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TILC SIGNED

Targeting Innate Lymphoid Cells

Total Cost €

EC-Contrib. €

Partnership

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TILC project word cloud

Explore the words cloud of the TILC project. It provides you a very rough idea of what is the project "TILC" about.

biology discovered roles preliminary revealing innate cytotoxic newly answers showing nk lymphoid ilc2 contribution ilc1 lymphocyte models complement vivo considerably unknown respective frontiers opens ligands dissecting natura commensals humans refuge data intestine unprecedented concerning organs dysbiosis vestiges repopulation questions immune function editing tumor building helper unclear cancer create manipulating notion nkp46 limiting deficiencies evolution ncrilc3 nature ilcs phylogenetic recognition tilc molecular cells functions explore immunity mice express surveillance appendix selective homeostasis cecum pressing perspectives mouse cfp clinical properdin ilc serve ilc3 hence gut selectively mode dissect challenged patients believe

Project "TILC" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITE D'AIX MARSEILLE Organization address address: Boulevard Charles Livon 58 city: Marseille postcode: 13284 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Total cost	2˙500˙000 €
EC max contribution	2˙500˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2015-AdG
Funding Scheme	ERC-ADG
Starting year	2017
Duration (year-month-day)	from 2017-01-01 to 2021-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITE D'AIX MARSEILLE UNIVERSITE D'AIX MARSEILLE Organization address address: Boulevard Charles Livon 58 city: Marseille postcode: 13284 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (Marseille)	coordinator	2˙500˙000.00

Map

Project objective

TILC focuses on Innate Lymphoid Cells (ILCs). ILCs are a newly discovered type of lymphocyte, and their study opens up new perspectives for understanding and manipulating of immunity. ILCs include cytotoxic ILCs (NK cells) and helper-like ILCs (ILC1, ILC2 & ILC3). Studies of ILC2 cells have advanced considerably, but much remains unknown about the respective roles of NK, ILC1 and ILC3 cells. TILC aims to explore new frontiers in ILC biology, by focusing on these subsets of ILCs in mice and humans, through five specific aims. 1. NK cells, ILC1 & NCRILC3 are known to express NKp46 in humans and mice, but the nature of the NKp46 ligands remains unclear, limiting our understanding of the biology of these three major ILC subsets. We thus aim to identify the NKp46 ligands, building on our preliminary data showing that Complement Factor P (CFP, Properdin) is involved in NKp46 recognition, hence revealing an unprecedented mode of immune recognition. 2. We also aim to create new mouse models selectively targeting these ILC subsets in vivo. We will then use these models for dissecting out the selective roles of ILC subsets in two major immune functions: cancer surveillance and gut homeostasis. 3. In cancer, we will investigate the contribution of these cells to tumor editing. 4. In the intestine, we will focus on the homeostasis of the cecum and appendix. These organs were long considered to be vestiges of evolution, but our own recent findings and those of phylogenetic studies have challenged this notion. We thus aim to address the role of ILC subsets in the cecum/appendix, and determine whether these organs serve as a refuge for repopulation with commensals after dysbiosis. 5. Finally, we aim to identify patients with deficiencies in ILCs, to dissect the function of these cells in natura. From the molecular scale to that of patients, we believe that TILC will provide answers to some of the most pressing questions concerning the role and clinical potential of NKp46 ILCs

