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LTPAM SIGNED

Low Temperature Plasma for Applications in Medicine

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

LTPAM project word cloud

Explore the words cloud of the LTPAM project. It provides you a very rough idea of what is the project "LTPAM" about.

resistant media chemical milieu generate air nuclear quantitative spectroscopy deeper atmospheric temperature aid chemicals rf cl magnetic fail cytotoxicity jet labelled onoo ion viral world progression burgeoning ambient mass direct molecular vast focussed biological lack tissue initial pressure precursors chemistries water antibiotic therapies isotopically reactive bio chromatography ionic created bacterial physical chemistry molecules anti sources resembling gas cancer abundant biomedical resonance liquids variety bacteria spectrometry goals structures diverse reacting responsible electron paramagnetic radical plasmas aerosols diagnostics generation utilise exposure plasma models clinical enhancement ltp lived identification biologically gels mimicking radicals emerged vivo influences standardise secondary employing species

Project "LTPAM" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITEIT ANTWERPEN Organization address address: PRINSSTRAAT 13 city: ANTWERPEN postcode: 2000 website: www.ua.ac.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Belgium [BE]
Total cost	172˙800 €
EC max contribution	172˙800 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-05-01 to 2019-04-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITEIT ANTWERPEN UNIVERSITEIT ANTWERPEN Organization address address: PRINSSTRAAT 13 city: ANTWERPEN postcode: 2000 website: www.ua.ac.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (ANTWERPEN)	coordinator	172˙800.00

Map

Project objective

Atmospheric pressure low temperature plasma (LTP) is a burgeoning field due to its vast potential in biomedical applications. Reacting with ambient air, these plasmas generate a variety of molecular, ionic and radical species, responsible for the anti-bacterial, anti-viral and anti-cancer properties of LTP. It is especially important when more traditional therapies fail, such as antibiotic-resistant bacteria. Recently, a large number of studies of the biological effects of LTP emerged, as well as diagnostics of the gas phase LTP, and various models. However, the chemical and physical processes in biologically relevant media still lack detailed understanding. Water is an essential part of the bio-milieu, and both initial and secondary LTP-induced chemistries in liquids require deeper studies. This project will aim at several goals, which will aid the progression of LTP towards wide and diverse clinical use. 1) It will utilise the RF COST plasma jet (created to standardise the LTP research in Europe and the world). The sources of the reactive species induced by the jet will be studied by employing isotopically labelled molecules. 2) The plasma-induced chemistry will be studied in conditions mimicking those in vivo: (i) generation of secondary species from Cl-, one of the most abundant chemicals in bio-media, and assessment of their cytotoxicity; and (ii) quantitative identification of short-lived reactive species (radicals) created by LTP in gels, structures resembling tissue (this is especially important in the case of direct plasma exposure where radical chemistry greatly influences processes in liquids). 3) The enhancement of LTP effects will be studied via generation of ONOO- from its precursors in plasmas with aerosols. The work will be focussed on liquids’ analysis by electron paramagnetic resonance and nuclear magnetic resonance spectroscopy, mass spectrometry, ion chromatography, etc.

