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Lifebrain SIGNED

Healthy minds from 0-100 years: Optimising the use of European brain imaging cohorts

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

Lifebrain project word cloud

Explore the words cloud of the Lifebrain project. It provides you a very rough idea of what is the project "Lifebrain" about.

enterprise health database birth brain longitudinal unparalleled policy methodological clinical disorders medium neuroimaging moderators total integrative biobanks decline therapeutic fine imaging collection earlier integration lifespan archives conceptual enrichment our obtain online maintenance public infrastructures cognitive examinations mental lay differences datasets synergies efficient onset harmonising databases harmonisation stages enriching aberrant contributions analytical exceeding grained protective preventive regional registries risk foundation linking sized intervention individuals genetic sme prevention integrating realized base life cohorts close stakeholders extensively age additional centres determinants data strategies course diagnosis national small

Project "Lifebrain" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITETET I OSLO Organization address address: PROBLEMVEIEN 5-7 city: OSLO postcode: 313 website: www.uio.no contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Norway [NO]
Project website	http://www.lifebrain.uio.no
Total cost	10˙768˙225 €
EC max contribution	10˙000˙000 € (93%)
Programme	1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
Code Call	H2020-SC1-2016-RTD
Funding Scheme	RIA
Starting year	2017
Duration (year-month-day)	from 2017-01-01 to 2021-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITETET I OSLO UNIVERSITETET I OSLO Organization address address: PROBLEMVEIEN 5-7 city: OSLO postcode: 313 website: www.uio.no contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (OSLO)	coordinator	2˙410˙087.00
2	VITAS AS VITAS AS Organization address address: GAUSTADALLEEN 21 city: OSLO postcode: 349 website: www.vitas.no contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (OSLO)	participant	1˙617˙360.00
3	UNIVERSITAET zu LUEBECK UNIVERSITAET zu LUEBECK Organization address address: RATZEBURGER ALLEE 160 city: LUBECK postcode: 23562 website: http://www.uni-luebeck.de/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (LUBECK)	participant	1˙277˙775.00
4	MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Organization address address: HOFGARTENSTRASSE 8 city: MUENCHEN postcode: 80539 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	682˙875.00
5	FOLKEHELSEINSTITUTTET FOLKEHELSEINSTITUTTET Organization address address: LOVISENBERGGATA 8 city: OSLO postcode: 456 website: www.fhi.no contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (OSLO)	participant	681˙685.00
6	UMEA UNIVERSITET UMEA UNIVERSITET Organization address address: UNIVERSITETOMRADET city: UMEA postcode: 901 87 website: www.umu.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (UMEA)	participant	643˙725.00
7	REGION HOVEDSTADEN REGION HOVEDSTADEN Organization address address: KONGENS VAENGE 2 city: HILLEROD postcode: 3400 website: www.regionh.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (HILLEROD)	participant	624˙406.00
8	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Organization address address: WELLINGTON SQUARE UNIVERSITY OFFICES city: OXFORD postcode: OX1 2JD website: www.ox.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (OXFORD)	participant	533˙775.00
9	STICHTING VUMC STICHTING VUMC Organization address address: DE BOELELAAN 1117 city: AMSTERDAM postcode: 1081 HV website: www.vumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	526˙402.00
10	UNIVERSITAT DE BARCELONA UNIVERSITAT DE BARCELONA Organization address address: GRAN VIA DE LES CORTS CATALANES 585 city: BARCELONA postcode: 8007 website: http://www.ub.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	435˙028.00
11	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	participant	417˙505.00
12	Stiftelsen Frischsenteret for samfunnsøkonomisk forskning Stiftelsen Frischsenteret for samfunnsøkonomisk forskning Organization address address: Gaustadalléen 21 city: Oslo postcode: 349 website: http://www.frisch.uio.no/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (Oslo)	participant	149˙375.00
13	MEDICAL RESEARCH COUNCIL MEDICAL RESEARCH COUNCIL Organization address address: NORTH STAR AVENUE POLARIS HOUSE 2 FLOOR DAVID PHILLIPS BUILDING city: SWINDON postcode: SN2 1FL website: www.mrc.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SWINDON)	participant	0.00
14	UNIVERSITE DE GENEVE UNIVERSITE DE GENEVE Organization address address: RUE DU GENERAL DUFOUR 24 city: GENEVE postcode: 1211 website: www.unige.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (GENEVE)	participant	0.00

