlén, Ann Brinkmalm, Johan Gobom
Proteomic studies of cerebrospinal fluid biomarkers of Alzheimer’s disease: an update
published pages: 1007-1020, ISSN: 1478-9450, DOI: 10.1080/14789450.2017.1384697
Expert Review of Proteomics 14/11 2019-06-18
2018 Lena L. Law, Rachael N. Rol, Stephanie A. Schultz, Ryan J. Dougherty, Dorothy F. Edwards, Rebecca L. Koscik, Catherine L. Gallagher, Cynthia M. Carlsson, Barbara B. Bendlin, Henrik Zetterberg, Kaj Blennow, Sanjay Asthana, Mark A. Sager, Bruce P. Hermann, Sterling C. Johnson, Dane B. Cook, Ozioma C. Okonkwo
Moderate intensity physical activity associates with CSF biomarkers in a cohort at risk for Alzheimer\'s disease
published pages: 188-195, ISSN: 2352-8729, DOI: 10.1016/j.dadm.2018.01.001
Alzheimer\'s & Dementia: Diagnosis, Assessment & Disease Monitoring 10 2019-06-18
2017 Philip S.J. Weston, Teresa Poole, Natalie S. Ryan, Akshay Nair, Yuying Liang, Kirsty Macpherson, Ronald Druyeh, Ian B. Malone, R. Laila Ahsan, Hugh Pemberton, Jana Klimova, Simon Mead, Kaj Blennow, Martin N. Rossor, Jonathan M. Schott, Henrik Zetterberg, Nick C. Fox
Serum neurofilament light in familial Alzheimer disease
published pages: 2167-2175, ISSN: 0028-3878, DOI: 10.1212/WNL.0000000000004667
Neurology 89/21 2019-06-18
2016 Henrik Zetterberg, Kaj Blennow
Fluid biomarkers for mild traumatic brain injury and related conditions
published pages: 563-574, ISSN: 1759-4758, DOI: 10.1038/nrneurol.2016.127
Nature Reviews Neurology 12/10 2019-06-18
2017 Andreas Pikwer, Markus Castegren, Sijal Namdar, Kaj Blennow, Henrik Zetterberg, Niklas Mattsson
Effects of surgery and propofol-remifentanil total intravenous anesthesia on cerebrospinal fluid biomarkers of inflammation, Alzheimer’s disease, and neuronal injury in humans: a cohort study
published pages: , ISSN: 1742-2094, DOI: 10.1186/s12974-017-0950-2
Journal of Neuroinflammation 14/1 2019-06-18
2016 Linnea Sandin, Liza Bergkvist, Sangeeta Nath, Claudia Kielkopf, Camilla Janefjord, Linda Helmfors, Henrik Zetterberg, Kaj Blennow, Hongyun Li, Camilla Nilsberth, Brett Garner, Ann-Christin Brorsson, Katarina KÃ¥gedal
Beneficial effects of increased lysozyme levels in Alzheimer\'s disease modelled in Drosophila melanogaster
published pages: 3508-3522, ISSN: 1742-464X, DOI: 10.1111/febs.13830
The FEBS Journal 283/19 2019-06-18
2018 Katie E. Osborn, Dandan Liu, Lauren R. Samuels, Elizabeth E. Moore, Francis E. Cambronero, Lealani Mae Y. Acosta, Susan P. Bell, Michelle A. Babicz, Elizabeth A. Gordon, Kimberly R. Pechman, L. Taylor Davis, Katherine A. Gifford, Timothy J. Hohman, Kaj Blennow, Henrik Zetterberg, Angela L. Jefferson
Cerebrospinal fluid β-amyloid 42 and neurofilament light relate to white matter hyperintensities
published pages: 18-25, ISSN: 0197-4580, DOI: 10.1016/j.neurobiolaging.2018.03.028
Neurobiology of Aging 68 2019-06-18
2016 Bob Olsson, Ronald Lautner, Ulf Andreasson, Annika Öhrfelt, Erik Portelius, Maria Bjerke, Mikko Hölttä, Christoffer Rosén, Caroline Olsson, Gabrielle Strobel, Elizabeth Wu, Kelly Dakin, Max Petzold, Kaj Blennow, Henrik Zetterberg
