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REJUVENATION SIGNED

Repair of Junctional Atrioventricular Conduction and Impulse Formation

Total Cost €

EC-Contrib. €

Partnership

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REJUVENATION project word cloud

Explore the words cloud of the REJUVENATION project. It provides you a very rough idea of what is the project "REJUVENATION" about.

therapies electrical biomaterials bridge patients background nodal full ready ventricular treatments biological nearly repair virtually av constructs cent strategies re atrio refined 20 regulatory compliant annually protect serious meet cells 8 create implantations cots pacing pacemaker therapy complications hardware catheters tracts permanent efforts hipscs block stem billion broaden medtronic final cell cellular substantial ventricle form quality pluripotent reduce requiring pacemakers impulse complication life healthcare optimization human setting restores vitro atrium interface 300 function sheep atrial arrival conduction time thereby patient euros representing clinical hallmark unleash tachycardia vivo invasive bypass tested implanted implantation area

Project "REJUVENATION" data sheet

The following table provides information about the project.

Coordinator	ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM Organization address address: MEIBERGDREEF 15 city: AMSTERDAM postcode: 1105AZ website: www.amc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Total cost	1˙499˙995 €
EC max contribution	1˙499˙995 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2016-STG
Funding Scheme	ERC-STG
Starting year	2017
Duration (year-month-day)	from 2017-04-01 to 2022-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM Organization address address: MEIBERGDREEF 15 city: AMSTERDAM postcode: 1105AZ website: www.amc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	coordinator	1˙499˙995.00

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Project objective

Background: To bypass hardware-related complication there have been substantial efforts to create biological pacemakers. Effective strategies have been identified and are now being refined for delivery of long-term function and clinical application. Yet, currently developed biological pacemakers only provide pacing to atrium or ventricle thereby aiming at ~20% of pacemaker patients. To unleash the full potential of biological pacing, targeting virtually every pacemaker patient, effective repair of atrio-ventricular (AV) conduction is crucial. With the arrival of advanced stem cell-based therapies, now is the time to meet this important challenge.

Objective: To develop a stem cell-based therapy that restores impulse formation and conduction at the interface between atrium and ventricle.

Approach: Human induced pluripotent stem cells (hiPSCs) will be used to produce cells with hallmark features of AV nodal cells. After in vitro testing, these cells will be implanted in vivo (together with biomaterials) to form AV bypass tracts in sheep that are in permanent AV block. In this setting, approaches will be tested for their ability to bridge electrical activity from the atrium to ventricle and protect the ventricle from atrial tachycardia. The final steps of this project focuses on the development of dedicated implantation catheters (in collaboration with Medtronic) and optimization of cellular constructs that are regulatory compliant and ready for clinical testing.

Impact: By developing novel therapies to re-establish AV impulse formation and conduction I will broaden the application area of biological pacing to nearly all patients. In Europe ~300.000 pacemakers are implanted annually representing cots of ~8 billion Euros. Five per cent of these implantations result in serious complications requiring re-implantation or other invasive treatments. Biological pacemakers are expected to reduce these complications, improve quality of life, and reduce healthcare costs.

Publications

List of publications.
year	authors and title	journal	last update
2019	VÃ©gh AMD, den Haan AD, CÃ³cera Ortega L, Verkerk AO, Sluijter JPG, Bakker D, van Amersfoorth S, van Veen TAB, Klerk M, Seppen J, de Bakker JMT, Christoffels VM, Geerts D, Goumans MJTH, Tan HL, Boink GJJ Cardiomyocyte Progenitor Cells as a Functional Gene Delivery Vehicle for Long-Term Biological Pacing published pages: , ISSN: 1420-3049, DOI: 10.3390/molecules24010181	Molecules	2019-10-17
2018	Mohan RA, Mommersteeg MTM, DomÃnguez JN, Choquet C, Wakker V, de Gier-de Vries C, Boink GJJ, Boukens BJ, Miquerol L, Verkerk AO, Christoffels VM Embryonic Tbx3+ cardiomyocytes form the mature cardiac conduction system by progressive fate restriction published pages: , ISSN: 0950-1991, DOI: 10.1242/dev.167361	Development	2019-10-17
2018	Saritha Adepu, Erik Oosterwerff, Vincent Christoffels, Gerard Boink Direct Reprograming to Regenerate Myocardium and Repair Its Pacemaker and Conduction System published pages: 48, ISSN: 2305-6320, DOI: 10.3390/medicines5020048	Medicines 5/2	2019-09-02
2018	Vincent W. W. van Eif, Harsha D. Devalla, Gerard J. J. Boink, Vincent M. Christoffels Transcriptional regulation of theÂ cardiac conduction system published pages: , ISSN: 1759-5002, DOI: 10.1038/s41569-018-0031-y	Nature Reviews Cardiology	2019-09-02

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The information about "REJUVENATION" are provided by the European Opendata Portal: CORDIS opendata.