Map

Project objective

Our main objective is to identify determinants of brain, cognitive and mental health at different stages of life. By integration, harmonisation and enrichment of major European neuroimaging studies of age differences and changes, we will obtain an unparalleled database of fine-grained brain, cognitive and mental health measures of more than 6.000 individuals. Longitudinal brain imaging, genetic and health data are available for a major part, as well as cognitive/mental health measures for extensively broader cohorts, exceeding 40.000 examinations in total. By linking these data, also to additional databases and biobanks, including birth registries, national and regional archives, and by enriching them with new online data collection and novel measures, we will address risk and protective factors of brain, cognitive and mental health throughout the lifespan. We will identify the pathways through which risk and protective factors work and their moderators. Through exploitation of, and synergies with, existing European infrastructures and initiatives, this approach of integrating, harmonising and enriching brain imaging datasets will make major conceptual, methodological and analytical contributions towards large integrative cohorts and their efficient exploitation. We will thus provide novel information on brain, cognitive and mental health maintenance, onset and course of brain, cognitive and mental disorders, and lay a foundation for earlier diagnosis of brain disorders, aberrant development and decline of brain, cognitive and mental health, as well as future preventive and therapeutic strategies. Working with stakeholders and health authorities, the project will provide the evidence base for policy strategies for prevention and intervention, improving clinical practice and public health policy for brain, cognitive and mental health. This project is realized by a close collaboration of small and medium-sized enterprise (SME) and major European brain research centres

Deliverables

List of deliverables.
DEC strategy and Operative plan â€“ Update	Documents, reports	2020-04-02 12:20:21
Lifebrain conference in Berlin	Documents, reports	2020-04-02 12:20:34
Policy reviews on cognitive & mental well-being across all age groups - I	Documents, reports	2020-04-02 12:19:56
Enrichment of existing cohorts by administration of buccal swabs for epigenetic analyses across WP4 tasks 2-6	Documents, reports	2020-04-02 09:25:13
Exploitation and IP management strategy - I	Documents, reports	2020-04-02 12:20:08
Online platform for collection of questionnaire and test data for data enrichment	Documents, reports	2020-04-02 09:25:55
DBS assays for relevant biomarkers for data enrichment	Documents, reports	2020-04-02 09:26:14
Enrichment of existing cohorts by home collection of DBS to be analysed across WP4 tasks 2-6	Documents, reports	2020-04-02 09:24:53
GWAS data and harmonization of genetic data across samples for genetic analyses across WP4 tasks 2-6	Documents, reports	2020-04-02 09:25:34
Lifebrain gender equity report (R)	Documents, reports	2020-02-20 09:42:24
DEC Strategy, Operative Plan and SOPs for the Lifebrain project	Documents, reports	2020-02-20 09:42:24
Kick-off meeting completed; advisory board, safety board, executive board instantiated	Documents, reports	2020-02-20 09:42:24
Risk and protective factors for cognitive and mental health in broader epidemiological samples	Documents, reports	2020-02-20 09:42:24
Online/mobile tools for stakeholder engagement conceptualized and developed	Documents, reports	2020-02-20 09:42:24
List of relevant stakeholders for project engagement	Documents, reports	2020-02-20 09:42:24
Multi-modal MRI-data processing stream which allows for a state-of-the art central integration of data across sites	Documents, reports	2020-02-20 09:42:24
Data obtained from national registries; incl standardization, integration, quality control and pooling with existing data across sites	Documents, reports	2020-02-20 09:42:24
Input to the Dissemination, Exploitation and Communication(DEC) plan (T5.1)	Documents, reports	2020-02-20 09:42:24
Novel longitudinal statistical tools, allowing to tackle challenges associated with multi-side mixed model lifespan data	Documents, reports	2020-02-20 09:42:24
Communication management routines and infrastructure implemented	Documents, reports	2020-02-20 09:42:24
Data storage and processing system to share data, manage data access and integrated analysis	Documents, reports	2020-02-20 09:42:24
Dissemination tools and communication strategies - I	Documents, reports	2020-02-20 09:42:24
Tool for post hoc harmonization of MRI data across sites, to allow integration of data from different scanners/sites	Documents, reports	2020-02-20 09:42:24
Enrichment of existing cohorts by online data collection	Documents, reports	2020-02-20 09:42:24
Financial and legal management routines implemented	Documents, reports	2020-02-20 09:42:24
Data harmonization guidelines and standardized data management/processing protocol across sites	Documents, reports	2020-02-20 09:42:24