Publications

List of publications.
year	authors and title	journal	last update
2019	Thorbald van Hall, Pascale AndrÃ©, Amir Horowitz, Dan Fu Ruan, Linda Borst, Robert Zerbib, Emilie Narni-Mancinelli, Sjoerd H. van der Burg, Eric Vivier Monalizumab: inhibiting the novel immune checkpoint NKG2A published pages: , ISSN: 2051-1426, DOI: 10.1186/s40425-019-0761-3	Journal for ImmunoTherapy of Cancer 7/1	2020-04-15
2018	Laura Chiossone, Eric Vivier Nouvelles frontiÃ¨res de la lutte contre le cancer published pages: 61-67, ISSN: 2105-0678, DOI: 10.1051/jbio/2019011	Biologie Aujourd\'hui 212/3-4	2020-04-15
2019	Jessica Vetters, Mary J. van Helden, Sigrid Wahlen, Simon J. Tavernier, Arne Martens, Farzaneh Fayazpour, Karl Vergote, Manon Vanheerswynghels, Kim Deswarte, Justine Van Moorleghem, Sofie De Prijck, Nozomi Takahashi, Peter Vandenabeele, Louis Boon, Geert van Loo, Eric Vivier, Bart N. Lambrecht, Sophie Janssens The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF published pages: 2010-2023, ISSN: 0022-1007, DOI: 10.1084/jem.20182164	Journal of Experimental Medicine 216/9	2020-04-15
2018	Linda Quatrini, Elisabeth Wieduwild, Bertrand Escaliere, Jessica Filtjens, Lionel Chasson, Caroline Laprie, Eric Vivier, Sophie Ugolini Endogenous glucocorticoids control host resistance to viral infection through the tissue-specific regulation of PD-1 expression on NK cells published pages: 954-962, ISSN: 1529-2908, DOI: 10.1038/s41590-018-0185-0	Nature Immunology 19/9	2019-09-09
2018	Francisca F. Almeida, Sara Tognarelli, Antoine MarÃ§ais, Andrew J. Kueh, Miriam E. Friede, Yang Liao, Simon N. Willis, Kylie Luong, Fabrice Faure, Francois E. Mercier, Justine Galluso, Matthew Firth, Emilie Narni-Mancinelli, Bushra Rais, David T. Scadden, Francesco Spallotta, Sandra Weil, Ariane Giannattasio, Franziska Kalensee, Tobias ZÃ¶ller, Nicholas D. Huntington, Ulrike Schleicher, Andreas G. A point mutation in the Ncr1 signal peptide impairs the development of innate lymphoid cell subsets published pages: e1475875, ISSN: 2162-402X, DOI: 10.1080/2162402x.2018.1475875	OncoImmunology 7/10	2019-09-09
2018	Susanna S Ng, Fernando Souza-Fonseca-Guimaraes, Fabian de Labastida Rivera, Fiona H Amante, Rajiv Kumar, Yulong Gao, Meru Sheel, Lynette Beattie, Marcela Montes de Oca, Camille Guillerey, Chelsea L Edwards, Rebecca J Faleiro, Teija Frame, Patrick T Bunn, Eric Vivier, Dale I Godfrey, Daniel G Pellicci, J Alejandro Lopez, Katherine T Andrews, Nicholas D Huntington, Mark J Smyth, James McCarthy, Chri Rapid loss of group 1 innate lymphoid cells during blood stage Plasmodium infection published pages: e1003, ISSN: 2050-0068, DOI: 10.1002/cti2.1003	Clinical & Translational Immunology 7/1	2019-09-09
2019	CharlÃ¨ne Niogret, S. M. Shahjahan Miah, Giorgia Rota, Nicolas P. Fonta, Haiping Wang, Werner Held, Walter Birchmeier, Veronica Sexl, Wentian Yang, Eric Vivier, Ping-Chih Ho, Laurent Brossay, Greta Guarda Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-09431-3	Nature Communications 10/1	2019-08-29
2018	Pascale AndrÃ©, Caroline Denis, Caroline Soulas, Clarisse Bourbon-Caillet, Julie Lopez, Thomas Arnoux, Mathieu BlÃ©ry, CÃ©cile Bonnafous, Laurent Gauthier, Ariane Morel, Benjamin Rossi, Romain Remark, Violette Breso, Elodie Bonnet, Guillaume Habif, Sophie Guia, Ana Ines Lalanne, Caroline Hoffmann, Olivier Lantz, JÃ©rÃ´me Fayette, AgnÃ¨s Boyer-Chammard, Robert Zerbib, Pierre Dodion, Hormas Ghadiall Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells published pages: 1731-1743.e13, ISSN: 0092-8674, DOI: 10.1016/j.cell.2018.10.014	Cell 175/7	2019-08-29
