SARCOM SIGNED
Selection for antimicrobial resistance in a complex community context
Total Cost €
0EC-Contrib. €
0Partnership
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Project "SARCOM" data sheet
The following table provides information about the project.
| Coordinator |
THE UNIVERSITY OF EXETER
Organization address contact info |
| Coordinator Country | United Kingdom [UK] |
| Total cost | 183˙454 € |
| EC max contribution | 183˙454 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2016 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-12-01 to 2019-11-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | THE UNIVERSITY OF EXETER | UK (EXETER) | coordinator | 183˙454.00 |
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Project objective
Increased antibiotic resistance (AMR) in a wide range of human pathogens is a growing public health threat, and the World Health Organization (WHO) forecasts a post-antibiotic era for the 21st century (WHO, 2014). The evolution of AMR in bacteria is determined by both the acquisition of resistance through horizontal gene transfer or chromosomal mutation and by the way resistance affects the competitive ability of a microbe in the presence and absence of antibiotics.
The majority of research on selection for AMR to date has focused on detailed in vitro studies of selection for AMR in specific bacterial clones. More significantly, no studies to date have explicitly investigated the implication of being embedded in a complex community for the evolution of AMR. Therefore, in the proposed research I aim to use a multidisciplinary approach by for the first time combining the precision of in vitro experimental evolution experiments with the high resolution of molecular biology to study the evolution and spread of AMR in complex community contexts.
The proposed project will allow me to complement my strong background in molecular biology and microbial ecology with evolutionary microbiology and novel bioinformatic approaches. Being situated in one of the most prominent microbial ecology and evolution laboratories worldwide, based at the Biosciences Department at the University of Exeter will be crucial for my personal development in becoming an independent European researcher. The University of Exeter provides an EU accredited program for academic training and personal career development.
The proposed research will moreover provide ample opportunities to instigate and be involved in internal and international collaboration with world-leading researchers in diverse research fields. Furthermore, I aim to raise public awareness to the threat AMR bacteria possess to human health and involve the public in mitigation strategies to avoid the spread of AMR genes.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Michiel Vos, Louise Sibleyras, Lai Ka Lo, Elze Hesse, William H Gaze, Uli Klümper Zinc can counteract selection for ciprofloxacin resistance published pages: 780981, ISSN: , DOI: |
bioRxiv | 2020-02-05 |
| 2018 |
Maria Arias-Andres, Uli Klümper, Keilor Rojas-Jimenez, Hans-Peter Grossart Microplastic pollution increases gene exchange in aquatic ecosystems published pages: 253-261, ISSN: 0269-7491, DOI: 10.1016/j.envpol.2018.02.058 |
Environmental Pollution 237 | 2020-02-05 |
| 2019 |
Uli Klümper, Mario Recker, Lihong Zhang, Xiaole Yin, Tong Zhang, Angus Buckling, William H. Gaze Selection for antimicrobial resistance is reduced when embedded in a natural microbial community published pages: 2927-2937, ISSN: 1751-7362, DOI: 10.1038/s41396-019-0483-z |
The ISME Journal 13/12 | 2020-02-05 |
| 2019 |
Uli Klümper, Arnaud Maillard, Elze Hesse, Florian Bayer, Stineke van Houte, Ben Longdon, Will Gaze, Angus Buckling Short-term evolution under copper stress increases probability of plasmid uptake published pages: 610873, ISSN: , DOI: |
bioRxiv | 2020-02-05 |
| 2019 |
Matthias C. Rillig, Anderson Abel de Souza Machado, Anika Lehmann, Uli Klümper Evolutionary implications of microplastics for soil biota published pages: 3, ISSN: 1448-2517, DOI: 10.1071/en18118 |
Environmental Chemistry 16/1 | 2020-02-05 |
| 2019 |
Zongbao Liu, Uli Klümper, Yang Liu, Yuchun Yang, Qiaoyan Wei, Jih-Gaw Lin, Ji-Dong Gu, Meng Li Metagenomic and metatranscriptomic analyses reveal activity and hosts of antibiotic resistance genes in activated sludge published pages: 208-220, ISSN: 0160-4120, DOI: 10.1016/j.envint.2019.05.036 |
Environment International 129 | 2020-02-05 |
| 2018 |
Kornelia Smalla, Kimberly Cook, Steven P Djordjevic, Uli Klümper, Michael Gillings Environmental dimensions of antibiotic resistance: assessment of basic science gaps published pages: , ISSN: 1574-6941, DOI: 10.1093/femsec/fiy195 |
FEMS Microbiology Ecology 94/12 | 2020-02-05 |
| 2019 |
Zongbao Liu, Uli Klümper, Lei Shi, Lei Ye, Meng Li From Pig Breeding Environment to Subsequently Produced Pork: Comparative Analysis of Antibiotic Resistance Genes and Bacterial Community Composition published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2019.00043 |
Frontiers in Microbiology 10 | 2020-02-05 |
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