Take a look to the deliverables list in detail: detailed list of Lifebrain deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Alexa M. Morcom, Richard N.A. Henson Increased Prefrontal Activity with Aging Reflects Nonspecific Neural Responses Rather than Compensation published pages: 7303-7313, ISSN: 0270-6474, DOI: 10.1523/jneurosci.1701-17.2018	The Journal of Neuroscience 38/33	2020-03-05
2019	Sana Suri, Anya Topiwala, Michael A. Chappell, Thomas W. Okell, Eniko Zsoldos, Archana Singh-Manoux, Mika KivimÃ¤ki, Clare E. Mackay, Klaus P. Ebmeier Association of Midlife Cardiovascular Risk Profiles With Cerebral Perfusion at Older Ages published pages: e195776, ISSN: 2574-3805, DOI: 10.1001/jamanetworkopen.2019.5776	JAMA Network Open 2/6	2020-03-05
2019	Kathy Y. Liu, Julio Acosta-Cabronero, Arturo Cardenas-Blanco, Clare Loane, Alex J. Berry, Matthew J. Betts, Rogier A. Kievit, Richard N. Henson, Emrah DÃ¼zel, Robert Howard, Dorothea HÃ¤mmerer InÂ vivo visualization of age-related differences in the locus coeruleus published pages: 101-111, ISSN: 0197-4580, DOI: 10.1016/j.neurobiolaging.2018.10.014	Neurobiology of Aging 74	2020-03-05
2019	Barbara Bodorkos Friedman, Sana Suri, Cristina SolÃ©-PadullÃ©s, Sandra DÃ¼zel, Christian A Drevon, William F C BaarÃ©, David BartrÃ©s-Faz, Anders M Fjell, Heidi Johansen-Berg, Kathrine S Madsen, Lars Nyberg, Brenda W J H Penninx, Claire Sexton, Kristine B Walhovd, EnikÅ‘ Zsoldos, Isabelle Budin-LjÃ¸sne Are People Ready for Personalized Brain Health? Perspectives of Research Participants in the Lifebrain Consortium published pages: , ISSN: 0016-9013, DOI: 10.1093/geront/gnz155	The Gerontologist	2020-03-05
2019	Anders M Fjell, Ã˜ystein SÃ¸rensen, Inge K Amlien, David BartrÃ©s-Faz, Didac MaciÃ¡ Bros, Nikolaus Buchmann, Ilja Demuth, Christian A Drevon, Sandra DÃ¼zel, Klaus P Ebmeier, Ane-Victoria Idland, Tim C Kietzmann, Rogier Kievit, Simone KÃ¼hn, Ulman Lindenberger, Athanasia M Mowinckel, Lars Nyberg, Darren Price, Claire E Sexton, Cristina SolÃ©-PadullÃ©s, Sara Pudas, Donatas Sederevicius, Sana Suri, G Self-reported sleep relates to hippocampal atrophy across the adult lifespan â€“ results from the Lifebrain consortium published pages: , ISSN: 0161-8105, DOI: 10.1093/sleep/zsz280	Sleep	2020-03-05
2019	Delia Fuhrmann, David Nesbitt, Meredith Shafto, James B. Rowe, Darren Price, Andrew Gadie, Rogier A. Kievit, Lorraine K. Tyler, Carol Brayne, Edward T. Bullmore, Andrew C. Calder, Rhodri Cusack, Tim Dalgleish, John Duncan, Richard N. Henson, Fiona E. Matthews, William D. Marslen-Wilson, James B. Rowe, Meredith A. Shafto, Karen Campbell, Teresa Cheung, Simon Davis, Linda Geerligs, Rogier Kievit, An Strong and specific associations between cardiovascular risk factors and white matter micro- and macrostructure in healthy aging published pages: 46-55, ISSN: 0197-4580, DOI: 10.1016/j.neurobiolaging.2018.10.005	Neurobiology of Aging 74	2020-03-05