Publications

List of publications.
year	authors and title	journal	last update
2019	Abraham Lin, Yury Gorbanev, Joey De Backer, Jinthe Van Loenhout, Wilma Van Boxem, Filip LemiÃ¨re, Paul Cos, Sylvia Dewilde, Evelien Smits, Annemie Bogaerts Non-Thermal Plasma as a Unique Delivery System of Short-Lived Reactive Oxygen and Nitrogen Species for Immunogenic Cell Death in Melanoma Cells published pages: 1802062, ISSN: 2198-3844, DOI: 10.1002/advs.201802062	Advanced Science	2019-04-25
2019	Yury Gorbanev, Jonas Van der Paal, Wilma Van Boxem, Sylvia Dewilde, Annemie Bogaerts Reaction of chloride anion with atomic oxygen in aqueous solutions: can cold plasma help in chemistry research? published pages: 4117-4121, ISSN: 1463-9076, DOI: 10.1039/c8cp07550f	Physical Chemistry Chemical Physics 21/8	2019-04-25
2018	Y. Gorbanev, C. C. W. Verlackt, S. Tinck, E. Tuenter, K. Foubert, P. Cos, A. Bogaerts Combining experimental and modelling approaches to study the sources of reactive species induced in water by the COST RF plasma jet published pages: 2797-2808, ISSN: 1463-9076, DOI: 10.1039/c7cp07616a	Physical Chemistry Chemical Physics 20/4	2019-04-25
2018	Eveline Torfs, Jure Vajs, MaÃra Bidart de Macedo, Freya Cools, Bieke Vanhoutte, Yury Gorbanev, Annemie Bogaerts, Luc Verschaeve, Guy Caljon, Louis Maes, Peter Delputte, Paul Cos, Janez KoÅ¡mrlj, Davie Cappoen Synthesis and in vitro investigation of halogenated 1,3-bis(4-nitrophenyl)triazenide salts as antitubercular compounds published pages: 631-640, ISSN: 1747-0277, DOI: 10.1111/cbdd.13087	Chemical Biology & Drug Design 91/2	2019-04-25
2017	Wilma Van Boxem, Jonas Van der Paal, Yury Gorbanev, Steven Vanuytsel, Evelien Smits, Sylvia Dewilde, Annemie Bogaerts Anti-cancer capacity of plasma-treated PBS: effect of chemical composition on cancer cell cytotoxicity published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-16758-8	Scientific Reports 7/1	2019-04-25
2018	Dominique Mannaerts, Ellen Faes, Paul Cos, Jacob J. BriedÃ©, Wilfried Gyselaers, Jerome Cornette, Yury Gorbanev, Annemie Bogaerts, Marc Spaanderman, Emeline Van Craenenbroeck, Yves Jacquemyn Oxidative stress in healthy pregnancy and preeclampsia is linked to chronic inflammation, iron status and vascular function published pages: e0202919, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0202919	PLOS ONE 13/9	2019-04-25
2018	Fatemeh Rezaei, Yury Gorbanev, Michael Chys, Anton Nikiforov, Stijn W. H. Van Hulle, Paul Cos, Annemie Bogaerts, Nathalie De Geyter Investigation of plasma-induced chemistry in organic solutions for enhanced electrospun PLA nanofibers published pages: 1700226, ISSN: 1612-8850, DOI: 10.1002/ppap.201700226	Plasma Processes and Polymers 15/6	2019-04-25
2019	Yury Gorbanev, Annemie Bogaerts Chemical Detection of Short-Lived Species Induced in Aqueous Media by Atmospheric Pressure Plasma published pages: , ISSN: , DOI:	Atmospheric Pressure Plasma	2019-04-25
2018	Yury Gorbanev, Angela Privat-Maldonado, Annemie Bogaerts Analysis of Short-Lived Reactive Species in Plasmaâ€“Airâ€“Water Systems: The Dos and the Do Nots published pages: 13151-13158, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.8b03336	Analytical Chemistry 90/22	2019-04-25
2018	Angela Privat-Maldonado, Yury Gorbanev, Sylvia Dewilde, Evelien Smits, Annemie Bogaerts Reduction of Human Glioblastoma Spheroids Using Cold Atmospheric Plasma: The Combined Effect of Short- and Long-Lived Reactive Species published pages: 394, ISSN: 2072-6694, DOI: 10.3390/cancers10110394	Cancers 10/11	2019-04-25
2018	Abraham Lin, Yury Gorbanev, Paul Cos, Evelien Smits, Annemie Bogaerts Plasma Elicits Immunogenic Death In Melanoma Cells published pages: 9, ISSN: 2212-8166, DOI: 10.1016/j.cpme.2017.12.013	Clinical Plasma Medicine 9	2019-04-25

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