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Halo SIGNED

Development and Application of a New Class of Halogenated Reagents to Commercially Valuable Targets

Total Cost €

EC-Contrib. €

Partnership

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Halo project word cloud

Explore the words cloud of the Halo project. It provides you a very rough idea of what is the project "Halo" about.

surgeons industry discovered irbm ingredients wp5 wp3 expertise competitveness manufacturing enantioselective drugs college wp7 preparation alcohols reaction intermediates prepare tolterodine ireland benzylic wp4 enantiopure alkoxylation packages active apis ezetimibe medicine serve drug platform expand wp6 routes meet economies biotechnology fluorination divided competition wp2 nagoya japan manufacture continues communication integrated exemplification api rcsi organic royal fluorides wp1 university pharmaceutical synthesis newly training

Project "Halo" data sheet

The following table provides information about the project.

Coordinator	ROYAL COLLEGE OF SURGEONS IN IRELAND Organization address address: Saint Stephen's Green 123 city: DUBLIN postcode: 2 website: www.rcsi.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Ireland [IE]
Total cost	292˙500 €
EC max contribution	292˙500 € (100%)
Programme	1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
Code Call	H2020-MSCA-RISE-2016
Funding Scheme	MSCA-RISE
Starting year	2017
Duration (year-month-day)	from 2017-01-01 to 2020-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ROYAL COLLEGE OF SURGEONS IN IRELAND ROYAL COLLEGE OF SURGEONS IN IRELAND Organization address address: Saint Stephen's Green 123 city: DUBLIN postcode: 2 website: www.rcsi.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (DUBLIN)	coordinator	130˙500.00
2	DESTINA GENOMICA DESTINA GENOMICA Organization address address: AVENIDA DE LA INNOACI0N 1 city: GRANADA postcode: 18100 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (GRANADA)	participant	81˙000.00
3	IRBM SCIENCE PARK SPA IRBM SCIENCE PARK SPA Organization address address: VIA PONTINA KM 30600 city: POMEZIA RM postcode: 40 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (POMEZIA RM)	participant	81˙000.00
4	NAGOYA INSTITUTE OF TECHNOLOGY NAGOYA INSTITUTE OF TECHNOLOGY Organization address address: 29 AZA KIICHI, GOKISO-CHO, SHOWA-KU city: NAGOYA postcode: 466-8555 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	JP (NAGOYA)	partner	0.00

Map

Project objective

The aim of this project is to expand upon a newly discovered platform reaction by developing new routes to Active Pharmaceutical Ingredients (APIs) Tolterodine and Ezetimibe and other advanced intermediates for the manufacture of drugs (i.e. benzylic fluorides and alcohols). It is planned that this platform will serve to enhance the competitveness of the European pharmaceutical manufacturing industry as it continues to face increased competition from other economies

In order to achieve this aim we need to bring together expertise in (i) Organic Synthesis [Royal College of Surgeons in Ireland, “RCSI”] (ii) Enantioselective fluorination [Nagoya University Japan, “Nagoya”] (iii) Drug development and production [Integrated Research in Biotechnology & Medicine, “IRBM”]

To meet the aim we have divided the project into the following work packages: WP1: Development of a new synthesis of Tolterodine. WP2: Scale up of synthesis of Tolterodine. WP3: Development of a new synthesis of Ezetimibe. WP4: Scale up of synthesis of Ezetimibe. WP5: Exemplification of alkoxylation to prepare enantiopure benzylic alcohols API intermediates WP6: Preparation of benzylic fluorides WP7: Management, Training, Dissemination & Communication

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The information about "HALO" are provided by the European Opendata Portal: CORDIS opendata.