2019	Ross Jacobucci, Andreas M. Brandmaier, Rogier A. Kievit A Practical Guide to Variable Selection in Structural Equation Modeling by Using Regularized Multiple-Indicators, Multiple-Causes Models published pages: 55-76, ISSN: 2515-2459, DOI: 10.1177/2515245919826527	Advances in Methods and Practices in Psychological Science 2/1	2020-03-05
2020	Paolo Ghisletta, Fabio Mason, Timo von Oertzen, Christopher Hertzog, Lars-GÃ¶ran Nilsson, Ulman Lindenberger On the use of growth models to study normal cognitive aging published pages: 88-96, ISSN: 0165-0254, DOI: 10.1177/0165025419851576	International Journal of Behavioral Development 44/1	2020-03-05
2018	M. AnatÃ¼rk, N. Demnitz, K.P. Ebmeier, C.E. Sexton A systematic review and meta-analysis of structural magnetic resonance imaging studies investigating cognitive and social activity levels in older adults published pages: 71-84, ISSN: 0149-7634, DOI: 10.1016/j.neubiorev.2018.06.012	Neuroscience & Biobehavioral Reviews 93	2020-02-20
2018	, Cam-Can; Henson, Richard; Valenzuela, Michael; Spink, Molly; Matthews, Fiona; Shafto, Meredith; Chan, Dennis; Kievit, Rogier Lifestyle activities in mid-life contribute to cognitive reserve in late-life, independent of education, occupation and late-life activities published pages: , ISSN: , DOI: 10.1101/267831	1	2020-02-20
2018	Kristine B. Walhovd, Anders M. Fjell, RenÃ© Westerhausen, Lars Nyberg, Klaus P. Ebmeier, Ulman Lindenberger, David BartrÃ©s-Faz, William F.C. BaarÃ©, Hartwig R. Siebner, Richard Henson, Christian A. Drevon, Gun Peggy StrÃ¸mstad Knudsen, Isabelle Budin LjÃ¸sne, Brenda W.J.H. Penninx, Paolo Ghisletta, Ole Rogeberg, Lorraine Tyler, Lars Bertram Healthy minds 0â€“100 years: Optimising the use of European brain imaging cohorts (â€œLifebrainâ€) published pages: 47-56, ISSN: 0924-9338, DOI: 10.1016/j.eurpsy.2017.12.006	European Psychiatry 50	2020-02-20
2017	Rogier A. Kievit, Andreas M. Brandmaier, Gabriel Ziegler, Anne-Laura van Harmelen, Susanne M.M. de Mooij, Michael Moutoussis, Ian M. Goodyer, Ed Bullmore, Peter B. Jones, Peter Fonagy, Ulman Lindenberger, Raymond J. Dolan Developmental cognitive neuroscience using latent change score models: A tutorial and applications published pages: , ISSN: 1878-9293, DOI: 10.1016/j.dcn.2017.11.007	Developmental Cognitive Neuroscience	2020-02-20
2018	Susanne M.M. de Mooij, Richard N.A. Henson, Lourens J. Waldorp, Rogier A. Kievit Age Differentiation within Gray Matter, White Matter, and between Memory and White Matter in an Adult Life Span Cohort published pages: 5826-5836, ISSN: 0270-6474, DOI: 10.1523/jneurosci.1627-17.2018	The Journal of Neuroscience 38/25	2020-02-20

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The information about "LIFEBRAIN" are provided by the European Opendata Portal: CORDIS opendata.