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MetResistance SIGNED

The role of tumour microenvironment in metastatic hormone-refractory prostate cancer

Total Cost €

EC-Contrib. €

Partnership

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MetResistance project word cloud

Explore the words cloud of the MetResistance project. It provides you a very rough idea of what is the project "MetResistance" about.

first patients tumor lineage multidisciplinary marginal models stromal missing transfer medicine preclinical underlying treat outcome lethal dependent mhrpc malignancy men benefit metastatic reporter 95 area cells standards tools innovative deaths significantly metresistance unfortunately androgen societies cancer representing bone threat vivo clinical indicate therapeutics genetic patient model made pathology human therapeutic causing combining mechanisms resistance plan hormone translate adt metastasis progression dynamic molecular tumour prostate designed therapy led mouse microscopy dramatically data microenvironment disease knockout preliminary humanized promotes extensive adoptive refractory standard relieve pc mimics vital care form

Project "MetResistance" data sheet

The following table provides information about the project.

Coordinator	THE UNIVERSITY OF EDINBURGH Organization address address: OLD COLLEGE, SOUTH BRIDGE city: EDINBURGH postcode: EH8 9YL website: www.ed.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	1˙498˙176 €
EC max contribution	1˙498˙176 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2016-STG
Funding Scheme	ERC-STG
Starting year	2017
Duration (year-month-day)	from 2017-04-01 to 2022-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE UNIVERSITY OF EDINBURGH THE UNIVERSITY OF EDINBURGH Organization address address: OLD COLLEGE, SOUTH BRIDGE city: EDINBURGH postcode: EH8 9YL website: www.ed.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (EDINBURGH)	coordinator	1˙498˙176.00

Map

Project objective

The goal of this proposal is to investigate the role of tumor microenvironment in metastatic hormone-refractory prostate cancer (mHRPC). Prostate Cancer (PC) is the most common malignancy in men in Europe while mHRPC is the most lethal form of the disease, causing over 95% of PC related deaths. Extensive clinical and preclinical research using state-of-the-art tumour models has led to the development of several new therapeutics that, unfortunately, provide only marginal patient benefit. One key element missing in standard preclinical models is the relevant metastasis microenvironment associated with mHRPC that may dramatically affect disease outcome. Here, I plan to significantly advance our understanding in mHRPC associated microenvironment with the first androgen dependent PC bone metastasis model I developed that mimics both the pathology and disease progression in patients. My preliminary data indicate that metastasis associated stromal cells may form a unique bone metastasis microenvironment that promotes mHRPC. I aim to identify the underlying molecular mechanisms using a multidisciplinary approach combining intra-vital microscopy, dynamic ADT resistance reporter system, innovative adoptive transfer approach and genetic tools of lineage specific knockout. This work is also designed to translate findings made in mouse models into human disease using innovative humanized in vivo models of mHRPC. The findings generated in this project will lead to innovative therapeutic approaches that can effectively treat mHRPC thus relieve this lethal threat on European societies. MetResistance will make a step change in the field of cancer medicine research by providing new standards to study therapy resistance of metastatic cancer an area representing the number one challenge in cancer research and patient care.

Publications

List of publications.
year	authors and title	journal	last update
2017	Cao J, Liu J, Xu R, Zhu X, Zhao X, Qian BZ Prognostic role of tumour-associated macrophages and macrophage scavenger receptor 1 in prostate cancer: A systematic review and meta-analysis. published pages: , ISSN: 1949-2553, DOI:	Oncotarget	2020-01-27
2018	Wu SQ, Xu R, Li XF, Zhao X, Qian BZ Prognostic roles of tumor associated macrophages in bladder cancer: a system review and meta-analysis. published pages: , ISSN: 1949-2553, DOI:	Oncotarget	2020-01-27
2017	Qian BZ Inflammation fires up cancer metastasis. published pages: , ISSN: 1044-579X, DOI:	Seminars in Cancer Biology	2020-01-27
2017	Laura GÃ³mez-Cuadrado, Natasha Tracey, Ruoyu Ma, Binzhi Qian, Valerie G. Brunton Mouse models of metastasis: progress and prospects published pages: 1061-1074, ISSN: 1754-8403, DOI: 10.1242/dmm.030403	Disease Models & Mechanisms 10/9	2020-01-27

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