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BRECASTEM SIGNED

Functional and Molecular Characterisation of Breast Cancer Stem Cells

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EC-Contrib. €

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Partnership

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 Outcomes and results

 BRECASTEM project word cloud

Explore the words cloud of the BRECASTEM project. It provides you a very rough idea of what is the project "BRECASTEM" about.

tumours    underlying    murine    mouse    impaired    characterise    homeostasis    types    identities    surface    regeneration    lineage    positive    containing    adult    driving    laboratory    event    host    maintenance    receptor    regenerate    luminal    cells    self    functional    puberty    carcinogenesis    pivotal    characterisation    ultimate    strategies    eliminate    leucine    heterogeneous    pregnancy    mutations    undergoes    repeat    capacities    molecular    remodelling    play    stem    caused    transformed    oncogenic    occurring    unknown    unipotent    mammary    cell    hierarchy    contributed    gland    observations    tumour    harbours    dramatically    lgr6    progenitors    transforming    plasticity    coupled    cancer    progenitor    led    deregulation    morphology    phenotypically    differentiation    function    rare    breast    cancers    therapeutic    renewal    mechanisms    incompletely    differences    extensive    organ    population    cellular    injury    proliferative    conversely    tissue    aggressiveness    depletion    consisting    give    protein    postnatally    cscs    every    replication    harbour   

Project "BRECASTEM" data sheet

The following table provides information about the project.

Coordinator		 THE FRANCIS CRICK INSTITUTE LIMITED 

Organization address
address: 1 MIDLAND ROAD
city: LONDON
postcode: NW1 1AT
website: www.crick.ac.uk

contact info
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 Coordinator Country United Kingdom [UK]
 Project website https://www.crick.ac.uk/research/labs/axel-behrens/areas-of-interest/lgr6-marks-a-cancerstem- cell-population-of-luminal-breast-cancer
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2019-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE FRANCIS CRICK INSTITUTE LIMITED UK (LONDON) coordinator 183˙454.00

Map

 Project objective

Every organ harbours adult stem cells which have the potential for long-term replication, together with the capacities of self-renewal and multi-lineage differentiation. These stem cells function in tissue homeostasis and contribute to regeneration in response to injury. In addition, many cancers are caused by transforming mutations occurring in tissue-specific progenitor cells. These transformed stem cells harbour long-term proliferative potential and the ability to regenerate tumours consisting of phenotypically heterogeneous cell types. The identities of cancer stem cells (CSCs) that give rise to breast tumours are incompletely understood.

The mammary gland is composed of a complex cellular hierarchy, which undergoes most of its development postnatally. To achieve this great plasticity, both stem and progenitor cells play a pivotal role in the extensive tissue remodelling occurring during puberty and pregnancy. Deregulation of stem and progenitor cells is a key event in mammary carcinogenesis. Recently, the host laboratory identified a rare unipotent progenitor cell population in the adult murine mammary gland characterized by the surface protein leucine-rich repeat-containing G-protein coupled receptor 6 (Lgr6). Oncogenic mutations in Lgr6-positive cells led to the formation of luminal mammary gland tumours, and contributed to tumour aggressiveness and maintenance. Conversely, depletion of Lgr6-positive progenitors in mouse luminal breast cancer dramatically impaired tumour growth and morphology. However, the underlying molecular mechanisms driving these observations are unknown.

The aim of this project is the characterisation of Lgr6-positive breast cancer stem cells, using functional and molecular approaches. We will characterise the molecular differences between cancer stem cells and non-stem cells, with the ultimate goal of identifying novel therapeutic strategies to eliminate breast cancer stem cells.

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The information about "BRECASTEM" are provided by the European Opendata Portal: CORDIS opendata.

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