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ResisTEST SIGNED

Developing a rapid diagnostic kit for antibiotic resistance

Total Cost €

EC-Contrib. €

Partnership

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ResisTEST project word cloud

Explore the words cloud of the ResisTEST project. It provides you a very rough idea of what is the project "ResisTEST" about.

sensitivity worldwide unprecedented million cultures infections specialized fast precision regard medical meantime training bacteria resistest causing alternative rationalize dna isolation amr causative fight erc enforced bacterial requirement misuse molecular biology spectrum time epidemic resistance advantage diagnostics costly limiting dire 2050 once antimicrobial drawbacks reduce monitoring hospitalization least administration detection kit antibiotics critical suspected stg gene abuse annually morbidity occurrences weeks staple marked expression diagnostic turnaround treatments treatment certain 700 pathogen longer prior expertise inefficient hence degree sequencing strains antibiotic deaths disruptive globally breakthrough sensitive putative attempts faster

Project "ResisTEST" data sheet

The following table provides information about the project.

Coordinator	UNIVERSIDAD AUTONOMA DE BARCELONA Organization address address: CALLE CAMPUS UNIVERSITARIO SN CERDANYOLA V city: CERDANYOLA DEL VALLES postcode: 8290 website: http://www.uab.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Total cost	150˙000 €
EC max contribution	150˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2018-PoC
Funding Scheme	ERC-POC
Starting year	2019
Duration (year-month-day)	from 2019-01-01 to 2020-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSIDAD AUTONOMA DE BARCELONA UNIVERSIDAD AUTONOMA DE BARCELONA Organization address address: CALLE CAMPUS UNIVERSITARIO SN CERDANYOLA V city: CERDANYOLA DEL VALLES postcode: 8290 website: http://www.uab.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (CERDANYOLA DEL VALLES)	coordinator	150˙000.00

Map

Project objective

Antimicrobial resistance (AMR) has become a worldwide epidemic, causing more than for 700.000 deaths per year globally, expected to rise to 10 million deaths annually, by 2050. AMR is associated with an increase in morbidity, longer hospitalization time and a marked increase in the associated medical costs. While several attempts are being enforced to reduce the misuse and abuse of antibiotics, we are in dire needs of methods to rationalize the use of antibiotics. Currently, bacterial cultures are the staple diagnostic method of AMR. However, this method presents important drawbacks, such as a long turnaround time, which can be up to two weeks for some bacterial strains, low sensitivity, and the requirement to have, at least to a certain degree, prior information on the putative causative bacteria. All in all, these factors lead to the administration of wide-spectrum antibiotics in the meantime, leading to inefficient treatments, antibiotic changes and AMR occurrences. Hence, it is critical developing novel diagnostic methods offering a faster, high-sensitive alternative to bacterial cultures, the staple in AMR diagnostics. While several systems, such as DNA sequencing, are currently being developed, they require costly equipment and specialized training, limiting its use. In this regard, in ResisTEST we take advantage of our expertise in molecular biology and the knowledge and technology developed in an ERC StG to propose a fast, high-sensitive AMR detection approach that, once further developed into a diagnostic kit, will allow the isolation and real-time monitoring of the expression of different resistance gene without the need of prior knowledge on the pathogen. Therefore, this disruptive approach could represent a significant breakthrough in the fight against AMR, allowing to define, with unprecedented precision, the antibiotic of choice for the treatment of infections where AMR is suspected.

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The information about "RESISTEST" are provided by the European Opendata Portal: CORDIS opendata.