CSF and blood biomarkers for the diagnosis of Alzheimer\'s disease: a systematic review and meta-analysis
published pages: 673-684, ISSN: 1474-4422, DOI: 10.1016/S1474-4422(16)00070-3
The Lancet Neurology 15/7 2019-06-18
2016 Ulf Andreasson, Kaj Blennow, Henrik Zetterberg
Update on ultrasensitive technologies to facilitate research on blood biomarkers for central nervous system disorders
published pages: 98-102, ISSN: 2352-8729, DOI: 10.1016/j.dadm.2016.05.005
Alzheimer\'s & Dementia: Diagnosis, Assessment & Disease Monitoring 3 2019-06-18
2016 Ibrahim Kaya, Dimitri Brinet, Wojciech Michno, Stina Syvänen, Dag Sehlin, Henrik Zetterberg, Kaj Blennow, Jörg Hanrieder
Delineating Amyloid Plaque Associated Neuronal Sphingolipids in Transgenic Alzheimer’s Disease Mice (tgArcSwe) Using MALDI Imaging Mass Spectrometry
published pages: 347-355, ISSN: 1948-7193, DOI: 10.1021/acschemneuro.6b00391
ACS Chemical Neuroscience 8/2 2019-06-18
2016 Josef Pannee, Erik Portelius, Lennart Minthon, Johan Gobom, Ulf Andreasson, Henrik Zetterberg, Oskar Hansson, Kaj Blennow
Reference measurement procedure for CSF amyloid beta (Aβ) 1-42 and the CSF Aβ 1-42 /Aβ 1-40 ratio - a cross-validation study against amyloid PET
published pages: 651-658, ISSN: 0022-3042, DOI: 10.1111/jnc.13838
Journal of Neurochemistry 139/4 2019-06-18
2017 Oskar Hansson, Shorena Janelidze, Sara Hall, Nadia Magdalinou, Andrew J. Lees, Ulf Andreasson, Niklas Norgren, Jan Linder, Lars Forsgren, Radu Constantinescu, Henrik Zetterberg, Kaj Blennow
Blood-based NfL
published pages: 930-937, ISSN: 0028-3878, DOI: 10.1212/WNL.0000000000003680
Neurology 88/10 2019-06-18
2018 Niklas Mattsson, Colin Groot, Willemijn J. Jansen, Susan M. Landau, Victor L. Villemagne, Sebastiaan Engelborghs, Mark M. Mintun, Alberto Lleo, José Luis Molinuevo, William J. Jagust, Giovanni B. Frisoni, Adrian Ivanoiu, Gaël Chételat, Catarina Resende de Oliveira, Karen M. Rodrigue, Johannes Kornhuber, Anders Wallin, Aleksandra Klimkowicz-Mrowiec, Ramesh Kandimalla, Julius Popp, Pauline P. Aalten, Dag Aarsland, Daniel Alcolea, Ina S. Almdahl, Inês Baldeiras, Mark A. van Buchem, Enrica Cavedo, Kewei Chen, Ann D. Cohen, Stefan Förster, Juan Fortea, Kristian S. Frederiksen, Yvonne Freund-Levi, Kiran Dip Gill, Olymbia Gkatzima, Timo Grimmer, Harald Hampel, Sanna-Kaisa Herukka, Peter Johannsen, Koen van Laere, Mony J. de Leon, Wolfgang Maier, Jan Marcusson, Olga Meulenbroek, Hanne M. Møllergård, John C. Morris, Barbara Mroczko, Arto Nordlund, Sudesh Prabhakar, Oliver Peters, Lorena Rami, Eloy Rodríguez-Rodríguez, Catherine M. Roe, Eckart Rüther, Isabel Santana, Johannes Schröder, Sang W. Seo, Hilkka Soininen, Luiza Spiru, Erik Stomrud, Hanne Struyfs, Charlotte E. Teunissen, Frans R.J. Verhey, Stephanie J.B. Vos, Linda J.C. van Waalwijk van Doorn, Gunhild Waldemar, Åsa K. Wallin, Jens Wiltfang, Rik Vandenberghe, David J. Brooks, Tormod Fladby, Christopher C. Rowe, Alexander Drzezga, Marcel M. Verbeek, Marie Sarazin, David A. Wolk, Adam S. Fleisher, William E. Klunk, Duk L. Na, Pascual Sánchez-Juan, Dong Young Lee, Agneta Nordberg, Magda Tsolaki, Vincent Camus, Juha O. Rinne, Anne M. Fagan, Henrik Zetterberg, Kaj Blennow, Gil D. Rabinovici, Oskar Hansson, Bart N.M. van Berckel, Wiesje M. van der Flier, Philip Scheltens, Pieter Jelle Visser, Rik Ossenkoppele
Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer\'s disease
published pages: , ISSN: 1552-5260, DOI: 10.1016/j.jalz.2018.02.009
Alzheimer\'s & Dementia 2019-06-18
2016 Joakim Bergman, Ann Dring, Henrik Zetterberg, Kaj Blennow, Niklas Norgren, Jonathan Gilthorpe, Tommy Bergenheim, Anders Svenningsson
Neurofilament light in CSF and serum is a sensitive marker for axonal white matter injury in MS
published pages: e271, ISSN: 2332-7812, DOI: 10.1212/NXI.0000000000000271
Neurology - Neuroimmunology Neuroinflammation 3/5 2019-06-18
2017 Suzanne J. Reid, Natasha E. Mckean, Kristen Henty, Erik Portelius, Kaj Blennow, Skye R. Rudiger, C. Simon Bawden, Renee R. Handley, Paul J. Verma, Richard L.M. Faull, Henry J. Waldvogel, Henrik Zetterberg, Russell G. Snell
Alzheimer\'s disease markers in the aged sheep ( Ovis aries )
published pages: 112-119, ISSN: 0197-4580, DOI: 10.1016/j.neurobiolaging.2017.06.020
Neurobiology of Aging 58 2019-06-18
2017 Pashtun Shahim, Yelverton Tegner, Niklas Marklund, Kina Höglund, Erik Portelius, David L. Brody, Kaj Blennow, Henrik Zetterberg
Astroglial activation and altered amyloid metabolism in human repetitive concussion
published pages: 1400-1407, ISSN: 0028-3878, DOI: 10.1212/WNL.0000000000003816
Neurology 88/15 2019-06-18
2018 Eileanoir B. Johnson, Lauren M. Byrne, Sarah Gregory, Filipe B. Rodrigues, Kaj Blennow, Alexandra Durr, Blair R. Leavitt, Raymund A. Roos, Henrik Zetterberg, Sarah J. Tabrizi, Rachael I. Scahill, Edward J. Wild
Neurofilament light protein in blood predicts regional atrophy in Huntington disease
published pages: e717-e723, ISSN: 0028-3878, DOI: 10.1212/WNL.0000000000005005
Neurology 90/8 2019-06-18
2017 Anders Martin Fjell, Ane-Victoria Idland, Roser Sala-Llonch, Leiv Otto Watne, Tom Borza, Anne Brækhus, Tarjei Lona, Henrik Zetterberg, Kaj Blennow, Torgeir Bruun Wyller, Kristine Beate Walhovd
Neuroinflammation and Tau Interact with Amyloid in Predicting Sleep Problems in Aging Independently of Atrophy
published pages: 1-11, ISSN: 1047-3211, DOI: 10.1093/cercor/bhx157
Cerebral Cortex 2019-06-18
2018 Marthe Gurine Førland, Annika Öhrfelt, Ingvild Dalen, Ole-Bjørn Tysnes, Kaj Blennow, Henrik Zetterberg, Kenn Freddy Pedersen, Guido Alves, Johannes Lange
Evolution of cerebrospinal fluid total α-synuclein in Parkinson\'s disease
published pages: 4-8, ISSN: 1353-8020, DOI: 10.1016/j.parkreldis.2018.01.018
Parkinsonism & Related Disorders 49 2019-06-18
2016 A. Jeppsson, Mikko Höltta, H. Zetterberg, K. Blennow, C. Wikkelsø, Mats Tullberg
Amyloid mis-metabolism in idiopathic normal pressure hydrocephalus
published pages: , ISSN: 2045-8118, DOI: 10.1186/s12987-016-0037-y
Fluids and Barriers of the CNS 13/1 2019-06-18
