Explore the words cloud of the DiVineGenoMe project. It provides you a very rough idea of what is the project "DiVineGenoMe" about.
The following table provides information about the project.
Coordinator |
UNIVERSITAT ZURICH
Organization address contact info |
Coordinator Country | Switzerland [CH] |
Total cost | 1˙500˙000 € |
EC max contribution | 1˙500˙000 € (100%) |
Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
Code Call | ERC-2016-STG |
Funding Scheme | ERC-STG |
Starting year | 2017 |
Duration (year-month-day) | from 2017-04-01 to 2022-03-31 |
Take a look of project's partnership.
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1 | UNIVERSITAT ZURICH | CH (Zürich) | coordinator | 1˙500˙000.00 |
Cells must ensure the integrity of their genome, and failure to do so can lead to mutations and cause disease. A sophisticated molecular network senses genomic lesions and coordinates their faithful repair with other DNA transactions, including transcription and DNA replication. Research over the last years has significantly advanced our understanding of the DNA damage response and continues to provide crucial insights that explain how cells deal with genotoxic stress to avoid malignant transformation.
More recently, the intriguing phenomenon of cellular heterogeneity reached into the limelight as it became increasingly clear that significant variability exists between individual cells, even of the same genetic background and cell type. Single cells matter, for instance during cellular transformation or tumor relapse, and cellular variability thus impacts disease development and therapeutic outcome. Its determinants are surprisingly unexplored, however, and have not been studied in context of genome integrity maintenance.
The main objective of this project is to systematically assess cellular heterogeneity in genome integrity maintenance and characterize its causes and consequences. Quantitative automated high-content imaging of large cell cohorts will be used to identify hitherto unknown determinants of variability in the cellular responses to genotoxic stress and dissect at the single cell level the variability in (1) the chromatin response to DNA double-strand breaks, (2) the cellular response to replication stress, and (3) the cellular capacity to trigger phase transitions, a newly emerging mechanism of dynamic compartmentalization, at sites of genomic lesions. This project will bridge two thus far independently developed research fields (genome stability and cellular heterogeneity), reveal how cell-to-cell variation impacts cell fate and survival in response to genotoxic stress, and may uncover ways to homogenize this response for improved cancer therapies.
year | authors and title | journal | last update |
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2018 |
Matthias Altmeyer Cells take a break when they are TIAR ed published pages: , ISSN: 1469-221X, DOI: 10.15252/embr.201847403 |
EMBO reports 20/1 | 2019-11-22 |
2019 |
Sinan Kilic, Aleksandra Lezaja, Marco Gatti, Eliana Bianco, Jone Michelena, Ralph Imhof, Matthias Altmeyer Phase separation of 53 BP 1 determines liquidâ€like behavior of DNA repair compartments published pages: , ISSN: 0261-4189, DOI: 10.15252/embj.2018101379 |
The EMBO Journal 38/16 | 2019-11-22 |
2019 |
Federico Teloni, Jone Michelena, Aleksandra Lezaja, Sinan Kilic, Christina Ambrosi, Shruti Menon, Jana Dobrovolna, Ralph Imhof, Pavel Janscak, Tuncay Baubec, Matthias Altmeyer Efficient Pre-mRNA Cleavage Prevents Replication-Stress-Associated Genome Instability published pages: 670-683.e12, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2018.11.036 |
Molecular Cell 73/4 | 2019-11-22 |
2018 |
Aleksandra Lezaja, Matthias Altmeyer Inherited DNA lesions determine G1 duration in the next cell cycle published pages: 24-32, ISSN: 1538-4101, DOI: 10.1080/15384101.2017.1383578 |
Cell Cycle 17/1 | 2019-05-06 |
2017 |
Stefania Pellegrino, Jone Michelena, Federico Teloni, Ralph Imhof, Matthias Altmeyer Replication-Coupled Dilution of H4K20me2 Guides 53BP1 to Pre-replicative Chromatin published pages: 1819-1831, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2017.05.016 |
Cell Reports 19/9 | 2019-05-06 |
2018 |
Michelena, Jone; Lezaja, Aleksandra; Teloni, Federico; Schmid, Thomas; Imhof, Ralph; Altmeyer, Matthias Analysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance published pages: , ISSN: 2041-1723, DOI: 10.5167/uzh-152720 |
Nature Communications | 2019-04-18 |
2018 |
Ina Klusmann, Kai Wohlberedt, Anna Magerhans, Federico Teloni, Jan O. Korbel, Matthias Altmeyer, Matthias Dobbelstein Chromatin modifiers Mdm2 and RNF2 prevent RNA:DNA hybrids that impair DNA replication published pages: 201809592, ISSN: 0027-8424, DOI: 10.1073/pnas.1809592115 |
Proceedings of the National Academy of Sciences | 2019-04-18 |
2018 |
Sara Przetocka, Antonio Porro, Hella A. Bolck, Christina Walker, Aleksandra Lezaja, Anika Trenner, Christine von Aesch, Sarah-Felicitas Himmels, Alan D. D’Andrea, Raphael Ceccaldi, Matthias Altmeyer, Alessandro A. Sartori CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress published pages: 568-582.e6, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2018.09.014 |
Molecular Cell 72/3 | 2019-04-18 |
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