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SynchroSelf TERMINATED

Harnessing reversibility of peptide Self-Assembly processes to Synchronise Extracellular Matrix substitutes with cellular driven tissue reconstruction

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 SynchroSelf project word cloud

Explore the words cloud of the SynchroSelf project. It provides you a very rough idea of what is the project "SynchroSelf" about.

scientific    worldwide    relatives    interdisciplinary    substitutes    diverse    diseases    tissues    components    functional    create    advantage    biomaterials    human    community    sciences    biochemistry    area    spectrum    unprecedented    healing    biology    degenerative    solutions    man    patient    perhaps    interactions    placing    extracellular    engineered    millions    restore    native    medicine    smart    consistently    self    cell    designed    vitro    huge    dynamic    matched    cancer    bottlenecks    trauma    copycat    substitute    complexity    systematically    irreversible    made    turnover    people    class    geometrical    mainly    aging    experimental    reversible    fundamental    synchroself    ischemia    life    assembly    care    material    efforts    wound    supramolecular    synchronise    generate    tissue    quality    attempt    spatial    watches    nature    chemistry    controls    ecm    start    function    time    endeavour    organs    pave    burdens    matrix    regenerative    central    health    therapies    materials    peptide    temporarily    scientists   

Project "SynchroSelf" data sheet

The following table provides information about the project.

Coordinator
QUEEN MARY UNIVERSITY OF LONDON 

Organization address
address: 327 MILE END ROAD
city: LONDON
postcode: E1 4NS
website: http://www.qmul.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  0000-00-00

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    QUEEN MARY UNIVERSITY OF LONDON UK (LONDON) coordinator 195˙454.00

Map

 Project objective

Irreversible tissue loss is a common feature in a large spectrum of health conditions (e.g. aging, trauma, cancer, degenerative diseases, ischemia, etc), placing huge burdens in patient relatives and health care systems. Therapies aiming to restore tissue function will have a great impact in the health and quality of life of millions of people worldwide.

Regenerative medicine is an interdisciplinary endeavour to create functional tissues and organs, where cell biology, biochemistry, chemistry and material sciences are central components to address human tissues complexity. The approach comprises the use of biomaterials that temporarily substitute the extracellular matrix (ECM). However, current engineered biomaterials have not fully matched the diverse functionality of native tissues. Thus, fundamental research in biomaterials for regenerative medicine has great potential to provide smart solutions to current bottlenecks in this scientific area.

In this project, biomaterials based on peptide self-assembly will be designed to take advantage of reversible supramolecular interactions, in order to create self-healing ECM substitutes. The dynamic nature of these materials will be addressed systematically in an attempt to copycat ECM turnover. So far, efforts from the materials scientific community have been mainly focused on controlling spatial and geometrical features. Perhaps it is time to start addressing consistently time variable controls in biomaterials design, and to pave the way to fully synchronise the biology and man-made materials’ “watches”. We expect that SynchroSelf will generate a new class of dynamic biomaterials that will enable scientists to study wound healing processes in vitro with unprecedented level of complexity and experimental control.

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The information about "SYNCHROSELF" are provided by the European Opendata Portal: CORDIS opendata.

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