2018 Ram A. Sharma, Andrew W. Varga, Omonigho M. Bubu, Elizabeth Pirraglia, Korey Kam, Ankit Parekh, Margaret Wohlleber, Margo D. Miller, Andreia Andrade, Clifton Lewis, Samuel Tweardy, Maja Buj, Po L. Yau, Reem Sadda, Lisa Mosconi, Yi Li, Tracy Butler, Lidia Glodzik, Els Fieremans, James S. Babb, Kaj Blennow, Henrik Zetterberg, Shou E. Lu, Sandra G. Badia, Sergio Romero, Ivana Rosenzweig, Nadia Gosselin, Girardin Jean-Louis, David M. Rapoport, Mony J. de Leon, Indu Ayappa, Ricardo S. Osorio
Obstructive Sleep Apnea Severity Affects Amyloid Burden in Cognitively Normal Elderly. A Longitudinal Study
published pages: 933-943, ISSN: 1073-449X, DOI: 10.1164/rccm.201704-0704OC
American Journal of Respiratory and Critical Care Medicine 197/7 2019-06-18
2018 Ã…sa Sandelius, Henrik Zetterberg, Kaj Blennow, Rocco Adiutori, Andrea Malaspina, Matilde Laura, Mary M. Reilly, Alexander M. Rossor
Plasma neurofilament light chain concentration in the inherited peripheral neuropathies
published pages: e518-e524, ISSN: 0028-3878, DOI: 10.1212/WNL.0000000000004932
Neurology 90/6 2019-06-18
2018 Wojciech Michno, Ibrahim Kaya, Sofie Nyström, Laurent Guerard, K. Peter R. Nilsson, Per Hammarström, Kaj Blennow, Henrik Zetterberg, Jörg Hanrieder
Multimodal Chemical Imaging of Amyloid Plaque Polymorphism Reveals Aβ Aggregation Dependent Anionic Lipid Accumulations and Metabolism
published pages: 8130-8138, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.8b01361
Analytical Chemistry 90/13 2019-06-18
2017 Lotta Agholme, Marcus Clarin, Eleni Gkanatsiou, Petronella Kettunen, Jasmine Chebli, Gunnar Brinkmalm, Kaj Blennow, Petra Bergström, Erik Portelius, Henrik Zetterberg
Low-dose γ-secretase inhibition increases secretion of Aβ peptides and intracellular oligomeric Aβ
published pages: 211-219, ISSN: 1044-7431, DOI: 10.1016/j.mcn.2017.10.009
Molecular and Cellular Neuroscience 85 2019-06-18
2018 Ibrahim Kaya, Henrik Zetterberg, Kaj Blennow, Jörg Hanrieder
Shedding Light on the Molecular Pathology of Amyloid Plaques in Transgenic Alzheimer’s Disease Mice Using Multimodal MALDI Imaging Mass Spectrometry
published pages: , ISSN: 1948-7193, DOI: 10.1021/acschemneuro.8b00121
ACS Chemical Neuroscience 2019-06-18
2018 Andre Strydom, Amanda Heslegrave, Carla M. Startin, Kin Y. Mok, John Hardy, Jurgen Groet, Dean Nizetic, Henrik Zetterberg
Neurofilament light as a blood biomarker for neurodegeneration in Down syndrome
published pages: , ISSN: 1758-9193, DOI: 10.1186/s13195-018-0367-x
Alzheimer\'s Research & Therapy 10/1 2019-06-18
2018 Willemijn J. Jansen, Rik Ossenkoppele, Betty M. Tijms, Anne M. Fagan, Oskar Hansson, William E. Klunk, Wiesje M. van der Flier, Victor L. Villemagne, Giovanni B. Frisoni, Adam S. Fleisher, Alberto Lleó, Mark A. Mintun, Anders Wallin, Sebastiaan Engelborghs, Duk L. Na, Gäel Chételat, José Luis Molinuevo, Susan M. Landau, Niklas Mattsson, Johannes Kornhuber, Osama Sabri, Christopher C. Rowe, Lucilla Parnetti, Julius Popp, Tormod Fladby, William J. Jagust, Pauline Aalten, Dong Young Lee, Rik Vandenberghe, Catarina Resende de Oliveira, Elisabeth Kapaki, Lutz Froelich, Adrian Ivanoiu, Tomasz Gabryelewicz, Marcel