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ResistEpist SIGNED

Dissection of the mechanisms causing the epistasis between antibiotic resistance mutations in Escherichia coli

Total Cost €

EC-Contrib. €

Partnership

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ResistEpist project word cloud

Explore the words cloud of the ResistEpist project. It provides you a very rough idea of what is the project "ResistEpist" about.

threat mutations nature resistance resistant imbalance proteostasis acquisition interactions causes epistatic infections single counteract additional biosynthesis certain combination genes bacterial resistances instability favouring acquiring understand double bacteria coli underlying decreased impair epistasis multiple mutation treatments mutants alleles antibiotic genomic action antibiotics preliminary alleviation phenotypes mutated health absence fitness escherichia usually existence public biological suggest mechanisms

Project "ResistEpist" data sheet

The following table provides information about the project.

Coordinator	FUNDACAO CALOUSTE GULBENKIAN Organization address address: AVENIDA BERNA 45 city: LISBOA postcode: 1000 website: www.igc.gulbenkian.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Portugal [PT]
Total cost	148˙635 €
EC max contribution	148˙635 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-RI
Starting year	2018
Duration (year-month-day)	from 2018-12-01 to 2021-02-01

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	FUNDACAO CALOUSTE GULBENKIAN FUNDACAO CALOUSTE GULBENKIAN Organization address address: AVENIDA BERNA 45 city: LISBOA postcode: 1000 website: www.igc.gulbenkian.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (LISBOA)	coordinator	148˙635.00

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Project objective

Antibiotic resistance is a major threat to public health. Bacteria can become resistant by acquiring genes that counteract the action of antibiotics or by mutation of their targets. These targets are usually involved in essential processes and typically resistance mutations can impair bacterial growth in absence of antibiotics. However, combination of certain mutated alleles can result in an alleviation of this cost, thus favouring the acquisition of multiple resistances. This project aims to understand the mechanisms underlying the epistasis between resistance mutations. Decreased biosynthesis has been considered the main cause of the fitness cost associated to antibiotic resistance mutations. However, our preliminary results suggest the existence of additional causes, such as genomic instability or proteostasis imbalance. The study of these phenotypes in single and double resistant mutants of Escherichia coli will allow us to determine the nature of these epistatic interactions, as well as further understanding essential biological processes, and will provide information for the development of new treatments against multi-resistant infections.

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The information about "RESISTEPIST" are provided by the European Opendata Portal: CORDIS opendata.