2018	Linda Quatrini, Eric Vivier, Sophie Ugolini Neuroendocrine regulation of innate lymphoid cells published pages: 120-136, ISSN: 0105-2896, DOI: 10.1111/imr.12707	Immunological Reviews 286/1	2019-08-29
2019	Adeline Crinier, Eric Vivier, Mathieu BlÃ©ry Helper-like innate lymphoid cells and cancer immunotherapy published pages: 101274, ISSN: 1044-5323, DOI: 10.1016/j.smim.2019.04.002	Seminars in Immunology	2019-08-29
2018	Adeline Crinier, Pierre Milpied, Bertrand EscaliÃ¨re, Christelle Piperoglou, Justine Galluso, AnaÃ¯s Balsamo, Lionel Spinelli, Inaki Cervera-Marzal, MikaÃ«l Ebbo, Mathilde Girard-Madoux, SÃ©bastien Jaeger, Emilie Bollon, Sami Hamed, Jean Hardwigsen, Sophie Ugolini, FrÃ©dÃ©ric VÃ©ly, Emilie Narni-Mancinelli, Eric Vivier High-Dimensional Single-Cell Analysis Identifies Organ-Specific Signatures and Conserved NK Cell Subsets in Humans and Mice published pages: 971-986.e5, ISSN: 1074-7613, DOI: 10.1016/j.immuni.2018.09.009	Immunity 49/5	2019-08-29
2018	Giorgia Rota, CharlÃ¨ne Niogret, Anh Thu Dang, Cristina Ramon Barros, Nicolas Pierre Fonta, Francesca Alfei, Leonor Morgado, Dietmar Zehn, Walter Birchmeier, Eric Vivier, Greta Guarda Shp-2 Is Dispensable for Establishing T Cell Exhaustion and for PD-1 Signaling InÂ Vivo published pages: 39-49, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2018.03.026	Cell Reports 23/1	2019-06-13
2017	Emilie Narni-Mancinelli, Laurent Gauthier, Myriam Baratin, Sophie Guia, Aurore Fenis, Ala-Eddine Deghmane, Benjamin Rossi, Patrick Fourquet, Bertrand EscaliÃ¨re, Yann M. Kerdiles, Sophie Ugolini, Muhamed-Kheir Taha, Eric Vivier Complement factor P is a ligand for the natural killer cellâ€“activating receptor NKp46 published pages: eaam9628, ISSN: 2470-9468, DOI: 10.1126/sciimmunol.aam9628	Science Immunology 2/10	2019-06-13
2018	Eric Vivier, David Artis, Marco Colonna, Andreas Diefenbach, James P. Di Santo, GÃ©rard Eberl, Shigeo Koyasu, Richard M. Locksley, Andrew N.J. McKenzie, Reina E. Mebius, Fiona Powrie, Hergen Spits Innate Lymphoid Cells: 10 Years On published pages: 1054-1066, ISSN: 0092-8674, DOI: 10.1016/j.cell.2018.07.017	Cell 174/5	2019-06-13
2019	Laurent Gauthier, Ariane Morel, Nadia Anceriz, Benjamin Rossi, Audrey Blanchard-Alvarez, Gwendoline Grondin, Sylvia Trichard, CÃ©dric Cesari, Melody Sapet, FrÃ©dÃ©ric Bosco, HÃ©lÃ¨ne Rispaud-Blanc, Franceline Guillot, StÃ©phanie Cornen, Alain Roussel, BÃ©atrice Amigues, Guillaume Habif, Flavien Caraguel, Sandrine Arrufat, Romain Remark, FranÃ§ois RomagnÃ©, Yannis Morel, Emilie Narni-Mancinelli, Er Multifunctional Natural Killer Cell Engagers Targeting NKp46 Trigger Protective Tumor Immunity published pages: 1701-1713.e16, ISSN: 0092-8674, DOI: 10.1016/j.cell.2019.04.041	Cell 177/7	2019-09-05
2018	Laura Chiossone, Pierre-Yves Dumas, Margaux Vienne, Eric Vivier Natural killer cells and other innate lymphoid cells in cancer published pages: 671-688, ISSN: 1474-1733, DOI: 10.1038/s41577-018-0061-z	Nature Reviews Immunology 18/11	2019-09-05
2018	Mathilde J.H. Girard-Madoux, Mercedes Gomez de AgÃ¼ero, Stephanie C. Ganal-Vonarburg, Catherine Mooser, Gabrielle T. Belz, Andrew J. Macpherson, Eric Vivier The immunological functions of the Appendix: An example of redundancy? published pages: 31-44, ISSN: 1044-5323, DOI: 10.1016/j.smim.2018.02.005	Seminars in Immunology 36	2019-09-05

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