M. Verbeek, Páscual Sanchez-Juan, Helmut Hildebrandt, Vincent Camus, Marzena Zboch, David J. Brooks, Alexander Drzezga, Juha O. Rinne, Andrew Newberg, Alexandre de Mendonça, Marie Sarazin, Gil D. Rabinovici, Karine Madsen, Milica G. Kramberger, Agneta Nordberg, Vincent Mok, Barbara Mroczko, David A. Wolk, Philipp T. Meyer, Magda Tsolaki, Philip Scheltens, Frans R. J. Verhey, Pieter Jelle Visser, Dag Aarsland, Daniel Alcolea, Myriam Alexander, Ina S. Almdahl, Steven E. Arnold, Inês Baldeiras, Henryk Barthel, Bart N.M. van Berckel, Kaj Blennow, Mark A. van Buchem, Enrica Cavedo, Kewei Chen, Elena Chipi, Ann D. Cohen, Stefan Förster, Juan Fortea, Kristian S. Frederiksen, Yvonne Freund-Levi, Olymbia Gkatzima, Mark Forrest Gordon, Timo Grimmer, Harald Hampel, Lucrezia Hausner, Sabine Hellwig, Sanna-Kaisa Herukka, Peter Johannsen, Aleksandra Klimkowicz-Mrowiec, Sebastian Köhler, Norman Koglin, Koen van Laere, Mony de Leon, Viviana Lisetti, Wolfgang Maier, Jan Marcusson, Olga Meulenbroek, Hanne M. Møllergård, John C. Morris, Arto Nordlund, Gerald P. Novak, George P. Paraskevas, Gayan Perera, Oliver Peters, Inez H. G. B. Ramakers, Lorena Rami, Eloy Rodríguez-Rodríguez, Catherine M. Roe, Uros Rot, Eckart Rüther, Isabel Santana, Johannes Schröder, Sang W. Seo, Hilkka Soininen, Luiza Spiru, Erik Stomrud, Hanne Struyfs, Charlotte E. Teunissen, Stephanie J. B. Vos, Linda J. C. van Waalwijk van Doorn, Gunhild Waldemar, Åsa K. Wallin, Jens Wiltfang, Henrik Zetterberg
Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia
published pages: 84, ISSN: 2168-622X, DOI: 10.1001/jamapsychiatry.2017.3391
JAMA Psychiatry 75/1 2019-06-18
2017 Albert M. Anderson, Jeffrey L. Lennox, Mark M. Mulligan, David W. Loring, Henrik Zetterberg, Kaj Blennow, Cari Kessing, Rajeth Koneru, Kirk Easley, William R. Tyor
Cerebrospinal fluid interferon alpha levels correlate with neurocognitive impairment in ambulatory HIV-Infected individuals
published pages: 106-112, ISSN: 1355-0284, DOI: 10.1007/s13365-016-0466-z
Journal of NeuroVirology 23/1 2019-06-18
2017 Sebastian Palmqvist, Michael Schöll, Olof Strandberg, Niklas Mattsson, Erik Stomrud, Henrik Zetterberg, Kaj Blennow, Susan Landau, William Jagust, Oskar Hansson
Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-01150-x
Nature Communications 8/1 2019-06-18
2016 Pashtun Shahim, Magnus Gren, Victor Liman, Ulf Andreasson, Niklas Norgren, Yelverton Tegner, Niklas Mattsson, Niels Andreasen, Martin Öst, Henrik Zetterberg, Bengt Nellgård, Kaj Blennow
Serum neurofilament light protein predicts clinical outcome in traumatic brain injury
published pages: , ISSN: 2045-2322, DOI: 10.1038/srep36791
Scientific Reports 6/1 2019-06-18
2016 Filipe Brogueira Rodrigues, Lauren M. Byrne, Peter McColgan, Nicola Robertson, Sarah J. Tabrizi, Henrik Zetterberg, Edward J. Wild
Cerebrospinal Fluid Inflammatory Biomarkers Reflect Clinical Severity in Huntington’s Disease
published pages: e0163479, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0163479
PLOS ONE 11/9 2019-06-18
2018 Lisbeth Evered, Brendan Silbert, David A. Scott, Henrik Zetterberg, Kaj Blennow
Association of Changes in Plasma Neurofilament Light and Tau Levels With Anesthesia and Surgery
published pages: 542, ISSN: 2168-6149, DOI: 10.1001/jamaneurol.2017.4913
JAMA Neurology 75/5 2019-06-18
2017 Avadhesh Kumar Singh, Lenka Novakova, Markus Axelsson, Clas Malmeström, Henrik Zetterberg, Jan Lycke, Susanna L. Cardell
High Interferon-γ Uniquely in Vδ1 T Cells Correlates with Markers of Inflammation and Axonal Damage in Early Multiple Sclerosis
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2017.00260
Frontiers in Immunology 8 2019-06-18
2017 Katarina Nägga, Anna-Märta Gustavsson, Erik Stomrud, Daniel Lindqvist, Danielle van Westen, Kaj Blennow, Henrik Zetterberg, Olle Melander, Oskar Hansson
Increased midlife triglycerides predict brain β-amyloid and tau pathology 20 years later
published pages: e73-e81, ISSN: 0028-3878, DOI: 10.1212/WNL.0000000000004749
Neurology 90/1 2019-06-18
2017 Ibrahim Kaya, Dimitri Brinet, Wojciech Michno, Mehmet Başkurt, Henrik Zetterberg, Kaj Blenow, Jörg Hanrieder
Novel Trimodal MALDI Imaging Mass Spectrometry (IMS3) at 10 μm Reveals Spatial Lipid and Peptide Correlates Implicated in Aβ Plaque Pathology in Alzheimer’s Disease
published pages: 2778-2790, ISSN: 1948-7193, DOI: 10.1021/acschemneuro.7b00314
ACS Chemical Neuroscience 8/12 2019-06-18
2017 G. G. Kovacs, U. Andreasson, V. Liman, G. Regelsberger, M. I. Lutz, K. Danics, E. Keller, H. Zetterberg, K. Blennow
Plasma and cerebrospinal fluid tau and neurofilament concentrations in rapidly progressive neurological syndromes: a neuropathology-based cohort
published pages: 1326-e77, ISSN: 1351-5101, DOI: 10.1111/ene.13389
European Journal of Neurology 24/11 2019-06-18
2017 H. Zetterberg
Review: Tau in biofluids - relation to pathology, imaging and clinical features
published pages: 194-199, ISSN: 0305-1846, DOI: 10.1111/nan.12378
Neuropathology and Applied Neurobiology 43/3 2019-06-18
2018 Laura Donker Kaat, Lieke H. Meeter, Wan Zheng Chiu, Shami Melhem, Agnita J.W. Boon, Kaj Blennow, Henrik Zetterberg, John C. van Swieten
Serum neurofilament light chain in progressive supranuclear palsy
published pages: , ISSN: 1353-8020, DOI: 10.1016/j.parkreldis.2018.06.018
Parkinsonism & Related Disorders 2019-06-18
2018 Tammaryn Lashley, Jonathan M. Schott, Philip Weston, Christina E. Murray, Henny Wellington, Ashvini Keshavan, Sandrine C. Foti, Martha Foiani, Jamie Toombs, Jonathan D. Rohrer, Amanda Heslegrave, Henrik Zetterberg
Molecular biomarkers of Alzheimer\'s disease: progress and prospects
published pages: dmm031781, ISSN: 1754-8403, DOI: 10.1242/dmm.031781
Disease Models & Mechanisms 11/5 2019-06-18
2017 Shorena Janelidze, Joakim Hertze, Katarina Nägga, Karin Nilsson, Christer Nilsson, Malin Wennström, Danielle van Westen, Kaj Blennow, Henrik Zetterberg, Oskar Hansson
Increased blood-brain barrier permeability is associated with dementia and diabetes but not amyloid pathology or APOE genotype
published pages: 104-112, ISSN: 0197-4580, DOI: 10.1016/j.neurobiolaging.2016.11.017
Neurobiology of Aging 51 2019-06-18
2018 M. Axelsson, M. Sjögren, O. Andersen, K. Blennow, H. Zetterberg, J. Lycke
Neurofilament light protein levels in cerebrospinal fluid predict long-term disability of Guillain-Barré syndrome: A pilot study
published pages: 143-150, ISSN: 0001-6314, DOI: 10.1111/ane.12927
Acta Neurologica Scandinavica 138/2 2019-06-18
2018 Lina Bergman, Henrik Zetterberg, Helena Kaihola, Henrik Hagberg, Kaj Blennow, Helena Ã…kerud
Blood-based cerebral biomarkers in preeclampsia: Plasma concentrations of NfL, tau, S100B and NSE during pregnancy in women who later develop preeclampsia - A nested case control study
published pages: e0196025, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0196025
PLOS ONE 13/5 2019-06-18
2016 Petra Bergström, Lotta Agholme, Faisal Hayat Nazir, Tugce Munise Satir, Jamie Toombs, Henrietta Wellington, Joakim Strandberg, Thomas Olsson Bontell, Hlin Kvartsberg, Maria Holmström, Cecilia Boreström, Stina Simonsson, Tilo Kunath, Anders Lindahl, Kaj Blennow, Eric Hanse, Erik Portelius, Selina Wray, Henrik Zetterberg
Amyloid precursor protein expression and processing are differentially regulated during cortical neuron differentiation
published pages: , ISSN: 2045-2322, DOI: 10.1038/srep29200
Scientific Reports 6/1 2019-06-18
2018 Flora H. Duits, Gunnar Brinkmalm, Charlotte E. Teunissen, Ann Brinkmalm, Philip Scheltens, Wiesje M. Van der Flier, Henrik Zetterberg, Kaj Blennow
Synaptic proteins in CSF as potential novel biomarkers for prognosis in prodromal Alzheimer’s disease
published pages: , ISSN: 1758-9193, DOI: 10.1186/s13195-017-0335-x
Alzheimer\'s Research & Therapy 10/1 2019-06-18
2017 Tobias Skillbäck, Louise Delsing, Jane Synnergren, Niklas Mattsson, Shorena Janelidze, Katarina Nägga, Lena Kilander, Ryan Hicks, Anders Wimo, Bengt Winblad, Oskar Hansson, Kaj Blennow, Maria Eriksdotter, Henrik Zetterberg
CSF/serum albumin ratio in dementias: a cross-sectional study on 1861 patients
published pages: 1-9, ISSN: 0197-4580, DOI: 10.1016/j.neurobiolaging.2017.06.028
Neurobiology of Aging 59 2019-06-18
2017 Niklas Mattsson, Michael Schöll, Olof Strandberg, Ruben Smith, Sebastian Palmqvist, Philip S Insel, Douglas Hägerström, Tomas Ohlsson, Henrik Zetterberg, Jonas Jögi, Kaj Blennow, Oskar Hansson
18 F‐AV‐1451 and CSF T‐tau and P‐tau as biomarkers in Alzheimer\'s disease
published pages: 1212-1223, ISSN: 1757-4676, DOI: 10.15252/emmm.201707809
EMBO Molecular Medicine 9/9 2019-06-18
2016 Annika Öhrfelt, Ann Brinkmalm, Julien Dumurgier, Gunnar Brinkmalm, Oskar Hansson, Henrik Zetterberg, Elodie Bouaziz-Amar, Jacques Hugon, Claire Paquet, Kaj Blennow
The pre-synaptic vesicle protein synaptotagmin is a novel biomarker for Alzheimer’s disease
published pages: , ISSN: 1758-9193, DOI: 10.1186/s13195-016-0208-8
Alzheimer\'s Research & Therapy 8/1 2019-06-18

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For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "PATHAD" are provided by the European Opendata Portal: CORDIS opendata.

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